LOCUS       NM_001305173            1785 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens serine protease 54 (PRSS54), transcript variant 2,
            mRNA.
ACCESSION   NM_001305173 XM_005255838
VERSION     NM_001305173.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Shen,C., Xiong,W., Li,C., Ge,H., Shen,Y., Tang,L., Zhang,H., Lu,S.,
            Fei,J. and Wang,Z.
  TITLE     Testis-specific serine protease PRSS54 regulates acrosomal granule
            localization and sperm head morphogenesis in micedagger
  JOURNAL   Biol Reprod 107 (4), 1139-1154 (2022)
   PUBMED   35863763
  REMARK    GeneRIF: Testis-specific serine protease PRSS54 regulates acrosomal
            granule localization and sperm head morphogenesis in micedagger.
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Stevenson,B.J., Iseli,C., Panji,S., Zahn-Zabal,M., Hide,W.,
            Old,L.J., Simpson,A.J. and Jongeneel,C.V.
  TITLE     Rapid evolution of cancer/testis genes on the X chromosome
  JOURNAL   BMC Genomics 8, 129 (2007)
   PUBMED   17521433
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009107.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001305173.1.
            
            Summary: This gene encodes a putative serine-type endopeptidase
            containing the peptidase S1 domain. Alternative splicing of this
            gene results in multiple transcript variants. [provided by RefSeq,
            Feb 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057843.1, SRR5189667.218565.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567164.6/ ENSP00000455024.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC009107.11        166464-166602       c
            140-364             AC009107.11        165562-165786       c
            365-455             AC009107.11        165309-165399       c
            456-633             AC009107.11        162536-162713       c
            634-892             AC009107.11        157514-157772       c
            893-1024            AC009107.11        156167-156298       c
            1025-1785           AC009107.11        151574-152334       c
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..1785
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /note="serine protease 54"
                     /db_xref="GeneID:221191"
                     /db_xref="HGNC:HGNC:26336"
     exon            1..139
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            140..364
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            365..455
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1558
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; plasma kallikrein-like protein 4; inactive
                     serine protease 54; cancer/testis antigen 67; testis
                     tissue sperm-binding protein Li 40a; protease, serine 54"
                     /codon_start=1
                     /product="inactive serine protease 54 isoform 1 precursor"
                     /protein_id="NP_001292102.1"
                     /db_xref="CCDS:CCDS32463.1"
                     /db_xref="GeneID:221191"
                     /db_xref="HGNC:HGNC:26336"
                     /translation="MVSAAGLSGDGKMRGVLLVLLGLLYSSTSCGVQKASVFYGPDPK
                     EGLVSSMEFPWVVSLQDSQYTHLAFGCILSEFWVLSIASAIQNRKDIVVIVGISNMDP
                     SKIAHTEYPVNTIIIHEDFDNNSMSNNIALLKTDTAMHFGNLVQSICFLGRMLHTPPV
                     LQNCWVSGWNPTSATGNHMTMSVLRKIFVKDLDMCPLYKLQKTECGSHTKEETKTACL
                     GDPGSPMMCQLQQFDLWVLRGVLNFGGETCPGLFLYTKVEDYSKWITSKAERAGPPLS
                     SLHHWEKLISFSHHGPNATMTQKTYSDSELGHVGSYLQGQRRTITHSRLGNSSRDSLD
                     VREKDVKESGRSPEASVQPLYYDYYGGEVGEGRIFAGQNRLYQPEEIILVSFVLVFFC
                     SSI"
     exon            456..633
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..892
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1024
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1785
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /note="hexamer: AGTAAA"
     polyA_site      1618
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
     regulatory      1756..1761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /note="hexamer: ACTAAA"
     polyA_site      1785
                     /gene="PRSS54"
                     /gene_synonym="CT67; KLKBL4"
                     /note="major polyA site"
ORIGIN      
        1 agtagaagaa atccttctgt tgaactctac tgtgtcaggc cagcctgagt tcatttctcc
       61 ttgagcagga acagttcatg gacgaactct gaggaccatt ctgaggacaa gaggcatcca
      121 gtgtcatgag tggaacatgc attttatggc tacagagtta aggcaagggt tgaattccac
      181 gagtcaaaaa gcagcccttt tcagagaccc aactctctgg ggtgctcagg ggcttgggct
      241 ggattgagaa gaaaactgac aagagtaagc tgccctctct tctctggcca tctcacaaac
      301 cacagtgcgg gccaactggt cctgcctctt taccacacag aaccaagcac tagggataag
      361 acagctgccc atggtgtccg cggcgggtct ctctggggat ggcaagatgc gaggggtgct
      421 cctggtgctg ctcggccttc tctattcttc caccagttgt ggcgtccaga aagcttccgt
      481 tttctacggt cctgacccca aggagggctt ggtcagcagc atggagttcc cgtgggtggt
      541 gtcgctgcag gactcccagt acacacacct ggctttcggc tgcatcctga gcgagttctg
      601 ggtcctcagc atcgcatccg ccattcagaa caggaaggac attgtcgtta tagtgggtat
      661 aagtaacatg gatcctagca agattgctca cacagagtat ccagtcaata ccatcatcat
      721 ccatgaggac tttgataaca actccatgag caacaacata gccctcctga agacagacac
      781 agcgatgcat tttggcaacc tggtccagtc catctgcttc ctcggcagaa tgctgcatac
      841 accaccagtc ttgcagaact gctgggtgtc aggatggaat cccacatctg caacaggaaa
      901 tcacatgacg atgagtgtcc tgaggaaaat cttcgtgaaa gatcttgaca tgtgtcccct
      961 atacaaactc cagaagacag aatgcggcag ccacacgaaa gaggaaacca agactgcctg
     1021 cttgggggac ccaggaagcc caatgatgtg ccagctacag cagttcgatc tgtgggttct
     1081 gagaggagtc ctgaacttcg gtggtgagac gtgccctggc ctgtttctgt acaccaaggt
     1141 ggaagactac agcaaatgga tcacatccaa ggctgagagg gccggccctc ccctgtcctc
     1201 actccaccac tgggaaaagt tgatttcttt ctcccaccat ggaccaaatg ccaccatgac
     1261 acagaagaca tattctgatt ctgaactggg ccatgttgga tcatacttgc agggacaaag
     1321 aaggaccatc acgcattcac gactaggaaa cagctctaga gatagtctag atgttaggga
     1381 gaaggatgta aaggaatcag gcaggtctcc tgaggcgtct gtacaaccct tatactatga
     1441 ctattacggt ggggaggtgg gggaaggtag gatttttgca ggtcagaaca ggttgtatca
     1501 gcccgaagaa atcatcttgg tttccttcgt gcttgttttc ttttgcagca gtatctagtc
     1561 caggagctac cccaccaaac tgaagagtaa actgagaatg ctgagtgcca ggcattcacc
     1621 atgctgtttt gatgtctgtt tttgatagtt gcacactggg gctgccacgg ataagcccat
     1681 ggcatacact gggctggctc tccctcctct atccctctcc caggtgtggg aaggtcactt
     1741 tcactatgct tgtgaactaa atgctggcta acaagtgtca aacca
//
