LOCUS       NM_001001317             913 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serine protease 58 (PRSS58), mRNA.
ACCESSION   NM_001001317
VERSION     NM_001001317.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Bubb,K.L., Bovee,D., Buckley,D., Haugen,E., Kibukawa,M.,
            Paddock,M., Palmieri,A., Subramanian,S., Zhou,Y., Kaul,R., Green,P.
            and Olson,M.V.
  TITLE     Scan of human genome reveals no new Loci under ancient balancing
            selection
  JOURNAL   Genetics 173 (4), 2165-2177 (2006)
   PUBMED   16751668
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Rowen,L., Koop,B.F. and Hood,L.
  TITLE     The complete 685-kilobase DNA sequence of the human beta T cell
            receptor locus
  JOURNAL   Science 272 (5269), 1755-1762 (1996)
   PUBMED   8650574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK122940.1 and AA625766.1.
            
            On May 17, 2019 this sequence version replaced NM_001001317.4.
            
            Summary: This gene encodes a member of the trypsin family of serine
            proteases. This gene and several related trypsinogen genes are
            localized to the T cell receptor beta locus on chromosome 7. This
            gene was previously described as a trypsinogen-like pseudogene, but
            it is now thought to be a protein-coding gene. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.27638.1, AK122940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547058.6/ ENSP00000447588.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-765               AK122940.1         1-765
            766-913             AA625766.1         11-158              c
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..913
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /note="serine protease 58"
                     /db_xref="GeneID:136541"
                     /db_xref="HGNC:HGNC:39125"
     exon            1..68
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /inference="alignment:Splign:2.1.0"
     exon            69..149
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..835
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /EC_number="3.4.21.4"
                     /note="trypsin-X3; protease, serine 58"
                     /codon_start=1
                     /product="serine protease 58 precursor"
                     /protein_id="NP_001001317.1"
                     /db_xref="CCDS:CCDS5871.1"
                     /db_xref="GeneID:136541"
                     /db_xref="HGNC:HGNC:39125"
                     /translation="MKFILLWALLNLTVALAFNPDYTVSSTPPYLVYLKSDYLPCAGV
                     LIHPLWVITAAHCNLPKLRVILGVTIPADSNEKHLQVIGYEKMIHHPHFSVTSIDHDI
                     MLIKLKTEAELNDYVKLANLPYQTISENTMCSVSTWSYNVCDIYKEPDSLQTVNISVI
                     SKPQCRDAYKTYNITENMLCVGIVPGRRQPCKEVSAAPAICNGMLQGILSFADGCVLR
                     ADVGIYAKIFYYIPWIENVIQNN"
     exon            150..288
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /inference="alignment:Splign:2.1.0"
     exon            289..545
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /inference="alignment:Splign:2.1.0"
     exon            546..685
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /inference="alignment:Splign:2.1.0"
     exon            686..913
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /inference="alignment:Splign:2.1.0"
     regulatory      897..902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /note="hexamer: TATAAA"
     polyA_site      913
                     /gene="PRSS58"
                     /gene_synonym="PRSS1; TRY1; TRYX3; UNQ2540"
                     /note="major polyA site"
ORIGIN      
        1 aaggctggca aaaaggagac cagacaggag gcgtctgtag agatatcatg aacttcaact
       61 tagctttgtt ttccagagac tggagctaaa ctgggctttc aacatcatca tgaagtttat
      121 cctcctctgg gctctcttga atctgactgt tgctttggcc tttaatccag attacacagt
      181 cagctccact cccccttact tggtctattt gaaatctgac tacttgccct gcgctggagt
      241 cctgatccac ccgctttggg tgatcacagc tgcacactgc aatttaccaa agcttcgggt
      301 gatattgggg gttacaatcc cagcagactc taatgaaaag catctgcaag tgattggcta
      361 tgagaagatg attcatcatc cacacttctc agtcacttct attgatcatg acatcatgct
      421 aatcaagctg aaaacagagg ctgaactcaa tgactatgtg aaattagcca acctgcccta
      481 ccaaactatc tctgaaaata ccatgtgctc tgtctctacc tggagctaca atgtgtgtga
      541 tatctacaaa gagcccgatt cactgcaaac tgtgaacatc tctgtaatct ccaagcctca
      601 gtgtcgcgat gcctataaaa cctacaacat cacggaaaat atgctgtgtg tgggcattgt
      661 gccaggaagg aggcagccct gcaaggaagt ttctgctgcc ccggcaatct gcaatgggat
      721 gcttcaagga atcctgtctt ttgcggatgg atgtgttttg agagctgatg ttggcatcta
      781 tgccaaaatt ttttactata taccctggat tgaaaatgta atccaaaata actgagctgt
      841 ggcagttgtg gaccatatga cacagcttgt ccccatcgtt cacctttaga attaaatata
      901 aattaactcc tca
//
