LOCUS       NM_012455              11342 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pleckstrin and Sec7 domain containing 4 (PSD4), mRNA.
ACCESSION   NM_012455
VERSION     NM_012455.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11342)
  AUTHORS   Zhang,X., Hu,Y., Pan,Y., Xiong,Y., Zhang,Y., Han,M., Dong,K.,
            Song,J., Liang,H., Ding,Z., Zhang,X., Zhu,H., Liu,Q., Lu,X.,
            Feng,Y., Chen,X., Zhang,Z. and Zhang,B.
  TITLE     DDR1 promotes hepatocellular carcinoma metastasis through
            recruiting PSD4 to ARF6
  JOURNAL   Oncogene 41 (12), 1821-1834 (2022)
   PUBMED   35140331
  REMARK    GeneRIF: DDR1 promotes hepatocellular carcinoma metastasis through
            recruiting PSD4 to ARF6.
REFERENCE   2  (bases 1 to 11342)
  AUTHORS   Shi,J., Song,S., Li,S., Zhang,K., Lan,Y. and Li,Y.
  TITLE     TNF-alpha/NF-kappaB signaling epigenetically represses PSD4
            transcription to promote alcohol-related hepatocellular carcinoma
            progression
  JOURNAL   Cancer Med 10 (10), 3346-3357 (2021)
   PUBMED   33932127
  REMARK    GeneRIF: TNF-alpha/NF-kappaB signaling epigenetically represses
            PSD4 transcription to promote alcohol-related hepatocellular
            carcinoma progression.
REFERENCE   3  (bases 1 to 11342)
  AUTHORS   Fayad,R., Rojas,M.V., Partisani,M., Finetti,P., Dib,S.,
            Abelanet,S., Virolle,V., Farina,A., Cabaud,O., Lopez,M.,
            Birnbaum,D., Bertucci,F., Franco,M. and Luton,F.
  TITLE     EFA6B regulates a stop signal for collective invasion in breast
            cancer
  JOURNAL   Nat Commun 12 (1), 2198 (2021)
   PUBMED   33850160
  REMARK    GeneRIF: EFA6B regulates a stop signal for collective invasion in
            breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11342)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 11342)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 11342)
  AUTHORS   Ueda,T., Hanai,A., Takei,T., Kubo,K., Ohgi,M., Sakagami,H.,
            Takahashi,S., Shin,H.W. and Nakayama,K.
  TITLE     EFA6 activates Arf6 and participates in its targeting to the
            Flemming body during cytokinesis
  JOURNAL   FEBS Lett 587 (11), 1617-1623 (2013)
   PUBMED   23603394
REFERENCE   7  (bases 1 to 11342)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 11342)
  AUTHORS   Morishige,M., Hashimoto,S., Ogawa,E., Toda,Y., Kotani,H.,
            Hirose,M., Wei,S., Hashimoto,A., Yamada,A., Yano,H., Mazaki,Y.,
            Kodama,H., Nio,Y., Manabe,T., Wada,H., Kobayashi,H. and Sabe,H.
  TITLE     GEP100 links epidermal growth factor receptor signalling to Arf6
            activation to induce breast cancer invasion
  JOURNAL   Nat Cell Biol 10 (1), 85-92 (2008)
   PUBMED   18084281
REFERENCE   9  (bases 1 to 11342)
  AUTHORS   Derrien,V., Couillault,C., Franco,M., Martineau,S.,
            Montcourrier,P., Houlgatte,R. and Chavrier,P.
  TITLE     A conserved C-terminal domain of EFA6-family ARF6-guanine
            nucleotide exchange factors induces lengthening of microvilli-like
            membrane protrusions
  JOURNAL   J Cell Sci 115 (Pt 14), 2867-2879 (2002)
   PUBMED   12082148
REFERENCE   10 (bases 1 to 11342)
  AUTHORS   Jackson,T.R., Kearns,B.G. and Theibert,A.B.
  TITLE     Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf
            signaling
  JOURNAL   Trends Biochem Sci 25 (10), 489-495 (2000)
   PUBMED   11050434
  REMARK    GeneRIF: One of the cytohesin family of guanine nucleotide exchange
            factors, Tic may act on the ARF family of GTP-binding proteins.  A
            PH domain with similar sequence and relative position to those in
            other cytohesins may allow association with phosphoinositides.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016683.7.
            
            On May 17, 2019 this sequence version replaced NM_012455.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073151.1, AK290045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245796.11/ ENSP00000245796.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC016683.7         11228-11311
            85-1251             AC016683.7         19603-20769
            1252-1368           AC016683.7         22214-22330
            1369-1444           AC016683.7         22622-22697
            1445-1823           AC016683.7         23134-23512
            1824-2033           AC016683.7         29637-29846
            2034-2114           AC016683.7         30305-30385
            2115-2227           AC016683.7         30515-30627
            2228-2286           AC016683.7         30849-30907
            2287-2376           AC016683.7         31116-31205
            2377-2420           AC016683.7         32984-33027
            2421-2581           AC016683.7         33404-33564
            2582-2652           AC016683.7         34821-34891
            2653-2819           AC016683.7         35004-35170
            2820-2964           AC016683.7         35997-36141
            2965-3108           AC016683.7         36340-36483
            3109-11342          AC016683.7         38415-46648
FEATURES             Location/Qualifiers
     source          1..11342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..11342
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="pleckstrin and Sec7 domain containing 4"
                     /db_xref="GeneID:23550"
                     /db_xref="HGNC:HGNC:19096"
                     /db_xref="MIM:614442"
     exon            1..84
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1251
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..3366
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="SEC7 homolog; ADP-ribosylation factor guanine
                     nucleotide-exchange factor 6; telomeric of interleukin-1
                     cluster protein; pleckstrin homology and SEC7
                     domain-containing protein 4; exchange factor for
                     ADP-ribosylation factor guanine nucleotide factor 6B;
                     exchange factor for ARF6 B; exchange factor for
                     ADP-ribosylation factor guanine nucleotide factor 6 B"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 4"
                     /protein_id="NP_036587.2"
                     /db_xref="CCDS:CCDS33276.1"
                     /db_xref="GeneID:23550"
                     /db_xref="HGNC:HGNC:19096"
                     /db_xref="MIM:614442"
                     /translation="MMGDYRLPDHPQPMEILNLYLGDSLEPHPGECPRETCSHEDPPE
                     PFEEQTWATDPPEPTRQNVPPWGSGVELTHLGSWVHQDGLEPCQEQTRATDPPESTRQ
                     DAPPWGSGVELTHLGSPSAQREHRQNTASPGSPVNSHLPGSPKQNRSTSTQVVFWAGI
                     LQAQMCVLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTGLHSSPPENEDSGEDSSEP
                     EGEGQAWLREGTPDSSPQWGAEEESMFFSNPLFLASPCSENSASGECFSWGASDSHAG
                     VRTGPESPATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKPHSICWAS
                     VAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWA
                     SLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPE
                     SESRGPGPRPSPASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEA
                     GEAPKPGEEVKSEGTARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSP
                     EEGQRPPAGDKLANGVRNNKVAWNLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEY
                     LSFFQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNPGIFPSVDSVHT
                     LTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEW
                     AVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQDADGKKTPW
                     GKRGWKMFHTLLRGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKK
                     PHVFQLRTADWRLYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRRFVRPIL
                     PVGPAQSSLEEQHRSHENCLDAAADDLLDLQRNLPERRGRGRELEEHRLRKEYLEYEK
                     TRYETYVQLLVARLHCPSDALDLWEEQLGREAGGTREPKLSLKKSHSSPSLHQDEAPT
                     TAKVKRNISERRTYRKIIPKRNRNQL"
     exon            1252..1368
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1444
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1823
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2033
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2114
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2227
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2286
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2376
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2420
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2581
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2652
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2819
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2964
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3108
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..11342
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4846..4851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="hexamer: AATAAA"
     polyA_site      4868
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="major polyA site"
     regulatory      5156..5161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="hexamer: ATTAAA"
     polyA_site      5177
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="major polyA site"
     regulatory      7704..7709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="hexamer: AATACA"
     polyA_site      7721
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
     regulatory      11322..11327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
                     /note="hexamer: AATAAA"
     polyA_site      11342
                     /gene="PSD4"
                     /gene_synonym="EFA6B; TIC"
ORIGIN      
        1 acattcactg ggcaagccga ctgtgagcca ggaagtgctc ttggggagcc caggccaagc
       61 catccattct tgggtccttt ggagggtaga tatggattcc cagtttctcc agcggccagt
      121 gctcccccta gtccacacag tgagaccgtg aaagcagatg ctccggggca ctcctgggca
      181 gcttttgctc agtggatgat gggtgactac agactccctg accaccccca gcccatggaa
      241 attctcaacc tgtacttggg agacagcctg gagccccacc caggagagtg cccaagggaa
      301 acgtgcagcc atgaggatcc accggagcct ttcgaggagc aaacctgggc cactgaccct
      361 cctgaaccta ccagacaaaa tgttcctccc tggggctccg gtgtggagct cacacacctg
      421 gggagctggg tccatcagga cgggctggag ccttgccagg agcaaacccg ggccactgac
      481 cctcctgaat ctaccagaca agatgctcct ccctggggct ccggtgtgga gctcacacac
      541 ctggggagcc cctctgccca gagggagcac aggcagaaca cagcatcacc agggtcacca
      601 gtgaacagcc atctaccggg gagcccaaag cagaaccgga gcacgtccac acaggtagtg
      661 ttctgggcag gcatcctgca ggcccagatg tgtgtcctag acctggagga ggagctggag
      721 aagacggaag ggctcaaggc tgggctgaaa tgctgtctcc ccacgccccc tgtggacctc
      781 cccggggaca cgggcctgca ctccagccca cctgagaatg aagactcagg ggaagacagc
      841 agtgagcctg agggagaggg ccaggcatgg ctgagagagg gaaccccaga ctcttcccca
      901 cagtggggag ctgaggagga gagcatgttc ttcagcaacc ccctcttcct ggcgagtcct
      961 tgctcagaga acagtgcttc tggagagtgc ttttcctggg gggcttcaga ctcccatgca
     1021 ggtgtgagga ctggacctga gagcccagcg actctggagc ctcccctccc agaagacaca
     1081 gtgctgtggg agctggaaag tgagccagat ttgggggacg gcgctgctat cagtgggcat
     1141 tgtacccctc cattccctgt gcccatctat aaaccacact ccatctgctg ggcctcagtg
     1201 gctgccgctg agggggctcc tgcagcacct cctggtcacg gggagagtga gggagatagg
     1261 cttggtcctg ctccatctgc agcaccgtgt gtggacgaag cattgacctg ggaatcagga
     1321 tgtgtcggat ctgatcttgg ccctgctgca catcctgtgc aaccttgggc ctctctcagc
     1381 cctgagggct ggcagagagg aggtcctttt tggccccagg tgactcttaa ctcccaggac
     1441 agagatgaga gggagggtgg acacccccag gaatctcttc cctgcacctt ggccccctgc
     1501 ccctggagga gcccagcttc ttctccagag cctagcagcc cagaatctga gagcagaggc
     1561 cctggtccca ggcccagccc tgcatcgtcc caggagggca gcccgcagct tcaacaccac
     1621 agctcaggca ttttgcccaa gtggacacta gatgcttcac agtcttcact cttggagacg
     1681 gatggggaac agccaagttc cttgaagaaa aaggaggcag gggaggcccc aaaaccaggc
     1741 gaggaagtaa agagtgaagg aacagccagg cctgcagaga ctggagacgt ccagcctgac
     1801 attcacctga cttctgcaga acatgagaat ctgaggacac cgatgaactc ttcttggctt
     1861 cctgggagcc ctatgcccca agcacagtcc ccagaggaag gccagagacc accagctgga
     1921 gacaagctag ctaatggcgt caggaacaac aaggtagcct ggaacttggc ctcacgcctc
     1981 tatcgcctgg agggcttccg gaagtctgaa gtggctgcct acctgcagaa gaacaatgac
     2041 tttagcaggg ctgtggctga ggagtacctg tccttcttcc agtttggagg ccagagtctg
     2101 gaccgagccc tccggagctt cctccaggcc ttggtgctca gtggggagac tcaggaacgg
     2161 gagcgaatcc tctaccagtt ctccagacgc ttccaccatt gcaatccggg gatcttcccc
     2221 tcagtagatt ctgtacacac cttgacatgt gcaatcatgc tgcttaacac ggacctgcat
     2281 ggacagaaca ttgggaagag catgagctgc caggaattca taaccaacct gaatgggctg
     2341 agggatggcg ggaacttccc caaggagctg ctgaaggccc tctactggtc tatccgcagc
     2401 gagaagctcg agtgggccgt ggatgaagaa gacacagcca gacctgagaa ggcccagccg
     2461 tccctgccag ctggcaagat gagcaagccc ttccttcagc tggctcagga tcccacagtg
     2521 cccacctaca agcagggcat cctggctcgg aaaatgcatc aagatgcaga cggcaagaag
     2581 acgccatggg gcaagcgtgg ctggaagatg ttccacacct tactgcgagg gatggttctc
     2641 tacttcctga agcagggaga agaccactgt ctggaggggg agagcttggt ggggcagatg
     2701 gtggatgagc ccgtgggggt gcaccactcg ctggccaccc ccgccacgca ttacaccaag
     2761 aagccgcacg tcttccagct gcgcacggct gactggcgcc tctacctctt ccaggcaccc
     2821 actgccaagg agatgagctc ctggatcgcg cgcatcaact tggctgcggc cacgcactcc
     2881 gcgccgccct tccccgccgc tgtgggctcc cagcgcagat tcgtgcggcc catcctgccc
     2941 gtgggccccg cccagagctc cctggaggag cagcatcgat cccacgagaa ctgcctggac
     3001 gctgccgcgg acgacctgct ggatctacag aggaacctgc cggagcggcg gggccgtggc
     3061 cgcgagctgg aggagcaccg cctgcggaag gagtacctgg agtacgagaa aacccgctac
     3121 gagacctacg tgcagctgct ggtggcccgc ctgcactgcc cctctgatgc tctggacctg
     3181 tgggaggagc agctggggag ggaagctgga ggcactcggg agcccaagct cagcctgaag
     3241 aagtcccact cgagcccgtc cctgcaccag gatgaggctc ccaccacggc caaggtgaag
     3301 cgcaacatct cagagcgcag aacctaccgg aagatcatcc ctaagcggaa ccgcaatcag
     3361 ctgtgaagcc agcaccacct cagagacact gttccctgct ccagggtaga cctgagatga
     3421 acctccctgg aggagactta tttcaatgag tccaccatga cggatgaggc acctcctttc
     3481 cctgctgaag gacaaacctt gtttccctgt ggccctcatt cttgtgctcc ctgaagcttt
     3541 cctaatattg ctgtgctccc caccaccccc atggcagtcc ctccgcagcc ccagtccctg
     3601 gccacgccca agggaagagg gaggtgagga cttgactttc ctcccagagc tcagcccatg
     3661 tcaccctcca ggccccagaa tccagagtgg cctcatttcc tagacttgct gagaactcag
     3721 cacttgtttg agaaccagtg cttatgtggt gtgcccttgg cttctggggg agagcttggg
     3781 gcagcagagg cccctgggca gcccagccag gggagccaca gccccaagga tggtcttgct
     3841 ctgggaatta ggtgaccttc ctggggaggc cccaggagag tgaatcaggg actcttgaga
     3901 aattcctaac cagcctcctg tgacccaggg agcagggtcg ctaaggtcct gcccactgag
     3961 gggacagcct tctgggcagg gacctcgggg ggcttcaagg gctctgcacg gctgtggggc
     4021 cctgtgcctt tgtctccttg tgtctccttt cccccgaagt agatgaaaca gtctcacata
     4081 cccaactgct catcaacaga gcagagctga tggcatgagt gagggctggg cggggtgggg
     4141 cctccagagc tttgcaggga accctggaac cctaggaaca aggagccttt gttccaacag
     4201 agcagagaag gaggttctct atgttcagac cactggagag gatagagagg taaaaggtgg
     4261 cgacagtttc ccttaggggt ctgcctggca ggagccacag ctcaggagag ttgtgaggga
     4321 tgggacggag gctggcgacc aggcgaggcc taggccaggc tcgggagact tttctgtgct
     4381 cctttctaca catgccttaa accttccttc ctgtggggtg cctggacccc ttccccatct
     4441 ctggcagctc agagggtctc tgctgctctc ccctgggaaa tcccctcatc ctgccctctg
     4501 gctgcctccc agctgggctt gttctctgag ggaggttccg gagactcatg gacttggggc
     4561 tctgcctgta ggaaggaggc tgggccggag ggaccagcca ccattgtctc tgttcagcca
     4621 agtgtgcaag taggctgccc gccaagaggg ggcctctgct acccgctgct gcctgccggc
     4681 tgacacactg cctccccagc cttcctgcta ggccaccctc ctcccttccc atgcttgtaa
     4741 ccagctctgg ggcttgcacc tccacaaagt aaggttggcc cttggaggcc atgtttgggt
     4801 ctccggccag ggcctagggc taggccatgc acccaatggg tgcacaataa ataacaggtc
     4861 aacaaagagg gaggtgtgtc agtgtgtgag gaagggaggt caggcagcta ggaccacctg
     4921 cagtgtggca ggcttcatcc ctctttgctc caagtgtgta tgtgtgtctg tgcatgtgtg
     4981 tagtgtctgt gtctgtgtgt tcatgcatat gcaggagtca cacggtcata ggccatcaaa
     5041 gctggaggag acctcagaat cattcattca cctacttgct catttattca ttcattcatt
     5101 ttgcagataa tatgggacgc tttctatgtg ccagtaccag gggattcaca aatgaattaa
     5161 acatgtccct gactccatga gttgacaatc ttgcccactg gtttcctgct ctcagtttac
     5221 agaggcactt ttatcttgct ggggaagtgt gctgaaaaga cacattccca gcccacaccc
     5281 agggatgctg attcagtcag cctgggtcag agggatagat aaatatgttt aaagctcctt
     5341 gggtaattct gatgtgtaag tagcagttag ctgcagtaga gtccaattgc ctcatttgat
     5401 tgaagtggaa tcccagcatc aagtggacat gacttttggc ccaagactga tgcttacaaa
     5461 ctaagtggag taggttattt gacctcactg aacatgcatc cttttttttt tttttttttt
     5521 tttttttttt tggagacgga gtttcgctct tgtaacccag gctggagtgc aatggtgtga
     5581 tcttggctga ctgcaacctc cactgaatca agcgattctc ctgcctcagc ctcccaagta
     5641 gctaggatta caggcgtgtg ccaccacgcc cggctatttt ttgtattttt agtagagatg
     5701 gggtttcgtc atgttggcta ggctggtctc gaactcctga cctcaggtag tctgcctgcc
     5761 tcggcccccc aaagtgctgg gattacaggc gtgaaccacc acacctggcc tatgcatcct
     5821 tatttctaaa accatgataa aaggtgaaag tctgaatgca tgtgtgtgtg acactttgat
     5881 gctcctttgc tcatgtagaa ccggcacctc tctttcacct gagcacgtgg aatcttcaga
     5941 gccagatgat ggtggctgcc tggcctgcca tagtcaatgc tgcccaggca cctctgcctg
     6001 gagggtctgg gttgtgggct gcagttatga catgtgacca cttggaggca ggcttgcatc
     6061 tttctagctt ctggctgctc aggtgtcctg ctgtggagct gagctgtgct ccctgaaagg
     6121 caggaagtta ttatgtgtgc ccctgtgcca tcaccgaacc aggaccttca acttcgtaaa
     6181 acccacagtg gcctgggcca ggactcccac catctaggga agcctctcct agggaaaaga
     6241 ctggggctct gacatcttcc tgcagatgga gagaaagaaa gacatctcag aagtctatgg
     6301 ggacagccta cagctcccca cagggttgct ccaggtaacg ctggaaggtg aaagctgagc
     6361 aggctccagt ccccatccta ggtatggaac agatcaaacc accacaggcc tatgtctgac
     6421 cttgttccca ccccatgctc ctctcccacc tgtgtccttc tctttgcagg agaagggaca
     6481 gacagaggtt ctcagtgatg agctcaggct ctggaagggc acttgaagtt tggctttagt
     6541 tcttcctttc ccatataggg gagctcagct tccagggtcc tgggcctgct gtgacccagg
     6601 ttgttactcc tgatataact gcttcctggg ctctcatgat ctcagctgag cctggctttc
     6661 tgctgatgat atttgtttgt tgcttgccag gcaccagggt agataaaaag atcaccaaga
     6721 cccgcacctt tttccttagg agggtctgag tcttcaggag acggagacat atggaatgtg
     6781 tcggggttgg aaggagcagg actggagggt cggggtgagg ggggcagagg gaaacagggc
     6841 cgtcagggtg gcctgaggcc agatcataca gggtctccaa tgcagccaag gagagtggct
     6901 ttttgtgaat gtgcagtgca actttttttt ttttttgaga cagagtctcg ctctgttgcc
     6961 caggctggag tgcaatggtg cgatctcagc tcactgcaac ctccgcctcc tgggttcaag
     7021 agattctcct ttcccagcct cccaagtagc tgggattaca ggcatgcacc accatgccca
     7081 gctaattttg tattttttag tagagacagg gtttcaccat gttggtcagg ctggtctcaa
     7141 actcctgacc tcaagtgatc cagctgcctc ggcctcccaa agcattggga tcacaggcgt
     7201 gagccaacgt gcctggccag tgcagtgcaa tttttaaaga gaagagtgcc aagctcaggg
     7261 cttggaggac agcctaggga ttttgtttta agaagatgag ctgggcgcgg tggctcatgc
     7321 ctgtaatccc agcactttgg gaggctgaag cgggcgcatc acctgagatc aggagttcga
     7381 gaccagcctg gccaacgtgg tgaaacccag tctttactaa aaatacaaaa aatagccggg
     7441 catggtggca catgcctata atcccagcta ctcaggaggc tgaagcagga gaatggcttg
     7501 aacccaggag gcggaggttg cagtgagctg aggttgcgcc attgcactcc agcctgggta
     7561 acagagcgag actctgtcga aaaagaaaaa aaagatgaaa tgccttgaaa aagtaaggcc
     7621 aatgggtagg gtcagaatat ggcctgcaaa tgcactgtac tatttgtgta acttatatgt
     7681 aaatctgaaa ttatttcaaa ataaatacaa aaagaaaaaa aggcaatatc ccagaacctt
     7741 gtgaaaacct ggccgtagca ggtccttttt cctcctgctg agctgagcag gcatgctcac
     7801 agatcctcaa ggtttcttga atggctactg tcctccccac tggcccctct gccaacacct
     7861 ctgcccctca gcttttctga tgcccatgcc ccctcaccag ctaactgtgg cttgcacctt
     7921 tacctgttcc cttcattttc ccttctccag aggaagaggt gctctccaca agcctgtgac
     7981 caactgttcc cctcagccgg cacactggct cctcttctcc tgcctgccac agacctctct
     8041 ccttcatggg cccactgggg ctctttgagc ctattctcta cccccttcat tatcatgcct
     8101 tgcaaacacc atcatgagca aaaatcaaag ctggtgttag actctcttgc tttccatagc
     8161 tgaccctggc ttccctgctt tctgtgatga attcacggta tgtgtgggct ttgccaactg
     8221 ttcccagccc ttaccaggtt cccattcata cctggctcta attcacacct tacaaatcgg
     8281 cgtccacccc acctttgcct gaaatggcac ctcctagggc aattgatggc tgcagtcatc
     8341 aactctgatg ccttctcagc cttcttccgc catcacctct cagcgacctt tggccttgat
     8401 agctatgtga tcatctacca gaccctgcac ccaggctcag cctgatcttg ccccagtggc
     8461 caggcccttg agtgggactg ccgggaattg agtccagctt ttctagccat ctgaccgtgg
     8521 ccagttagcc tcttatgttc tgtttgcttc tctataaaat ggggataata acactactta
     8581 tgtcacaagg tcctcatgaa gattaagtga aattatgcac gtaaacatct cagaacaatg
     8641 cctggcacag aagggacacc tgtgaggtta gctattaatt catagcctca ccagacttac
     8701 cccacgtctg ctcccctcct cctttgggct ctggcttagg ctctgccctc atgcatgcca
     8761 tcctgcttgg atgctgggta gctttgcact tggctctgcc ttggcctgca aataacaaat
     8821 ctgagctcaa atgagcttta gcagaaaagg actttgattg gctccaatag ctgaataatc
     8881 tgtatccagg tcaggtgagg cttcatctcg ggcttcactc tgattcaagg ccccttttct
     8941 ctcttgttct tttgggggct ccatctccca ggcctatgag caggaacaac cctcatgctt
     9001 ccaagatggc cccaggaact ctcaagatcc attttcttgg tgcaaatata gcagaaagtg
     9061 actctctgct tcctggaagt ttcaaactca aatccaggaa tagtctcctg tagcagcctg
     9121 ccttgggccg tgtgcccata tctgagccag tcactagagc caggggttta aggagatcag
     9181 agtccacttc tggagaggat gagagtgaag tcagcaccac caaaacatag ggaccagctg
     9241 tggagaaatt gtgagtactg gaaggacagg ataggaggaa tggatgatgg ggagaaaacc
     9301 gactaatatg cagatgccct ttcctccaag aggccttccc taagtcttcc tccttcagtt
     9361 tctattacat gaaactctgt aactctcctc tcctctctcc tcttcttttt tttttttttt
     9421 tttttgagat ggagtcttgc tcggtcgccc aggctggagt gcggtggcat gatctcggct
     9481 cactgcaagc tctgcctccc gagttcacgc cattctcctg cctcagcctc ccgagtagct
     9541 gggactacag gcgcccgcta ccatgcccgg ctaatttttt tgtattttta gtagagacgg
     9601 ggtttcaccg tgttagccag gatggtctca atctcctgat cttgtgatcc gcctgcctca
     9661 gcctcccaaa gtgctgggat tacaggcgta agccaccacg ccccggccct cttcatttct
     9721 ttttgcctct ctgcttccag agcaacataa actccctgtg ggcaggaact gggattgttg
     9781 atttccactg cttccccagg gcctgatatc tagagtcgaa agaatgcaca tctcaaaact
     9841 atgtcctggt tctttttcta ctttcttgca tattcttttt caggcaggag tgcagtggca
     9901 cgatctcaat tcactgcaac ctctgcctcc cgggttcaag caattctcct tcctcagcct
     9961 cctgagtagc tgggattaca ggcatgcacc accacaccca gctaatcttt gtattttcag
    10021 tagagatggg gtttcaccat gttggtcagg ctggtctcaa actcctgacc tcgtgatccg
    10081 ccggcctctg cctcccaaag tactggtgca tattcttttt ctgtctttcc tgctactccc
    10141 tcttgctctt cccaccccta aactatgtag cctcaaagat cttacctggc tgactgctgg
    10201 gctttcaaga tagtttctgg aagaagtctc taaatctaag ccttcaactc tcatctctgt
    10261 tctgaatttc agacctggaa ttctaactgt ccacaataca tggctcctca atatatcttc
    10321 ctgaaattac aaatgaccat acggtacagg tgttactata ttacctgtaa gaccacactc
    10381 ggtgtcatct cctgcaaact agtcctctcc tgactcctct gtttctgtga gtgattctgc
    10441 gatggcttga ggtcatccgt ttgctttgaa agatcacaca ccaggataca tacagagatg
    10501 tgacccggat ggatggacct ttgcctcaca atcagggtag aagcctctgg ttttcttatt
    10561 tctttgtcct cctctgtggt gtgacacagg ttcaggagga ggtacccaga cacagaagag
    10621 atgctttccc tgtgcaggct tgctgacagt cttgcccacc actcctggcc tcctccctct
    10681 acatgtccac attcgctgct ctgaccctga gttggaccca gctaggaatt gtgacttcag
    10741 ttactagtat ttcctctgag cctctagtca tggtcatggg ctaatctgta tatgaaaacc
    10801 cacttgaaag aaatcccagt gctgaagaaa gaattgaaac atacagatcg tttctttgct
    10861 caagggagtg tggatttcag tgctctcact gagcagaggc tgagggtgac caccttggat
    10921 cttcctgcag gacacagccc agagaaactg agcctgaatt tgctgccatg ttttgaggac
    10981 attatccacg ctagtctctt tcatctgggc cgaggtgggt aattttcctt agagtcaagt
    11041 actagaaaaa gttttgcttc ttctaagagc tggtacattg ccctcttgtg aatgagagcc
    11101 atgtatgtga ccacaacacc ctttcagttg accactaaga gactgaaggc caattccgga
    11161 tcaactttac agccgcctac ggcctgctat accacccatg gcatagtttc tgtggtctga
    11221 tgctttattt tttattgcat tttactaatt tatggcatgc atatcatatg agcagtctca
    11281 aatcctcccc agaacaaggt gaggaatata ttaatattta aaataaaata aacaaaatgt
    11341 ca
//
