LOCUS       NM_198464               1139 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens serine protease 55 (PRSS55), transcript variant 1,
            mRNA.
ACCESSION   NM_198464 XM_114622
VERSION     NM_198464.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Liu,M., Hu,Z., Qi,L., Wang,J., Zhou,T., Guo,Y., Zeng,Y., Zheng,B.,
            Wu,Y., Zhang,P., Chen,X., Tu,W., Zhang,T., Zhou,Q., Jiang,M.,
            Guo,X., Zhou,Z. and Sha,J.
  TITLE     Scanning of novel cancer/testis proteins by human testis proteomic
            analysis
  JOURNAL   Proteomics 13 (7), 1200-1210 (2013)
   PUBMED   23436708
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Neth,P., Profanter,B., Geissler,C., Nagler,D.K., Nerlich,A.,
            Sommerhoff,C.P. and Jochum,M.
  TITLE     T-SP1: a novel serine protease-like protein predominantly expressed
            in testis
  JOURNAL   Biol Chem 389 (12), 1495-1504 (2008)
   PUBMED   18844450
  REMARK    GeneRIF: T-SP1 protein was detectable in prostate cancer and in
            some ovarian cancer tissues, indicating tumor-related synthesis of
            T-SP1
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104964.12, BC033497.1 and
            AY358867.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_198464.3.
            
            Summary: This gene encodes a member of a group of membrane-anchored
            chymotrypsin (S1)-like serine proteases. The enocoded protein is
            primarily expressed in the Leydig and Sertoli cells of the testis
            and may be involved in male fertility. Alternate splicing results
            in multiple transcript variants. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358867.1, SRR5189667.346936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328655.8/ ENSP00000333003.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC104964.12        120991-121004       c
            15-39               BC033497.1         1-25
            40-184              AY358867.1         1-145
            185-185             AC104964.12        120820-120820       c
            186-688             AY358867.1         147-649
            689-689             AC104964.12        113594-113594       c
            690-863             AY358867.1         651-824
            864-864             AC104964.12        107992-107992       c
            865-1138            AY358867.1         826-1099
            1139-1139           AC104964.12        107717-107717       c
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1139
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /note="serine protease 55"
                     /db_xref="GeneID:203074"
                     /db_xref="HGNC:HGNC:30824"
                     /db_xref="MIM:615144"
     exon            1..208
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1113
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable serine protease UNQ9391/PRO34284;
                     testis serine protease 1; tryptophan/serine protease;
                     protease, serine 55"
                     /codon_start=1
                     /product="serine protease 55 isoform 1 precursor"
                     /protein_id="NP_940866.2"
                     /db_xref="CCDS:CCDS5976.1"
                     /db_xref="GeneID:203074"
                     /db_xref="HGNC:HGNC:30824"
                     /db_xref="MIM:615144"
                     /translation="MLLFSVLLLLSLVTGTQLGPRTPLPEAGVAILGRARGAHRPQPP
                     HPPSPVSECGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWW
                     ILTAAHCLYSEELFPEELSVVLGTNDLTSPSMEIKEVASIILHKDFKRANMDNDIALL
                     LLASPIKLDDLKVPICLPTQPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMD
                     WEECSKMFPKLTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGKSC
                     GEKNTPGIYTSLVNYNLWIEKVTQLEGRPFNAEKRRTSVKQKPMGSPVSGVPEPGSPR
                     SWLLLCPLSHVLFRAILY"
     exon            209..401
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /inference="alignment:Splign:2.1.0"
     exon            402..652
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /inference="alignment:Splign:2.1.0"
     exon            653..795
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1139
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /note="hexamer: AATAGA"
     polyA_site      1139
                     /gene="PRSS55"
                     /gene_synonym="CT153; T-SP1; TSP1; UNQ9391"
                     /note="major polyA site"
ORIGIN      
        1 actgcctcag ccctggcctc tgtcaccccc gggcccacag cacagcccag ggccatgctc
       61 ctgttctcag tgttgctgct cctgtccctg gtcacgggaa ctcagctcgg tccacggact
      121 cctctcccag aggctggagt ggctatccta ggcagggcta ggggagccca ccgccctcag
      181 ccccctcatc cccccagccc agtcagtgaa tgtggtgaca gatctatttt cgagggaaga
      241 actcggtatt ccagaatcac aggggggatg gaggcggagg tgggtgagtt tccgtggcag
      301 gtgagtattc aggcaagaag tgaacctttc tgtggcggct ccatcctcaa caagtggtgg
      361 attctcactg cggctcactg cttatattcc gaggagctgt ttccagaaga actgagtgtc
      421 gtgctgggga ccaacgactt aactagccca tccatggaaa taaaggaggt cgccagcatc
      481 attcttcaca aagactttaa gagagccaac atggacaatg acattgcctt gctgctgctg
      541 gcttcgccca tcaagctcga tgacctgaag gtgcccatct gcctccccac gcagcccggc
      601 cctgccacat ggcgcgaatg ctgggtggca ggttggggcc agaccaatgc tgctgacaaa
      661 aactctgtga aaacggatct gatgaaagcg ccaatggtca tcatggactg ggaggagtgt
      721 tcaaagatgt ttccaaaact taccaaaaat atgctgtgtg ccggatacaa gaatgagagc
      781 tatgatgcct gcaagggtga cagtgggggg cctctggtct gcaccccaga gcctggtgag
      841 aagtggtacc aggtgggcat cataagctgg ggaaagagct gtggagagaa gaacacccca
      901 gggatataca cctcgttggt gaactacaac ctctggatcg agaaagtgac ccagctagag
      961 ggcaggccct tcaatgcaga gaaaaggagg acttctgtca aacagaaacc tatgggctcc
     1021 ccagtctcgg gagtcccaga gccaggcagc cccagatcct ggctcctgct ctgtcccctg
     1081 tcccatgtgt tgttcagagc tattttgtac tgataataaa atagaggcta ttctttcaa
//
