LOCUS       NM_183375               1408 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens serine protease 48 (PRSS48), transcript variant 1,
            mRNA.
ACCESSION   NM_183375
VERSION     NM_183375.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1408)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1408)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1408)
  AUTHORS   Di Cera,E.
  TITLE     Serine proteases
  JOURNAL   IUBMB Life 61 (5), 510-515 (2009)
   PUBMED   19180666
  REMARK    Review article
REFERENCE   4  (bases 1 to 1408)
  AUTHORS   Rawlings,N.D., Morton,F.R., Kok,C.Y., Kong,J. and Barrett,A.J.
  TITLE     MEROPS: the peptidase database
  JOURNAL   Nucleic Acids Res 36 (Database issue), D320-D325 (2008)
   PUBMED   17991683
REFERENCE   5  (bases 1 to 1408)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   6  (bases 1 to 1408)
  AUTHORS   Hedstrom,L.
  TITLE     Serine protease mechanism and specificity
  JOURNAL   Chem Rev 102 (12), 4501-4524 (2002)
   PUBMED   12475199
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104819.4 and BC121109.1.
            
            On Jun 10, 2021 this sequence version replaced NM_183375.4.
            
            Transcript Variant: This variant (1) represents the allele encoded
            by the reference genome (GRCh38) and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005378.1, BC121109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455694.7/ ENSP00000401328.2
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC104819.4         32413-32424
            13-166              BC121109.1         5-158
            167-173             AC104819.4         35150-35156
            174-876             BC121109.1         166-868
            877-883             AC104819.4         46583-46589
            884-999             BC121109.1         876-991
            1000-1408           AC104819.4         46706-47114
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..1408
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /note="serine protease 48"
                     /db_xref="GeneID:345062"
                     /db_xref="HGNC:HGNC:24635"
     exon            1..64
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..999
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /EC_number="3.4.21.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; epidermis-specific serine protease-like
                     protein; testicular tissue protein Li 65; protease, serine
                     48"
                     /codon_start=1
                     /product="serine protease 48 isoform 1 precursor"
                     /protein_id="NP_899231.4"
                     /db_xref="CCDS:CCDS47145.1"
                     /db_xref="GeneID:345062"
                     /db_xref="HGNC:HGNC:24635"
                     /translation="MGPAGCAFTLLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVS
                     LHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITVGDSRKRVKYYVSKI
                     VIHPKYQDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESS
                     DRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQNMKDSCKG
                     DSGGPLSCHIDGVWIQTGVVSWGLECGKSLPGVYTNVIYYQKWINATISRANNLDFSD
                     FLFPIVLLSLALLRPSCAFGPNTIHRVGTVAEAVACIQGWEENAWRFSPRGR"
     exon            65..227
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /inference="alignment:Splign:2.1.0"
     exon            228..493
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /inference="alignment:Splign:2.1.0"
     exon            494..663
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /inference="alignment:Splign:2.1.0"
     exon            664..1408
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggacagag acatgggccc tgctggctgt gccttcacgc tgctccttct gctggggatc
       61 tcagtgtgtg ggcaacctgt atactccagc cgcgttgtag gtggccagga tgctgctgca
      121 gggcgctggc cttggcaggt cagcctacac tttgaccaca actttatctg tggaggttcc
      181 ctcgtcagtg agaggttgat actgacagca gcacactgca tacaaccgac ctggactact
      241 ttttcatata ctgtgtggct aggatcgatt acagtaggtg actcaaggaa acgtgtgaag
      301 tactacgtgt ccaaaatcgt catccatccc aagtaccaag atacaacggc agacgtcgcc
      361 ttgttgaaac tgtcctctca agtcaccttc acttctgcca tcctgcctat ttgcttgccc
      421 agtgtcacaa agcagttggc aattccaccc ttttgttggg tgaccggatg gggaaaagtt
      481 aaggaaagtt cagatagaga ttaccattct gcccttcagg aagcagaagt acccattatt
      541 gaccgccagg cttgtgaaca gctctacaat cccatcggta tcttcttgcc agcactggag
      601 ccagtcatca aggaagacaa gatttgtgct ggtgatactc aaaacatgaa ggatagttgc
      661 aagggtgatt ctggagggcc tctgtcgtgt cacattgatg gtgtatggat ccagacagga
      721 gtagtaagct ggggattaga atgtggtaaa tctcttcctg gagtctacac caatgtaatc
      781 tactaccaaa aatggattaa tgccactatt tcaagagcca acaatctaga cttctctgac
      841 ttcttgttcc ctattgtcct actctctctg gctctcctgc gtccctcctg tgcctttgga
      901 cctaacacta tacacagagt aggcactgta gctgaagctg ttgcttgcat acagggctgg
      961 gaagagaatg catggagatt tagtcccagg ggcagataac tcacaggaga gccactgcta
     1021 accctgggtg actttattta caatttgaaa tgattttgtt tttaaggttt ttgattttgg
     1081 aagttttggg gttggaatgt gaagagttaa gaaataaaac tgtcacttct gtacattctt
     1141 tgtccttgac taatgcatct tccaagacag gaaggatgtc ctctatgaat aagcatttgt
     1201 agacacaaat taaatagcta taagactaat gtgtcttcca aggcaggaag atgtcctcta
     1261 tgaataagta tttgtagaca caaattaaat agctactaca gaggcaggca agtatctgtg
     1321 atgacacagg aaaatataat aagggtctac ctcgtgccca tgggttgcat catgggattt
     1381 tagtctatta tttctcacct tctctatt
//
