LOCUS       NM_173502               2811 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens serine protease 36 (PRSS36), transcript variant 1,
            mRNA.
ACCESSION   NM_173502
VERSION     NM_173502.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Cal,S., Quesada,V., Llamazares,M., Diaz-Perales,A., Garabaya,C. and
            Lopez-Otin,C.
  TITLE     Human polyserase-2, a novel enzyme with three tandem serine
            protease domains in a single polypeptide chain
  JOURNAL   J Biol Chem 280 (3), 1953-1961 (2005)
   PUBMED   15536082
  REMARK    GeneRIF: analysis of post-translational processing mechanisms of
            polyserase-2 revealed that this novel polyprotein is a secreted
            enzyme whose three protease domains remain as an integral part of a
            single polypeptide chain
            Erratum:[J Biol Chem. 2018 Jul 27;293(30):11784. doi:
            10.1074/jbc.AAC118.004649.. PMID: 30054290]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290310.1, AC009088.9, AK297997.1 and AI864473.1.
            
            On May 17, 2019 this sequence version replaced NM_173502.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ627034.1, AK075142.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268281.9/ ENSP00000268281.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1299              AK290310.1         29-1327
            1300-1300           AC009088.9         25740-25740         c
            1301-1728           AK290310.1         1329-1756
            1729-1729           AC009088.9         24699-24699         c
            1730-2809           AK297997.1         1699-2778
            2810-2811           AI864473.1         8-9                 c
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2811
                     /gene="PRSS36"
                     /note="serine protease 36"
                     /db_xref="GeneID:146547"
                     /db_xref="HGNC:HGNC:26906"
                     /db_xref="MIM:610560"
     exon            1..68
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2599
                     /gene="PRSS36"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; polyserine protease-2; polyserase-2; protease,
                     serine 36"
                     /codon_start=1
                     /product="polyserase-2 isoform 1 precursor"
                     /protein_id="NP_775773.2"
                     /db_xref="CCDS:CCDS32436.1"
                     /db_xref="GeneID:146547"
                     /db_xref="HGNC:HGNC:26906"
                     /db_xref="MIM:610560"
                     /translation="MARHLLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPS
                     ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWS
                     VLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCL
                     PRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNL
                     TLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVF
                     TAVATYEAWIREQVMGSEPGPAFPTQPQKTQSDPQEPREENCTIALPECGKAPRPGAW
                     PWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLPSRPRAE
                     RVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWG
                     RGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWN
                     DSRWSLLCQEEGTWFLAGIRDFPSGCLRPRAFFPLQTHGPWISHVTRGAYLEDQLAWD
                     WGPDGEETETQTCPPHTEHGACGLRLEAAPVGVLWPWLAEVHVAGDRVCTGILLAPGW
                     VLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLRPPLAL
                     LELSSRVEPSPSALPICLHPAGIPPGASCWVLGWKEPQDRVPVAAAVSILTQRICDCL
                     YQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQGSRELFAAIGP
                     EEAWISQTVGEANFLPPSGSPHWPTGGSNLCPPELAKASGSPHAVYFLLLLTLLIQS"
     exon            69..104
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            105..140
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            141..303
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            304..584
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            585..751
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1001
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1131
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1388
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1552
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1790
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1932
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2198
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2320
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2811
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2793..2798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS36"
                     /note="hexamer: AATAAA"
     polyA_site      2811
                     /gene="PRSS36"
                     /note="major polyA site"
ORIGIN      
        1 acttggctct gcctccgctg actctagcgc catggcccgg cacctgctcc tcccccttgt
       61 gatgcttgtc atcagtccca tcccaggagc cttccaggac tcagctctca gtcctaccca
      121 ggaagaacct gaagatctgg actgcgggcg ccctgagccc tcggcccgca tcgtgggggg
      181 ctcaaacgcg cagccgggca cctggccttg gcaagtgagc ctgcaccatg gaggtggcca
      241 catctgcggg ggctccctca tcgccccctc ctgggtcctc tccgctgctc actgtttcat
      301 gacgaatggg acgctggagc ccgcggccga gtggtcggta ctgctgggcg tgcactccca
      361 ggacgggccc ctggacggcg cgcacacccg cgcagtggcc gccatcgtgg tgccggccaa
      421 ctacagccaa gtggagctgg gcgccgacct ggccctgctg cgcctggcct cacccgccag
      481 cctgggcccc gccgtgtggc ctgtctgcct gccccgcgcc tcacaccgct tcgtgcacgg
      541 caccgcctgc tgggccaccg gctggggaga cgtccaggag gcagatcctc tgcctctccc
      601 ctgggtgcta caggaagtgg agctaaggct gctgggcgag gccacctgtc aatgtctcta
      661 cagccagccc ggtcccttca acctcactct ccagatattg ccagggatgc tgtgtgctgg
      721 ctacccagag ggccgcaggg acacctgcca gggtgactct ggggggcccc tggtctgtga
      781 ggaaggcggc cgctggttcc aggcaggaat caccagcttt ggctttggct gtggacggag
      841 aaaccgccct ggagttttca ctgctgtggc tacctatgag gcatggatac gggagcaggt
      901 gatgggttca gagcctgggc ctgcctttcc cacccagccc cagaagaccc agtcagatcc
      961 ccaggagccc agggaggaga actgcaccat tgccctgcct gagtgcggga aggccccgcg
     1021 gccaggggcc tggccctggg aggcccaggt gatggtgcca ggatccagac cctgccatgg
     1081 ggcgctggtg tctgaaagct gggtcttggc acctgccagc tgctttctgg acccgaacag
     1141 ctccgacagc ccaccccgcg acctcgacgc ctggcgcgtg ctgctgccct cgcgcccgcg
     1201 cgcggagcgg gtggcgcgcc tggtgcagca cgagaacgct tcgtgggaca acgcctcgga
     1261 cctggcgctg ctgcagctgc gcacgcccgt gaacctgagc gcggcttcgc ggcccgtgtg
     1321 cctaccccac ccggaacact acttcctgcc cgggagccgc tgccgcctgg cccgctgggg
     1381 ccgcggggaa cccgcgcttg gcccaggcgc gctgctggag gcggagctgt taggcggctg
     1441 gtggtgccac tgcctgtacg gccgccaggg ggcggcagta ccgctgcccg gagacccgcc
     1501 gcacgcgctc tgccctgcct accaggaaaa ggaggaggtg ggcagctgct ggaatgactc
     1561 gcgttggagc cttttgtgcc aggaggaggg gacctggttt ctggctggaa tcagagactt
     1621 tcccagtggc tgtctacgtc cccgagcctt cttccctctg cagactcatg gcccatggat
     1681 cagccatgtg actcggggag cctacctgga ggaccagcta gcctgggatt ggggccctga
     1741 tggggaggag actgagacac agacttgtcc cccacacaca gagcatggtg cctgtggcct
     1801 gcggctggag gctgctccag tgggggtcct gtggccctgg ctggcagagg tgcatgtggc
     1861 tggtgatcga gtctgcactg ggatcctcct ggccccaggc tgggtcctgg cagccactca
     1921 ctgtgtcctc aggccaggct ctacaacagt gccttacatt gaagtgtatc tgggccgggc
     1981 aggggccagc tccctcccac agggccacca ggtatcccgc ttggtcatca gcatccggct
     2041 gccccagcac ctgggactca ggccccccct ggccctcctg gagctgagct cccgggtgga
     2101 gccctcccca tcagccctgc ccatctgtct ccacccggcg ggtatccccc cgggggccag
     2161 ctgctgggtg ttgggctgga aagaacccca ggaccgagtc cctgtggctg ctgctgtctc
     2221 catcttgaca caacgaatct gtgactgcct ctatcagggc atcctgcccc ctggaaccct
     2281 ctgtgtcctg tatgcagagg ggcaggagaa caggtgtgag atgacctcag caccgcccct
     2341 cctgtgccag atgacggaag ggtcctggat cctcgtgggc atggctgttc aagggagccg
     2401 ggagctgttt gctgccattg gtcctgaaga ggcctggatc tcccagacag tgggagaggc
     2461 caacttcctg ccccccagtg gctccccaca ctggcccact ggaggcagca atctctgccc
     2521 cccagaactg gccaaggcct cgggatcccc gcatgcagtc tacttcctgc tcctgctgac
     2581 tctcctgatc cagagctgag gggctagggt cccagcacca cttccccctt ctccaccctc
     2641 tacttcccgc ccagtggggc tggaatgtgg cccagccggc tggaacctca agggccccac
     2701 ccaccgagat tgcagcggct ctggctaatt gggcctcagt gcccgggcta ttttgaaccc
     2761 aggaatcctt gggggtggtg ggaggagcgg acaataaagg tgtaaacaca g
//
