LOCUS       NM_001085382            4646 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens prosaposin like 1 (PSAPL1), mRNA.
ACCESSION   NM_001085382
VERSION     NM_001085382.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4646)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4646)
  AUTHORS   Zhang,Z.D., Frankish,A., Hunt,T., Harrow,J. and Gerstein,M.
  TITLE     Identification and analysis of unitary pseudogenes: historic and
            contemporary gene losses in humans and other primates
  JOURNAL   Genome Biol 11 (3), R26 (2010)
   PUBMED   20210993
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ991252.1, BC063708.1 and
            AC080003.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001085382.1.
            
            Summary: This gene encodes a protein that is related to the
            glycoprotein prosaposin. Based on sequence similarity between the
            encoded protein and prosaposin, it is predicted that the encoded
            protein is a preproprotein that is proteolytically processed to
            generate multiple protein products. These predicted products
            include saposins A-like, B-like, C-like, and D-like, which may play
            a role in the lysosomal degradation of sphingolipids. [provided by
            RefSeq, Jul 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ991252.1, BC048325.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319098.7/ ENSP00000317445.4
            polymorphic pseudogene :: PMID: 20210993
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4594              DQ991252.1         44-4637
            4595-4637           BC063708.1         1238-1280
            4638-4646           AC080003.6         161372-161380       c
FEATURES             Location/Qualifiers
     source          1..4646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..4646
                     /gene="PSAPL1"
                     /note="prosaposin like 1"
                     /db_xref="GeneID:768239"
                     /db_xref="HGNC:HGNC:33131"
     exon            1..4646
                     /gene="PSAPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1617
                     /gene="PSAPL1"
                     /note="proactivator polypeptide-like 1; prosaposin-like
                     protein 1"
                     /codon_start=1
                     /product="proactivator polypeptide-like 1 preproprotein"
                     /protein_id="NP_001078851.1"
                     /db_xref="CCDS:CCDS47009.1"
                     /db_xref="GeneID:768239"
                     /db_xref="HGNC:HGNC:33131"
                     /translation="MLCALLLLPSLLGATRASPTSGPQECAKGSTVWCQDLQTAARCG
                     AVGYCQGAVWNKPTAKSLPCDVCQDIAAAAGNGLNPDATESDILALVMKTCEWLPSQE
                     SSAGCKWMVDAHSSAILSMLRGAPDSAPAQVCTALSLCEPLQRHLATLRPLSKEDTFE
                     AVAPFMANGPLTFHPRQAPEGALCQDCVRQVSRLQEAVRSNLTLADLNIQEQCESLGP
                     GLAVLCKNYLFQFFVPADQALRLLPPQELCRKGGFCEELGAPARLTQVVAMDGVPSLE
                     LGLPRKQSEMQMKAGVTCEVCMNVVQKLDHWLMSNSSELMITHALERVCSVMPASITK
                     ECIILVDTYSPSLVQLVAKITPEKVCKFIRLCGNRRRARAVHDAYAIVPSPEWDAENQ
                     GSFCNGCKRLLTVSSHNLESKSTKRDILVAFKGGCSILPLPYMIQCKHFVTQYEPVLI
                     ESLKDMMDPVAVCKKVGACHGPRTPLLGTDQCALGPSFWCRSQEAAKLCNAVQHCQKH
                     VWKEMHLHAGEHA"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSAPL1"
                     /note="hexamer: TATAAA"
     polyA_site      2673
                     /gene="PSAPL1"
                     /note="major polyA site"
     regulatory      4624..4629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PSAPL1"
                     /note="hexamer: AATATA"
     polyA_site      4646
                     /gene="PSAPL1"
ORIGIN      
        1 atagcagcag ccactgctgg gtactctgga gccagagagt ccctgggcag catgctgtgt
       61 gccctgctcc tcctgcccag cctcctgggg gccaccaggg ccagccccac ctcaggcccc
      121 caggagtgtg caaagggctc cacggtgtgg tgtcaggatc tgcagacagc tgccaggtgc
      181 ggggctgtgg ggtactgcca aggggccgta tggaacaaac ccaccgcgaa gtctctgccc
      241 tgcgacgtat gccaggacat agcagccgcc gctggcaatg ggctgaaccc tgacgccacg
      301 gagtctgaca tcctggcttt ggtgatgaag acctgtgagt ggctccccag ccaggagtct
      361 tcagccggat gcaagtggat ggtggatgcc cacagttcgg ccatcctgag catgctccgt
      421 ggggccccgg acagtgcccc ggcacaggtg tgcacagcgc tcagcctctg tgagccgctg
      481 cagaggcacc tggccaccct gaggccactc tccaaagagg acacctttga ggctgtggct
      541 ccgttcatgg ccaatgggcc ccttaccttc cacccccgcc aggcgcctga aggagctctg
      601 tgccaagact gtgtacggca ggtctcccga ctccaggagg ctgtccggtc caacttgacc
      661 ttggccgact tgaacatcca ggagcagtgt gagtccttgg ggcctggcct ggccgtcctc
      721 tgcaagaact acctcttcca gttttttgtc cctgctgacc aagcactgag gcttctcccc
      781 ccgcaggagc tctgcaggaa ggggggattc tgtgaggagc taggggcacc tgcccgtttg
      841 actcaagtag tggccatgga cggggtcccc tccctggagc tggggttgcc aaggaaacag
      901 agcgagatgc agatgaaggc cggtgtgacc tgtgaggtgt gcatgaacgt ggtgcagaag
      961 ctggaccact ggctcatgtc caacagctct gagctcatga tcacccatgc cctggagcgc
     1021 gtgtgctcgg taatgcctgc ctctatcacg aaggagtgca tcatcttggt ggacacctac
     1081 agcccctcct tggtgcagct tgtggccaaa atcaccccag agaaggtgtg caagttcatc
     1141 cgtctgtgtg gcaaccggag gcgggcccgg gcagtccatg atgcctatgc catcgtgccg
     1201 tccccagagt gggacgcgga gaaccagggc agcttctgca atgggtgcaa gaggctgctc
     1261 acggtgtcct cccacaactt ggagagcaag agcaccaagc gagacatcct ggtggccttc
     1321 aagggtggct gcagcatcct gccgctgccc tatatgatcc agtgcaagca cttcgtcacc
     1381 cagtacgagc ccgtgctcat tgagagtctc aaggacatga tggaccccgt ggctgtgtgc
     1441 aagaaggtgg gggcctgcca cggccccagg accccactgc tgggcaccga ccagtgtgcc
     1501 ctgggcccaa gcttctggtg caggagccag gaggccgcca agctgtgcaa cgctgtgcaa
     1561 cactgccaga agcatgtatg gaaagagatg cacctccacg ctggggaaca cgcgtgaccg
     1621 tggctgccag agacccagag cctgctagcg aggcccatga ggtgggtgct ttccccatcc
     1681 ccatttcaca aatgaaaaac tgaagctctg aggagggagg ctgggaagga gcagagctga
     1741 agttcaaaac caagtattcc tgatcccgaa agcctctctc ttaacaacgg tgccgcacag
     1801 ctttgccctt gaaagcatct ctactggacc ggaacacact catgtgcccc gctccctgac
     1861 ccagccaagg ctgccctctc atctccaagg ctgagatgtt gccggtggtc ccatgagagc
     1921 ctgcccatgg gctcaggtgc ccctttacct tctgctggat ggacatctgg ctgtgagcca
     1981 ggctggggtc atggccgggg tgagcggagg caggggtgga cggaggcttc gagggcccat
     2041 cactagtagg gtcattacct cttgccaaca gccgggggtg ggagtctggg tctcgctcag
     2101 gccagagctt ctcaacctgg agtccctggg ggtggctgcc aaaggtgtgt atgacaagca
     2161 cgtatccctg gacatttccg gggagaggtc tggggctttg gtcacattct ccaagggctg
     2221 ctgggcttcg gagcagtccc cccccatgtc tcagccacta cagggtccct ctctctcctt
     2281 gcaccccaga ccctccgctg ccctggtaat gagcagaagg aaagtcttgg ggtgtgctca
     2341 aagtcaggag agcaaaatat gccaggcaaa agctcccggg aaaagccgga ggagtctggg
     2401 gtggccaccg ggatgtggag cagcgagggc aaagacggtg aacacagccc tccagctgtc
     2461 tgagcctcag ttttctaatc tgtagaatgg ggatgatcat acctgcctca caagaatgtt
     2521 gagacaattc acagagacgt tctggagccc ctttcccccg agaccggcat tcatgagtct
     2581 gctgggacca gaaaacccat ctcaggggcc cagcggggca cccaggagag tctggcggtg
     2641 caagcgctgt ataaaccaca agcgttctcc aaatgccgtg tgccgtgttt ttattctcag
     2701 ggaaggcgca gatcccagag ctgctacaac agcctccacc ttaccctggt gcctccacct
     2761 cgccccggtg ccccctctgg cagaaagcct ccgggggggg tttccatctg ggttcaagtg
     2821 ctcctgtggt ttctgctcct gctgtttggc ccccctaaga cactgtgccc cctccaggag
     2881 agcccctggg catgaccctg cagtgtcctt gcagctggcc cagcatctgc acgcagcagg
     2941 tgctcacaca tctgggagcc gcacacatga gtcccggggg tggaagctgg tatttcacct
     3001 gaggcccatg gattaattct cctcttgagt aagaggtgcg ccaggcctgg atggacggga
     3061 tgtgagcggg tgctgttttc caagaggcca cacccgagct cttaagtaaa cgtcgcagac
     3121 ctgggccacc gccccaggaa cacaggcaca ctgggcctga gattctggat gcctcagaag
     3181 tggcccctat tggctgggca ggcctgggcc cgctgggcag tcccacaaaa gataaggcca
     3241 gcaaggggtg gtggtcgtgc ctggccaccg gatgggccat gggaaggcag ctctgcacca
     3301 gactccaaaa cacaggggcc cgaagttgtt ggcctcagta tctgcctctt cccctgagac
     3361 cacccaccct ctccaggagc agccccagag gctctctgtc tgcctgccgg taggtgttcc
     3421 cacctgacac actctctggg acaggatgga gccataggcc ctcctctggc ttggctgtga
     3481 gtcgggagga tgcctaccgg gaagtatgtg tgacatgacc tgaaatcccc cgacaggtca
     3541 cctgggagag gccgggagag ggcaagcgcc acacctgcca ggtggcccag ctcagcccac
     3601 ctgcccccac cccagagcta cctgcagtgg gtggtcaggg tggggtgtcc ccacaccctc
     3661 ttccctaccc accccttggg cctgggtacc agctgctccc acagacccac tgagcacatg
     3721 cgtctccact agatggttgc ccgtgatgaa cggagctcac tggccatgac cccacaggcc
     3781 cagctgcaca cccaggtcat gagcacggcc ctgccccacc cccatagggg ccctctgacc
     3841 cctccactca ctcatccgcc accaaagctg tggaggcctg tggcagggtc tcagtcacct
     3901 ccatcccctg tgcccggaac caagcccgga acacaggagg tgctctgcaa gtgctcgtgg
     3961 ggagtggctg ccttggggtc taaaggcaga gaggcaggag gagcaaggga cgggcccact
     4021 ggtgctgacg gcagcaccac cattcagcac tgagactgag gcttaaggag tccatccaaa
     4081 tgactccata gccgccgcgt tcaggctgga aaaggctttt cagcggaggg tgctgtaact
     4141 gtccagctgt gggagaggag ataccagccc aggagaagag cagctggccc tactgggcct
     4201 agaagtttgg gagacccatc ccagcaagga tgggaaatca agacagatgt tgagcatgga
     4261 tttcccagag gtggtgactg cgccgcacag aggagcatct ctgcctggga ggagggagag
     4321 ggctcccgcc gggctgccag agccgagcaa gtacctgcac cttcagccag acacatgctg
     4381 ggcattcttc agatgccatc gtaaggcgga ggcctgggac gtcccagaac acctatggat
     4441 gctgcccctc gggctttctc ggccacacca gatgcagagg ggctgtggga gcctggaaaa
     4501 gggcttggtg gtccagctgc tttgttgttg ttgtttttgt tttgtttgtt tgtttgtttg
     4561 tttgttttgg cttggggctt ttcttagaag tgatgtgttg ttagaaactt caaaccagat
     4621 acaaatatac ccaacgatgt tctctc
//
