LOCUS       NM_005672                982 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens prostate stem cell antigen (PSCA), transcript variant
            1, mRNA.
ACCESSION   NM_005672
VERSION     NM_005672.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 982)
  AUTHORS   Sarker,P., Pereira,G.M.V., Khullar,V., Yu,J. and Cartwright,R.
  TITLE     VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract
            Infections in Women: Genetic Association Study
  JOURNAL   Int Urogynecol J 35 (3), 695-701 (2024)
   PUBMED   38407596
  REMARK    GeneRIF: VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent
            Urinary Tract Infections in Women: Genetic Association Study.
REFERENCE   2  (bases 1 to 982)
  AUTHORS   Wang,X.F., Liu,D.L. and Geng,L.
  TITLE     The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric
            and Bladder Cancer: A Meta-Analysis
  JOURNAL   Genet Test Mol Biomarkers 27 (2), 44-55 (2023)
   PUBMED   36853840
  REMARK    GeneRIF: The PSCA rs2294008 (C/T) Polymorphism Increases the Risk
            of Gastric and Bladder Cancer: A Meta-Analysis.
REFERENCE   3  (bases 1 to 982)
  AUTHORS   Mahmoud,M.M., Abdel Hamid,F.F., Abdelgawad,I., Ismail,A., Malash,I.
            and Ibrahim,D.M.
  TITLE     Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in
            Prostate Cancer Patients
  JOURNAL   Asian Pac J Cancer Prev 24 (1), 223-229 (2023)
   PUBMED   36708571
  REMARK    GeneRIF: Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA
            in Prostate Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 982)
  AUTHORS   Wu,C., Wang,G., Yang,M., Huang,L., Yu,D., Tan,W. and Lin,D.
  TITLE     Two genetic variants in prostate stem cell antigen and gastric
            cancer susceptibility in a Chinese population
  JOURNAL   Mol Carcinog 48 (12), 1131-1138 (2009)
   PUBMED   19554573
  REMARK    GeneRIF: Genetic variations in prostate stem cell antigen is
            associated with gastric cancer.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 982)
  AUTHORS   Matsuo,K., Tajima,K., Suzuki,T., Kawase,T., Watanabe,M.,
            Shitara,K., Misawa,K., Ito,S., Sawaki,A., Muro,K., Nakamura,T.,
            Yamao,K., Yamamura,Y., Hamajima,N., Hiraki,A. and Tanaka,H.
  TITLE     Association of prostate stem cell antigen gene polymorphisms with
            the risk of stomach cancer in Japanese
  JOURNAL   Int J Cancer 125 (8), 1961-1964 (2009)
   PUBMED   19582881
  REMARK    GeneRIF: Prostate stem cell antigen polymorphisms are associated
            with stomach cancer.
REFERENCE   6  (bases 1 to 982)
  AUTHORS   Wu,X., Ye,Y., Kiemeney,L.A., Sulem,P., Rafnar,T., Matullo,G.,
            Seminara,D., Yoshida,T., Saeki,N., Andrew,A.S., Dinney,C.P.,
            Czerniak,B., Zhang,Z.F., Kiltie,A.E., Bishop,D.T., Vineis,P.,
            Porru,S., Buntinx,F., Kellen,E., Zeegers,M.P., Kumar,R., Rudnai,P.,
            Gurzau,E., Koppova,K., Mayordomo,J.I., Sanchez,M., Saez,B.,
            Lindblom,A., de Verdier,P., Steineck,G., Mills,G.B., Schned,A.,
            Guarrera,S., Polidoro,S., Chang,S.C., Lin,J., Chang,D.W.,
            Hale,K.S., Majewski,T., Grossman,H.B., Thorlacius,S.,
            Thorsteinsdottir,U., Aben,K.K., Witjes,J.A., Stefansson,K.,
            Amos,C.I., Karagas,M.R. and Gu,J.
  TITLE     Genetic variation in the prostate stem cell antigen gene PSCA
            confers susceptibility to urinary bladder cancer
  JOURNAL   Nat Genet 41 (9), 991-995 (2009)
   PUBMED   19648920
  REMARK    GeneRIF: Genetic variation in PSCA confers susceptibility to
            urinary bladder cancer.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2009 Oct;41(10):1156. Guarrera, Simonetta
            [added]; Polidoro, Silvia [added]]
REFERENCE   7  (bases 1 to 982)
  AUTHORS   Sakamoto,H., Yoshimura,K., Saeki,N., Katai,H., Shimoda,T.,
            Matsuno,Y., Saito,D., Sugimura,H., Tanioka,F., Kato,S.,
            Matsukura,N., Matsuda,N., Nakamura,T., Hyodo,I., Nishina,T.,
            Yasui,W., Hirose,H., Hayashi,M., Toshiro,E., Ohnami,S., Sekine,A.,
            Sato,Y., Totsuka,H., Ando,M., Takemura,R., Takahashi,Y.,
            Ohdaira,M., Aoki,K., Honmyo,I., Chiku,S., Aoyagi,K., Sasaki,H.,
            Ohnami,S., Yanagihara,K., Yoon,K.A., Kook,M.C., Lee,Y.S.,
            Park,S.R., Kim,C.G., Choi,I.J., Yoshida,T., Nakamura,Y. and
            Hirohashi,S.
  CONSRTM   Study Group of Millennium Genome Project for Cancer
  TITLE     Genetic variation in PSCA is associated with susceptibility to
            diffuse-type gastric cancer
  JOURNAL   Nat Genet 40 (6), 730-740 (2008)
   PUBMED   18488030
  REMARK    GeneRIF: Genetic variation in PSCA is associated with
            susceptibility to diffuse-type gastric cancer
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 982)
  AUTHORS   Schlosser,E., Otero,C., Wuensch,C., Kessler,B., Edelmann,M.,
            Brunisholz,R., Drexler,I., Legler,D.F. and Groettrup,M.
  TITLE     A novel cytosolic class I antigen-processing pathway for
            endoplasmic-reticulum-targeted proteins
  JOURNAL   EMBO Rep 8 (10), 945-951 (2007)
   PUBMED   17853904
  REMARK    GeneRIF: Result shows PSCA contains the cleavage site of the ER
            signal peptidase and the resulting cleavage products fail to bind
            to HLA-A(*)0201 and are not recognized by T lymphocytes.
REFERENCE   9  (bases 1 to 982)
  AUTHORS   Gu,Z., Thomas,G., Yamashiro,J., Shintaku,I.P., Dorey,F.,
            Raitano,A., Witte,O.N., Said,J.W., Loda,M. and Reiter,R.E.
  TITLE     Prostate stem cell antigen (PSCA) expression increases with high
            gleason score, advanced stage and bone metastasis in prostate
            cancer
  JOURNAL   Oncogene 19 (10), 1288-1296 (2000)
   PUBMED   10713670
REFERENCE   10 (bases 1 to 982)
  AUTHORS   Reiter,R.E., Gu,Z., Watabe,T., Thomas,G., Szigeti,K., Davis,E.,
            Wahl,M., Nisitani,S., Yamashiro,J., Le Beau,M.M., Loda,M. and
            Witte,O.N.
  TITLE     Prostate stem cell antigen: a cell surface marker overexpressed in
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1735-1740 (1998)
   PUBMED   9465086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB993163.1, BC048808.1 and
            AI685668.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005672.4.
            
            Summary: This gene encodes a glycosylphosphatidylinositol-anchored
            cell membrane glycoprotein. In addition to being highly expressed
            in the prostate it is also expressed in the bladder, placenta,
            colon, kidney, and stomach. This gene is up-regulated in a large
            proportion of prostate cancers and is also detected in cancers of
            the bladder and pancreas. This gene includes a polymorphism that
            results in an upstream start codon in some individuals; this
            polymorphism is thought to be associated with a risk for certain
            gastric and bladder cancers. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023582.2, SRR5189658.194276.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301258.5/ ENSP00000301258.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CB993163.1         67-77
            12-978              BC048808.1         1-967
            979-982             AI685668.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..982
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /note="prostate stem cell antigen"
                     /db_xref="GeneID:8000"
                     /db_xref="HGNC:HGNC:9500"
                     /db_xref="MIM:602470"
     exon            1..69
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..389
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /codon_start=1
                     /product="prostate stem cell antigen preproprotein"
                     /protein_id="NP_005663.2"
                     /db_xref="CCDS:CCDS47925.2"
                     /db_xref="GeneID:8000"
                     /db_xref="HGNC:HGNC:9500"
                     /db_xref="MIM:602470"
                     /translation="MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARI
                     RAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLP
                     ALGLLLWGPGQL"
     exon            70..177
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /inference="alignment:Splign:2.1.0"
     exon            178..982
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /inference="alignment:Splign:2.1.0"
     regulatory      959..964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /note="hexamer: AATAAA"
     polyA_site      982
                     /gene="PSCA"
                     /gene_synonym="lncPSCA; PRO232"
                     /note="major polyA site"
ORIGIN      
        1 acagcccacc agtgaccacg aaggctgtgc tgcttgccct gttgatggca ggcttggccc
       61 tgcagccagg cactgccctg ctgtgctact cctgcaaagc ccaggtgagc aacgaggact
      121 gcctgcaggt ggagaactgc acccagctgg gggagcagtg ctggaccgcg cgcatccgcg
      181 cagttggcct cctgaccgtc atcagcaaag gctgcagctt gaactgcgtg gatgactcac
      241 aggactacta cgtgggcaag aagaacatca cgtgctgtga caccgacttg tgcaacgcca
      301 gcggggccca tgccctgcag ccggctgctg ccatccttgc gctgctccct gcactcggcc
      361 tgctgctctg gggacccggc cagctctagg ctctgggggg ccccgctgca gcccacactg
      421 ggtgtggtgc cccaggcctc tgtgccactc ctcacacacc cggcccagtg ggagcctgtc
      481 ctggttcctg aggcacatcc taacgcaagt ctgaccatgt atgtctgcgc ccctgtcccc
      541 caccctgacc ctcccatggc cctctccagg actcccaccc ggcagatcgg ctctattgac
      601 acagatccgc ctgcagatgg cccctccaac cctctctgct gctgtttcca tggcccagca
      661 ttctccaccc ttaaccctgt gctcaggcac ctcttccccc aggaagcctt ccctgcccac
      721 cccatctatg acttgagcca ggtctggtcc gtggtgtccc ccgcacccag caggggacag
      781 gcactcagga gggcccggta aaggctgaga tgaagtggac tgagtagaac tggaggacag
      841 gagtcgacgt gagttcctgg gagtctccag agatggggcc tggaggcctg gaggaagggg
      901 ccaggcctca cattcgtggg gctccctgaa tggcagcctc agcacagcgt aggcccttaa
      961 taaacacctg ttggataagc ca
//
