LOCUS       NM_032333               5801 bp    mRNA    linear   PRI 07-SEP-2020
DEFINITION  Homo sapiens peroxiredoxin like 2A (PRXL2A), transcript variant 1,
            mRNA.
ACCESSION   NM_032333
VERSION     NM_032333.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5801)
  AUTHORS   Oh CK, Ha M, Han ME, Heo HJ, Myung K, Lee Y, Oh SO and Kim YH.
  TITLE     FAM213A is linked to prognostic significance in acute myeloid
            leukemia through regulation of oxidative stress and myelopoiesis
  JOURNAL   Hematol Oncol 38 (3), 381-389 (2020)
   PUBMED   32124993
  REMARK    GeneRIF: FAM213A is linked to prognostic significance in acute
            myeloid leukemia through regulation of oxidative stress and
            myelopoiesis.
REFERENCE   2  (bases 1 to 5801)
  AUTHORS   Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH, Chang KW and Lin
            SC.
  TITLE     miR-125b suppresses oral oncogenicity by targeting the
            anti-oxidative gene PRXL2A
  JOURNAL   Redox Biol 22, 101140 (2019)
   PUBMED   30785086
  REMARK    GeneRIF: this study has pinpointed novel clues demonstrating that
            downregulation of miR-125b suppressor underlies upregulation of
            PRXL2A in OSCC, and this then protects the affected tumor cells
            from oxidative stress.
REFERENCE   3  (bases 1 to 5801)
  AUTHORS   He H, Guo F, Li Y, Saaoud F, Kimmis BD, Sandhu J, Fan M, Maulik D,
            Lessner S, Papasian CJ, Fan D, Jiang Z and Fu M.
  TITLE     Adiporedoxin suppresses endothelial activation via inhibiting MAPK
            and NF-kappaB signaling
  JOURNAL   Sci Rep 6, 38975 (2016)
   PUBMED   27941911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5801)
  AUTHORS   Guo F, He H, Fu ZC, Huang S, Chen T, Papasian CJ, Morse LR, Xu Y,
            Battaglino RA, Yang XF, Jiang Z, Xin HB and Fu M.
  TITLE     Adipocyte-derived PAMM suppresses macrophage inflammation by
            inhibiting MAPK signalling
  JOURNAL   Biochem. J. 472 (3), 309-318 (2015)
   PUBMED   26438880
  REMARK    GeneRIF: results suggest that adipocyte-derived PAMM may suppress
            macrophage activation by inhibiting MAPK signalling pathway.
REFERENCE   5  (bases 1 to 5801)
  AUTHORS   Xu Y, Morse LR, da Silva RAB, Wang D and Battaglino RA.
  TITLE     A short report: PAMM, a novel antioxidant protein, induced by
            oxidative stress
  JOURNAL   Redox Biol 6, 446-453 (2015)
   PUBMED   26402163
  REMARK    GeneRIF: Antioxidant stress induces PAMM mRNA expression in human
            peripheral blood mononuclear cells .
REFERENCE   6  (bases 1 to 5801)
  AUTHORS   Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T,
            Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK and Pilch PF.
  TITLE     Adiporedoxin, an upstream regulator of ER oxidative folding and
            protein secretion in adipocytes
  JOURNAL   Mol Metab 4 (11), 758-770 (2015)
   PUBMED   26629401
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5801)
  AUTHORS   Xu Y, Morse LR, da Silva RA, Odgren PR, Sasaki H, Stashenko P and
            Battaglino RA.
  TITLE     PAMM: a redox regulatory protein that modulates osteoclast
            differentiation
  JOURNAL   Antioxid. Redox Signal. 13 (1), 27-37 (2010)
   PUBMED   19951071
  REMARK    GeneRIF: The PAMM is a redox regulatory protein that modulates
            osteoclast differentiation in vitro. PAMM expression may affect
            bone resorption in vivo and help to maintain bone mass.
REFERENCE   8  (bases 1 to 5801)
  AUTHORS   Castellano S, Novoselov SV, Kryukov GV, Lescure A, Blanco E, Krol
            A, Gladyshev VN and Guigo R.
  TITLE     Reconsidering the evolution of eukaryotic selenoproteins: a novel
            nonmammalian family with scattered phylogenetic distribution
  JOURNAL   EMBO Rep. 5 (1), 71-77 (2004)
   PUBMED   14710190
REFERENCE   9  (bases 1 to 5801)
  AUTHORS   Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
            Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
            Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
            Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
            Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
            Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
            K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
            A, Wood WI, Godowski P and Gray A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074643.1, BC071938.1, AI589570.1, AA829725.1 and AC021028.12.
            
            On Nov 22, 2018 this sequence version replaced NM_032333.4.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1,
            2, 3 and 4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.331178.1,
                                           SRR3476690.985112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606162.6/ ENSP00000482445.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-671               AK074643.1         11-681
            672-1342            BC071938.1         599-1269
            1343-1677           AI589570.1         1-335               c
            1678-1683           AA829725.1         26-31               c
            1684-5801           AC021028.12        26009-30126
FEATURES             Location/Qualifiers
     source          1..5801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..5801
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /note="peroxiredoxin like 2A"
                     /db_xref="GeneID:84293"
                     /db_xref="HGNC:HGNC:28651"
                     /db_xref="MIM:617165"
     exon            1..93
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            94..273
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..785
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; peroxiredoxin (PRX)-like 2 activated in M-CSF
                     stimulated monocytes; UPF0765 protein C10orf58;
                     peroxiredoxin-like 2 activated in M-CSF stimulated
                     monocytes; redox-regulatory protein PAMM; redox-regulatory
                     protein FAM213A; family with sequence similarity 213
                     member A; Adiporedoxin"
                     /codon_start=1
                     /product="peroxiredoxin-like 2A isoform 1 precursor"
                     /protein_id="NP_115709.3"
                     /db_xref="CCDS:CCDS7368.1"
                     /db_xref="GeneID:84293"
                     /db_xref="HGNC:HGNC:28651"
                     /db_xref="MIM:617165"
                     /translation="MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKA
                     ALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSML
                     DQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWY
                     NFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKM
                     IKPQTLASEKK"
     exon            274..365
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            366..506
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            507..671
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            672..5801
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /note="major polyA site"
     regulatory      5772..5777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /note="hexamer: AATAAA"
     polyA_site      5801
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcccct gggaccctcc gggccgggcg gtttggcccc ttagcgcccg ggcgtcgggg
       61 cggtaaaagg ccggcagaag ggaggcactt gagaaatgtc tttcctccag gacccaagtt
      121 tcttcaccat ggggatgtgg tccattggtg caggagccct gggggctgct gccttggcat
      181 tgctgcttgc caacacagac gtgtttctgt ccaagcccca gaaagcggcc ctggagtacc
      241 tggaggatat agacctgaaa acactggaga aggaaccaag gactttcaaa gcaaaggagc
      301 tatgggaaaa aaatggagct gtgattatgg ccgtgcggag gccaggctgt ttcctctgtc
      361 gagaggaagc tgcggatctg tcctccctga aaagcatgtt ggaccagctg ggcgtccccc
      421 tctatgcagt ggtaaaggag cacatcagga ctgaagtgaa ggatttccag ccttatttca
      481 aaggagaaat cttcctggat gaaaagaaaa agttctatgg tccacaaagg cggaagatga
      541 tgtttatggg atttatccgt ctgggagtgt ggtacaactt cttccgagcc tggaacggag
      601 gcttctctgg aaacctggaa ggagaaggct tcatccttgg gggagttttc gtggtgggat
      661 caggaaagca gggcattctt cttgagcacc gagaaaaaga atttggagac aaagtaaacc
      721 tactttctgt tctggaagct gctaagatga tcaaaccaca gactttggcc tcagagaaaa
      781 aatgattgtg tgaaactgcc cagctcaggg ataaccaggg acattcacct gtgttcatgg
      841 gatgtattgt ttccactcgt gtccctaagg agtgagaaac ccatttatac tctactctca
      901 gtatggatta ttaatgtatt ttaatattct gtttaggccc actaaggcaa aatagcccca
      961 aaacaagact gacaaaaatc tgaaaaacta atgaggatta ttaagctaaa acctgggaaa
     1021 taggaggctt aaaattgact gccaggctgg gtgcagtggc tcacacctgt aatcccagca
     1081 ctttgggagg ccaaggtgag caagtcactt gaggtcggga gttcgagacc agcctgagca
     1141 acatggcgaa accccgtctc tactaaaaat acaaaaatca cccgggtgtg gtggcaggca
     1201 cctgtagtcc cagctacccg ggaggctgag gcaggagaat cacttgaacc tgggaggtgg
     1261 aggttgcggt gagctgagat cacaccactg tattccagcc tgggtgactg agactctaac
     1321 taaaaaaaaa aaaaaaaaaa aattgattgc tgtgcctcat tacaaatgca tatgatgttt
     1381 gagtgctgtt gtttgaaatt atttttcttt tcgggtcttc aaaaattcaa gaaaagttga
     1441 tgattgactt gaagattaca aaatttaagg ttttttggca tgtgtgtttt ctattaataa
     1501 ttggttatat gatgtcaaag taatactttc ataatagaat tgacatgctc tgggatagtt
     1561 tgacaaaggt aaattataaa gtgaaatctc ttgtttcatt atcttccatt ctaacctcag
     1621 agatctgttt ctctagaaaa aatgtccatc tctggcttta ataaaattat gcatcagaaa
     1681 tcacctgtat gtataagatt ttctgataaa actaataatt atatttacca tataattggc
     1741 tgaaagtaaa aaaagtcagc attctccatg gctgaggggt aaagtgcctc gggggattcc
     1801 tctggttcta gctatctaag tggtttgaaa atgaccagga aaaattcatc ctgtcattca
     1861 cgttagtaat tttgctgtct ttcctagagg aatgactttg gtgtttaaaa ttggtagctg
     1921 tttttctatt ggtcttttag cctaatttgg caaatcagaa gaaaggacat agagatgatg
     1981 aaatataact ttatcttttt tgtttgaatt ttgtcgtgta agtttgagtg acatcatcaa
     2041 gacctaccag ggagctcggc cacagggagt ctactcaagg catcaaactg gcccaggagt
     2101 agaaaggtgg gggtggaaat aggaaatagt gtttacccag gggactggcc cagccaggag
     2161 gagaaaggaa tcagtgttta cccaggaaag caagaatgga tactgatgtt ggaggtaaag
     2221 ctgggaaagt aggagagcat cgggattgag tatgcagagt gagttagggt tgagtggttc
     2281 gggactaaga cccactaaga ccatgcctgc acctgacttc atgtagcagt ggttgcatgg
     2341 ggtatgcatg ggcccttaaa gggctgggct tctgcagcat ttgaggccat agcctttggt
     2401 acttgcacag ggttggtacc tgtcatcctt gggactccag ctactgatag gataactcag
     2461 tacctaaact tagaacttta atacctaaga cacttgatgg tgaaacagtt ctcttgcaac
     2521 taaagaagaa cctgaggtca ggtgtggtgg ctcacgcctg taatcctagc actttgggaa
     2581 gtcgaggtag aaggatcact tgaggtcagg agttcgagac cagcctggcc agcatggtga
     2641 aaccccatct ctactaaaaa tacaaaatat tagacagacg gggtggtaca tgcctgtaat
     2701 cccagctact tgggaggctg aggcaggaga atcgcttgaa cccaggaggc agaggttgca
     2761 gtgagccgag atcgtgccac tgcactccag cttgggcaac aagagcgaaa ctccatatca
     2821 aaaaaaaaaa cctgagagga cattgcacca atggagatgc atcaagagaa acatgtttgg
     2881 ttttttgtga gctctcacca acttttttcc cctgggtcct cacgtgcagt gtggtcttct
     2941 ctttctgatt agcatgtcat tttggaaaga gcactggatt gagtcatgag gcataatcaa
     3001 tttctagttt accagtgtga tcttaagcaa agatctaact cattggcaaa atgggcgtga
     3061 ttccttccca ttcagggctg tttatgataa gtcactgagg gaatgataaa tattatgaca
     3121 ctgcttctca gactgtaatg tacatgcaca tcacataagg accttattaa aatggagact
     3181 taaaaagctg gacgctaaag gcaataatga cagattttac tcaataacta ctgcagaagg
     3241 agagagtcct cagtatagaa ctgagcttag ctccaatctg tgcagaggtg atggaatttt
     3301 aaagagggga gggaggaggt tcaaatagaa ctagggaagt gcaaaattac aaaaagctgg
     3361 taaggagatt ggtcaatgtg attcggctat ctgtgtctac taactctcaa atttatttat
     3421 caaagttagg atcctagcct cccacagaga ccaggagtcg gccttatcat tcctgataat
     3481 tatatgacaa agggatggct cccagaaaaa gtgagaaaca cattcctgtg cagcagaaga
     3541 tacatatatc ccccaaaggg acagaaagga tttacaattg taaattttat aaagtatgtc
     3601 ctctaagaag agggagggac tgggtgccat ggctcatgcc tataatccca gcactttggg
     3661 tggccaaggt gggtgcatca cctgaggtca ggagttcaag agcagcctgg ccaacatggt
     3721 gaaaccctgt ctctactaaa aatacaaaag ttagcctgtt gtggtggcgc gcacctgtaa
     3781 tcccagctac tcgggtggct gaggcaggag aatcgcttga acccaggagg cggagggtgc
     3841 agtgagccgg gatcacgcca ctgcacttca gcctgggtga cagagtgtga ctccatctca
     3901 agaaaaacga gggagattag aaacctatga tcaggcattg gctgaaacaa atggtaaatt
     3961 cttttggcag ccttgagctt ccccaggcag ggacccaaag gggcctgggt tatccctgag
     4021 acagggcctt gagctgctag aaactatgct agtgtttgtt caagtctctc cgtgtccggg
     4081 gtgagcaaaa ttgtttgtgc tgaaaatcaa tgatttgcag ctctcaagat tccagtgggc
     4141 agtctgggtg ggcctgagtt tctgcttttt ttttttcttt atgtacaggg tcttgctctg
     4201 tcacctaggc tagagtgtaa ttagtggccc cagtcatggc tcactgcagc tgcaaactgg
     4261 ctgcaagctg ttctggctca gcctaccaag ttactgggct tacaggtgga tgccaccgta
     4321 cccaacagat tttatttttg tagggatggg ggtctccctg tattgcccag gctggtctca
     4381 aactcctggc ctcccaaagt gtttagatta caggtgtaag ccaccacacg tggccagcct
     4441 ctgcatttct aacaggttcc aggtgatctt gatgttctgc tggtccatgg gtcacacttt
     4501 gagaagcatg gttctaaagg actatacaga ttaaagtcat taatctctgt gggctttgga
     4561 cttgaagttt cagcagcctt tgacaagcat ttgcaggttt cctttttatt tatttgataa
     4621 actgagaatc cacatgcaaa gaaatgcaag aaaattcaaa gaacgtaaga aaatgtcctt
     4681 gctgtaaagc tggtggttct caatctcgga tacacagtag aatcacctgg tgcgggggtt
     4741 gggggcgggg tgcagtgtaa aaattattaa atcagaatct ctggggtagg ccccaagcaa
     4801 cttttttttt ttttttttta gatagaatct tgcttgtcac ctaggctaga gtgcagtaat
     4861 gcaatcatgg ctcactgctg ccttaacttc tgggctcaag tgatatcctc ccacctcagc
     4921 ctccctagta gctgggacta caggcgtgga ctaccacacc caacaaattt ttaaattttt
     4981 tgtagaggca agctcttata ctatcttgca caggctggtc tcgaactcct gggctcaagc
     5041 agtcatcctg cctcagcctt ccaaagctca gggattacag acatgagcca cagcaccagg
     5101 ccaacaatat ttcttaaagc tcctggagtg attccaatat gcagccaagg ttgaaaacca
     5161 ccctttaaaa ggctcggcat ccagtgtgga agaccagcac actcacgtca ggagacctta
     5221 cctggagcca ggatgcccct gatcatctct gataacttta aaaggaaggc ctcagaagca
     5281 gccccagaag caaaagtttc tctctgacct tctcctgccc tcttgtttct ggcttttcat
     5341 tctcccccaa ggctacccat agaaactaga atccctcttc cccaaggcag gtcatcagaa
     5401 accagaaccg gttttaccca aagccagcca taaaacctaa aaatagtcct ctcactcccc
     5461 attccccttt ctgtgtaaaa actggttgga aagaaatgat ctgacctacc gtgtttgact
     5521 gtcgtaagat acccattcca gagagggtcc caccccgtgc ccagaaggaa ggaatcctgc
     5581 acagagaggc caagaagaat ctagacagcc ttgctgggtt tcccctctca gtctattact
     5641 attagatcat acccttcttg tccaatcata tttctacaca gtccataatc tgttgaacct
     5701 aaacataaaa atggacaatt cccctgtatc ttggggtctt cattctgagg gctcacatac
     5761 aattatgatc aaataaattt gtttgctttt tctcctgtta a
//
