LOCUS       NM_001412886           10282 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens pleckstrin and Sec7 domain containing 3 (PSD3),
            transcript variant 25, mRNA.
ACCESSION   NM_001412886
VERSION     NM_001412886.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10282)
  AUTHORS   Mancina,R.M., Sasidharan,K., Lindblom,A., Wei,Y., Ciociola,E.,
            Jamialahmadi,O., Pingitore,P., Andreasson,A.C., Pellegrini,G.,
            Baselli,G., Mannisto,V., Pihlajamaki,J., Karja,V., Grimaudo,S.,
            Marini,I., Maggioni,M., Becattini,B., Tavaglione,F., Dix,C.,
            Castaldo,M., Klein,S., Perelis,M., Pattou,F., Thuillier,D.,
            Raverdy,V., Dongiovanni,P., Fracanzani,A.L., Stickel,F., Hampe,J.,
            Buch,S., Luukkonen,P.K., Prati,D., Yki-Jarvinen,H., Petta,S.,
            Xing,C., Schafmayer,C., Aigner,E., Datz,C., Lee,R.G., Valenti,L.,
            Linden,D. and Romeo,S.
  TITLE     PSD3 downregulation confers protection against fatty liver disease
  JOURNAL   Nat Metab 4 (1), 60-75 (2022)
   PUBMED   35102341
  REMARK    GeneRIF: PSD3 downregulation confers protection against fatty liver
            disease.
REFERENCE   2  (bases 1 to 10282)
  AUTHORS   Gong,S., Xu,C., Wang,L., Liu,Y., Owusu,D., Bailey,B.A., Li,Y. and
            Wang,K.
  TITLE     Genetic association analysis of polymorphisms in PSD3 gene with
            obesity, type 2 diabetes, and HDL cholesterol
  JOURNAL   Diabetes Res Clin Pract 126, 105-114 (2017)
   PUBMED   28237857
  REMARK    GeneRIF: Common variants in PSD3 were associated with obesity, T2D
            and HDL level
REFERENCE   3  (bases 1 to 10282)
  AUTHORS   Kanamarlapudi,V.
  TITLE     Exchange factor EFA6R requires C-terminal targeting to the plasma
            membrane to promote cytoskeletal rearrangement through the
            activation of ADP-ribosylation factor 6 (ARF6)
  JOURNAL   J Biol Chem 289 (48), 33378-33390 (2014)
   PUBMED   25296758
  REMARK    GeneRIF: EFA6R regulated ARF6 localization and thereby actin stress
            fiber loss.
REFERENCE   4  (bases 1 to 10282)
  AUTHORS   Sandholm,N., Forsblom,C., Makinen,V.P., McKnight,A.J.,
            Osterholm,A.M., He,B., Harjutsalo,V., Lithovius,R., Gordin,D.,
            Parkkonen,M., Saraheimo,M., Thorn,L.M., Tolonen,N., Waden,J.,
            Tuomilehto,J., Lajer,M., Ahlqvist,E., Mollsten,A.,
            Marcovecchio,M.L., Cooper,J., Dunger,D., Paterson,A.D., Zerbini,G.,
            Groop,L., Tarnow,L., Maxwell,A.P., Tryggvason,K. and Groop,P.H.
  CONSRTM   SUMMIT Consortium; FinnDiane Study Group
  TITLE     Genome-wide association study of urinary albumin excretion rate in
            patients with type 1 diabetes
  JOURNAL   Diabetologia 57 (6), 1143-1153 (2014)
   PUBMED   24595857
REFERENCE   5  (bases 1 to 10282)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10282)
  AUTHORS   Li,J., Liu,F., Wang,H., Liu,X., Liu,J., Li,N., Wan,F., Wang,W.,
            Zhang,C., Jin,S., Liu,J., Zhu,P. and Liu,Y.
  TITLE     Systematic mapping and functional analysis of a family of human
            epididymal secretory sperm-located proteins
  JOURNAL   Mol Cell Proteomics 9 (11), 2517-2528 (2010)
   PUBMED   20736409
REFERENCE   7  (bases 1 to 10282)
  AUTHORS   Xu,J., Zheng,S.L., Isaacs,S.D., Wiley,K.E., Wiklund,F., Sun,J.,
            Kader,A.K., Li,G., Purcell,L.D., Kim,S.T., Hsu,F.C., Stattin,P.,
            Hugosson,J., Adolfsson,J., Walsh,P.C., Trent,J.M., Duggan,D.,
            Carpten,J., Gronberg,H. and Isaacs,W.B.
  TITLE     Inherited genetic variant predisposes to aggressive but not
            indolent prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 2136-2140 (2010)
   PUBMED   20080650
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 10282)
  AUTHORS   Ng,D., Hu,N., Hu,Y., Wang,C., Giffen,C., Tang,Z.Z., Han,X.Y.,
            Yang,H.H., Lee,M.P., Goldstein,A.M. and Taylor,P.R.
  TITLE     Replication of a genome-wide case-control study of esophageal
            squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (7), 1610-1615 (2008)
   PUBMED   18649358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 10282)
  AUTHORS   Pils,D., Horak,P., Gleiss,A., Sax,C., Fabjani,G., Moebus,V.J.,
            Zielinski,C., Reinthaller,A., Zeillinger,R. and Krainer,M.
  TITLE     Five genes from chromosomal band 8p22 are significantly
            down-regulated in ovarian carcinoma: N33 and EFA6R have a potential
            impact on overall survival
  JOURNAL   Cancer 104 (11), 2417-2429 (2005)
   PUBMED   16270321
  REMARK    GeneRIF: Down regulated in ovarian cancer or absent in ovarian
            cancer and impact survival.
REFERENCE   10 (bases 1 to 10282)
  AUTHORS   Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
            Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
            and Chen,W.F.
  TITLE     Large scale identification of human hepatocellular
            carcinoma-associated antigens by autoantibodies
  JOURNAL   J Immunol 169 (2), 1102-1109 (2002)
   PUBMED   12097419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087821.5, AC090420.6, AC100800.2 and AC120051.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.187559.1,
                                           SRR14372079.1150817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC087821.5         86234-86499         c
            267-332             AC090420.6         216532-216597       c
            333-527             AC090420.6         198090-198284       c
            528-608             AC090420.6         197908-197988       c
            609-721             AC090420.6         194656-194768       c
            722-780             AC090420.6         192681-192739       c
            781-870             AC090420.6         158835-158924       c
            871-914             AC100800.2         109899-109942       c
            915-1108            AC100800.2         86870-87063         c
            1109-1179           AC100800.2         54621-54691         c
            1180-1337           AC100800.2         29385-29542         c
            1338-1482           AC100800.2         26785-26929         c
            1483-1626           AC100800.2         10466-10609         c
            1627-10282          AC120051.5         12338-20993
FEATURES             Location/Qualifiers
     source          1..10282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..10282
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="pleckstrin and Sec7 domain containing 3"
                     /db_xref="GeneID:23362"
                     /db_xref="HGNC:HGNC:19093"
                     /db_xref="MIM:614440"
     exon            1..266
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            267..332
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            333..527
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1842
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="isoform 21 is encoded by transcript variant 25;
                     ADP-ribosylation factor guanine nucleotide factor 6; PH
                     and SEC7 domain-containing protein 3; hepatocellular
                     carcinoma-associated antigen 67; pleckstrin homology and
                     SEC7 domain-containing protein 3; epididymis tissue
                     protein Li 20mP; exchange factor for ARF6 D; exchange
                     factor for ADP-ribosylation factor guanine nucleotide
                     factor 6 D"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 3 isoform
                     21"
                     /protein_id="NP_001399815.1"
                     /db_xref="GeneID:23362"
                     /db_xref="HGNC:HGNC:19093"
                     /db_xref="MIM:614440"
                     /translation="MGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDV
                     AKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSN
                     RYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFS
                     KDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDI
                     PHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKA
                     LSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN
                     CVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRS
                     YPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSH
                     SSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT"
     exon            528..608
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            609..721
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            722..780
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            781..870
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            871..914
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1108
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1179
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1337
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1482
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1626
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..10282
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10259..10264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="hexamer: AATAAA"
     polyA_site      10282
                     /gene="PSD3"
                     /gene_synonym="EFA6D; EFA6R; HCA67"
                     /note="major polyA site"
ORIGIN      
        1 gtgttgagag aggaggctgg gaagaggggg acgtcctcct tcaacttctt tcaagttcgt
       61 atccctgagc ccctgaggga tccagtggca ttctgggaga atgtcactgc ggagtcagtg
      121 tgtagcagtt tgtacttgca acagaagcag ctttagaagt acattaaaag agcccttgcg
      181 gaagatgaaa gtttgctgag cagatggaat gggagaatgc tcttcaattc ctgacaaaat
      241 tatgggcaga ctgtttgctg acgaagactc cgaagaaagg agtgtatcct ctgaggggaa
      301 gttccagact ggcaggtcta ttttggcttc agcaatgctg gggtgaaaac aacacggcta
      361 gaagctcatt ctgaaatggg gagcactgaa attttggaaa aggagacccc agaaaatctc
      421 agtaatggta ccagcagcaa tgtggaagca gccaaaaggt tggccaaacg cctttatcag
      481 ctggacagat tcaaaagatc agatgttgca aaacaccttg gcaagaacaa cgaatttagc
      541 aaactagttg cagaagaata tctgaagttt tttgatttta caggaatgac gctggatcag
      601 tcactcaggt atttctttaa agcattctct cttgtgggag aaactcaaga acgagagaga
      661 gttttaatac acttctccaa tagatatttt tattgtaacc cagataccat tgcttcacaa
      721 gatggagtcc attgccttac ctgtgcaata atgcttctta ataccgatct acatggccac
      781 aatattggaa agaagatgac ctgtcaggag ttcattgcaa atctgcaagg ggtaaatgag
      841 ggtgttgatt tctccaagga tctgctgaaa gctctgtaca actcaatcaa gaatgagaag
      901 cttgaatggg cagtagatga tgaagagaaa aaaaagtctc cctcagaaag tactgaggag
      961 aaagctaacg gaacacatcc aaagaccatc agtcgtattg gaagtactac taacccattt
     1021 ttggacattc ctcatgatcc aaatgctgct gtgtacaaaa gtggattctt ggctcggaaa
     1081 attcatgcag atatggatgg aaagaagact ccaagaggaa aacgaggatg gaaaaccttt
     1141 tatgctgtac tgaagggaac agttctttac ttgcaaaagg atgaatacaa gccagaaaag
     1201 gccttgtctg aagaggactt gaaaaacgct gtgagtgtgc accacgcatt ggcatccaag
     1261 gccacggact atgagaagaa accaaacgtg tttaaactta aaactgccga ctggagggtc
     1321 ttgctttttc aaactcagag cccagaggaa atgcaagggt ggataaacaa aatcaattgt
     1381 gtggcagctg tattttctgc accaccattt ccagcagcaa tcggctctca gaagaagttt
     1441 agccgcccac ttctgcctgc cactacaaca aaactgtctc aggaggagca actgaagtca
     1501 catgaaagta agctgaagca gatcaccacc gagctggccg agcaccgctc atatcccccc
     1561 gacaagaagg tcaaagccaa ggacgtcgat gagtacaaac tgaaagacca ctatctggag
     1621 tttgagaaaa cccgctatga aatgtatgtc agcattctca aggaaggagg caaagagcta
     1681 ctgagtaacg atgaaagcga ggctgcagga ctgaagaagt cgcactcgag tccttcgctg
     1741 aacccggata cttctccaat cactgccaaa gtcaagcgta acgtgtcaga gaggaaggat
     1801 caccgacctg aaacaccaag cattaagcaa aaagttactt agagtccatc tgcggccagg
     1861 aagtgctggt catggagcaa aatagggttt ttcaagatct ttctggtaat ccgtgaatat
     1921 atttaaaaaa aaaaagtctg tgacaaaacg gtgcattagt aattttttct attgtatatt
     1981 tttgttagtt tctgtacaga ttgtctttgc tcttgatttc ttttgctttg atgatttttg
     2041 caacttgata gctaatgcac cttttctgtg aggaggaggg gatcgtgatt tcagaatgaa
     2101 ttatgtatcc cttctctttt ggttttctct tgtttgcagt ctgctcagtt gttttatgta
     2161 ttctcatatc aactgttaaa ctttttttta aggttaaaga atttaatcca ttgtgaaaca
     2221 cttaactgga caaactgtag ttttagtaaa ttctagctgg agttaatata cgcctttata
     2281 tgtgaaatct tgcccagtca cagaggtaga attgagcact cacagatgct ccagtaagaa
     2341 tcacagtgct gggaatctag ttgctccaat atgaggcagc ttcatgtgca gcttagcact
     2401 tgttgttgag atcggaccct gctggaagca gggaaaagaa gcgtgaagat cgtaggattg
     2461 agaacttagg gaagcacatt agcttgcttg aagtgctgat tccatttcag ccaagcaagg
     2521 gaaagaggaa gtggagtcat tttgcctttg aaggctgagg aaagattgat acccagttaa
     2581 ttttgtttgc taaaggatgg gggcaataat cggcccttga ggagctgcag cagtaggcat
     2641 gtgctcagtc tgcaggaatt gttacctcac tcccacaggg tctagactag aaatccatca
     2701 tctctatcgt tgatatcctt ccatccagga atagattttt cttactctac atatgtgtgt
     2761 gtgcgtgcgt gtgtgtgcgt gtgtgggcat ggggttgtgt cctggttgtg atattgaggt
     2821 cttccttcct aacaaattaa tactaaaatg aaacagcttt tcttgtgtcc ttaagacaaa
     2881 ataaggaagg aaaacgtagc tgcagttgtc cacgatggat attggttctt taaaatatat
     2941 ctgaaagtag tagtcagaat gaattatggt tggaaaactg aggaatcttc tggttgcagg
     3001 tgcaaagtga ctttgtttat tcttgtctca gtctccttga tagccacttc actctgctac
     3061 tactcaactt tctcctaaaa atacttcatc tattttcagt cctttctttc tgtctactca
     3121 aaatggttct attaactttg cagtcatgag cttgttccag ttacagtccc tttgaagttc
     3181 agggtgataa acagaatatt cttctgtaga ggaagagaaa ggagtgaaag tttagcccac
     3241 tgagacctag agctttgtga tttcctaacc ttgaaactct gtaatcccta aagttaaaat
     3301 ctccgcaagt ggcacaactt cagaactaat agtatcactt tgatttttct ttttcctccc
     3361 ttagaaagtt tctctagttc tatagtttat ttgttgaagg tactatgacc aaagaatcag
     3421 ctgctctaca ggaatagcat ggttccagtg aattagagaa aacctgctgt aaagccatgg
     3481 tagtgtctaa gtggtatgtt attatgatgt actagcattt atttacagaa ttatttatta
     3541 acgtttactt ccttcccctc tgtaaatgtc catgactatt gcccagagaa ggcttacccc
     3601 tctctagggt tgcagttgct ttctttgtaa taagtatttt gccacacctg taaaaaaaaa
     3661 aacctcactt ttaactctct gccttgtttg ggtaaaggca gtaactaagt ttatgtttca
     3721 gaactgcaaa acaaacagga tagttaccaa tatggcccat gtatcagatt gatttttgta
     3781 gcctctcact gaatccaaca tatccacaag caagttatct gtctttctac ctgataatct
     3841 aaattatcag gatatttgtt ttctgcctaa atgtttatac taagccgagg ggagagaggt
     3901 acctagacca tgtcatctac aagcttcagt aactaaagaa aaaggaactt ccctgagtgg
     3961 cttgaatgtg tttgcccaca gtctatatct atgtatatag aatgtctgta tgtattttac
     4021 ttatttaata tacattgaat ggtaccttgc tacagtattt ctgacattta gagtagtgtt
     4081 gaaatactcg gctagcatca gcaccactat agcactgtcc gtgtcatatg agtcactaat
     4141 attaactcca gggacttctg gataggctaa tagatcattg gatacgaagg gctcttttga
     4201 agcttcagta taccatgttt gcatagttta tctttaaaaa caactttaaa ggttcttttg
     4261 tgagccagga tctcagactg ccgtagcatg atgctgtcca tctttagcgc atgggctgag
     4321 aacacctctt ccctgaggct tctgaaggtt gctgtctgtc atgagtgcat gaaggaggcc
     4381 aagagtttat gctatgggag gaaacagtca ctgatttgcc tagattctga gagtctggcc
     4441 catagccaac cacattttcc tttgggataa tttatttcct gtggcatcta gccagaagaa
     4501 attgaggatg tttcctttca cagctgctcc aagcctgttg cccaattcac ggtacaaggg
     4561 agcacccctt ccctttcctc tgaaggtacg ccacccacct ccgtcgccca cctcagcgcc
     4621 caggagcctt gggacttcct tccatatgat aaatcattct tcttcacgtc aatacacttc
     4681 atattaattt ctagtacaga aaatcttgac agctatcaga atgccttggt catagtgttg
     4741 ttgcaaaatt gaccatacag gtggcccatg tataaaatct gaattttagg ggtttgtccc
     4801 cacctcgcat gctggctttt acagggaggt gtctgggatt cctcattagc aatcaaaact
     4861 taattactgg gatgcagagt ccttacttta tcgccagccc gtaggcattt ctgaagtgca
     4921 cttttttgaa acatcatttt gctaactctc agcagtgtct aattaaactg agcaatactt
     4981 ttgtgaattt taattaatct cagcaaaacc atgatgggag agagtcctct gatggaaatg
     5041 tagtccctgg attatgtgta acctttttat tcctcttaga tgcagaggat agaaagcatt
     5101 ttttggtgca gtggtcttgt ggcaaacaca agaccctcta tgcgtctcca actgttatcc
     5161 taatctagaa aatgaggact ggcccctggg caaaagtgac atgaggaatt tactctggaa
     5221 gaggaaaatc tgggtggctt tccaaggcta agataggttt gtatttcacc ctgtggccaa
     5281 gctacagaac ttctgagatt gtggaagaat ttttgcaacc agcagggaaa gaggcctctt
     5341 actgcctaaa cacaaagtta cactgagctt ttctactgtc ctttgcctat tgctccctct
     5401 atcatgtaaa gatctgggaa ggatgagagg cagggcctgc ttgtcatgag ctgcactctt
     5461 ttctttttaa ctaatcattg acaattggaa gaaaattgac gttaaagaag tttctccatt
     5521 gtcttactaa caaaaccttt tgggtttcat taattgtcct tgaaattgag ttcctttggc
     5581 atttttcctt gcagtcatca gttaagcatg ttgcatcctg aattcacaga agtttagctt
     5641 tgcaggtttg aatctctgta atttaactcc cgtggacttg gtcgagtttt cagcaggttg
     5701 ggagccacct ctcttcattt cagcagtgag tcatcccttg acttttcaaa tgacagaatt
     5761 ttttccaatt gtaaaattag cactgtaaaa caaagaacca aagtggcatc ctaagagttg
     5821 ttaaacctga agtctagttt atgaggaatt gtccaagttg gagtttaaat agtatctgct
     5881 tttgtctcaa agcatctaag ttattctgac agaaaatggt aagtcagctt tgcaggcaga
     5941 tgcgcctctg ggcctcctac cttgctccac agctttctgg ccatcttgtc tcccaggcca
     6001 tgccactgct ctgccacatg tcagcaaatt tctttccacc agtcttatag catcttacat
     6061 gatcaaatca tcacagaata accccgtgat agattattga tagcaataga gaggggcttt
     6121 gtcactgatt tttctctcag attccttttc catctctcat ccataaagga aggactgaaa
     6181 tccaaaggca ttctcctttt gtacctacag tatccagaac ccacgtgggc agccttctgc
     6241 ttatgacaat aattggccca ttgcatgcag agagaatgtc ttcatagaga gaatgtcatt
     6301 aaatacttga atctgcatga cagtttgact tgaatgcaac agcaggaaaa ttttgcaagt
     6361 tacataattg tatatacagt aggttttctt aagtctcttc ggttcatcct ttgtaatttg
     6421 tgtgtgtatc tgtagtattg caggcttttg gagactattc ttacaggcag tatgtcagtc
     6481 atcaaagaaa atgctgtcac ctgccattgt tgtatttgtg ggtatttata gttgtatgta
     6541 tgtaaatgca tcagtgtgta gattgcatat cagtgtatgg tacatgtaca tcaaaattat
     6601 ttttgtcctt aatcagtgtg atatgaaaag caagtacaac ctcataggac tgattatata
     6661 atgaagttgt tgagagtata tatagtggta ttgttttatt aaacttaaac tcaaataata
     6721 ttttgattaa aatttttaat aagactttat gctagaaaat tctttgagct ttgaatcacc
     6781 agggcaaaaa tgactttcaa ctaaccttgt gaatcttttg cagtgtactg tgtgcaatac
     6841 caagggcata gctccctgta atttgggaaa tacagaaaga aaagaaaaaa aaaaaaaaag
     6901 gcagcctgtg cagtcttagt aactttagta ttaagagcac ttaaagtcaa actgacaatt
     6961 ttgggcttat tacaaaatgt gatgctttaa agcacacgtt ctttattgtt gttgtaatta
     7021 gtccataaaa aatatagctt tcggaagaat taagtaccca ccatatcatt tatgtatttg
     7081 tgtatgtttt acgggagatc aaaccactct cgtggtgccg catccgtact cgcttgactt
     7141 ggaagaaata tcacaagcac taaagtatat cagggcatcc caggattggg tactgtatcc
     7201 taggtttgca gttgcagaaa ttagcatcta gtgtcacagg taaaagaatt tcaggaccag
     7261 gtttaaactt tattttaaat atttttatac ttaggtctct ttttcctgcc tctccccaaa
     7321 gaagagccac tggccttagt tgtttgagct tactgcttat attatagagt gtaaataggt
     7381 aactagagac taaaatttta ttaaccagca tgtttggtat atttaaagca gtgactgagt
     7441 gtgtttgagt gagtggctga gtgcagtgtc ttttgtttaa acacactgcc tcgtgtcttt
     7501 gtagctgatt cagagagttt gaattgtggg gtgggagact aacttcagct ccaggctgca
     7561 gtaatgtgtt ggtagttaca cttgaggcat ttttttgttg ttgttaatta actctatagt
     7621 ctcaaactat ttttgcaaat atatcatttt tcctaattgg ttcttgacgt gcagtggact
     7681 ggctctgtga atgattggca gggtcttagt tttgcgagag tatttccttc taagaattat
     7741 tgtgatctgc agaaacagcc atttgattca aaaatcatgt agaaaaggag taggagaagc
     7801 aaaacgtttc atttttgggc cttaaccatt tgaaatgttt ggactttaaa cataaagcca
     7861 tggagtttat aaagccaagt aaccatttga tatggataat aatatctact ctagagagag
     7921 tatatatatg cacattgatt tttaatgctg ttaagatact tttgtaaaac tgtaggaaca
     7981 agagtaatta gaccaaattg aagcttaggg gacagtaaag tggttgcttt ccatttaggg
     8041 taaccatgca tgtggttagt cctctcctcc tgagattcag aaccagttga ctgtcccctt
     8101 aggtgtataa ggagaaaagt tgacatgtct gggacctctg acatgtgtac acatgcttgc
     8161 acacatgcac acacagtgaa tgttttaagt tatacaaaca taagacctta agatgcaaag
     8221 agccagaata ttctaaagag gtgatgaaca gagggggtgg aaactgcatc acagatgttt
     8281 tccaagggcc agggtggaat ctgagctcta gtgtctgact ttgagatgca ttatattttt
     8341 aacacataaa tgaggggatc catatcacat tctttcttgt ggaccaccaa attgaaggct
     8401 ttcttgtaat tcacaagcag cagctctcca gcatctctcc gtagcctggg tgaagtccca
     8461 gaagctggtg tgcatcattt tccaaggtgg cagagctgct tgctctgcag atcattcctt
     8521 tgagagagga gtacaagtga agaaacaagg aggcacttcc tgtaggagca ctgatgtgcc
     8581 ttgtccacac tcccctctga gctttactgg taagagagct ccgactgaac atgctgagca
     8641 gttgagcact tttccatcag caacaacagc gaggatggaa atggaaagga accgaactaa
     8701 aatgcatttc cctttgcagg gcagagagct aagctcttag gaatagtgtt atagaaataa
     8761 gcaccctaac ttcaattcct gaaaatgttg gttaatggag agaattttgg agtttcactt
     8821 aatattttcc catcggtcgc cataaataag tcttcaggcg ctcctagaag agtcccagcc
     8881 caaggctcga ttaaggacca cactgcaggt ctgaggctca ctgctctgag tcctgaacac
     8941 cagagccctg cagagagtgg tgataacaca tcatctctgc aaagaggaac ctctcccccg
     9001 gccgccactt cactcaggct tctactgagc agcaaggaca gcctgggttt caaatgccac
     9061 ttcccctgct ttagggatcc aggtgtcctg atagcgtgac cctgctgagg caaggtatca
     9121 actccgagag tgactgagtc actgagcgtg gcacatgaac aaacgtcatg acaaagattc
     9181 tctgagtgaa gttaacacca cgtattttac ctttgcaaaa aacaaactgg caccctgagt
     9241 tctaactacg gacggacgat atctttgcct ccacacccag attcctggaa atggctaacg
     9301 tttcctttct aggggaaggg tcgaggaata ctcaagtgct agcttagcag ctttgttcag
     9361 tccagatcag agctgttagg taaaggccta accacctccc tgcagtctct tatatctcaa
     9421 gctttaggaa cccatttcta aatgtacact agcggagaat ttatattgtc agccttgatt
     9481 accataggac aggcagaaag gcgataattt gtatctttta atataaaaga agcttttaac
     9541 ttttccagcc tattataata actgagttat attcactgtg gctcaaacta attggcattg
     9601 tggaacattt ctttaccttc aaagttttct ccaccaatca tttcagttct attgcagtcc
     9661 tggtgccata tgtcccctgc aaattgtgaa agtaattagt gacaaaatag cagcctgctc
     9721 cttttcaatg gcgaaactgt cggcattagc agttttgggt aagctggcgg tactataaca
     9781 cgtactggaa acctgttcct catcaccacc taccagattc tggaaatgcc gtcttctaga
     9841 aaacgatggc gtttgtggtg gtcttctttt gaaaggaaca gtaatttgtg tggatattgt
     9901 taaagtgttt aaagaatatt ttgacaatta agtttacatt ttacaattgc tttatttttt
     9961 attaaaatag ttgtatataa atattaccct atttcactgt tgttcaagta aatctaaacc
    10021 ttgtagacaa gtgagtcatc tgatatgtat agaagctgtg atatatagag tacatttatt
    10081 gtgtaaatgt ttatgaatat aattgttcct gtgtttttat aagttgggga tattttgttg
    10141 ttttacggca acaaaattta ttgcatttaa atggttttta tgtaatagaa atcacgcaaa
    10201 atagtgaagg atttaaaata tgtatatgat acatgtaaat gtacaaactt tagaaagaaa
    10261 taaatccaac aaatttcaat ca
//
