LOCUS       NM_001258290            2796 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens serine protease 36 (PRSS36), transcript variant 2,
            mRNA.
ACCESSION   NM_001258290
VERSION     NM_001258290.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   2  (bases 1 to 2796)
  AUTHORS   Cal,S., Quesada,V., Llamazares,M., Diaz-Perales,A., Garabaya,C. and
            Lopez-Otin,C.
  TITLE     Human polyserase-2, a novel enzyme with three tandem serine
            protease domains in a single polypeptide chain
  JOURNAL   J Biol Chem 280 (3), 1953-1961 (2005)
   PUBMED   15536082
  REMARK    GeneRIF: analysis of post-translational processing mechanisms of
            polyserase-2 revealed that this novel polyprotein is a secreted
            enzyme whose three protease domains remain as an integral part of a
            single polypeptide chain
            Erratum:[J Biol Chem. 2018 Jul 27;293(30):11784. doi:
            10.1074/jbc.AAC118.004649.. PMID: 30054290]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290310.1, BC144615.1, AC009088.9, AK297997.1 and AI864473.1.
            
            On May 31, 2019 this sequence version replaced NM_001258290.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region, compared to variant 1. This results in a
            shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144615.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK290310.1         29-33
            6-1299              BC144615.1         1-1294
            1300-1300           AC009088.9         25740-25740         c
            1301-1713           BC144615.1         1296-1708
            1714-1714           AC009088.9         24699-24699         c
            1715-2728           BC144615.1         1710-2723
            2729-2794           AK297997.1         2713-2778
            2795-2796           AI864473.1         8-9                 c
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2796
                     /gene="PRSS36"
                     /note="serine protease 36"
                     /db_xref="GeneID:146547"
                     /db_xref="HGNC:HGNC:26906"
                     /db_xref="MIM:610560"
     exon            1..68
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2584
                     /gene="PRSS36"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; polyserine protease-2; polyserase-2; protease,
                     serine 36"
                     /codon_start=1
                     /product="polyserase-2 isoform 2 precursor"
                     /protein_id="NP_001245219.1"
                     /db_xref="CCDS:CCDS58453.1"
                     /db_xref="GeneID:146547"
                     /db_xref="HGNC:HGNC:26906"
                     /db_xref="MIM:610560"
                     /translation="MARHLLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPS
                     ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWS
                     VLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCL
                     PRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNL
                     TLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVF
                     TAVATYEAWIREQVMGSEPGPAFPTQPQKTQSDPQEPREENCTIALPECGKAPRPGAW
                     PWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLPSRPRAE
                     RVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWG
                     RGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEENDSRWS
                     LLCQEEGTWFLAGIRDFPSGCLRPRAFFPLQTHGPWISHVTRGAYLEDQLAWDWGPDG
                     EETETQTCPPHTEHGACGLRLEAAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVLAAT
                     HCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLRPPLALLELSS
                     RVEPSPSALPICLHPAGIPPGASCWVLGWKEPQDRVPVAAAVSILTQRICDCLYQGIL
                     PPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQGSRELFAAIGPEEAWI
                     SQTVGEANFLPPSGSPHWPTGGSNLCPPELAKASGSPHAVYFLLLLTLLIQS"
     exon            69..104
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            105..140
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            141..303
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            304..584
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            585..751
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1001
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1131
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1388
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1537
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1775
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1917
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2183
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2305
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2796
                     /gene="PRSS36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2778..2783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS36"
                     /note="hexamer: AATAAA"
     polyA_site      2796
                     /gene="PRSS36"
                     /note="major polyA site"
ORIGIN      
        1 acttggctct gcctccgctg actctagcgc catggcccgg cacctgctcc tcccccttgt
       61 gatgcttgtc atcagtccca tcccaggagc cttccaggac tcagctctca gtcctaccca
      121 ggaagaacct gaagatctgg actgcgggcg ccctgagccc tcggcccgca tcgtgggggg
      181 ctcaaacgcg cagccgggca cctggccttg gcaagtgagc ctgcaccatg gaggtggcca
      241 catctgcggg ggctccctca tcgccccctc ctgggtcctc tccgctgctc actgtttcat
      301 gacgaatggg acgctggagc ccgcggccga gtggtcggta ctgctgggcg tgcactccca
      361 ggacgggccc ctggacggcg cgcacacccg cgcagtggcc gccatcgtgg tgccggccaa
      421 ctacagccaa gtggagctgg gcgccgacct ggccctgctg cgcctggcct cacccgccag
      481 cctgggcccc gccgtgtggc ctgtctgcct gccccgcgcc tcacaccgct tcgtgcacgg
      541 caccgcctgc tgggccaccg gctggggaga cgtccaggag gcagatcctc tgcctctccc
      601 ctgggtgcta caggaagtgg agctaaggct gctgggcgag gccacctgtc aatgtctcta
      661 cagccagccc ggtcccttca acctcactct ccagatattg ccagggatgc tgtgtgctgg
      721 ctacccagag ggccgcaggg acacctgcca gggtgactct ggggggcccc tggtctgtga
      781 ggaaggcggc cgctggttcc aggcaggaat caccagcttt ggctttggct gtggacggag
      841 aaaccgccct ggagttttca ctgctgtggc tacctatgag gcatggatac gggagcaggt
      901 gatgggttca gagcctgggc ctgcctttcc cacccagccc cagaagaccc agtcagatcc
      961 ccaggagccc agggaggaga actgcaccat tgccctgcct gagtgcggga aggccccgcg
     1021 gccaggggcc tggccctggg aggcccaggt gatggtgcca ggatccagac cctgccatgg
     1081 ggcgctggtg tctgaaagct gggtcttggc acctgccagc tgctttctgg acccgaacag
     1141 ctccgacagc ccaccccgcg acctcgacgc ctggcgcgtg ctgctgccct cgcgcccgcg
     1201 cgcggagcgg gtggcgcgcc tggtgcagca cgagaacgct tcgtgggaca acgcctcgga
     1261 cctggcgctg ctgcagctgc gcacgcccgt gaacctgagc gcggcttcgc ggcccgtgtg
     1321 cctaccccac ccggaacact acttcctgcc cgggagccgc tgccgcctgg cccgctgggg
     1381 ccgcggggaa cccgcgcttg gcccaggcgc gctgctggag gcggagctgt taggcggctg
     1441 gtggtgccac tgcctgtacg gccgccaggg ggcggcagta ccgctgcccg gagacccgcc
     1501 gcacgcgctc tgccctgcct accaggaaaa ggaggagaat gactcgcgtt ggagcctttt
     1561 gtgccaggag gaggggacct ggtttctggc tggaatcaga gactttccca gtggctgtct
     1621 acgtccccga gccttcttcc ctctgcagac tcatggccca tggatcagcc atgtgactcg
     1681 gggagcctac ctggaggacc agctagcctg ggattggggc cctgatgggg aggagactga
     1741 gacacagact tgtcccccac acacagagca tggtgcctgt ggcctgcggc tggaggctgc
     1801 tccagtgggg gtcctgtggc cctggctggc agaggtgcat gtggctggtg atcgagtctg
     1861 cactgggatc ctcctggccc caggctgggt cctggcagcc actcactgtg tcctcaggcc
     1921 aggctctaca acagtgcctt acattgaagt gtatctgggc cgggcagggg ccagctccct
     1981 cccacagggc caccaggtat cccgcttggt catcagcatc cggctgcccc agcacctggg
     2041 actcaggccc cccctggccc tcctggagct gagctcccgg gtggagccct ccccatcagc
     2101 cctgcccatc tgtctccacc cggcgggtat ccccccgggg gccagctgct gggtgttggg
     2161 ctggaaagaa ccccaggacc gagtccctgt ggctgctgct gtctccatct tgacacaacg
     2221 aatctgtgac tgcctctatc agggcatcct gccccctgga accctctgtg tcctgtatgc
     2281 agaggggcag gagaacaggt gtgagatgac ctcagcaccg cccctcctgt gccagatgac
     2341 ggaagggtcc tggatcctcg tgggcatggc tgttcaaggg agccgggagc tgtttgctgc
     2401 cattggtcct gaagaggcct ggatctccca gacagtggga gaggccaact tcctgccccc
     2461 cagtggctcc ccacactggc ccactggagg cagcaatctc tgccccccag aactggccaa
     2521 ggcctcggga tccccgcatg cagtctactt cctgctcctg ctgactctcc tgatccagag
     2581 ctgaggggct agggtcccag caccacttcc cccttctcca ccctctactt cccgcccagt
     2641 ggggctggaa tgtggcccag ccggctggaa cctcaagggc cccacccacc gagattgcag
     2701 cggctctggc taattgggcc tcagtgcccg ggctattttg aacccaggaa tccttggggg
     2761 tggtgggagg agcggacaat aaaggtgtaa acacag
//
