LOCUS       NM_183062               1285 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens serine protease 38 (PRSS38), transcript variant 1,
            mRNA.
ACCESSION   NM_183062
VERSION     NM_183062.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1285)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731702.12 and AL356323.15.
            
            On Jul 13, 2021 this sequence version replaced NM_183062.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130400.1, BN000131.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366757.4/ ENSP00000355719.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AL731702.12        39056-39245
            191-353             AL731702.12        39471-39633
            354-625             AL731702.12        40590-40861
            626-768             AL356323.15        26064-26206
            769-1285            AL356323.15        26548-27064
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..1285
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /note="serine protease 38"
                     /db_xref="GeneID:339501"
                     /db_xref="HGNC:HGNC:29625"
     exon            1..190
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1023
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serine protease MPN2; marapsin 2; protease,
                     serine 38"
                     /codon_start=1
                     /product="serine protease 38 isoform 1 precursor"
                     /protein_id="NP_898885.1"
                     /db_xref="CCDS:CCDS1563.1"
                     /db_xref="GeneID:339501"
                     /db_xref="HGNC:HGNC:29625"
                     /translation="MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQPENQGIS
                     LTGSVACGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCF
                     HRDKNIKIYDMYVGLVNLRVAGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRI
                     VFSESVLPVCLATPEVNLTSANCWATGWGLVSKQGETSDELQEMQLPLILEPWCHLLY
                     GHMSYIMPDMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPG
                     VYASVSYFSKWICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL"
     exon            191..353
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..625
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..768
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1285
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1266..1271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /note="hexamer: ATTAAA"
     polyA_site      1285
                     /gene="PRSS38"
                     /gene_synonym="MPN2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggagct agtcacccgc tgggggcgct gcctcgagcc tcatggctgc ccctgcttcc
       61 gtcatgggcc cactcgggcc ctctgccctg ggccttctgc tgctgctcct ggtggtggcc
      121 cctccccggg tcgcagcatt ggtccacaga cagccagaga accagggaat ctccctaact
      181 ggcagcgtgg cctgtggtcg gcccagcatg gaggggaaaa tcctgggcgg cgtccctgcg
      241 cccgagagga agtggccgtg gcaggtcagc gtgcactacg caggcctcca cgtctgcggc
      301 ggctccatcc tcaatgagta ctgggtgctg tcagctgcgc actgctttca cagggacaag
      361 aatatcaaaa tctatgacat gtacgtaggc ctcgtaaacc tcagggtggc cggcaaccac
      421 acccagtggt atgaggtgaa cagggtgatc ctgcacccca catatgagat gtaccacccc
      481 atcggaggtg acgtggccct ggtgcagctg aagacccgca ttgtgttttc tgagtccgtg
      541 ctcccggttt gccttgcaac tccagaagtg aaccttacca gtgccaattg ctgggctacg
      601 ggatggggac tagtctcaaa acaaggtgag acctcagacg agctgcagga gatgcagctc
      661 ccgctgatcc tggagccctg gtgccacctg ctctacggac acatgtccta catcatgccc
      721 gacatgctgt gtgctgggga catcctgaat gctaagaccg tgtgtgaggg cgactccggg
      781 ggcccacttg tctgtgaatt caaccgcagc tggttgcaga ttggaattgt gagctggggc
      841 cgaggctgct ccaaccctct gtaccctgga gtgtatgcca gtgtttccta tttctcaaaa
      901 tggatatgtg ataacataga aatcacgccc actcctgctc agccagcccc tgctctctct
      961 ccagctctgg ggcccactct cagcgtccta atggccatgc tggctggctg gtcagtgctg
     1021 tgaggtcagg atacccactc taggattctc atggctgcac accctgcccc agcccagctg
     1081 cctccagacc cctaagcatc tcctgtcctg gcctctctga agcagacaag ggccacctat
     1141 cccgggggtg gatgctgagt ccaggaggtg atgagcaagt gtacaaaaga aaaaagggaa
     1201 gggggagagg ggctggtcag ggagaaccca gcttgggcag agtgcacctg agatttgata
     1261 agatcattaa atatttacaa agcaa
//
