LOCUS       NM_001039503            2149 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens serine protease 53 (PRSS53), mRNA.
ACCESSION   NM_001039503
VERSION     NM_001039503.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2149)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2149)
  AUTHORS   Pankratz,N., Beecham,G.W., DeStefano,A.L., Dawson,T.M.,
            Doheny,K.F., Factor,S.A., Hamza,T.H., Hung,A.Y., Hyman,B.T.,
            Ivinson,A.J., Krainc,D., Latourelle,J.C., Clark,L.N., Marder,K.,
            Martin,E.R., Mayeux,R., Ross,O.A., Scherzer,C.R., Simon,D.K.,
            Tanner,C., Vance,J.M., Wszolek,Z.K., Zabetian,C.P., Myers,R.H.,
            Payami,H., Scott,W.K. and Foroud,T.
  CONSRTM   PD GWAS Consortium
  TITLE     Meta-analysis of Parkinson's disease: identification of a novel
            locus, RIT2
  JOURNAL   Ann Neurol 71 (3), 370-384 (2012)
   PUBMED   22451204
REFERENCE   3  (bases 1 to 2149)
  AUTHORS   Stuart,P.E., Nair,R.P., Ellinghaus,E., Ding,J., Tejasvi,T.,
            Gudjonsson,J.E., Li,Y., Weidinger,S., Eberlein,B., Gieger,C.,
            Wichmann,H.E., Kunz,M., Ike,R., Krueger,G.G., Bowcock,A.M.,
            Mrowietz,U., Lim,H.W., Voorhees,J.J., Abecasis,G.R.,
            Weichenthal,M., Franke,A., Rahman,P., Gladman,D.D. and Elder,J.T.
  TITLE     Genome-wide association analysis identifies three psoriasis
            susceptibility loci
  JOURNAL   Nat Genet 42 (11), 1000-1004 (2010)
   PUBMED   20953189
REFERENCE   4  (bases 1 to 2149)
  AUTHORS   Cal,S., Peinado,J.R., Llamazares,M., Quesada,V., Moncada-Pazos,A.,
            Garabaya,C. and Lopez-Otin,C.
  TITLE     Identification and characterization of human polyserase-3, a novel
            protein with tandem serine-protease domains in the same polypeptide
            chain
  JOURNAL   BMC Biochem 7, 9 (2006)
   PUBMED   16566820
  REMARK    GeneRIF: Comparative analysis of polyserase-3 with the two human
            polyserases described to date, revealed that this novel polyprotein
            is more closely related to polyserase-2 than to polyserase-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2149)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135050.3.
            
            On Jul 13, 2021 this sequence version replaced NM_001039503.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ627035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280606.7/ ENSP00000280606.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC135050.3         144630-144821       c
            193-213             AC135050.3         143684-143704       c
            214-376             AC135050.3         143415-143577       c
            377-642             AC135050.3         142511-142776       c
            643-797             AC135050.3         142215-142369       c
            798-1017            AC135050.3         141842-142061       c
            1018-1168           AC135050.3         140988-141138       c
            1169-1413           AC135050.3         140658-140902       c
            1414-1559           AC135050.3         140436-140581       c
            1560-1776           AC135050.3         139997-140213       c
            1777-2149           AC135050.3         139315-139687       c
FEATURES             Location/Qualifiers
     source          1..2149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2149
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /note="serine protease 53"
                     /db_xref="GeneID:339105"
                     /db_xref="HGNC:HGNC:34407"
                     /db_xref="MIM:610561"
     exon            1..192
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1796
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /EC_number="3.4.21.-"
                     /note="polyserase-3; EDTP308; polyserine protease 3;
                     protease, serine 53"
                     /codon_start=1
                     /product="serine protease 53 precursor"
                     /protein_id="NP_001034592.1"
                     /db_xref="CCDS:CCDS42153.1"
                     /db_xref="GeneID:339105"
                     /db_xref="HGNC:HGNC:34407"
                     /db_xref="MIM:610561"
                     /translation="MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTV
                     PGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGL
                     SPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWA
                     TGWDQDTSDAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQG
                     PCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAA
                     FLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEE
                     AVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGAYTHPEGGYDMALLLLAQPV
                     TLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQTVPVTLLGPRACSRLHAA
                     PGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARP
                     AVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC"
     exon            193..213
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            214..376
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            377..642
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            643..797
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1017
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1168
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1413
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1559
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1776
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2149
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="PRSS53"
                     /gene_synonym="POL3S; UNQ308"
                     /note="major polyA site"
ORIGIN      
        1 agctaggaac tgctggctag ggcaagcaga cagctgaatc ctagccaact ggaggtggag
       61 cagaggtgga gccagggaga cccaggtggc ctctctcaga gtggagcaca ggtggcagag
      121 tggcccgggg cagcatgaag tggtgctggg gcccagtgct gctcatcgcg ggtgccacag
      181 tcctcatgga gggtcttcaa gccgctcagc gtgcctgtgg acagcgtggc cccggccccc
      241 ccaagcctca ggagggcaac acagtccctg gcgagtggcc ctggcaggcc agtgtgagga
      301 ggcaaggagc ccacatctgc agcggctccc tggtggcaga cacctgggtc ctcactgctg
      361 cccactgctt tgaaaaggca gcagcaacag aactgaattc ctggtcagtg gtcctgggtt
      421 ctctgcagcg tgagggactc agccctgggg ccgaagaggt gggggtggct gccctgcagt
      481 tgcccagggc ctataaccac tacagccagg gctcagacct ggccctgctg cagctcgccc
      541 accccacgac ccacacaccc ctctgcctgc cccagcccgc ccatcgcttc ccctttggag
      601 cctcctgctg ggccactggc tgggatcagg acaccagtga tgctcctggg accctacgca
      661 atctgcgcct gcgtctcatc agtcgcccca catgtaactg tatctacaac cagctgcacc
      721 agcgacacct gtccaacccg gcccggcctg ggatgctatg tgggggcccc cagcctgggg
      781 tgcagggccc ctgtcaggga gattccgggg gccctgtgct gtgcctcgag cctgacggac
      841 actgggttca ggctggcatc atcagctttg catcaagctg tgcccaggag gacgctcctg
      901 tgctgctgac caacacagct gctcacagtt cctggctgca ggctcgagtt cagggggcag
      961 ctttcctggc ccagagccca gagaccccgg agatgagtga tgaggacagc tgtgtagcct
     1021 gtggatcctt gaggacagca ggtccccagg caggagcacc ctccccatgg ccctgggagg
     1081 ccaggctgat gcaccaggga cagctggcct gtggcggagc cctggtgtca gaggaggcgg
     1141 tgctaactgc tgcccactgc ttcattgggc gccaggcccc agaggaatgg agcgtagggc
     1201 tggggaccag accggaggag tggggcctga agcagctcat cctgcatgga gcctacaccc
     1261 accctgaggg gggctacgac atggccctcc tgctgctggc ccagcctgtg acactgggag
     1321 ccagcctgcg gcccctctgc ctgccctatc ctgaccacca cctgcctgat ggggagcgtg
     1381 gctgggttct gggacgggcc cgcccaggag caggcatcag ctccctccag acagtgcccg
     1441 tgaccctcct ggggcctagg gcctgcagcc ggctgcatgc agctcctggg ggtgatggca
     1501 gccctattct gccggggatg gtgtgtacca gtgctgtggg tgagctgccc agctgtgagg
     1561 gcctgtctgg ggcaccactg gtgcatgagg tgaggggcac atggttcctg gccgggctgc
     1621 acagcttcgg agatgcttgc caaggccccg ccaggccggc ggtcttcacc gcgctccctg
     1681 cctatgagga ctgggtcagc agtttggact ggcaggtcta cttcgccgag gaaccagagc
     1741 ccgaggctga gcctggaagc tgcctggcca acataagcca accaaccagc tgctgacagg
     1801 ggacctggcc attctcagga caagagaatg caggcaggca aatggcatta ctgcccctgt
     1861 cctccccacc ctgtcatgtg tgattccagg caccagggca ggcccagaag cccagcagct
     1921 gtgggaagga acctgcctgg ggccacaggt gcccactccc caccctgcag gacaggggtg
     1981 tctgtggaca ctcccacacc caactctgct accaagcagg cgtctcagct ttcctcctcc
     2041 tttacccttt cagatacaat cacgccagcc acgttgtttt gaaaatttct ttttttgggg
     2101 ggcagcagtt ttcctttttt taaacttaaa taaattgtta caaaataga
//
