LOCUS       NP_899231                328 aa            linear   PRI 17-DEC-2024
DEFINITION  serine protease 48 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_899231
VERSION     NP_899231.4
DBSOURCE    REFSEQ: accession NM_183375.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 328)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 328)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (residues 1 to 328)
  AUTHORS   Di Cera,E.
  TITLE     Serine proteases
  JOURNAL   IUBMB Life 61 (5), 510-515 (2009)
   PUBMED   19180666
  REMARK    Review article
REFERENCE   4  (residues 1 to 328)
  AUTHORS   Rawlings,N.D., Morton,F.R., Kok,C.Y., Kong,J. and Barrett,A.J.
  TITLE     MEROPS: the peptidase database
  JOURNAL   Nucleic Acids Res 36 (Database issue), D320-D325 (2008)
   PUBMED   17991683
REFERENCE   5  (residues 1 to 328)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   6  (residues 1 to 328)
  AUTHORS   Hedstrom,L.
  TITLE     Serine protease mechanism and specificity
  JOURNAL   Chem Rev 102 (12), 4501-4524 (2002)
   PUBMED   12475199
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104819.4 and BC121109.1.
            
            On Jul 19, 2017 this sequence version replaced NP_899231.3.
            
            Transcript Variant: This variant (1) represents the allele encoded
            by the reference genome (GRCh38) and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005378.1, BC121109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455694.7/ ENSP00000401328.2
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     Protein         1..328
                     /product="serine protease 48 isoform 1 precursor"
                     /EC_number="3.4.21.-"
                     /note="epidermis-specific serine protease-like protein;
                     testicular tissue protein Li 65; protease, serine 48"
                     /calculated_mol_wt=34052
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1936
     mat_peptide     21..328
                     /product="Serine protease 48. /id=PRO_5000095975"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7RTY5.2)"
                     /calculated_mol_wt=34052
     Region          28..265
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            28
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(68,114,220)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(214,239,241)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     Site            263
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7RTY5.2)"
     CDS             1..328
                     /gene="PRSS48"
                     /gene_synonym="ESSPL"
                     /coded_by="NM_183375.5:13..999"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS47145.1"
                     /db_xref="GeneID:345062"
                     /db_xref="HGNC:HGNC:24635"
ORIGIN      
        1 mgpagcaftl llllgisvcg qpvyssrvvg gqdaaagrwp wqvslhfdhn ficggslvse
       61 rliltaahci qptwttfsyt vwlgsitvgd srkrvkyyvs kivihpkyqd ttadvallkl
      121 ssqvtftsai lpiclpsvtk qlaippfcwv tgwgkvkess drdyhsalqe aevpiidrqa
      181 ceqlynpigi flpalepvik edkicagdtq nmkdsckgds ggplschidg vwiqtgvvsw
      241 glecgkslpg vytnviyyqk winatisran nldfsdflfp ivllslallr pscafgpnti
      301 hrvgtvaeav aciqgweena wrfsprgr
//
