LOCUS       NM_002779               3824 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens pleckstrin and Sec7 domain containing (PSD),
            transcript variant 1, mRNA.
ACCESSION   NM_002779
VERSION     NM_002779.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3824)
  AUTHORS   Macia,E., Partisani,M., Wang,H., Lacas-Gervais,S., Le Clainche,C.,
            Luton,F. and Franco,M.
  TITLE     The C-terminal domain of EFA6A interacts directly with F-actin and
            assembles F-actin bundles
  JOURNAL   Sci Rep 9 (1), 19209 (2019)
   PUBMED   31844082
  REMARK    GeneRIF: The C-terminal domain of EFA6A interacts directly with
            F-actin and assembles F-actin bundles.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3824)
  AUTHORS   Milanini,J., Fayad,R., Partisani,M., Lecine,P., Borg,J.P.,
            Franco,M. and Luton,F.
  TITLE     EFA6 proteins regulate lumen formation through alpha-actinin 1
  JOURNAL   J Cell Sci 131 (3) (2018)
   PUBMED   29246944
  REMARK    GeneRIF: EFA6A recruits alpha-actinin 1 (ACTN1) through direct
            binding.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3824)
  AUTHORS   Hanai,A., Ohgi,M., Yagi,C., Ueda,T., Shin,H.W. and Nakayama,K.
  TITLE     Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming
            body and play important roles in cytokinesis
  JOURNAL   J Biochem 159 (2), 201-208 (2016)
   PUBMED   26330566
  REMARK    GeneRIF: Arf GTPases are likely to be locally activated by EFA6 and
            in turn targeted to the Flemming body to complete cytokinesis.
REFERENCE   4  (bases 1 to 3824)
  AUTHORS   Sironi,C., Teesalu,T., Muggia,A., Fontana,G., Marino,F.,
            Savaresi,S. and Talarico,D.
  TITLE     EFA6A encodes two isoforms with distinct biological activities in
            neuronal cells
  JOURNAL   J Cell Sci 122 (Pt 12), 2108-2118 (2009)
   PUBMED   19494129
REFERENCE   5  (bases 1 to 3824)
  AUTHORS   Casanova,J.E.
  TITLE     Regulation of Arf activation: the Sec7 family of guanine nucleotide
            exchange factors
  JOURNAL   Traffic 8 (11), 1476-1485 (2007)
   PUBMED   17850229
  REMARK    Review article
REFERENCE   6  (bases 1 to 3824)
  AUTHORS   Decressac,S., Franco,M., Bendahhou,S., Warth,R., Knauer,S.,
            Barhanin,J., Lazdunski,M. and Lesage,F.
  TITLE     ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a
            GDP/GTP exchange factor for ARF6
  JOURNAL   EMBO Rep 5 (12), 1171-1175 (2004)
   PUBMED   15540117
REFERENCE   7  (bases 1 to 3824)
  AUTHORS   Brown,F.D., Rozelle,A.L., Yin,H.L., Balla,T. and Donaldson,J.G.
  TITLE     Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane
            traffic
  JOURNAL   J Cell Biol 154 (5), 1007-1017 (2001)
   PUBMED   11535619
REFERENCE   8  (bases 1 to 3824)
  AUTHORS   Chavrier,P. and Franco,M.
  TITLE     Expression, purification, and biochemical properties of EFA6, a
            Sec7 domain-containing guanine exchange factor for ADP-ribosylation
            factor 6 (ARF6)
  JOURNAL   Methods Enzymol 329, 272-279 (2001)
   PUBMED   11210544
REFERENCE   9  (bases 1 to 3824)
  AUTHORS   Franco,M., Peters,P.J., Boretto,J., van Donselaar,E., Neri,A.,
            D'Souza-Schorey,C. and Chavrier,P.
  TITLE     EFA6, a sec7 domain-containing exchange factor for ARF6,
            coordinates membrane recycling and actin cytoskeleton organization
  JOURNAL   EMBO J 18 (6), 1480-1491 (1999)
   PUBMED   10075920
REFERENCE   10 (bases 1 to 3824)
  AUTHORS   Perletti,L., Talarico,D., Trecca,D., Ronchetti,D.,
            Fracchiolla,N.S., Maiolo,A.T. and Neri,A.
  TITLE     Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10,
            which contains Sec7 and pleckstrin-homology domains
  JOURNAL   Genomics 46 (2), 251-259 (1997)
   PUBMED   9417912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB095931.1.
            
            On Nov 24, 2018 this sequence version replaced NM_002779.4.
            
            Summary: This gene encodes a Plekstrin homology and SEC7
            domains-containing protein that functions as a guanine nucleotide
            exchange factor. The encoded protein regulates signal transduction
            by activating ADP-ribosylation factor 6. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB095931.1, BC037332.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000020673.6/ ENSP00000020673.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3824              AB095931.1         360-4183
FEATURES             Location/Qualifiers
     source          1..3824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..3824
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /note="pleckstrin and Sec7 domain containing"
                     /db_xref="GeneID:5662"
                     /db_xref="HGNC:HGNC:9507"
                     /db_xref="MIM:602327"
     exon            1..85
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            86..822
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..3243
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /note="isoform 1 is encoded by transcript variant 1; PH
                     and SEC7 domain-containing protein 1; exchange factor for
                     ARF6 A; exchange factor for ADP-ribosylation factor
                     guanine nucleotide factor 6; pleckstrin homology and SEC7
                     domain-containing protein 1; pleckstrin-Sec7
                     domains-containing"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 1 isoform
                     1"
                     /protein_id="NP_002770.3"
                     /db_xref="CCDS:CCDS31272.1"
                     /db_xref="GeneID:5662"
                     /db_xref="HGNC:HGNC:9507"
                     /db_xref="MIM:602327"
                     /translation="MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTG
                     SLLRRVAGPGPRGRELGRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVI
                     FRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLP
                     ARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQ
                     GDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVA
                     VGRAAKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPR
                     PGPLPGPHPSLGSGNEDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGT
                     SPSADGPDSFSCVFEAILESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPA
                     PRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDS
                     LGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLY
                     RLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQE
                     RERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNL
                     EGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRISGGSG
                     SGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQ
                     KEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQ
                     MQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAM
                     ASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDA
                     VEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSGRRKP"
     exon            823..925
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1292
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1721
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1916
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1997
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2110
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2169
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2259
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2303
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2494
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2565
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2723
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2868
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3012
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3824
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /note="hexamer: ATTAAA"
     polyA_site      3824
                     /gene="PSD"
                     /gene_synonym="EFA6; EFA6A; PSD1; TYL"
                     /note="major polyA site"
ORIGIN      
        1 aaacgggagc cgcgctgcct tcacagctca gctgggccca gcctctcctc tgtctctcct
       61 cggtctcagc tctgggcgag cagcggcctg tctgaagagc atgcagcccc cttactcccc
      121 gcctggcctc gccatccctg cccccccagc ctgacccccg gccccagcat ggcccagggt
      181 gccatgcgct tctgctcgga aggcgactgt gccatctccc caccacgatg cccacgccgc
      241 tggctccccg aaggcccggt gccccagagc cccccagcca gcatgtatgg cagcacaggc
      301 tccttgctac ggcgagtggc aggtccaggt cctcgaggcc gggaactggg acgtgtgaca
      361 gcaccctgta cacctctgcg tggccccccc tcaccccgtg ttgctccctc accctgggca
      421 ccctcttcac ccactgggca gcccccaccc ggggcccaga gctctgtggt catcttccgc
      481 tttgtggaga aggccagtgt gaggccactg aatgggctac ctgctccagg gggcttgagt
      541 cggagctggg atctgggtgg ggtttctcct cccaggccca ccccagccct tgggcctggc
      601 tccaaccgga agttacggct ggaagcatcc acatcagacc cactccccgc cagaggaggc
      661 tcggccctac ctggcagccg gaaccttgta catgggccgc cagccccacc ccaggttgga
      721 gcagatggcc tttactcctc tctccccaat gggctggggg gcccccctga gcgcctggcc
      781 acactcttcg gaggacctgc tgacactgga ttcctgaacc agggggatac ctggtcctcc
      841 ccccgggaag tctcctctca tgcccagaga atcgctagag ccaaatggga attcttctat
      901 ggctccttgg acccccccag ctcaggtgct aagcccccag agcaggcccc cccatctcca
      961 cctggggtgg gctcaaggca gggctctggg gtggctgtgg ggcgagcagc caagtactcc
     1021 gagacagacc tggacacggt gcccctgagg tgctaccgcg agactgacat cgatgaggtg
     1081 ctggctgagc gggaggaggc cgactcggcc atcgaaagtc agcccagctc tgagggccca
     1141 ccaggcactg cctacccacc tgccccacgg cccggcccac tccctggccc tcatcccagc
     1201 ctcggcagtg gcaatgagga tgaggacgac gatgaggcag gtggggaaga agatgtggac
     1261 gacgaggtgt ttgaggcctc tgaaggggcc cggccaggga gccggatgcc tctcaagtca
     1321 cctgtgccct ttctacctgg gacgagcccc tcggctgatg ggcctgactc tttcagttgt
     1381 gtgttcgaag ccatcctgga gtcacaccgg gccaaaggca cctcctatac cagcctcgcc
     1441 tcgctggagg ccttggcctc acctggccca acccagagcc ccttcttcac ctttgagctg
     1501 cctccccaac cccctgcacc ccggcccgac ccaccagctc ccgccccact tgcccctctt
     1561 gaaccggatt ctggtaccag ctctgctgct gatggtcctt ggacacagag aggggaggag
     1621 gaggaggcag aggccagagc caagctggcc ccagggaggg agccccctag tccctgccac
     1681 tcagaggaca gccttgggct gggggcagca ccccttggca gcgaaccacc cctgagccag
     1741 ctggtgtccg actcagactc agagctggac agcacagagc ggctggccct gggaagcaca
     1801 gacaccttgt ccaatgggca gaaagcggac ctggaggctg cgcagcgcct ggccaagagg
     1861 ctgtaccgac tagatggctt caggaaggcc gatgtggccc ggcacctggg caagaacaat
     1921 gacttcagca aactggtggc tggggagtac ctcaagttct ttgtcttcac gggcatgact
     1981 ctggaccaag ctctcagggt gtttctgaag gagctggcct taatgggtga gacccaggaa
     2041 cgagagcgcg tgctggccca cttctcccag cgatacttcc agtgcaatcc tgaagccctg
     2101 tcctcagagg acggcgccca cacgctgacc tgtgcgctca tgctgctcaa cacggatctc
     2161 cacggccata acatcgggaa gcgcatgacc tgcggggact tcatcgggaa cctggagggc
     2221 ctcaatgatg gcggcgactt ccctagggag ctgctcaagg ccttgtacag ctccatcaag
     2281 aatgagaagc tgcagtgggc catagacgag gaggagctga gacgctctct gtctgagttg
     2341 gccgacccca accccaaggt catcaagcgg atcagcgggg gcagtggcag tggctccagc
     2401 cctttcctgg acctgactcc cgagcctggg gctgccgtct acaagcacgg ggccctggtg
     2461 cgaaaggtgc acgcagaccc tgactgcagg aagacacctc ggggcaagcg gggctggaag
     2521 agcttccacg ggatcctcaa gggcatgatc ctctacctgc agaaggagga gtacaagcct
     2581 gggaaggccc tttcagagac ggagctcaag aatgccatca gcatccacca tgccctggcc
     2641 actcgtgcca gtgactacag caagaggccc cacgtcttct acctgcgcac agctgactgg
     2701 cgggtcttcc tcttccaggc cccgagcctg gagcagatgc agtcctggat cactcgcatc
     2761 aatgtagtag ccgctatgtt ctctgcgccc cccttcccag ctgctgttag ctcccaaaag
     2821 aagttcagcc gccctctcct gcccagcgct gccacccgcc tctcccagga ggagcaggtg
     2881 cggacccacg aggccaagct gaaggccatg gcaagtgagc tgcgggagca ccgggccgcc
     2941 cagctgggca agaagggccg gggcaaggag gctgaagagc agcggcagaa ggaggcctac
     3001 ctggagtttg agaaatcccg ctacagcacc tatgcagcgc tgcttcgggt caagctgaag
     3061 gcaggcagtg aggagctgga tgcagtggag gcagcactgg cccaggccgg gagcacagag
     3121 gatggactcc ctccttctca ctccagtccc tccctgcagc ccaaaccctc cagccagccc
     3181 cgggctcagc gtcacagctc agagcctcgg ccaggggcag gcagtgggcg gcggaagccc
     3241 tgagatgagg tttagggtgg ggagtgcctg ctgggcacct gaaggatgac atggccctgc
     3301 ctgagcccgg gccggcctcg ggccacccac gagggcctcc cggcctaggg cccgaccgcg
     3361 ccggacgcgg tgtccggggc agggcagggc tggggcctgg gcctcaggag cctaggctag
     3421 gggcacctcc gagagcccct ttttgtgata atgttttgca ctttttcgta cagggtgggc
     3481 gggggcggga ggggctagcg cccctgaact tttgatgctt tttttttgtg tgggagaggc
     3541 ctgatgccgt ttctgctttc tgctgagacc acccccaccc tgacaccatc agtccccctc
     3601 tgtcctgggg cctggcttgg acagagacca ggatttgggg ctgagctggt ttcccctcct
     3661 tcctccccaa gggcttactc tttctcttgc tggaggtgga ggaagggcgt ccatgccaag
     3721 gccccatacc tgggccgggg gcagcacggc ctggctttcc cccgcttcag tgggccttgc
     3781 cctttgtaca gcctccaccc ccattaaaac tgctctggac ttgc
//
