LOCUS       NP_115709                229 aa            linear   PRI 07-SEP-2020
DEFINITION  peroxiredoxin-like 2A isoform 1 precursor [Homo sapiens].
ACCESSION   NP_115709
VERSION     NP_115709.3
DBSOURCE    REFSEQ: accession NM_032333.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 229)
  AUTHORS   Oh CK, Ha M, Han ME, Heo HJ, Myung K, Lee Y, Oh SO and Kim YH.
  TITLE     FAM213A is linked to prognostic significance in acute myeloid
            leukemia through regulation of oxidative stress and myelopoiesis
  JOURNAL   Hematol Oncol 38 (3), 381-389 (2020)
   PUBMED   32124993
  REMARK    GeneRIF: FAM213A is linked to prognostic significance in acute
            myeloid leukemia through regulation of oxidative stress and
            myelopoiesis.
REFERENCE   2  (residues 1 to 229)
  AUTHORS   Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH, Chang KW and Lin
            SC.
  TITLE     miR-125b suppresses oral oncogenicity by targeting the
            anti-oxidative gene PRXL2A
  JOURNAL   Redox Biol 22, 101140 (2019)
   PUBMED   30785086
  REMARK    GeneRIF: this study has pinpointed novel clues demonstrating that
            downregulation of miR-125b suppressor underlies upregulation of
            PRXL2A in OSCC, and this then protects the affected tumor cells
            from oxidative stress.
REFERENCE   3  (residues 1 to 229)
  AUTHORS   He H, Guo F, Li Y, Saaoud F, Kimmis BD, Sandhu J, Fan M, Maulik D,
            Lessner S, Papasian CJ, Fan D, Jiang Z and Fu M.
  TITLE     Adiporedoxin suppresses endothelial activation via inhibiting MAPK
            and NF-kappaB signaling
  JOURNAL   Sci Rep 6, 38975 (2016)
   PUBMED   27941911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 229)
  AUTHORS   Guo F, He H, Fu ZC, Huang S, Chen T, Papasian CJ, Morse LR, Xu Y,
            Battaglino RA, Yang XF, Jiang Z, Xin HB and Fu M.
  TITLE     Adipocyte-derived PAMM suppresses macrophage inflammation by
            inhibiting MAPK signalling
  JOURNAL   Biochem. J. 472 (3), 309-318 (2015)
   PUBMED   26438880
  REMARK    GeneRIF: results suggest that adipocyte-derived PAMM may suppress
            macrophage activation by inhibiting MAPK signalling pathway.
REFERENCE   5  (residues 1 to 229)
  AUTHORS   Xu Y, Morse LR, da Silva RAB, Wang D and Battaglino RA.
  TITLE     A short report: PAMM, a novel antioxidant protein, induced by
            oxidative stress
  JOURNAL   Redox Biol 6, 446-453 (2015)
   PUBMED   26402163
  REMARK    GeneRIF: Antioxidant stress induces PAMM mRNA expression in human
            peripheral blood mononuclear cells .
REFERENCE   6  (residues 1 to 229)
  AUTHORS   Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T,
            Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK and Pilch PF.
  TITLE     Adiporedoxin, an upstream regulator of ER oxidative folding and
            protein secretion in adipocytes
  JOURNAL   Mol Metab 4 (11), 758-770 (2015)
   PUBMED   26629401
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 229)
  AUTHORS   Xu Y, Morse LR, da Silva RA, Odgren PR, Sasaki H, Stashenko P and
            Battaglino RA.
  TITLE     PAMM: a redox regulatory protein that modulates osteoclast
            differentiation
  JOURNAL   Antioxid. Redox Signal. 13 (1), 27-37 (2010)
   PUBMED   19951071
  REMARK    GeneRIF: The PAMM is a redox regulatory protein that modulates
            osteoclast differentiation in vitro. PAMM expression may affect
            bone resorption in vivo and help to maintain bone mass.
REFERENCE   8  (residues 1 to 229)
  AUTHORS   Castellano S, Novoselov SV, Kryukov GV, Lescure A, Blanco E, Krol
            A, Gladyshev VN and Guigo R.
  TITLE     Reconsidering the evolution of eukaryotic selenoproteins: a novel
            nonmammalian family with scattered phylogenetic distribution
  JOURNAL   EMBO Rep. 5 (1), 71-77 (2004)
   PUBMED   14710190
REFERENCE   9  (residues 1 to 229)
  AUTHORS   Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
            Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
            Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
            Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
            Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
            Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
            K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
            A, Wood WI, Godowski P and Gray A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074643.1, BC071938.1, AI589570.1, AA829725.1 and AC021028.12.
            
            On Jun 5, 2007 this sequence version replaced NP_115709.2.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1,
            2, 3 and 4 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.331178.1,
                                           SRR3476690.985112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606162.6/ ENSP00000482445.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     Protein         1..229
                     /product="peroxiredoxin-like 2A isoform 1 precursor"
                     /note="peroxiredoxin (PRX)-like 2 activated in M-CSF
                     stimulated monocytes; UPF0765 protein C10orf58;
                     peroxiredoxin-like 2 activated in M-CSF stimulated
                     monocytes; redox-regulatory protein PAMM; redox-regulatory
                     protein FAM213A; family with sequence similarity 213
                     member A; Adiporedoxin"
                     /calculated_mol_wt=22307
     sig_peptide     1..34
                     /inference="protein motif:SignalP:3.0"
                     /note="The cleavage site of the signal peptide has not
                     been experimentally determined."
                     /calculated_mol_wt=3475
     mat_peptide     35..229
                     /product="peroxiredoxin-like 2A isoform 1"
                     /calculated_mol_wt=22307
     Region          48..201
                     /region_name="PRX_like2"
                     /note="Peroxiredoxin (PRX)-like 2 family; hypothetical
                     proteins that show sequence similarity to PRXs. Members of
                     this group contain a CXXC motif, similar to TRX. The
                     second cysteine in the motif corresponds to the
                     peroxidatic cysteine of PRX, however, these...; cd02970"
                     /db_xref="CDD:239268"
     Site            order(85,88)
                     /site_type="active"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:239268"
     CDS             1..229
                     /gene="PRXL2A"
                     /gene_synonym="Adrx; C10orf58; FAM213A; PAMM"
                     /coded_by="NM_032333.5:96..785"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS7368.1"
                     /db_xref="GeneID:84293"
                     /db_xref="HGNC:HGNC:28651"
                     /db_xref="MIM:617165"
ORIGIN      
        1 msflqdpsff tmgmwsigag algaaalall lantdvflsk pqkaaleyle didlktleke
       61 prtfkakelw ekngavimav rrpgcflcre eaadlsslks mldqlgvply avvkehirte
      121 vkdfqpyfkg eifldekkkf ygpqrrkmmf mgfirlgvwy nffrawnggf sgnlegegfi
      181 lggvfvvgsg kqgillehre kefgdkvnll svleaakmik pqtlasekk
//
