LOCUS       NM_015310              11704 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens pleckstrin and Sec7 domain containing 3 (PSD3),
            transcript variant 1, mRNA.
ACCESSION   NM_015310 NM_018422
VERSION     NM_015310.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11704)
  AUTHORS   Mancina,R.M., Sasidharan,K., Lindblom,A., Wei,Y., Ciociola,E.,
            Jamialahmadi,O., Pingitore,P., Andreasson,A.C., Pellegrini,G.,
            Baselli,G., Mannisto,V., Pihlajamaki,J., Karja,V., Grimaudo,S.,
            Marini,I., Maggioni,M., Becattini,B., Tavaglione,F., Dix,C.,
            Castaldo,M., Klein,S., Perelis,M., Pattou,F., Thuillier,D.,
            Raverdy,V., Dongiovanni,P., Fracanzani,A.L., Stickel,F., Hampe,J.,
            Buch,S., Luukkonen,P.K., Prati,D., Yki-Jarvinen,H., Petta,S.,
            Xing,C., Schafmayer,C., Aigner,E., Datz,C., Lee,R.G., Valenti,L.,
            Linden,D. and Romeo,S.
  TITLE     PSD3 downregulation confers protection against fatty liver disease
  JOURNAL   Nat Metab 4 (1), 60-75 (2022)
   PUBMED   35102341
  REMARK    GeneRIF: PSD3 downregulation confers protection against fatty liver
            disease.
REFERENCE   2  (bases 1 to 11704)
  AUTHORS   Gong,S., Xu,C., Wang,L., Liu,Y., Owusu,D., Bailey,B.A., Li,Y. and
            Wang,K.
  TITLE     Genetic association analysis of polymorphisms in PSD3 gene with
            obesity, type 2 diabetes, and HDL cholesterol
  JOURNAL   Diabetes Res Clin Pract 126, 105-114 (2017)
   PUBMED   28237857
  REMARK    GeneRIF: Common variants in PSD3 were associated with obesity, T2D
            and HDL level
REFERENCE   3  (bases 1 to 11704)
  AUTHORS   Kanamarlapudi,V.
  TITLE     Exchange factor EFA6R requires C-terminal targeting to the plasma
            membrane to promote cytoskeletal rearrangement through the
            activation of ADP-ribosylation factor 6 (ARF6)
  JOURNAL   J Biol Chem 289 (48), 33378-33390 (2014)
   PUBMED   25296758
  REMARK    GeneRIF: EFA6R regulated ARF6 localization and thereby actin stress
            fiber loss.
REFERENCE   4  (bases 1 to 11704)
  AUTHORS   Sandholm,N., Forsblom,C., Makinen,V.P., McKnight,A.J.,
            Osterholm,A.M., He,B., Harjutsalo,V., Lithovius,R., Gordin,D.,
            Parkkonen,M., Saraheimo,M., Thorn,L.M., Tolonen,N., Waden,J.,
            Tuomilehto,J., Lajer,M., Ahlqvist,E., Mollsten,A.,
            Marcovecchio,M.L., Cooper,J., Dunger,D., Paterson,A.D., Zerbini,G.,
            Groop,L., Tarnow,L., Maxwell,A.P., Tryggvason,K. and Groop,P.H.
  CONSRTM   SUMMIT Consortium; FinnDiane Study Group
  TITLE     Genome-wide association study of urinary albumin excretion rate in
            patients with type 1 diabetes
  JOURNAL   Diabetologia 57 (6), 1143-1153 (2014)
   PUBMED   24595857
REFERENCE   5  (bases 1 to 11704)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11704)
  AUTHORS   Li,J., Liu,F., Wang,H., Liu,X., Liu,J., Li,N., Wan,F., Wang,W.,
            Zhang,C., Jin,S., Liu,J., Zhu,P. and Liu,Y.
  TITLE     Systematic mapping and functional analysis of a family of human
            epididymal secretory sperm-located proteins
  JOURNAL   Mol Cell Proteomics 9 (11), 2517-2528 (2010)
   PUBMED   20736409
REFERENCE   7  (bases 1 to 11704)
  AUTHORS   Xu,J., Zheng,S.L., Isaacs,S.D., Wiley,K.E., Wiklund,F., Sun,J.,
            Kader,A.K., Li,G., Purcell,L.D., Kim,S.T., Hsu,F.C., Stattin,P.,
            Hugosson,J., Adolfsson,J., Walsh,P.C., Trent,J.M., Duggan,D.,
            Carpten,J., Gronberg,H. and Isaacs,W.B.
  TITLE     Inherited genetic variant predisposes to aggressive but not
            indolent prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 2136-2140 (2010)
   PUBMED   20080650
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 11704)
  AUTHORS   Ng,D., Hu,N., Hu,Y., Wang,C., Giffen,C., Tang,Z.Z., Han,X.Y.,
            Yang,H.H., Lee,M.P., Goldstein,A.M. and Taylor,P.R.
  TITLE     Replication of a genome-wide case-control study of esophageal
            squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (7), 1610-1615 (2008)
   PUBMED   18649358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 11704)
  AUTHORS   Pils,D., Horak,P., Gleiss,A., Sax,C., Fabjani,G., Moebus,V.J.,
            Zielinski,C., Reinthaller,A., Zeillinger,R. and Krainer,M.
  TITLE     Five genes from chromosomal band 8p22 are significantly
            down-regulated in ovarian carcinoma: N33 and EFA6R have a potential
            impact on overall survival
  JOURNAL   Cancer 104 (11), 2417-2429 (2005)
   PUBMED   16270321
  REMARK    GeneRIF: Down regulated in ovarian cancer or absent in ovarian
            cancer and impact survival.
REFERENCE   10 (bases 1 to 11704)
  AUTHORS   Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
            Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
            and Chen,W.F.
  TITLE     Large scale identification of human hepatocellular
            carcinoma-associated antigens by autoantibodies
  JOURNAL   J Immunol 169 (2), 1102-1109 (2002)
   PUBMED   12097419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009884.8, AK091317.1, AC087821.5, AF243495.2 and AC120051.5.
            
            On Nov 23, 2018 this sequence version replaced NM_015310.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.228809.1, AK091317.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327040.13/ ENSP00000324127.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC009884.8         43075-43091
            18-675              AK091317.1         1-658
            676-677             AC087821.5         104443-104444       c
            678-1618            AK091317.1         661-1601
            1619-2202           AF243495.2         9-592
            2203-3346           AK091317.1         2186-3329
            3347-11704          AC120051.5         12636-20993
FEATURES             Location/Qualifiers
     source          1..11704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..11704
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="pleckstrin and Sec7 domain containing 3"
                     /db_xref="GeneID:23362"
                     /db_xref="HGNC:HGNC:19093"
                     /db_xref="MIM:614440"
     exon            1..141
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3264
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor guanine nucleotide factor 6; PH
                     and SEC7 domain-containing protein 3; hepatocellular
                     carcinoma-associated antigen 67; pleckstrin homology and
                     SEC7 domain-containing protein 3; epididymis tissue
                     protein Li 20mP; exchange factor for ARF6 D; exchange
                     factor for ADP-ribosylation factor guanine nucleotide
                     factor 6 D"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 3 isoform
                     1"
                     /protein_id="NP_056125.3"
                     /db_xref="CCDS:CCDS43720.1"
                     /db_xref="GeneID:23362"
                     /db_xref="HGNC:HGNC:19093"
                     /db_xref="MIM:614440"
                     /translation="MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTS
                     DHGGSTLLPPNVTNEFPEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHS
                     GLDSVTEGPKDVREAPSQSHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDA
                     VSSFSVQQVEKELDTASRKTQRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLT
                     ALLTGDTQAEISQIMNNGRKGAVCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSAL
                     GREHPGGCDRSSSMGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFETSLQRTASPDS
                     KESSKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSGTFSPVRLDESGEDEV
                     FLQENKQHLEKTPKPERDRERISEQEEHVKGEDEDILGPGYTEDSTDVYSSQFETILD
                     NTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSGGGHQDILSVS
                     ADGGIVMGYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEIL
                     EKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKF
                     FDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTC
                     AIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVD
                     DEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHAD
                     MDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKAT
                     DYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKF
                     SRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHY
                     LEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVS
                     ERKDHRPETPSIKQKVT"
     exon            142..250
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            251..1358
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1754
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1949
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2030
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2143
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2202
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2292
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2336
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2530
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2601
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2759
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2904
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3048
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..11704
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11681..11686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="hexamer: AATAAA"
     polyA_site      11704
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtcccg ggagctcaac aaagagcacg cggcgctggc cgccggcact cgcgccctga
       61 ggctgcggcc ccggagcgcc cggcggcggt ttcggcgcgc ggccgggctg gcgatggaag
      121 atggaaggaa ggagcgcagc ggcagagaca tttgtttggg tgaacaatgc atctgcacat
      181 tcccagagtg ttgccaaggc caaatatgaa tttttatttg gcagatctga agggaaagct
      241 ccagatacta gtgatcatgg aggaagcact ttactcccac caaatgtcac aaatgaattt
      301 ccagaatatg ggaccatgga ggaaggtgga gaaggcctaa gggcttctct ggaatttgat
      361 ggtgaggctc tgccatgcca cccacaagag cagcagggtg tccagcctct tactggctgc
      421 cactctgggc tcgacagtgt tacagaagga ccaaaagatg tcagagaggc cccctctcaa
      481 agtcatctca aggaacaaag tttacagccc attgactctt tgatttcagc tctgaaagcc
      541 acagaagcca gaatcatttc cggaacatta caggctacaa aggtactgga ccaagatgct
      601 gtttctagtt tttcagttca gcaggtggaa aaagagctgg acactgccag tcgtaaaaca
      661 cagagagtca acaaaacgct ccctgctggc caaaaaaatt taccagaaat acctctttca
      721 gctgaagtaa caacggagga aagtttttat ttgagcatcc agaaagatct caccgcgctg
      781 ttaactggag acactcaggc agagatttcc cagataatga ataatgggag gaaaggggct
      841 gtctgtgtgc aggagccatc ttgtcctttg gcctccctcg ggagctcagc agtgacctgc
      901 cactctgcag gcagtgttgg tttcttgaaa gagcagaggt ctgctcttgg gagagagcac
      961 ccagggggat gtgatcgaag cagctccatg ggacgcccag gccgggtcaa acatgtggaa
     1021 tttcaaggag tggaaatact gtggacagga ggagacaaga gagagaccca gcatcctata
     1081 gattttgaga catcactgca aagaacagcc tctcctgaca gcaaagagtc ttccaaagtg
     1141 ccacgccatc tcatctcatc agctggtttg tgtaattcaa gtagtttaac tgagaatgtt
     1201 tgggatgaat cctggaaagc tccttcagag aggcctggca ctagctcggg gacattttcc
     1261 cctgtgcgtc ttgatgagag tggagaggat gaagtcttcc tacaggaaaa caaacagcat
     1321 cttgagaaga cacctaaacc agagagagac agggaaagga tcagcgaaca agaggagcac
     1381 gttaaggggg aagatgaaga catccttggg cctggatata cggaggactc caccgacgtg
     1441 tacagctccc agtttgaaac cattttggac aacacttctt tatactacag tgcagagtcc
     1501 ctggagacat tatactcaga gcctgatagc tattttagct ttgaaatgcc cctcactcca
     1561 atgatacaac agcgcattaa agaaggtggt cagttcttgg agaggacatc agggggagga
     1621 catcaggata tcctgagtgt gtctgcagat ggtggcatcg tgatgggcta ttctagtggc
     1681 gtcaccaatg ggctgaatga tgccagcgac tccatctaca cgaaaggcac cccggagatt
     1741 gctttctggg gaagcaatgc tggggtgaaa acaacacggc tagaagctca ttctgaaatg
     1801 gggagcactg aaattttgga aaaggagacc ccagaaaatc tcagtaatgg taccagcagc
     1861 aatgtggaag cagccaaaag gttggccaaa cgcctttatc agctggacag attcaaaaga
     1921 tcagatgttg caaaacacct tggcaagaac aacgaattta gcaaactagt tgcagaagaa
     1981 tatctgaagt tttttgattt tacaggaatg acgctggatc agtcactcag gtatttcttt
     2041 aaagcattct ctcttgtggg agaaactcaa gaacgagaga gagttttaat acacttctcc
     2101 aatagatatt tttattgtaa cccagatacc attgcttcac aagatggagt ccattgcctt
     2161 acctgtgcaa taatgcttct taataccgat ctacatggcc acaatattgg aaagaagatg
     2221 acctgtcagg agttcattgc aaatctgcaa ggggtaaatg agggtgttga tttctccaag
     2281 gatctgctga aagctctgta caactcaatc aagaatgaga agcttgaatg ggcagtagat
     2341 gatgaagaga aaaaaaagtc tccctcagaa agtactgagg agaaagctaa cggaacacat
     2401 ccaaagacca tcagtcgtat tggaagtact actaacccat ttttggacat tcctcatgat
     2461 ccaaatgctg ctgtgtacaa aagtggattc ttggctcgga aaattcatgc agatatggat
     2521 ggaaagaaga ctccaagagg aaaacgagga tggaaaacct tttatgctgt actgaaggga
     2581 acagttcttt acttgcaaaa ggatgaatac aagccagaaa aggccttgtc tgaagaggac
     2641 ttgaaaaacg ctgtgagtgt gcaccacgca ttggcatcca aggccacgga ctatgagaag
     2701 aaaccaaacg tgtttaaact taaaactgcc gactggaggg tcttgctttt tcaaactcag
     2761 agcccagagg aaatgcaagg gtggataaac aaaatcaatt gtgtggcagc tgtattttct
     2821 gcaccaccat ttccagcagc aatcggctct cagaagaagt ttagccgccc acttctgcct
     2881 gccactacaa caaaactgtc tcaggaggag caactgaagt cacatgaaag taagctgaag
     2941 cagatcacca ccgagctggc cgagcaccgc tcatatcccc ccgacaagaa ggtcaaagcc
     3001 aaggacgtcg atgagtacaa actgaaagac cactatctgg agtttgagaa aacccgctat
     3061 gaaatgtatg tcagcattct caaggaagga ggcaaagagc tactgagtaa cgatgaaagc
     3121 gaggctgcag gactgaagaa gtcgcactcg agtccttcgc tgaacccgga tacttctcca
     3181 atcactgcca aagtcaagcg taacgtgtca gagaggaagg atcaccgacc tgaaacacca
     3241 agcattaagc aaaaagttac ttagagtcca tctgcggcca ggaagtgctg gtcatggagc
     3301 aaaatagggt ttttcaagat ctttctggta atccgtgaat atatttaaaa aaaaaaagtc
     3361 tgtgacaaaa cggtgcatta gtaatttttt ctattgtata tttttgttag tttctgtaca
     3421 gattgtcttt gctcttgatt tcttttgctt tgatgatttt tgcaacttga tagctaatgc
     3481 accttttctg tgaggaggag gggatcgtga tttcagaatg aattatgtat cccttctctt
     3541 ttggttttct cttgtttgca gtctgctcag ttgttttatg tattctcata tcaactgtta
     3601 aacttttttt taaggttaaa gaatttaatc cattgtgaaa cacttaactg gacaaactgt
     3661 agttttagta aattctagct ggagttaata tacgccttta tatgtgaaat cttgcccagt
     3721 cacagaggta gaattgagca ctcacagatg ctccagtaag aatcacagtg ctgggaatct
     3781 agttgctcca atatgaggca gcttcatgtg cagcttagca cttgttgttg agatcggacc
     3841 ctgctggaag cagggaaaag aagcgtgaag atcgtaggat tgagaactta gggaagcaca
     3901 ttagcttgct tgaagtgctg attccatttc agccaagcaa gggaaagagg aagtggagtc
     3961 attttgcctt tgaaggctga ggaaagattg atacccagtt aattttgttt gctaaaggat
     4021 gggggcaata atcggccctt gaggagctgc agcagtaggc atgtgctcag tctgcaggaa
     4081 ttgttacctc actcccacag ggtctagact agaaatccat catctctatc gttgatatcc
     4141 ttccatccag gaatagattt ttcttactct acatatgtgt gtgtgcgtgc gtgtgtgtgc
     4201 gtgtgtgggc atggggttgt gtcctggttg tgatattgag gtcttccttc ctaacaaatt
     4261 aatactaaaa tgaaacagct tttcttgtgt ccttaagaca aaataaggaa ggaaaacgta
     4321 gctgcagttg tccacgatgg atattggttc tttaaaatat atctgaaagt agtagtcaga
     4381 atgaattatg gttggaaaac tgaggaatct tctggttgca ggtgcaaagt gactttgttt
     4441 attcttgtct cagtctcctt gatagccact tcactctgct actactcaac tttctcctaa
     4501 aaatacttca tctattttca gtcctttctt tctgtctact caaaatggtt ctattaactt
     4561 tgcagtcatg agcttgttcc agttacagtc cctttgaagt tcagggtgat aaacagaata
     4621 ttcttctgta gaggaagaga aaggagtgaa agtttagccc actgagacct agagctttgt
     4681 gatttcctaa ccttgaaact ctgtaatccc taaagttaaa atctccgcaa gtggcacaac
     4741 ttcagaacta atagtatcac tttgattttt ctttttcctc ccttagaaag tttctctagt
     4801 tctatagttt atttgttgaa ggtactatga ccaaagaatc agctgctcta caggaatagc
     4861 atggttccag tgaattagag aaaacctgct gtaaagccat ggtagtgtct aagtggtatg
     4921 ttattatgat gtactagcat ttatttacag aattatttat taacgtttac ttccttcccc
     4981 tctgtaaatg tccatgacta ttgcccagag aaggcttacc cctctctagg gttgcagttg
     5041 ctttctttgt aataagtatt ttgccacacc tgtaaaaaaa aaaacctcac ttttaactct
     5101 ctgccttgtt tgggtaaagg cagtaactaa gtttatgttt cagaactgca aaacaaacag
     5161 gatagttacc aatatggccc atgtatcaga ttgatttttg tagcctctca ctgaatccaa
     5221 catatccaca agcaagttat ctgtctttct acctgataat ctaaattatc aggatatttg
     5281 ttttctgcct aaatgtttat actaagccga ggggagagag gtacctagac catgtcatct
     5341 acaagcttca gtaactaaag aaaaaggaac ttccctgagt ggcttgaatg tgtttgccca
     5401 cagtctatat ctatgtatat agaatgtctg tatgtatttt acttatttaa tatacattga
     5461 atggtacctt gctacagtat ttctgacatt tagagtagtg ttgaaatact cggctagcat
     5521 cagcaccact atagcactgt ccgtgtcata tgagtcacta atattaactc cagggacttc
     5581 tggataggct aatagatcat tggatacgaa gggctctttt gaagcttcag tataccatgt
     5641 ttgcatagtt tatctttaaa aacaacttta aaggttcttt tgtgagccag gatctcagac
     5701 tgccgtagca tgatgctgtc catctttagc gcatgggctg agaacacctc ttccctgagg
     5761 cttctgaagg ttgctgtctg tcatgagtgc atgaaggagg ccaagagttt atgctatggg
     5821 aggaaacagt cactgatttg cctagattct gagagtctgg cccatagcca accacatttt
     5881 cctttgggat aatttatttc ctgtggcatc tagccagaag aaattgagga tgtttccttt
     5941 cacagctgct ccaagcctgt tgcccaattc acggtacaag ggagcacccc ttccctttcc
     6001 tctgaaggta cgccacccac ctccgtcgcc cacctcagcg cccaggagcc ttgggacttc
     6061 cttccatatg ataaatcatt cttcttcacg tcaatacact tcatattaat ttctagtaca
     6121 gaaaatcttg acagctatca gaatgccttg gtcatagtgt tgttgcaaaa ttgaccatac
     6181 aggtggccca tgtataaaat ctgaatttta ggggtttgtc cccacctcgc atgctggctt
     6241 ttacagggag gtgtctggga ttcctcatta gcaatcaaaa cttaattact gggatgcaga
     6301 gtccttactt tatcgccagc ccgtaggcat ttctgaagtg cacttttttg aaacatcatt
     6361 ttgctaactc tcagcagtgt ctaattaaac tgagcaatac ttttgtgaat tttaattaat
     6421 ctcagcaaaa ccatgatggg agagagtcct ctgatggaaa tgtagtccct ggattatgtg
     6481 taaccttttt attcctctta gatgcagagg atagaaagca ttttttggtg cagtggtctt
     6541 gtggcaaaca caagaccctc tatgcgtctc caactgttat cctaatctag aaaatgagga
     6601 ctggcccctg ggcaaaagtg acatgaggaa tttactctgg aagaggaaaa tctgggtggc
     6661 tttccaaggc taagataggt ttgtatttca ccctgtggcc aagctacaga acttctgaga
     6721 ttgtggaaga atttttgcaa ccagcaggga aagaggcctc ttactgccta aacacaaagt
     6781 tacactgagc ttttctactg tcctttgcct attgctccct ctatcatgta aagatctggg
     6841 aaggatgaga ggcagggcct gcttgtcatg agctgcactc ttttcttttt aactaatcat
     6901 tgacaattgg aagaaaattg acgttaaaga agtttctcca ttgtcttact aacaaaacct
     6961 tttgggtttc attaattgtc cttgaaattg agttcctttg gcatttttcc ttgcagtcat
     7021 cagttaagca tgttgcatcc tgaattcaca gaagtttagc tttgcaggtt tgaatctctg
     7081 taatttaact cccgtggact tggtcgagtt ttcagcaggt tgggagccac ctctcttcat
     7141 ttcagcagtg agtcatccct tgacttttca aatgacagaa ttttttccaa ttgtaaaatt
     7201 agcactgtaa aacaaagaac caaagtggca tcctaagagt tgttaaacct gaagtctagt
     7261 ttatgaggaa ttgtccaagt tggagtttaa atagtatctg cttttgtctc aaagcatcta
     7321 agttattctg acagaaaatg gtaagtcagc tttgcaggca gatgcgcctc tgggcctcct
     7381 accttgctcc acagctttct ggccatcttg tctcccaggc catgccactg ctctgccaca
     7441 tgtcagcaaa tttctttcca ccagtcttat agcatcttac atgatcaaat catcacagaa
     7501 taaccccgtg atagattatt gatagcaata gagaggggct ttgtcactga tttttctctc
     7561 agattccttt tccatctctc atccataaag gaaggactga aatccaaagg cattctcctt
     7621 ttgtacctac agtatccaga acccacgtgg gcagccttct gcttatgaca ataattggcc
     7681 cattgcatgc agagagaatg tcttcataga gagaatgtca ttaaatactt gaatctgcat
     7741 gacagtttga cttgaatgca acagcaggaa aattttgcaa gttacataat tgtatataca
     7801 gtaggttttc ttaagtctct tcggttcatc ctttgtaatt tgtgtgtgta tctgtagtat
     7861 tgcaggcttt tggagactat tcttacaggc agtatgtcag tcatcaaaga aaatgctgtc
     7921 acctgccatt gttgtatttg tgggtattta tagttgtatg tatgtaaatg catcagtgtg
     7981 tagattgcat atcagtgtat ggtacatgta catcaaaatt atttttgtcc ttaatcagtg
     8041 tgatatgaaa agcaagtaca acctcatagg actgattata taatgaagtt gttgagagta
     8101 tatatagtgg tattgtttta ttaaacttaa actcaaataa tattttgatt aaaattttta
     8161 ataagacttt atgctagaaa attctttgag ctttgaatca ccagggcaaa aatgactttc
     8221 aactaacctt gtgaatcttt tgcagtgtac tgtgtgcaat accaagggca tagctccctg
     8281 taatttggga aatacagaaa gaaaagaaaa aaaaaaaaaa aggcagcctg tgcagtctta
     8341 gtaactttag tattaagagc acttaaagtc aaactgacaa ttttgggctt attacaaaat
     8401 gtgatgcttt aaagcacacg ttctttattg ttgttgtaat tagtccataa aaaatatagc
     8461 tttcggaaga attaagtacc caccatatca tttatgtatt tgtgtatgtt ttacgggaga
     8521 tcaaaccact ctcgtggtgc cgcatccgta ctcgcttgac ttggaagaaa tatcacaagc
     8581 actaaagtat atcagggcat cccaggattg ggtactgtat cctaggtttg cagttgcaga
     8641 aattagcatc tagtgtcaca ggtaaaagaa tttcaggacc aggtttaaac tttattttaa
     8701 atatttttat acttaggtct ctttttcctg cctctcccca aagaagagcc actggcctta
     8761 gttgtttgag cttactgctt atattataga gtgtaaatag gtaactagag actaaaattt
     8821 tattaaccag catgtttggt atatttaaag cagtgactga gtgtgtttga gtgagtggct
     8881 gagtgcagtg tcttttgttt aaacacactg cctcgtgtct ttgtagctga ttcagagagt
     8941 ttgaattgtg gggtgggaga ctaacttcag ctccaggctg cagtaatgtg ttggtagtta
     9001 cacttgaggc atttttttgt tgttgttaat taactctata gtctcaaact atttttgcaa
     9061 atatatcatt tttcctaatt ggttcttgac gtgcagtgga ctggctctgt gaatgattgg
     9121 cagggtctta gttttgcgag agtatttcct tctaagaatt attgtgatct gcagaaacag
     9181 ccatttgatt caaaaatcat gtagaaaagg agtaggagaa gcaaaacgtt tcatttttgg
     9241 gccttaacca tttgaaatgt ttggacttta aacataaagc catggagttt ataaagccaa
     9301 gtaaccattt gatatggata ataatatcta ctctagagag agtatatata tgcacattga
     9361 tttttaatgc tgttaagata cttttgtaaa actgtaggaa caagagtaat tagaccaaat
     9421 tgaagcttag gggacagtaa agtggttgct ttccatttag ggtaaccatg catgtggtta
     9481 gtcctctcct cctgagattc agaaccagtt gactgtcccc ttaggtgtat aaggagaaaa
     9541 gttgacatgt ctgggacctc tgacatgtgt acacatgctt gcacacatgc acacacagtg
     9601 aatgttttaa gttatacaaa cataagacct taagatgcaa agagccagaa tattctaaag
     9661 aggtgatgaa cagagggggt ggaaactgca tcacagatgt tttccaaggg ccagggtgga
     9721 atctgagctc tagtgtctga ctttgagatg cattatattt ttaacacata aatgagggga
     9781 tccatatcac attctttctt gtggaccacc aaattgaagg ctttcttgta attcacaagc
     9841 agcagctctc cagcatctct ccgtagcctg ggtgaagtcc cagaagctgg tgtgcatcat
     9901 tttccaaggt ggcagagctg cttgctctgc agatcattcc tttgagagag gagtacaagt
     9961 gaagaaacaa ggaggcactt cctgtaggag cactgatgtg ccttgtccac actcccctct
    10021 gagctttact ggtaagagag ctccgactga acatgctgag cagttgagca cttttccatc
    10081 agcaacaaca gcgaggatgg aaatggaaag gaaccgaact aaaatgcatt tccctttgca
    10141 gggcagagag ctaagctctt aggaatagtg ttatagaaat aagcacccta acttcaattc
    10201 ctgaaaatgt tggttaatgg agagaatttt ggagtttcac ttaatatttt cccatcggtc
    10261 gccataaata agtcttcagg cgctcctaga agagtcccag cccaaggctc gattaaggac
    10321 cacactgcag gtctgaggct cactgctctg agtcctgaac accagagccc tgcagagagt
    10381 ggtgataaca catcatctct gcaaagagga acctctcccc cggccgccac ttcactcagg
    10441 cttctactga gcagcaagga cagcctgggt ttcaaatgcc acttcccctg ctttagggat
    10501 ccaggtgtcc tgatagcgtg accctgctga ggcaaggtat caactccgag agtgactgag
    10561 tcactgagcg tggcacatga acaaacgtca tgacaaagat tctctgagtg aagttaacac
    10621 cacgtatttt acctttgcaa aaaacaaact ggcaccctga gttctaacta cggacggacg
    10681 atatctttgc ctccacaccc agattcctgg aaatggctaa cgtttccttt ctaggggaag
    10741 ggtcgaggaa tactcaagtg ctagcttagc agctttgttc agtccagatc agagctgtta
    10801 ggtaaaggcc taaccacctc cctgcagtct cttatatctc aagctttagg aacccatttc
    10861 taaatgtaca ctagcggaga atttatattg tcagccttga ttaccatagg acaggcagaa
    10921 aggcgataat ttgtatcttt taatataaaa gaagctttta acttttccag cctattataa
    10981 taactgagtt atattcactg tggctcaaac taattggcat tgtggaacat ttctttacct
    11041 tcaaagtttt ctccaccaat catttcagtt ctattgcagt cctggtgcca tatgtcccct
    11101 gcaaattgtg aaagtaatta gtgacaaaat agcagcctgc tccttttcaa tggcgaaact
    11161 gtcggcatta gcagttttgg gtaagctggc ggtactataa cacgtactgg aaacctgttc
    11221 ctcatcacca cctaccagat tctggaaatg ccgtcttcta gaaaacgatg gcgtttgtgg
    11281 tggtcttctt ttgaaaggaa cagtaatttg tgtggatatt gttaaagtgt ttaaagaata
    11341 ttttgacaat taagtttaca ttttacaatt gctttatttt ttattaaaat agttgtatat
    11401 aaatattacc ctatttcact gttgttcaag taaatctaaa ccttgtagac aagtgagtca
    11461 tctgatatgt atagaagctg tgatatatag agtacattta ttgtgtaaat gtttatgaat
    11521 ataattgttc ctgtgttttt ataagttggg gatattttgt tgttttacgg caacaaaatt
    11581 tattgcattt aaatggtttt tatgtaatag aaatcacgca aaatagtgaa ggatttaaaa
    11641 tatgtatatg atacatgtaa atgtacaaac tttagaaaga aataaatcca acaaatttca
    11701 atca
//
