LOCUS       NM_153698               2899 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens peroxiredoxin like 2C (PRXL2C), mRNA.
ACCESSION   NM_153698 XM_114685
VERSION     NM_153698.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Zhang,B., Wu,J., Cai,Y., Luo,M., Wang,B. and Gu,Y.
  TITLE     AAED1 modulates proliferation and glycolysis in gastric cancer
  JOURNAL   Oncol Rep 40 (2), 1156-1164 (2018)
   PUBMED   29901208
REFERENCE   2  (bases 1 to 2899)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (bases 1 to 2899)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   4  (bases 1 to 2899)
  AUTHORS   Castellano,S., Novoselov,S.V., Kryukov,G.V., Lescure,A., Blanco,E.,
            Krol,A., Gladyshev,V.N. and Guigo,R.
  TITLE     Reconsidering the evolution of eukaryotic selenoproteins: a novel
            nonmammalian family with scattered phylogenetic distribution
  JOURNAL   EMBO Rep 5 (1), 71-77 (2004)
   PUBMED   14710190
REFERENCE   5  (bases 1 to 2899)
  AUTHORS   Gilligan,P., Brenner,S. and Venkatesh,B.
  TITLE     Fugu and human sequence comparison identifies novel human genes and
            conserved non-coding sequences
  JOURNAL   Gene 294 (1-2), 35-44 (2002)
   PUBMED   12234665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM843088.1, BF445089.1, BU631382.1 and AL353578.18.
            
            On Nov 23, 2018 this sequence version replaced NM_153698.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136503.1, SRR5189658.104786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375234.8/ ENSP00000364382.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               BM843088.1         1-457
            458-737             BF445089.1         333-612
            738-1225            BU631382.1         18-505              c
            1226-2899           AL353578.18        20587-22260
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..2899
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /note="peroxiredoxin like 2C"
                     /db_xref="GeneID:195827"
                     /db_xref="HGNC:HGNC:16881"
     exon            1..228
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..717
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /note="UPF0308 protein C9orf21; ahpC/TSA antioxidant
                     enzyme domain-containing protein 1; thioredoxin-like
                     protein AAED1; AhpC/TSA antioxidant enzyme domain
                     containing 1"
                     /codon_start=1
                     /product="peroxiredoxin-like 2C"
                     /protein_id="NP_714542.1"
                     /db_xref="CCDS:CCDS35073.1"
                     /db_xref="GeneID:195827"
                     /db_xref="HGNC:HGNC:16881"
                     /translation="MAAPAPVTRQVSGAAALVPAPSGPDSGQPLAAAVAELPVLDARG
                     QRVPFGALFRERRAVVVFVRHFLCYICKEYVEDLAKIPRSFLQEANVTLIVIGQSSYH
                     HIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASSGQSPHIKSNLLSGSLQSLWR
                     AVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFT
                     NRPSVIHV"
     exon            229..297
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            298..351
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            352..457
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            458..589
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            590..2899
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1197..1202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /note="hexamer: AATAAA"
     polyA_site      1225
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /note="major polyA site"
     regulatory      2880..2885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /note="hexamer: AATGAA"
     polyA_site      2899
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
ORIGIN      
        1 gacagagcgg acccaggccc tcggccgccc cgcgtcatgg ccgcgccggc cccggtcacg
       61 cggcaggtta gcggcgccgc cgccctggtc ccggccccga gcggccccga cagcgggcag
      121 cccctggcgg ccgccgtggc cgagctgccg gtgctggacg cccgcgggca gcgggtaccg
      181 ttcggcgcgc tgttccggga gcgccgcgcc gtggtggtgt tcgtgcggca tttcctgtgt
      241 tacatctgca aggaatacgt agaggatctg gccaaaatcc ccaggagttt cttacaagaa
      301 gcaaatgtca cccttatagt gattggacag tcatcctacc atcatattga gcctttttgc
      361 aagctgactg gatattctca tgaaatctat gtcgatcctg agagagaaat ttataaaaga
      421 ttgggaatga aaagaggtga agaaattgct tcctcaggac agagccccca cataaaatca
      481 aatctactct caggaagcct tcagagcctg tggcgggcag tgactggccc tctctttgat
      541 tttcaaggag acccagctca gcaaggtgga accctcattt taggtccagg taacaacatc
      601 cattttatac accgcgatag gaataggttg gatcacaaac ctatcaactc tgttttacag
      661 cttgtaggag ttcagcatgt gaactttaca aacagacctt cagttatcca tgtgtgactt
      721 aaaatgcact cagtcacttt caactggacc ttctggaatg tgaccttcaa tgcctgggtg
      781 taatatcctc gtgcagtgtc taacctgctg tcccttccca gcctttgagg agttagggaa
      841 gcataaaggg ggcttgaacc tgttgaattg catgctggga agcatcagtt gtcaaaatat
      901 gttatatact tccattttat aacttttaac attttataca aaaaaaatga atatacaaaa
      961 tataacttta aaagctataa aatcataaat actctaaatt attttacatt atggtatatt
     1021 cagtcaatga aagagttttt tggcaatata aattctgaca gtatataagg ggacaggaga
     1081 acaacacaag accattatat tcagtgaaga aggcaaaata tcaaatctgt caacaatgta
     1141 actgcatttt tatatgtata tatttgtatt tttgtatgct ttggaaaaag acaggaaata
     1201 aacaccaaaa tgttgccagt aggtatctct gtgttaagat tagtgttatt attttctttt
     1261 ctgtactttt ctgtatttcc caactgttat ataatgagca tgattaatat tgtagggcca
     1321 ggaaaaggtc tttaaacatt ataggacaat tttatgccac ataacaacct tcacaaaaga
     1381 gcaaaattat ataagctgta gtccactttt ccatcgtaat tgctttactc agaggaagtg
     1441 tggcaatccg aacatttcac atatagccag tgtccacagc accttctcaa actacatact
     1501 tgctatccgt ttcactagga ttttgggggg ttgggggagc tatggagaaa aaaattgttt
     1561 tagatattta agatatgtat ttaaaaatat ggtcagtgtg ctttttgaaa gggaactata
     1621 agaatttttt tttttttttt ttttgagatg gagtctcact ctgttgccca ggctggagtg
     1681 cagtggcatg atctcggctc actgcaagtt ccgcctcccg ggttcacgcc attctcctgc
     1741 ctcagcctcc cgagtagctg ggactacagg cacccaccac cacgcccggc taattttttg
     1801 tatttttatt agagacgggg tttcactgtg ttataacagc caggatggtc ttgacctcct
     1861 gacctcatga tccgcccacc tcggcctccc aatgtgttgg gattacaggt atgagccacc
     1921 ttgcctggct tttttttttt tttttttttt tttttttttg agatggagtc ttgctctgtc
     1981 gcccaggctg gagtgcaatg gctcaatctc agctcactgc aacttccgcc tccttggttc
     2041 aagcaattct gcctcagcct cccaagtagc tgggattaca ggcacccgcc accatacctg
     2101 gctactttta gtagagacgg ggttccacca tgttggccag gctggtctcg aactccatac
     2161 ctcaggtgat ccgtctgcct cggcctccca aagtgctaga attgcaggcg ttagccacca
     2221 ttcccggcca agaattgtta aaatttttta aaacttggta acttaaatgt acactatggt
     2281 ttagttatgc attcctagag aactgctatt tctcaccctc aaactgctct tatttgggag
     2341 acttgttatc tttcattttt ctagaatttt tttttttttt ttgagacgga gtttcactct
     2401 tgttgcacag gatggagtgc aatggcacga tctcggctca ctgcaacctc cacctcccgg
     2461 gttcaagtga ttctcctgcc tcagcctcct gagtagctga gattacaggc atgcgccacc
     2521 atgcctggct aagtttctat tttttagtaa agatggagtt tctccatgtc ggtcaggctg
     2581 gtctcgaact cccgacctca ggtgatctgc ctgcctcagc ctcccaaagt gctaggatta
     2641 taggcatgag ccaccgcgcc cggcctattt ttctagaatc ttaatatgtt tagttgggag
     2701 gtgtcccaga aatcctgatg aaaagtatag caaaatcaga attttggtaa tgattagcaa
     2761 gtataatact gctttgaact cagtactttt atatgaagca tataaagtta caaaaaaaac
     2821 taatgtattc aaatatttga atatatcttc atgtttgtat aatgttttta ttcaataaaa
     2881 atgaaatttc tcatttaaa
//
