LOCUS       NM_004676               1238 bp    mRNA    linear   PRI 01-FEB-2024
DEFINITION  Homo sapiens PTPN13 like Y-linked (PRY), mRNA.
ACCESSION   NM_004676
VERSION     NM_004676.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1238)
  AUTHORS   Repping,S., van Daalen,S.K., Korver,C.M., Brown,L.G.,
            Marszalek,J.D., Gianotten,J., Oates,R.D., Silber,S., van der
            Veen,F., Page,D.C. and Rozen,S.
  TITLE     A family of human Y chromosomes has dispersed throughout northern
            Eurasia despite a 1.8-Mb deletion in the azoospermia factor c
            region
  JOURNAL   Genomics 83 (6), 1046-1052 (2004)
   PUBMED   15177557
REFERENCE   2  (bases 1 to 1238)
  AUTHORS   Stouffs,K., Lissens,W., Verheyen,G., Van Landuyt,L., Goossens,A.,
            Tournaye,H., Van Steirteghem,A. and Liebaers,I.
  TITLE     Expression pattern of the Y-linked PRY gene suggests a function in
            apoptosis but not in spermatogenesis
  JOURNAL   Mol Hum Reprod 10 (1), 15-21 (2004)
   PUBMED   14665702
REFERENCE   3  (bases 1 to 1238)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   4  (bases 1 to 1238)
  AUTHORS   Stouffs,K., Lissens,W., Van Landuyt,L., Tournaye,H., Van
            Steirteghem,A. and Liebaers,I.
  TITLE     Characterization of the genomic organization, localization and
            expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4)
  JOURNAL   Mol Hum Reprod 7 (7), 603-610 (2001)
   PUBMED   11420382
REFERENCE   5  (bases 1 to 1238)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF000988.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 27, 2002 this sequence version replaced NM_004676.1.
            
            Summary: This gene is located in the nonrecombining portion of the
            Y chromosome, and expressed specifically in testis. It encodes a
            protein which has a low degree of similarity to protein tyrosine
            phosphatase, non-receptor type 13. Two nearly identical copies of
            this gene exist within a palindromic region. This record represents
            the more telomeric copy. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF000988.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303728.5/ ENSP00000302319.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1238
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /note="PTPN13 like Y-linked"
                     /db_xref="GeneID:9081"
                     /db_xref="HGNC:HGNC:14024"
                     /db_xref="MIM:400019"
     exon            1..88
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /inference="alignment:Splign:2.1.0"
     exon            89..175
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /inference="alignment:Splign:2.1.0"
     exon            176..296
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..671
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /note="testis-specific PTP-BL-related protein on Y"
                     /codon_start=1
                     /product="PTPN13-like protein, Y-linked"
                     /protein_id="NP_004667.2"
                     /db_xref="CCDS:CCDS14799.1"
                     /db_xref="GeneID:9081"
                     /db_xref="HGNC:HGNC:14024"
                     /db_xref="MIM:400019"
                     /translation="MGATGLGFLLSWRQDNLNGTDCQGCNILYFSETTGSMCSELSLN
                     RGLEARRKKDLKDSFLWRYGKVGCISLPLREMTAWINPPQISEIFQGYHQRVHGADAL
                     SLQTNSLRSRLSSQCLGQSFLLRTLERGRGFRALGDICGHVHEED"
     exon            297..412
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /inference="alignment:Splign:2.1.0"
     exon            413..1238
                     /gene="PRY"
                     /gene_synonym="PRY1; PTPN13LY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaagagga gcacaccaca ccagaaacag acatcttgca gtgtttcact gtctcaacct
       61 tatctgcaca gtccgaggtc agtctgagag agcttctgag agacccagga tgaagggatg
      121 cagtgaggtc aagagcccaa ccttctttca ctgacaccca cctctaagga ctcagagaga
      181 catgaataaa atgggcctca acaatcccaa gagaccactc aaggacaatg ggagccactg
      241 ggcttggctt tctactttcc tggagacaag acaatttgaa tggcactgac tgccagggat
      301 gcaatatttt atacttctct gagactacgg ggagcatgtg ttctgaactt tccttgaaca
      361 gaggtcttga ggccagaagg aagaaggatc ttaaagactc atttctctgg agatatggga
      421 aggttggctg tatctcactt ccacttcgtg agatgaccgc ctggattaac ccaccccaaa
      481 tttcagagat tttccaaggc taccaccaga gggtgcacgg agctgatgca ctgagcctgc
      541 aaaccaactc tctgagaagc aggttatctt cacagtgcct cggacagagc ttccttctca
      601 ggacactcga gagaggccgt ggtttcaggg cacttgggga catctgtggc cacgttcatg
      661 aagaagacta agcctacttc atctcaggac ccgcccaaga gtggccgcgg ctttgggaca
      721 cctggggtcg ggtccaccat gaggataaaa cctccttctc ttctggacat gtccaggagt
      781 ggccgttgct acaagtcacc tggtgctacg accagggtga gaataaagac gtctcctcag
      841 gaccctccca ggagagtaca tggcattgag acatctggcg gccaagtgag gaaaagacac
      901 cctgtctgca gcacccagaa ctgaggaggg gcactgccct gggccttact tcccagccct
      961 ggcctccaat tctgacctta caaaagtgtc ccttgagtga ggcagtgacc acgcattgtc
     1021 acagctacca aagtgtggtt tgcagatgat ctgggcttgt ttctggcaga gattctggta
     1081 cagagaaagg agaggcgctg agtggaacca cgatgggctg aggccagggg agacatcaca
     1141 acctccaaca acactttttt tcatgcttta ataactcatt tttcttagag aactaaagta
     1201 gttgaaacaa tatagaaaca ttttttaagt aggcatat
//
