LOCUS       NP_714542                226 aa            linear   PRI 28-APR-2025
DEFINITION  peroxiredoxin-like 2C [Homo sapiens].
ACCESSION   NP_714542 XP_114685
VERSION     NP_714542.1
DBSOURCE    REFSEQ: accession NM_153698.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 226)
  AUTHORS   Zhang,B., Wu,J., Cai,Y., Luo,M., Wang,B. and Gu,Y.
  TITLE     AAED1 modulates proliferation and glycolysis in gastric cancer
  JOURNAL   Oncol Rep 40 (2), 1156-1164 (2018)
   PUBMED   29901208
REFERENCE   2  (residues 1 to 226)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (residues 1 to 226)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   4  (residues 1 to 226)
  AUTHORS   Castellano,S., Novoselov,S.V., Kryukov,G.V., Lescure,A., Blanco,E.,
            Krol,A., Gladyshev,V.N. and Guigo,R.
  TITLE     Reconsidering the evolution of eukaryotic selenoproteins: a novel
            nonmammalian family with scattered phylogenetic distribution
  JOURNAL   EMBO Rep 5 (1), 71-77 (2004)
   PUBMED   14710190
REFERENCE   5  (residues 1 to 226)
  AUTHORS   Gilligan,P., Brenner,S. and Venkatesh,B.
  TITLE     Fugu and human sequence comparison identifies novel human genes and
            conserved non-coding sequences
  JOURNAL   Gene 294 (1-2), 35-44 (2002)
   PUBMED   12234665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM843088.1, BF445089.1, BU631382.1 and AL353578.18.
            
            On May 6, 2005 this sequence version replaced XP_114685.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136503.1, SRR5189658.104786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375234.8/ ENSP00000364382.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     Protein         1..226
                     /product="peroxiredoxin-like 2C"
                     /note="UPF0308 protein C9orf21; ahpC/TSA antioxidant
                     enzyme domain-containing protein 1; thioredoxin-like
                     protein AAED1; AhpC/TSA antioxidant enzyme domain
                     containing 1"
                     /calculated_mol_wt=24725
     Region          34..195
                     /region_name="PRX_like2"
                     /note="Peroxiredoxin (PRX)-like 2 family; hypothetical
                     proteins that show sequence similarity to PRXs. Members of
                     this group contain a CXXC motif, similar to TRX. The
                     second cysteine in the motif corresponds to the
                     peroxidatic cysteine of PRX, however, these...; cd02970"
                     /db_xref="CDD:239268"
     Site            order(68,71)
                     /site_type="active"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:239268"
     CDS             1..226
                     /gene="PRXL2C"
                     /gene_synonym="AAED1; C9orf21"
                     /coded_by="NM_153698.2:37..717"
                     /db_xref="CCDS:CCDS35073.1"
                     /db_xref="GeneID:195827"
                     /db_xref="HGNC:HGNC:16881"
ORIGIN      
        1 maapapvtrq vsgaaalvpa psgpdsgqpl aaavaelpvl dargqrvpfg alfrerravv
       61 vfvrhflcyi ckeyvedlak iprsflqean vtlivigqss yhhiepfckl tgysheiyvd
      121 pereiykrlg mkrgeeiass gqsphiksnl lsgslqslwr avtgplfdfq gdpaqqggtl
      181 ilgpgnnihf ihrdrnrldh kpinsvlqlv gvqhvnftnr psvihv
//
