LOCUS       NM_002785               1532 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pregnancy specific beta-1-glycoprotein 11 (PSG11),
            transcript variant 1, mRNA.
ACCESSION   NM_002785
VERSION     NM_002785.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1532)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1532)
  AUTHORS   Zhao,L., Triche,E.W., Walsh,K.M., Bracken,M.B., Saftlas,A.F.,
            Hoh,J. and Dewan,A.T.
  TITLE     Genome-wide association study identifies a maternal copy-number
            deletion in PSG11 enriched among preeclampsia patients
  JOURNAL   BMC Pregnancy Childbirth 12, 61 (2012)
   PUBMED   22748001
  REMARK    GeneRIF: recurrent deletions that may confer risk for preeclampsia
            include a potentially functionally important copy-number deletion
            in the PSG11 gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1532)
  AUTHORS   Teglund,S., Zhou,G.Q. and Hammarstrom,S.
  TITLE     Characterization of cDNA encoding novel pregnancy-specific
            glycoprotein variants
  JOURNAL   Biochem Biophys Res Commun 211 (2), 656-664 (1995)
   PUBMED   7794280
REFERENCE   4  (bases 1 to 1532)
  AUTHORS   Olsen,A., Teglund,S., Nelson,D., Gordon,L., Copeland,A.,
            Georgescu,A., Carrano,A. and Hammarstrom,S.
  TITLE     Gene organization of the pregnancy-specific glycoprotein region on
            human chromosome 19: assembly and analysis of a 700-kb cosmid
            contig spanning the region
  JOURNAL   Genomics 23 (3), 659-668 (1994)
   PUBMED   7851895
REFERENCE   5  (bases 1 to 1532)
  AUTHORS   Plouzek,C.A., Watanabe,S. and Chou,J.Y.
  TITLE     Cloning and expression of a new pregnancy-specific beta
            1-glycoprotein member
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1532-1538 (1991)
   PUBMED   1840485
REFERENCE   6  (bases 1 to 1532)
  AUTHORS   Thompson,J., Koumari,R., Wagner,K., Barnert,S., Schleussner,C.,
            Schrewe,H., Zimmermann,W., Muller,G., Schempp,W., Zaninetta,D. et
            al.
  TITLE     The human pregnancy-specific glycoprotein genes are tightly linked
            on the long arm of chromosome 19 and are coordinately expressed
  JOURNAL   Biochem Biophys Res Commun 167 (2), 848-859 (1990)
   PUBMED   1690992
  REMARK    Erratum:[Biochem Biophys Res Commun 1990 May 16;168(3):1325]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG619770.1, BF084984.1, BC020711.1, R66665.1, BE767872.1 and
            AC005947.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002785.2.
            
            Summary: The human pregnancy-specific glycoproteins (PSGs) are a
            group of molecules that are mainly produced by the placental
            syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of
            the carcinoembryonic antigen (CEA) family, which belongs to the
            immunoglobulin superfamily. For additional general information
            about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM,
            Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M69245.1, ERR279852.575.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000320078.12/
                                                ENSP00000319140.7
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               BG619770.1         12-353
            343-553             BF084984.1         165-375
            554-886             BC020711.1         188-520
            887-1004            R66665.1           245-362
            1005-1191           BE767872.1         118-304
            1192-1531           AC005947.1         28634-28973         c
            1532-1532           AC005947.1         28633-28633         c
FEATURES             Location/Qualifiers
     source          1..1532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1532
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /note="pregnancy specific beta-1-glycoprotein 11"
                     /db_xref="GeneID:5680"
                     /db_xref="HGNC:HGNC:9516"
                     /db_xref="MIM:176401"
     exon            1..161
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1105
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PS-beta-G-11; PS-beta-G-13; pregnancy-specific
                     beta-1-glycoprotein 13"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 11
                     isoform 1 precursor"
                     /protein_id="NP_002776.3"
                     /db_xref="CCDS:CCDS12614.2"
                     /db_xref="GeneID:5680"
                     /db_xref="HGNC:HGNC:9516"
                     /db_xref="MIM:176401"
                     /translation="MGPLSAPPCTEHIKWKGLLLTALLLNFWNLPTTAQVMIEAQPPK
                     VSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETVY
                     SNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTGYFTFTLYLETPKPSISSSNLNPRE
                     AMETVILTCNPETPDASYLWWMNGQSLPMTHRMQLSETNRTLFLFGVTKYTAGPYECE
                     IWNSGSASRSDPVTLNLLHGPDLPRIFPSVTSYYSGENLDLSCFANSNPPAQYSWTIN
                     GKFQLSGQKLFIPQITPKHNGLYACSARNSATGEESSTSLTIRVIAPPGLGTFAFNNP
                     T"
     exon            162..527
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /inference="alignment:Splign:2.1.0"
     exon            528..806
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1061
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1145
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1532
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1509..1514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /note="hexamer: AATAAA"
     polyA_site      1532
                     /gene="PSG11"
                     /gene_synonym="PSBG-11; PSBG-13; PSG13; PSG14"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagga aggacagcac agctgacagc cgtgctctgg aagcttctgg atcctaggct
       61 catctccaca gaggagaaca tgcacgcagc agagatcatg gggcccctct cagcccctcc
      121 ctgcacagag cacatcaaat ggaaggggct cctgctcaca gcattacttt taaacttctg
      181 gaacttgcct accactgccc aagtcatgat tgaagcccag ccacccaaag tgtccgaggg
      241 gaaggatgtt cttctacttg tccacaattt gccccagaat cttactggct acatctggta
      301 caaagggcaa atcagggacc tctaccatta cattacatca tatgtagtag acggtcaaat
      361 aattatatat ggaccggcat acagtggacg agaaacagta tattccaatg catccctgct
      421 gatccagaat gtcacccggg aggacgcagg atcctacacc ttacacatca taaagcgagg
      481 tgatgggact agaggagtaa ctggatattt caccttcacc ttatacctgg agactcccaa
      541 gccctccatc tccagcagca acttaaaccc cagggaggcc atggagactg tgatcttaac
      601 ctgtaatcct gagactccgg acgcaagcta cctgtggtgg atgaatggtc agagcctccc
      661 tatgactcat aggatgcagc tgtctgaaac caacaggacc ctctttctat ttggtgtcac
      721 aaagtatact gcaggaccct atgaatgtga aatatggaac tcagggagtg ccagccgcag
      781 tgacccagtc accctgaatc tcctccatgg tccagacctc cccagaattt tcccttcagt
      841 cacctcttac tattcaggag agaacctcga cttgtcctgc ttcgcaaact ctaacccacc
      901 agcacagtat tcttggacaa ttaatgggaa gtttcagcta tcaggacaaa agctctttat
      961 ccctcagatt actccaaagc ataatgggct ctatgcttgc tctgctcgta actcagccac
     1021 tggcgaggaa agctccacat ccttgacaat cagagtcatt gctcctccag gattaggaac
     1081 ttttgctttc aataatccaa cgtagcagcc gtgatgtcat ttttgtattt caggaagact
     1141 ggcaggagat ttatggaaaa gactatgaaa aggactcttg aatacaagtt cctgataact
     1201 tcaagatcat accactggac taagaacttt caaaattttg atgaacaggc tgataccttc
     1261 atgaaattca agacaaagaa gaaaagaact ccatttcatt ggactaaata acaaaaggat
     1321 aatgttttca taatttttta ttggaaaatg tgctgatttt ttgaatgttt tatcctccag
     1381 atttatgaat ttttttcttc agcaattggt aaagtatact tttgtaaaca aaaattgaaa
     1441 catttgcttt tgctctctga gtgccccaga attgggaatc tattcatgaa tattcatatg
     1501 tttatggtaa taaagttatt tgcacaagtt ta
//
