LOCUS       NM_058179               2206 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens phosphoserine aminotransferase 1 (PSAT1), transcript
            variant 1, mRNA.
ACCESSION   NM_058179
VERSION     NM_058179.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Liu,Y., Xun,W., Zhao,T., Huang,M., Sun,L., Wen,G., Kang,X., Wang,J.
            and Han,T.
  TITLE     Interplay between acetylation and ubiquitination controls PSAT1
            protein stability in lung adenocarcinoma
  JOURNAL   Commun Biol 7 (1), 1365 (2024)
   PUBMED   39433916
  REMARK    GeneRIF: Interplay between acetylation and ubiquitination controls
            PSAT1 protein stability in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Du,X., Wang,Y. and Gao,F.
  TITLE     PSAT1 is upregulated by METTL3 to attenuate high glucose-induced
            retinal pigment epithelial cell apoptosis and oxidative stress
  JOURNAL   Diagn Pathol 19 (1), 138 (2024)
   PUBMED   39407268
  REMARK    GeneRIF: PSAT1 is upregulated by METTL3 to attenuate high
            glucose-induced retinal pigment epithelial cell apoptosis and
            oxidative stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2206)
  AUTHORS   Zhang,X., Wang,S., Li,W., Wang,J., Gong,Y., Chen,Q., Cao,S.,
            Pang,D. and Gao,S.
  TITLE     PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen
            Receptor-Negative Breast Cancer Cell
  JOURNAL   Biomolecules 14 (8), 990 (2024)
   PUBMED   39199378
  REMARK    GeneRIF: PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in
            Estrogen Receptor-Negative Breast Cancer Cell.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2206)
  AUTHORS   Ye,J., Huang,X., Tian,S., Wang,J., Wang,H., Feng,H., Zhao,X.,
            Cao,S., Xuan,Y., Li,X., Ma,X., Huang,Y. and Zhang,X.
  TITLE     Upregulation of serine metabolism enzyme PSAT1 predicts poor
            prognosis and promotes proliferation, metastasis and drug
            resistance of clear cell renal cell carcinoma
  JOURNAL   Exp Cell Res 437 (1), 113977 (2024)
   PUBMED   38373588
  REMARK    GeneRIF: Upregulation of serine metabolism enzyme PSAT1 predicts
            poor prognosis and promotes proliferation, metastasis and drug
            resistance of clear cell renal cell carcinoma.
REFERENCE   5  (bases 1 to 2206)
  AUTHORS   Vie,N., Copois,V., Bascoul-Mollevi,C., Denis,V., Bec,N., Robert,B.,
            Fraslon,C., Conseiller,E., Molina,F., Larroque,C., Martineau,P.,
            Del Rio,M. and Gongora,C.
  TITLE     Overexpression of phosphoserine aminotransferase PSAT1 stimulates
            cell growth and increases chemoresistance of colon cancer cells
  JOURNAL   Mol Cancer 7, 14 (2008)
   PUBMED   18221502
  REMARK    GeneRIF: Overexpression of phosphoserine aminotransferase is
            associated with colorectal cancer development
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2206)
  AUTHORS   Hart,C.E., Race,V., Achouri,Y., Wiame,E., Sharrard,M., Olpin,S.E.,
            Watkinson,J., Bonham,J.R., Jaeken,J., Matthijs,G. and Van
            Schaftingen,E.
  TITLE     Phosphoserine aminotransferase deficiency: a novel disorder of the
            serine biosynthesis pathway
  JOURNAL   Am J Hum Genet 80 (5), 931-937 (2007)
   PUBMED   17436247
REFERENCE   7  (bases 1 to 2206)
  AUTHORS   Baek,J.Y., Jun,D.Y., Taub,D. and Kim,Y.H.
  TITLE     Characterization of human phosphoserine aminotransferase involved
            in the phosphorylated pathway of L-serine biosynthesis
  JOURNAL   Biochem J 373 (Pt 1), 191-200 (2003)
   PUBMED   12633500
  REMARK    GeneRIF: nucleotide sequence and enzymatic activity of two isoforms
            generated by alternative splicing; differential expression
            depending upon tissue specificity and cellular proliferation status
REFERENCE   8  (bases 1 to 2206)
  AUTHORS   Basurko,M.J., Marche,M., Darriet,M. and Cassaigne,A.
  TITLE     Phosphoserine aminotransferase, the second step-catalyzing enzyme
            for serine biosynthesis
  JOURNAL   IUBMB Life 48 (5), 525-529 (1999)
   PUBMED   10637769
REFERENCE   9  (bases 1 to 2206)
  AUTHORS   van der Crabben,S.N. and de Koning,T.J.
  TITLE     Serine Deficiency Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37347880
REFERENCE   10 (bases 1 to 2206)
  AUTHORS   Misrahi,M., Atger,M. and Milgrom,E.
  TITLE     A novel progesterone-induced messenger RNA in rabbit and human
            endometria. Cloning and sequence analysis of the complementary DNA
  JOURNAL   Biochemistry 26 (13), 3975-3982 (1987)
   PUBMED   3651428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC332195.1 and BC004863.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_058179.3.
            
            Summary: This gene encodes a member of the class-V
            pyridoxal-phosphate-dependent aminotransferase family. The encoded
            protein is a phosphoserine aminotransferase and decreased
            expression may be associated with schizophrenia. Mutations in this
            gene are also associated with phosphoserine aminotransferase
            deficiency. Alternative splicing results in multiple transcript
            variants. Pseudogenes of this gene have been defined on chromosomes
            1, 3, and 8. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as PSAT
            beta).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.625555.1,
                                           SRR3476690.325692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376588.4/ ENSP00000365773.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               DC332195.1         24-406
            384-2206            BC004863.2         365-2187
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.2"
     gene            1..2206
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /note="phosphoserine aminotransferase 1"
                     /db_xref="GeneID:29968"
                     /db_xref="HGNC:HGNC:19129"
                     /db_xref="MIM:610936"
     exon            1..146
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1199
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /EC_number="2.6.1.52"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endometrial progesterone-induced protein;
                     phosphohydroxythreonine aminotransferase; phosphoserine
                     transaminase"
                     /codon_start=1
                     /product="phosphoserine aminotransferase isoform 1"
                     /protein_id="NP_478059.1"
                     /db_xref="CCDS:CCDS6660.1"
                     /db_xref="GeneID:29968"
                     /db_xref="HGNC:HGNC:19129"
                     /db_xref="MIM:610936"
                     /translation="MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSH
                     RSSDFAKIINNTENLVRELLAVPDNYKVIFLQGGGCGQFSAVPLNLIGLKAGRCADYV
                     VTGAWSAKAAEEAKKFGTINIVHPKLGSYTKIPDPSTWNLNPDASYVYYCANETVHGV
                     EFDFIPDVKGAVLVCDMSSNFLSKPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLG
                     FALRECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQ
                     TIYEIIDNSQGFYVCPVEPQNRSKMNIPFRIGNAKGDDALEKRFLDKALELNMLSLKG
                     HRSVGGIRASLYNAVTIEDVQKLAAFMKKFLEMHQL"
     exon            147..207
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            208..277
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            278..483
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            484..656
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            657..826
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            827..955
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1093
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..2206
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /note="hexamer: ATTAAA"
     polyA_site      2206
                     /gene="PSAT1"
                     /gene_synonym="EPIP; NLS2; PSA; PSAT; PSATD"
                     /note="major polyA site"
ORIGIN      
        1 gcagactctc accgcagcgg ccaggaacgc cagccgttca cgcgttcggt cctccttggc
       61 tgactcaccg ccctggccgc cgcaccatgg acgcccccag gcaggtggtc aactttgggc
      121 ctggtcccgc caagctgccg cactcagtgt tgttagagat acaaaaggaa ttattagact
      181 acaaaggagt tggcattagt gttcttgaaa tgagtcacag gtcatcagat tttgccaaga
      241 ttattaacaa tacagagaat cttgtgcggg aattgctagc tgttccagac aactataagg
      301 tgatttttct gcaaggaggt gggtgcggcc agttcagtgc tgtcccctta aacctcattg
      361 gcttgaaagc aggaaggtgt gctgactatg tggtgacagg agcttggtca gctaaggccg
      421 cagaagaagc caagaagttt gggactataa atatcgttca ccctaaactt gggagttata
      481 caaaaattcc agatccaagc acctggaacc tcaacccaga tgcctcctac gtgtattatt
      541 gcgcaaatga gacggtgcat ggtgtggagt ttgactttat acccgatgtc aagggagcag
      601 tactggtttg tgacatgtcc tcaaacttcc tgtccaagcc agtggatgtt tccaagtttg
      661 gtgtgatttt tgctggtgcc cagaagaatg ttggctctgc tggggtcacc gtggtgattg
      721 tccgtgatga cctgctgggg tttgccctcc gagagtgccc ctcggtcctg gaatacaagg
      781 tgcaggctgg aaacagctcc ttgtacaaca cgcctccatg tttcagcatc tacgtcatgg
      841 gcttggttct ggagtggatt aaaaacaatg gaggtgccgc ggccatggag aagcttagct
      901 ccatcaaatc tcaaacaatt tatgagatta ttgataattc tcaaggattc tacgtttgtc
      961 cagtggagcc ccaaaataga agcaagatga atattccatt ccgcattggc aatgccaaag
     1021 gagatgatgc tttagaaaaa agatttcttg ataaagctct tgaactcaat atgttgtcct
     1081 tgaaagggca taggtctgtg ggaggcatcc gggcctctct gtataatgct gtcacaattg
     1141 aagacgttca gaagctggcc gccttcatga aaaaattttt ggagatgcat cagctatgaa
     1201 cacatcctaa ccaggatata ctctgttctt gaacaacata caaagtttaa agtaacttgg
     1261 ggatggctac aaaaagttaa cacagtattt ttctcaaatg aacatgttta ttgcagattc
     1321 ttcttttttg aaagaacaac agcaaaacat ccacaactct gtaaagctgg tgggacctaa
     1381 tgtcacctta attctgactt gaactggaag cattttaaga aatcttgttg cttttctaac
     1441 aaattcccgc gtattttgcc tttgctgcta ctttttctag ttagatttca aacttgcctg
     1501 tggacttaat aatgcaagtt gcgattaatt atttctggag tcatgggaac acacagcaca
     1561 gagggtaggg gggccctcta ggtgctgaat ctacacatct gtggggtctc ctgggttcag
     1621 cggctgttga ttcaaggtca acattgacca ttggaggagt ggtttaagag tgccaggcga
     1681 agggcaaact gtagatcgat ctttatgctg ttattacagg agaagtgaca tactttatat
     1741 atgtttatat tagcaaggtc tgtttttaat accatatact ttatatttct atacatttat
     1801 atttctaata atacagttat cactgatata tgtagacact tttagaattt attaaatcct
     1861 tgaccttgtg cattatagca ttccattagc aagagttgta ccccctcccc agtcttcgcc
     1921 ttcctctttt taagctgttt tatgaaaaag acctagaagt tcttgattca tttttaccat
     1981 tctttccata ggtagaagag aaagttgatt ggttggttgt ttttcaatta tgccattaaa
     2041 ctaaacattt ctgttaaatt accctatcct ttgttctcta ctgttttctt tgtaatgtat
     2101 gactacgaga gtgatacttt gctgaaaagt ctttccccta ttgtttatct attgtcagta
     2161 ttttatgttg aatatgtaaa gaacattaaa gtcctaaaac atctaa
//
