LOCUS       NM_001008270            1239 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens serine protease 37 (PRSS37), transcript variant 1,
            mRNA.
ACCESSION   NM_001008270 XM_059830
VERSION     NM_001008270.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Liu,J., Shen,C., Fan,W., Chen,Y., Zhang,A., Feng,Y., Li,Z.,
            Kuang,Y. and Wang,Z.
  TITLE     Low levels of PRSS37 protein in sperm are associated with many
            cases of unexplained male infertility
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 48 (11), 1058-1065 (2016)
   PUBMED   27649891
  REMARK    GeneRIF: Sperm with low PRSS37 contents exhibit abnormal activation
            of the proacrosin/acrosin system and premature proteolysis of
            ADAM2, which may impair the functional competence of human sperm in
            vivo
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093638.4, AK172866.1, BC137353.1 and AA628371.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001008270.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172866.1, BC137354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350549.8/ ENSP00000297767.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC093638.4         14420-14483         c
            65-274              AK172866.1         1-210
            275-1180            BC137353.1         1-906
            1181-1239           AA628371.1         23-81               c
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1239
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /note="serine protease 37"
                     /db_xref="GeneID:136242"
                     /db_xref="HGNC:HGNC:29211"
     exon            1..470
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..1144
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable inactive trypsin-X2; probable inactive
                     serine protease 37; Peptidase S1 domain-containing protein
                     LOC136242; protease, serine 37"
                     /codon_start=1
                     /product="probable inactive serine protease 37 isoform 1
                     precursor"
                     /protein_id="NP_001008271.2"
                     /db_xref="CCDS:CCDS34764.1"
                     /db_xref="GeneID:136242"
                     /db_xref="HGNC:HGNC:29211"
                     /translation="MKYVFYLGVLAGTFFFADSSVQKEDPAPYLVYLKSHFNPCVGVL
                     IKPSWVLAPAHCYLPNLKVMLGNFKSRVRDGTEQTINPIQIVRYWNYSHSAPQDDLML
                     IKLAKPAMLNPKVQPLTLATTNVRPGTVCLLSGLDWSQENSGRHPDLRQNLEAPVMSD
                     RECQKTEQGKSHRNSLCVKFVKVFSRIFGEVAVATVICKDKLQGIEVGHFMGGDVGIY
                     TNVYKYVSWIENTAKDK"
     exon            471..612
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..866
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1003
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1239
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1219..1224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="PRSS37"
                     /gene_synonym="TRYX2"
                     /note="major polyA site"
ORIGIN      
        1 aaacctcagg acacttactc cctgagctaa ggtaaagaat attgtccctc atagccctgg
       61 tctcagaaac tctgtgggga agataagtcc tgagcctaga gctgccattt ccacagacaa
      121 ctgaactacc ttcaaacaga tgtgttttta ggggcagcag atagaaggag ctgaatccag
      181 gagtttcctt ccctgaaatg ccccaacaga ggcacagtcc tccaccttcc ctggaacaga
      241 gggctttcat ctgtctctct gaagccatct ccctcccctg tttatgccca gagctgcttt
      301 ccaatcccat ggagtgcctc cgtatctaac catagccact gagtctacca ggtgttcctg
      361 agaagacaac taagccaacc gctccacact ctgctgattt tcttctacat ctcacagggg
      421 gaagagctgg atcaccatga aatatgtctt ctatttgggt gtcctcgctg ggacattttt
      481 ctttgctgac tcatctgttc agaaagaaga ccctgctccc tatttggtgt acctcaagtc
      541 tcacttcaac ccctgtgtgg gcgtcctcat caaacccagc tgggtgctgg ccccagctca
      601 ctgctattta ccaaatctga aagtgatgct gggaaatttc aagagcagag tcagagacgg
      661 tactgaacag acaattaacc ccattcagat cgtccgctac tggaactaca gtcatagcgc
      721 cccacaggat gacctcatgc tcatcaagct ggctaagcct gccatgctca atcccaaagt
      781 ccagcccctt accctcgcca ccaccaatgt caggccaggc actgtctgtc tactctcagg
      841 tttggactgg agccaagaaa acagtggccg acaccctgac ttgcggcaga acctggaggc
      901 ccccgtgatg tctgatcgag aatgccaaaa aacagaacaa ggaaaaagcc acaggaattc
      961 cttatgtgtg aaatttgtga aagtattcag ccgaattttt ggggaggtgg ccgttgctac
     1021 tgtcatctgc aaagacaagc tccagggaat cgaggtgggg cacttcatgg gaggggacgt
     1081 cggcatctac accaatgttt acaaatatgt atcctggatt gagaacactg ctaaggacaa
     1141 gtgagaccct acttctccct ctgcattcca ctggctctgc catggactat acaagcagat
     1201 aattttccct ctattcaaaa taaaatctcc aaatgaaaa
//
