LOCUS       NM_152371               2747 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens peroxiredoxin like 2B (PRXL2B), transcript variant 2,
            mRNA.
ACCESSION   NM_152371
VERSION     NM_152371.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Yoshikawa,K., Takei,S., Hasegawa-Ishii,S., Chiba,Y., Furukawa,A.,
            Kawamura,N., Hosokawa,M., Woodward,D.F., Watanabe,K. and Shimada,A.
  TITLE     Preferential localization of prostamide/prostaglandin F synthase in
            myelin sheaths of the central nervous system
  JOURNAL   Brain Res 1367, 22-32 (2011)
   PUBMED   20950588
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Moriuchi,H., Koda,N., Okuda-Ashitaka,E., Daiyasu,H., Ogasawara,K.,
            Toh,H., Ito,S., Woodward,D.F. and Watanabe,K.
  TITLE     Molecular characterization of a novel type of
            prostamide/prostaglandin F synthase, belonging to the
            thioredoxin-like superfamily
  JOURNAL   J Biol Chem 283 (2), 792-801 (2008)
   PUBMED   18006499
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Castellano,S., Novoselov,S.V., Kryukov,G.V., Lescure,A., Blanco,E.,
            Krol,A., Gladyshev,V.N. and Guigo,R.
  TITLE     Reconsidering the evolution of eukaryotic selenoproteins: a novel
            nonmammalian family with scattered phylogenetic distribution
  JOURNAL   EMBO Rep 5 (1), 71-77 (2004)
   PUBMED   14710190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC351872.1, BC022547.1, AF425266.1, AK075273.1 and BM976058.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152371.4.
            
            Transcript Variant: This variant (2) uses a different splice site
            in an internal coding region exon, compared to variant 1. The
            resulting protein (isoform b) is shorter when it is compared to
            isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF425266.1, SRR7410570.6091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000419916.8/
                                                ENSP00000394405.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DC351872.1         3-93
            92-493              BC022547.1         59-460
            494-502             AF425266.1         465-473
            503-962             BC022547.1         470-929
            963-2742            AK075273.1         910-2689
            2743-2747           BM976058.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..2747
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /note="peroxiredoxin like 2B"
                     /db_xref="GeneID:127281"
                     /db_xref="HGNC:HGNC:28390"
     exon            1..172
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..706
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /EC_number="1.11.1.20"
                     /note="isoform b is encoded by transcript variant 2;
                     prostamide/prostaglandin F synthase; prostamide/PGF
                     synthase; prostamide/PG F synthase; thioredoxin-type PGF
                     synthase; family with sequence similarity 213 member B"
                     /codon_start=1
                     /product="prostamide/prostaglandin F synthase isoform b"
                     /protein_id="NP_689584.5"
                     /db_xref="CCDS:CCDS44.3"
                     /db_xref="GeneID:127281"
                     /db_xref="HGNC:HGNC:28390"
                     /translation="MSTVDLARVGACILKHAVTGEAVELRSLWREHACVVAGLRRFGC
                     VVCRWIAQDLSSLAGLLDQHGVRLVGVGPEALGLQEFLDGDYFAGELYLDESKQLYKE
                     LGFKRYNSLSILPAALGKPVRDVAAKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLL
                     HFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV"
     exon            173..377
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     exon            378..429
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     exon            430..493
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     exon            494..569
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     exon            570..688
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     exon            689..2747
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /note="hexamer: AATAAA"
     polyA_site      2747
                     /gene="PRXL2B"
                     /gene_synonym="C1orf93; FAM213B"
                     /note="major polyA site"
ORIGIN      
        1 ggggcttggg gctggatcta tgagccggga gcggggatcc aggagcgagg agccgggagc
       61 ggggaacagg gagtcgggga gccgggaacc agggctggca gcggccgcca tgagcacggt
      121 ggaccttgct cgcgtgggcg cgtgcatcct gaagcatgcg gtgaccgggg aggccgtgga
      181 gctgcggagc ctgtggcggg agcacgcgtg cgtggtggcc gggctgcggc gcttcgggtg
      241 cgtggtgtgc cgctggatcg cccaggacct cagcagcctt gctgggctcc tggaccaaca
      301 cggcgtgcgc ctggtgggcg tagggcccga ggccctgggt ctgcaggagt tcctggacgg
      361 cgactacttc gcgggagagc tctacctgga tgagagcaag cagctttaca aggagctagg
      421 cttcaagcgg tacaacagcc tgagcatcct cccagcagct ctggggaagc ccgtgcgtga
      481 tgtggctgcc aaggccaagg ctgttggcat ccaggggaac ttgtctgggg acctgctgca
      541 gagcggaggg ctgctggtgg tcagcaaagg tggtgataaa gtgctcctgc atttcgtcca
      601 gaagtcccca ggcgactacg tccccaagga gcacatcctg caggtcctgg gcatctctgc
      661 ggaggtctgt gccagcgacc cgcctcagtg tgacagagag gtgtgaggga ggcgaaggcc
      721 ctggcctccg aggatctggg tggcgtctgc tgccctaggt gtgctggaag tccacttgga
      781 agaactgttc cggaggcgct gggtcgggat gccgaacctc tcctgatccg ccggcagcaa
      841 cgagccatta aaactgcagt tcctgaccac gcactgcttc gcaggctccg agccctgcat
      901 cctccacagc ccccgccttg ctcactgttg ggccctcagg gcgggcaggg tggctgtgag
      961 tcccaggtgt catcttcctg ctctgcgact ttctctggag accttgggcc tttggcctgt
     1021 ggggcactgg ggatggtaac ctcactgccc cgtcactccc ttcaaaggcg acagacccaa
     1081 gcccacgtca ggagaggagc gtggggtcag ctccagcagg gtcggggtca gtgcctgtgt
     1141 ctggtggggg ccactcagga gagttgggtt ttcagggcag agatgggctt gattccacct
     1201 ggtggggtgg gtggaccctg gagactctca ggtgatgggc cagcctgccc caaggctctt
     1261 tactgatgtc agaatcattg tttgcacctg ctgggtatgg cctttggggc ggccggcccg
     1321 ggagggtctt agtctaatta ggtgtgtcca gcttcttggc cacctttccc tggggaccct
     1381 aacaggccca gagcagagcc ccttacctcc caggtcagac tacctgctca ggccctcccc
     1441 tcccatgcag gccgatgaca actgcagccc tctctgcact ccctagtcca gacctgggga
     1501 ccactgtggg ttcctgtggg tctcccggct cccttcctgc ccccaatgcc acccttgcag
     1561 tggccattta aaaatgcata gcaggtgacc cactgcgtcc ctttgcgttc agcccctcct
     1621 ctggctttca gttacaccaa gctaaaattt caggttccca gctgcagctc tctgggtccc
     1681 ccggtgcccc agtggggctc cccgcatctg aatgtgtggt ccctgggggt gggcacttgg
     1741 gggcatcctg gtcactgctg gccctagcat tggaccctag gagacctgac tggaactggc
     1801 tccctcccca tcagctccca gctgtcactc tctcccaccc ccgggcagct gttttgccca
     1861 agaccactgc tacctgttta cccaccctgg tccctcccag acaagcaagg cctctgattt
     1921 ctttgaagca tttacttagc tcaagtctga agctgtagat actggaagac aatgcacctt
     1981 ggagggtggg caggacacag ttgattgtct ctacagagct gtgacggggg cactgagccc
     2041 cgcgggtgtc tgtggagggg gctccggtcc aggtactgca ctggacactg ctcatccctg
     2101 ggtgtcaggc aggtggctgc accctaggcc aggcgcagag gcctggcagg caggcttggc
     2161 atggttggcc ggggcgggac gtacactggg tcgccgctag ctgcaccttc gcacagatgc
     2221 ctccgagcag cgggtgggcg tgggccgcac agcgcggcag ggccttggct accacacgcg
     2281 gcatcgctcc ttggggtgca tgggggtgcc ccgggcacag tggaacgtgt ctgcgaaggc
     2341 ggccaggttc tgcagcgacc ccagtaccct gtgggtgggt gggtgtgaca gcaggagcat
     2401 tgccatcttg gacaaacatg gccattttaa gttctccgtg attaaaaacc agcccaaaac
     2461 atcagcctaa tggctcatgt cagtatgagc agaaacattt caaccatgag ataaaccccc
     2521 atctgaccag aaacatgcca atcctgagaa taacctcccc tccagccaga gatattccaa
     2581 ctctgcaata aaactctcct tcacacagaa acattcgcag cctgcggtag gctccccctt
     2641 cctaaaccct taaatgccct tagtctgtaa gagaatgtcc ctgaccgaaa tcggccagaa
     2701 gcccctctca ggtttattcc caaaataaac ctgtctctgt tgagcca
//
