LOCUS       NM_173814              12142 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens protogenin (PRTG), mRNA.
ACCESSION   NM_173814 XM_370866 XM_934331 XM_941491 XM_945227
VERSION     NM_173814.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12142)
  AUTHORS   Xiang,T., Yuan,C., Guo,X., Wang,H., Cai,Q., Xiang,Y., Luo,W. and
            Liu,G.
  TITLE     The novel ZEB1-upregulated protein PRTG induced by Helicobacter
            pylori infection promotes gastric carcinogenesis through the
            cGMP/PKG signaling pathway
  JOURNAL   Cell Death Dis 12 (2), 150 (2021)
   PUBMED   33542225
  REMARK    GeneRIF: The novel ZEB1-upregulated protein PRTG induced by
            Helicobacter pylori infection promotes gastric carcinogenesis
            through the cGMP/PKG signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12142)
  AUTHORS   Leslie,E.J., Carlson,J.C., Shaffer,J.R., Buxo,C.J., Castilla,E.E.,
            Christensen,K., Deleyiannis,F.W.B., Field,L.L., Hecht,J.T.,
            Moreno,L., Orioli,I.M., Padilla,C., Vieira,A.R., Wehby,G.L.,
            Feingold,E., Weinberg,S.M., Murray,J.C. and Marazita,M.L.
  TITLE     Association studies of low-frequency coding variants in
            nonsyndromic cleft lip with or without cleft palate
  JOURNAL   Am J Med Genet A 173 (6), 1531-1538 (2017)
   PUBMED   28425186
  REMARK    GeneRIF: We found that a burden of low-frequency coding variants in
            N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of
            Nonsyndromic cleft lip with or without cleft palate (NSCL/P) .
            Low-frequency variants in other genes were associated with
            decreased risk of NSCL/P. These results demonstrate that
            low-frequency variants contribute to the genetic etiology of NSCL/P
REFERENCE   3  (bases 1 to 12142)
  AUTHORS   Song,J., Kim,D., Chun,C.H. and Jin,E.J.
  TITLE     MicroRNA-9 regulates survival of chondroblasts and cartilage
            integrity by targeting protogenin
  JOURNAL   Cell Commun Signal 11, 66 (2013)
   PUBMED   24007463
  REMARK    GeneRIF: PRTG is regulated by miRNA9, plays an inhibitory action on
            survival of chondroblasts and articular chondrocytes during
            chondrogenesis and osteoarthritis pathogenesis.
            Erratum:[Cell Commun Signal. 2019 Nov 28;17(1):158. doi:
            10.1186/s12964-019-0483-7.. PMID: 31779635]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12142)
  AUTHORS   Watanabe,Y. and Nakamura,H.
  TITLE     Nuclear translocation of intracellular domain of Protogenin by
            proteolytic cleavage
  JOURNAL   Dev Growth Differ 54 (2), 167-176 (2012)
   PUBMED   22150322
REFERENCE   5  (bases 1 to 12142)
  AUTHORS   Wigg,K.G., Feng,Y., Crosbie,J., Tannock,R., Kennedy,J.L.,
            Ickowicz,A., Malone,M., Schachar,R. and Barr,C.L.
  TITLE     Association of ADHD and the Protogenin gene in the chromosome
            15q21.3 reading disabilities linkage region
  JOURNAL   Genes Brain Behav 7 (8), 877-886 (2008)
   PUBMED   19076634
  REMARK    GeneRIF: Identified association of attention deficit hyperactivity
            disorder (ADHD) to Protogenin (PRTG), a gene that potentially plays
            a role in cell migration and axon growth.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 12142)
  AUTHORS   Toyoda,R., Nakamura,H. and Watanabe,Y.
  TITLE     Identification of protogenin, a novel immunoglobulin superfamily
            gene expressed during early chick embryogenesis
  JOURNAL   Gene Expr Patterns 5 (6), 778-785 (2005)
   PUBMED   15922677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009997.7, CN352630.1,
            CN352629.1, AY630258.1, CN369786.1, CN369787.1, BQ215513.1,
            AC012378.10, CN283887.1, DA737881.1, DA732429.1, CN360440.1,
            AK023283.1, CN360445.1, AK022857.1, CN371161.1, CN371167.1,
            CN371165.1 and CN371162.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173814.5.
            
            Summary: This gene encodes a member of the immunoglobulin
            superfamily. The encoded transmembrane protein has been associated
            with the development of various tissues, especially neurogenesis.
            It has been suggested that this gene may be associated with
            attention deficit hyperactivity disorder (ADHD). [provided by
            RefSeq, Nov 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.208240.1, AY630258.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389286.9/ ENSP00000373937.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC009997.7         38240-38272         c
            34-93               CN352630.1         1-60
            94-94               AC009997.7         38179-38179         c
            95-173              CN352629.1         31-109
            174-4288            AY630258.1         1-4115
            4289-4891           CN369786.1         20-622
            4892-5305           CN369787.1         127-540
            5306-5745           BQ215513.1         270-709
            5746-5746           AC012378.10        79848-79848         c
            5747-5801           BQ215513.1         711-765
            5802-6424           CN283887.1         74-696
            6425-6450           DA737881.1         94-119
            6451-6457           DA732429.1         444-450
            6458-6520           DA737881.1         126-188
            6521-6562           DA732429.1         513-554
            6563-6988           DA737881.1         231-656
            6989-7421           CN360440.1         187-619
            7422-7680           AK023283.1         385-643
            7681-8159           CN360445.1         45-523
            8160-9904           AK023283.1         1123-2867
            9905-10936          AK022857.1         642-1673
            10937-10978         CN371161.1         464-505
            10979-11156         AK022857.1         1686-1863
            11157-11639         CN371167.1         7-489
            11640-11961         CN371165.1         299-620
            11962-12134         AK022857.1         2669-2841
            12135-12142         CN371162.1         292-299
FEATURES             Location/Qualifiers
     source          1..12142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..12142
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /note="protogenin"
                     /db_xref="GeneID:283659"
                     /db_xref="HGNC:HGNC:26373"
                     /db_xref="MIM:613261"
     exon            1..315
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3674
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /note="protogenin homolog (Gallus gallus); immunoglobulin
                     superfamily, DCC subclass, member 5; shen-dan"
                     /codon_start=1
                     /product="protogenin precursor"
                     /protein_id="NP_776175.2"
                     /db_xref="CCDS:CCDS42040.1"
                     /db_xref="GeneID:283659"
                     /db_xref="HGNC:HGNC:26373"
                     /db_xref="MIM:613261"
                     /translation="MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKE
                     PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRR
                     GEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISS
                     HPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSME
                     ASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSI
                     DVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPE
                     SLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI
                     YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVI
                     AYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV
                     TQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQV
                     LELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPEL
                     HLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDP
                     RRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFL
                     HWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLH
                     VDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTIL
                     YASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAV
                     LPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYR
                     SKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMPMIMPNSFIDA
                     KGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQPGTTVLISD
                     EDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLSSVISTT
                     PPNL"
     exon            316..618
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            619..763
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            764..897
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1035
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1194
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1354
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1602
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1767
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..2073
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2262
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2358
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2545
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2673
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2844
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3027
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3148
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3314
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3419
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..12142
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12115..12120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /note="hexamer: AATAAA"
     polyA_site      12142
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /note="major polyA site"
ORIGIN      
        1 actccgcccc cagccggact ctcaggcccc ttgcttctcg cgagcggccg tccgagcacc
       61 agcctcgccg ccgcagagac gctcgccacg ccggtgccgg agccggagcg gggagccagg
      121 ctgcgtgcga ccagccgcag agcagagagc gcccggggcg ggggccgcag acggacaggg
      181 gctctgggcg gccggggagc atgcccgcgc ggctacgctg aatggcgcct cctctgcgac
      241 ccctcgcccg gctgcgaccg ccggggatgc tgctccgcgc gctcctgctc ctgctgctgc
      301 tcagtccttt gccaggagtg tggtgcttta gcgaactgtc ttttgtaaaa gaaccacagg
      361 atgtaactgt cacaagaaag gacccagtcg ttttagattg ccaggctcac ggagaagttc
      421 ctattaaggt cacatggttg aaaaatggag caaaaatgtc tgaaaataaa cggatcgagg
      481 ttctttctaa cggctcttta tacatcagtg aggtggaagg caggcgagga gagcagtccg
      541 atgaaggatt ttatcagtgc ttggcaatga acaaatatgg agccattctt agtcaaaaag
      601 ctcatcttgc cttatcaact atttctgcat ttgaagtcca gccaatttcc actgaggtcc
      661 acgaaggtgg agttgctcga tttgcatgca agatttcatc ccaccctcct gcagtcataa
      721 catgggagtt caatcggaca actctaccta tgactatgga caggataact gccctaccaa
      781 caggagtatt gcagatctat gatgtcagcc aaagggattc tggaaattat cgttgtattg
      841 ctgccactgt agcccaccga cgtaaaagta tggaggcctc gctaactgtg attccagcta
      901 aggagtcaaa atccttccac acaccaacaa ttatagcagg tccacagaac ataacaacat
      961 ctcttcatca gactgtagtt ttggaatgca tggccacagg aaatcccaaa ccaatcattt
     1021 cttggagccg ccttgatcac aaatccattg atgtctttaa tactcgggta cttggaaatg
     1081 gtaatctcat gatatctgat gtcaggctac aacatgctgg agtatatgtt tgtcgggcca
     1141 ctacccctgg cacacgcaac tttacagttg ctatggcaac tttaactgta ttagctcctc
     1201 cttcatttgt tgaatggcca gaaagtttaa caaggcctcg agctggcact gctcgatttg
     1261 tgtgtcaggc agaaggaatc ccctctccca agatgtcatg gttgaaaaat ggaaggaaga
     1321 tacattcgaa tggtagaatt aaaatgtaca acagtaaatt ggtaattaac cagattattc
     1381 ctgaagatga tgctatttat cagtgcatgg ctgagaatag ccaaggatct attttatcta
     1441 gagccagact gactgtagtg atgtcagaag acagacccag tgctccctat aatgtacatg
     1501 ctgaaaccat gtcaagctca gccattcttt tagcctggga gaggccactt tataattcag
     1561 acaaagtcat tgcctattct gtacactaca tgaaagcaga aggtttaaat aatgaagagt
     1621 atcaagtagt catcggaaat gacacaactc attatattat tgatgactta gagcctgcca
     1681 gcaattatac tttctacatt gtagcatata tgccaatggg agccagccag atgtctgacc
     1741 atgtgacaca gaatactcta gaggatgttc ccctgagacc tcctgaaatt agtttgacaa
     1801 gtcgaagtcc cactgatatt ctcatctcct ggctgccaat cccagccaaa tatcggcggg
     1861 gccaagtggt gctgtatcgc ttgtctttcc gcctaagtac tgagaattca atccaagttc
     1921 tggagctccc ggggaccacg catgagtacc ttttggaagg cctgaaacct gacagtgtct
     1981 acctggttcg gattactgct gccaccagag tggggctggg agagtcatca gtatggactt
     2041 cacataggac gcccaaagct acaagcgtga aagcccctaa gtctccagag ttgcatttgg
     2101 agcctctgaa ctgtaccacc atttctgtga ggtggcagca agatgtagag gacacagctg
     2161 ctattcaggg ctacaagctg tactacaagg aagaagggca gcaggagaat gggcccattt
     2221 tcttggatac caaggaccta ctctatactc tcagtggctt agaccccaga agaaaatatc
     2281 atgtgagact cctggcttac aacaacatag acgatggcta tcaggcagat cagactgtca
     2341 gcactccagg atgcgtgtct gttcgtgatc gcatggtccc tcctccacca ccaccccacc
     2401 atctctatgc gaaggctaac acctcatctt ccatcttcct gcactggagg aggcctgcat
     2461 tcaccgctgc acaaatcatt aactacacca tccgctgtaa tcctgttggc ctgcagaatg
     2521 cttctttggt tctgtacctt caaacatcag aaactcacat gttggttcaa ggtctagaac
     2581 caaacaccaa atacgaattt gccgttcgat tacatgtgga tcagctttcc agtccttgga
     2641 gccctgtagt ctaccattct actcttccag aagcaccagc aggcccacca gttggagtaa
     2701 aagtgacatt aatagaggat gacactgccc tggtttcttg gaaaccccct gatggcccag
     2761 aaacagttgt gacccgctat actatcttat atgcatctag gaaggcctgg attgcaggag
     2821 agtggcaggt cttacaccgt gaaggggcaa taaccatggc tttgctagaa aacttggtag
     2881 caggaaatgt gtacattgtc aagatatctg catccaatga ggtgggagaa ggaccctttt
     2941 caaattctgt ggagctggca gtacttccaa aggaaacctc tgaatcaaat cagaggccca
     3001 agcgtttaga ttctgctgat gccaaagttt attcaggata ttaccatctg gaccaaaaat
     3061 caatgactgg cattgctgta ggtgttggca tagccttgac ctgcatcctc atctgtgttc
     3121 tcatcttgat ataccgaagt aaagccagga aatcatctgc ttccaagacg gcacagaatg
     3181 gaactcaaca gttacctcgt accagtgcct ccttagctag tggaaatgag gtaggaaaga
     3241 acctggaagg agctgtagga aatgaagaat ctttaatgcc aatgatcatg ccaaacagct
     3301 tcattgatgc aaagggagga actgacctga taattaatag ctatggtcct ataattaaaa
     3361 acaactctaa gaaaaagtgg ttttttttcc aagactcaaa gaagatacaa gttgagcagc
     3421 ctcaaagaag atttactcca gcggtctgct tttaccagcc aggcaccact gtattaatca
     3481 gtgatgaaga ctcccctagc tccccaggtc agacaaccag cttctcaaga ccctttggtg
     3541 ttgcagctga tacagaacat tcagcaaata gtgaaggcag ccatgagact ggggattctg
     3601 ggcggttttc tcatgagtcc aacgatgaga tacatctgtc ctcagttata agtaccacac
     3661 cccccaacct ctgattcttt cactggcagt gattcaggtg gagattccgc attgaggaag
     3721 tgtgaagacc ctgctgtgtc atctgttagt gagcagactt cctccttagt tctgcagccg
     3781 ccatctgcca tgctatgctt tgataaaaat gattttccaa tctagacggc catgctcagg
     3841 tattctcacc attaaatctg ttcgaaggac aatgaacagg gaaccaaagc cttttgtgaa
     3901 aatcttaata tctttatggg gtattttagc tttttttgaa tgtgttttgt tttttatttt
     3961 taaacttgtg taatttgaat gtttcattgt cagcaatgtg aaagaacggt cgagatgttt
     4021 gactggatta taaaatatat cactggagca aagggaagac ttttgaaagc ccctttgctg
     4081 actatctacc tcagtttgcc tcccggcaaa ctctgaagac aactttgtta cctcatttgt
     4141 tgttatagtt tatctcagct acataaccaa tgatacttcc tagtagtatt gtgttttcat
     4201 tgctgtacgt gtaatgtgtg tgatcaaagg agtcatatag gtagatgagt aagaatgttt
     4261 atctgaagct ctgatttttt taaaaaaaga aactatgaca tctgcatggt ttggataagt
     4321 tcatacctct ggctgtgagg accgttaaac cactgagaag aggaaaagtg gggctatttc
     4381 ttctaacgat gaccaaaaca agaaagtata tttcttttga gaacagaact attcaatacc
     4441 aggtagggat cattttgctt aaaaggcctt tatgttttgg gcattagagt ctgagtgctt
     4501 tatctcctat atcccaaacc tcaagctgcc cagaactgtg ccttttctac cttccccttt
     4561 gcctgacggt tggccaaagg ctgcactgtc tagtttgcaa agcatcctca actttgccag
     4621 tattagttgc aaaaccccat gcagaatatg gatttttaaa gaaaatgggt taaggtggtt
     4681 ttttttcttt ttttaaatcc cagtttggct taaaggagtg aagacatttc atgaactatt
     4741 aagaatgaag gtaaatgcaa cagtagacag taaaatgaac tcgaagttat tatggtaaca
     4801 gtgcctttca gtataatgaa attctttgcc ttataccttt ttaatattca tgaaattgtt
     4861 taggaacagg agtacaaaaa gttgccttaa gagtttcttg gattttatca gtaactattt
     4921 tgatgtatag tatcttacca aggcattttt tttaagtgca ggttttgttt agggataaat
     4981 attcagagtt ctaccaccct acttgtgttt tcttgaattc tttagagaat atggtatcta
     5041 cttaatcttc cttcagtgtc agtgctgtga atgaggaatg ctaactccag gagtgagtta
     5101 atcctcttgc aggtttgaaa tcagcaaatt gtttactcag ctacataaca taggcctttt
     5161 ctccgtcatg agacagttac ctaggtgccg agcagtggga gaggataaag aactaaacgc
     5221 gtgtagagaa ggggtcccat atccttttaa aagtattttt tcaaattttc tggaagtgac
     5281 ttttgattct cattttaaaa ggaatcataa tgggtttaca cttgaaatgc tttgttccta
     5341 gaggaggcag ggtcatgttc actgatgttc taaaatcaaa ggaatattag cagataatag
     5401 tcccagcatc atctgctagt ctaatgactg tagatataac atttttaatt tttttaaatc
     5461 tgtaattttg tgccaaactg gatgtgatta agactaaagt tcaatgccag caaccacttc
     5521 tgaactaaac tcagagtccc ccagttagtt atctaagtac ggaattcatc gcaaaacaaa
     5581 caaaaaagca gagctttagg tgaacagtct gcagcaagga aaaatgctgc tcctgccttt
     5641 atagctcctg ttttatacta cctcctttta aagttattct agtgttattt tttttcctgt
     5701 actcagggaa cgttttgtta cttttgagct gcctcatgga agcataggca gattgacagg
     5761 gtatagcgct ttgtggttgg taagtagaag tatatagggc caacttttat cagtatctaa
     5821 aattaagtac agtgagatca ttttattttt aagctttcat taaaaggcaa acaaaatcta
     5881 aagctgaaac atcatccatc atggttatgg aagatgtgtc taggactaca tgaattcgag
     5941 tggttttaaa tggctaaaaa gacgagctaa agtccttgag gaaagtattt tgtttgtttg
     6001 gtttttgatg aataggctta tagttacaat agaactttag gctataacta tttgataatt
     6061 atttaacagt acatttttta ccttttcatt ttgttcttat acggactttt tcataataat
     6121 tctgttacca aagaattttc agtagaaaat aaaattttga ttataattcc ccccaaattg
     6181 aattaactag aagcatttat agatatgaaa cttacacaag tagttactaa cccaaaacaa
     6241 tagggtttat attgattgtt gtagttaaat agattagtaa tgttaactac cttattgtta
     6301 ccagagcatt taaaataagt tgtaatactt tctttaccag cagatcgttc caaagaattt
     6361 caggtatagt tttttcttca gcaagtaaat cttcaactat acagtattaa agtattttta
     6421 tattgttgaa actacttgtt ggagagaaaa tttttttttt ttaccaaaaa taaatacttt
     6481 ggtctcattg aataagatat ttagtaatac agcaaagact tctttttact tgaccaaatc
     6541 aagcttcttt gaagtcttaa gtatgaaatt gtaattaaaa tgtgaagatt ttcactcatt
     6601 tttcatagtg gtattacttc atggtattgt acttcaaagg ggctaatatg caaatggtaa
     6661 ctattttctt ttccaaagat gtatttgctg taagtactga tacctgcatg tcatttttat
     6721 gccaaatatt acaagatact gctcatcagt attttcatac caaagaccat taagatgtat
     6781 aggttagcct gtaagtaagt aaagatgagc agatttgaaa taaatttatt tagaggccga
     6841 tagagaatct agctttagta gcaaaaaata tcaaagggct aagtttacat aattaaaagc
     6901 aatacaatta tattggtatt tatcagtgtt tttattcaag tactttttat cagcaaatta
     6961 aaaagaaaaa aaccaaagat atttaaggtt acctccgcat ataggcaaat atagttgtac
     7021 attaaactgt tgtttcttgt ttttatgtta aaccaaacat gtctcttcgg aacacagtct
     7081 gtatacaaat aacatgcatg aggactttcc atttaatctg tgattcagcc acatgatgtt
     7141 tttgccaaat gatgtgatac tttccaaagc accttgagtg tgaaatgtca acagaaatat
     7201 cagcaagctt ttatgttgca gagtattatg gtacctctga attagcctgt atagttctct
     7261 tcctgcttta agcattacct ggttagctca gacggcttga ggcagtccct taataatagg
     7321 gatgcttttc atctctaagg atgtaagagg caaacaaatc atgtcattct ttaagtgggc
     7381 tatgctttga tagatgtgct ctttaaaggt gtgagattgg aatttagagt tgttaaattg
     7441 aaatgtttgc attgcaccaa aggagctcag ttttcaaact ttaatggaac cttgggtaaa
     7501 gggaaaaaat ttttaatgaa atctggggtt ttatattttg attagcctaa aagtaaaaat
     7561 acagctttat ccattaagtg acttttaaaa atcagttttg ccataccaaa gaaattagat
     7621 tcttagtgtc acatgctata cttttgtctg tgcttgaaac gagcaatgcc aacattggga
     7681 acaatgacag aggtttgcat cagtttgtct tggctttgtt aaggacttct gccagaaatg
     7741 tgctcgtggt tgacaaccca ggatcattgt tcaagttctt atgcagacac ctttgaaaac
     7801 aattcagatc gtgtcacaag aatttggaat tgaaaatatc atttattttt taatgcaaga
     7861 atacccagat gtggtttcac ttcagcagta gctatagtgg ttcacttata tacatttctg
     7921 tttcactgaa tgtaaatttt gaatactgaa tgtaaaaaaa aaactccagt tatattgaaa
     7981 cagtcactaa gactgcacat gtgttttgca gactttcttc ctgaccattt gccacatggg
     8041 tctctgataa gattctgttg gtttaatagt caaaataatc tttgcagttt gtgagcactg
     8101 agtagcaggt tctggagact accatataca accagttgtc taattgtgat ttttttattg
     8161 atgtttagaa gaatgtaacc gtagagttct gtgttaagtt gatttatgct caggacataa
     8221 gatcacaggc taatgcaatg tgtatgtttc aggctttaat cttctcaatt tcccttttta
     8281 agccgttgat ggtgtttaag attaacatga cagtcttgta tttttaccag atactgtatt
     8341 atttttccta ttgctgctgt aacacattac catgaaggtg gtggcttaaa ataacacaaa
     8401 tttttcttaa gttctgcaga tcagaagtct aacacaggtc tccctgggac aaaatcaagg
     8461 cgcttgcagg gctgtttctt tttgaggctt tagggaaaaa tctatttcct tttctagttt
     8521 tttaaggctg ggaacccctc cttccatctt caaagccagc catgtagcat ctctctgaag
     8581 ctccttccgt tatcatttct ctttgtccaa ccccagctga tacaggttat ctaggtttaa
     8641 ggattccagt gatcacattg agcccaccta aataatccag gataatctcc ccaactgaag
     8701 ttcctcaact taatcacatc tacagagttc cttttgctat gtttggtaac atattcactg
     8761 gttccaggga tttgggcatg gacttctgta ggtggccagt attttgccca caacaggtac
     8821 attctttctg tggaattctg atccctgtaa aatgtctgta gcattaaaga gattggaaat
     8881 ctgaggtcat gtgccccttg gggatcttta aagattaaaa gcatgaaaac tttgacttgt
     8941 agcctaccaa aattatacac taaactttct ctccaaaata cttgtgaaac aatttatctt
     9001 taaagtttct gaatatgtgc ttcataaaat aacatctcat gtttatcagc aagtgtccta
     9061 aatatttgcg tctaacttta tggaatttat tcagaaaaag aattgaaaac tcttcttata
     9121 gttacccttt ctccttttct cttcagtggt tatgttgctg gggaagagtt gggggaagac
     9181 ctcaaaacac aggaactcag agtgatgaac aggaccatgc tcaagtttat tctttgtttt
     9241 cttttaatga catattcaca acattcacaa ctttctgcct ttaaatctgg ttcctctctt
     9301 cagcttcacc aagccactga atgcttttca gttttattaa ccctcacatt ccccatcctt
     9361 ctcagcaaga gcctctcctt atgccatcag catgtatata catttcctag gaaatttgat
     9421 ctttcttgtc attctttttt ggttccaatc ggccttttcc tggttctcaa agctctagtt
     9481 tcttctaatt tctggatcat cgcaagtctg gccctctttg aactttaaaa cataatgtct
     9541 aattccaccc caattttcag catttcttca actaaatcga taaagctgtc tccattatga
     9601 gaaaggccag aataatactc cgagtaagca taagaaagct ggtcatttta caacttctcc
     9661 cgactctagg aagtaatatg atgccatttg ttgagcatct acagtgtgcc aagcacatgg
     9721 ttcatctctg caaactgctg ctacattctg taaagcaagt attatccgca ttttagggat
     9781 taggaacagc ttcctgatct cttgccaaaa gtcacagcta gtgagtggtt taggcaagat
     9841 acaaacccta gttagttaat ccttactcag aagtgtatag gactatgata cattgtctca
     9901 gcttaaaaaa aaaaaaaaaa aaaaaaggta tttaatcacc cagggtcata gtgccttcca
     9961 tagtgtgacc agatacaact gttttttcct tgtatccaca aaagccaggt tgtgtcagaa
    10021 caacctttct acagagtaat aaccaatcga aaaagagaag actaccttat ttaaatccac
    10081 ttattcacag gagggattaa ggcggctgta actcatccct tatcatctcc taatttctct
    10141 cctccaaaac cttccattta tctcagctaa aattgtgtct gaaggctgtt tgtacttaga
    10201 gttacattac aaataaggta ggcatggttt ctagagtcct tttctagtca agcatttcct
    10261 tattcgacaa tgtcttcaga attgcatttt atcttttgta attttctgta gctcccatat
    10321 tccaaacagg aattcattga cttgaaaaag tcaggtgtgt aaacagtaat cctttcttgt
    10381 taggtctgaa gagttcatga ttttttatga atataaacta atttattatt tgcattaatg
    10441 taggagacag caaagttaac ggagagtcat aaaacagaac aagtataagt taggctttgg
    10501 agcacctaag ttctaatctt gacaattttg agaatcgttt ggtacaaaaa ttcttaaact
    10561 gtttctgtgc cttctccatc catgaaatga ggataatttt tttgtgcaaa atgaaacaat
    10621 agtactttga aaacttaaga gaaaattcaa gtgtaaataa tcataatctg aaactcattt
    10681 gtatgaggct gtgaaagatt ttacagactc tttcttttca agtcagcctt tgcaattata
    10741 ttttgccttt gttgaaatga aaaatgtttg catctcccgt acgcatacac aaaaccaata
    10801 gaagaaagtg gttggtaaaa gatatagctg aaatggaaac actcatatgt taggtggata
    10861 aaatcataag agaaaatggg aattgactgt actttcaaag tactaaattt gaagtcatct
    10921 tactccaatt taagtcatat atatatatat atatatatat atatatatat atatatatat
    10981 atatatattg gcttttaaag agttaaagag agaatcagat ctgtccagca ggatagatgg
    11041 gtgaggagaa aagtacatat ttaggatttt tctctaaaag atctttttca agattatgga
    11101 gtattttaat atttctgcaa actattccaa atgaatgcat tttatatagg gcaacacata
    11161 ctggcacctg attctggttt attcgagttc atatgtaggg tttgttggga agaattatat
    11221 gattggcttc tttttttaga ggaaatattt tccctttttt cttatccata tactattctg
    11281 aacagctttg cagatttcct taagttcata gcttgtaagt agttcatggt atatagacat
    11341 agtcttgact tacaactgaa aaaaaattta tgttacagaa gtttattttt tctatggaac
    11401 tgtctttaaa aacaaaaata ttacaaatct tgaccttgaa atattctgtt tcctgttatc
    11461 acattctgga tatctatttt gtttgcaaat gaaaattatt actgatgatt agcaacttga
    11521 gcctgttaat aggaaattgc aaagcctgaa tacacacaca ttgccttagc ctatcagtag
    11581 agtagaggac atatgttaag aaaatgtgtc tgcttgttgc tgttgttgga caaaatttta
    11641 tgtctgtgtg tatgattttt ttttttctat tttcttcaaa gatgtgaatt aaatgaaagt
    11701 gtgggagcca gttaaattat tttgtattat gggtgttctg gatcctttca ctccgtatac
    11761 cattttcttg taagggcagc atttgtagac ttgctaatgg actgtagagc tgagctatat
    11821 taattttata cttgactcag gggatcagtt ctgtgaatgc cattgcacga agaaagcaaa
    11881 tgtttgcctt gattttgaat gtatcttttt aatgtcttct taaaacatat ttgtttaata
    11941 atgtagattt gttttttttt ttctagtatc atagtaaata ttgcttagta cttgccccca
    12001 ccccactggg tagtttatat actaccctat aggtcatgcc aaaaatgaat aaaagtttaa
    12061 atgccaaaat gtttatgaaa ctgctgtcta aatactgatt gattgcacaa tttaaataaa
    12121 agctttcctt agttaaaaaa ga
//
