LOCUS       NM_153362               2444 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serine protease 35 (PRSS35), transcript variant 2,
            mRNA.
ACCESSION   NM_153362
VERSION     NM_153362.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2444)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   2  (bases 1 to 2444)
  AUTHORS   Goes,F.S., Hamshere,M.L., Seifuddin,F., Pirooznia,M.,
            Belmonte-Mahon,P., Breuer,R., Schulze,T., Nothen,M., Cichon,S.,
            Rietschel,M., Holmans,P., Zandi,P.P., Craddock,N. and Potash,J.B.
  CONSRTM   Bipolar Genome Study (BiGS)
  TITLE     Genome-wide association of mood-incongruent psychotic bipolar
            disorder
  JOURNAL   Transl Psychiatry 2 (10), e180 (2012)
   PUBMED   23092984
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2444)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2444)
  AUTHORS   Letra,A., Menezes,R., Fonseca,R.F., Govil,M., McHenry,T.,
            Murphy,M.J., Hennebold,J.D., Granjeiro,J.M., Castilla,E.E.,
            Orioli,I.M., Martin,R., Marazita,M.L., Bjork,B.C. and Vieira,A.R.
  TITLE     Novel cleft susceptibility genes in chromosome 6q
  JOURNAL   J Dent Res 89 (9), 927-932 (2010)
   PUBMED   20511563
  REMARK    GeneRIF: We provide further evidence of the involvement of
            chromosome 6q in cleft lip/palate and suggest PRSS35 as a novel
            candidate gene.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2444)
  AUTHORS   Miyakoshi,K., Murphy,M.J., Yeoman,R.R., Mitra,S., Dubay,C.J. and
            Hennebold,J.D.
  TITLE     The identification of novel ovarian proteases through the use of
            genomic and bioinformatic methodologies
  JOURNAL   Biol Reprod 75 (6), 823-835 (2006)
   PUBMED   16870946
  REMARK    GeneRIF: Mouse ortholog of human PRSS35 is an ovary-selectively
            expressed gene.
REFERENCE   6  (bases 1 to 2444)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA251169.1, BC037170.1 and AL121939.12.
            
            On Nov 24, 2018 this sequence version replaced NM_153362.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037170.1, SRR1660807.155494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369700.4/ ENSP00000358714.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA251169.1         60-77
            19-20               BC037170.1         1-2
            21-21               AL121939.12        29465-29465
            22-851              BC037170.1         4-833
            852-852             AL121939.12        41023-41023
            853-2444            BC037170.1         835-2426
FEATURES             Location/Qualifiers
     source          1..2444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.2"
     gene            1..2444
                     /gene="PRSS35"
                     /gene_synonym="C6orf158; dJ223E3.1"
                     /note="serine protease 35"
                     /db_xref="GeneID:167681"
                     /db_xref="HGNC:HGNC:21387"
     exon            1..161
                     /gene="PRSS35"
                     /gene_synonym="C6orf158; dJ223E3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..2444
                     /gene="PRSS35"
                     /gene_synonym="C6orf158; dJ223E3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1423
                     /gene="PRSS35"
                     /gene_synonym="C6orf158; dJ223E3.1"
                     /note="inactive serine protease 35; protease, serine 35"
                     /codon_start=1
                     /product="inactive serine protease 35 precursor"
                     /protein_id="NP_699193.2"
                     /db_xref="CCDS:CCDS4999.1"
                     /db_xref="GeneID:167681"
                     /db_xref="HGNC:HGNC:21387"
                     /translation="MENMLLWLIFFTPGWTLIDGSEMEWDFMWHLRKVPRIVSERTFH
                     LTSPAFEADAKMMVNTVCGIECQKELPTPSLSELEDYLSYETVFENGTRTLTRVKVQD
                     LVLEPTQNITTKGVSVRRKRQVYGTDSRFSILDKRFLTNFPFSTAVKLSTGCSGILIS
                     PQHVLTAAHCVHDGKDYVKGSKKLRVGLLKMRNKSGGKKRRGSKRSRREASGGDQREG
                     TREHLRERAKGGRRRKKSGRGQRIAEGRPSFQWTRVKNTHIPKGWARGGMGDATLDYD
                     YALLELKRAHKKKYMELGISPTIKKMPGGMIHFSGFDNDRADQLVYRFCSVSDESNDL
                     LYQYCDAESGSTGSGVYLRLKDPDKKNWKRKIIAVYSGHQWVDVHGVQKDYNVAVRIT
                     PLKYAQICLWIHGNDANCAYG"
     regulatory      2418..2423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS35"
                     /gene_synonym="C6orf158; dJ223E3.1"
                     /note="hexamer: AATAAA"
     polyA_site      2444
                     /gene="PRSS35"
                     /gene_synonym="C6orf158; dJ223E3.1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtctcag tggcgagctc tgggtgctgt ggcccggcct tggcggggcg gcctccggct
       61 caggctggct gagaggctcc cagctgcagc gtccccgccc gcctcctcgg gagctctgat
      121 ctcagctgac agtgccctcg gggaccaaac aagcctggca ggacaaaatt agaagatcaa
      181 aatggaaaat atgctgcttt ggttgatatt tttcacccct gggtggaccc tcattgatgg
      241 atctgaaatg gaatgggatt ttatgtggca cttgagaaag gtaccccgga ttgtcagtga
      301 aaggactttc catctcacca gccccgcatt tgaggcagat gctaagatga tggtaaatac
      361 agtgtgtggc atcgaatgcc agaaagaact cccaactccc agcctttctg aattggagga
      421 ttatctttcc tatgagactg tctttgagaa tggcacccga accttaacca gggtgaaagt
      481 tcaagatttg gttcttgagc cgactcaaaa tatcaccaca aagggagtat ctgttaggag
      541 aaagagacag gtgtatggca ccgacagcag gttcagcatc ttggacaaaa ggttcttaac
      601 caatttccct ttcagcacag ctgtgaagct ttccacgggc tgtagtggca ttctcatttc
      661 ccctcagcat gttctaactg ctgcccactg tgttcatgat ggaaaggact atgtcaaagg
      721 gagtaaaaag ctaagggtag ggttgttgaa gatgaggaat aaaagtggag gcaagaaacg
      781 tcgaggttct aagaggagca ggagagaagc tagtggtggt gaccaaagag agggtaccag
      841 agagcatctg cgggagagag cgaagggtgg gagaagaaga aaaaaatctg gccggggtca
      901 gaggattgcc gaagggaggc cttcctttca gtggacccgg gtcaagaata cccacattcc
      961 gaagggctgg gcacgaggag gcatggggga cgctaccttg gactatgact atgctcttct
     1021 ggagctgaag cgtgctcaca aaaagaaata catggaactt ggaatcagcc caacgatcaa
     1081 gaaaatgcct ggtggaatga tccacttctc aggatttgat aacgataggg ctgatcagtt
     1141 ggtctatcgg ttttgcagtg tgtccgacga atccaatgat ctcctttacc aatactgcga
     1201 tgctgagtcg ggctccaccg gttcgggggt ctatctgcgt ctgaaagatc cagacaaaaa
     1261 gaattggaag cgcaaaatca ttgcggtcta ctcagggcac cagtgggtgg atgtccacgg
     1321 ggttcagaag gactacaacg ttgctgttcg catcactccc ctaaaatacg cccagatttg
     1381 cctctggatt cacgggaacg atgccaattg tgcttacggc taacagagac ctgaaacagg
     1441 gcggtgtatc atctaaatca cagagaaaac cagctctgct taccgtagtg agatcacttc
     1501 ataggttatg cctggacttg aactctgtca atagcatttc aacatttttc aaaatcagga
     1561 gattttcgtc catttaaaaa atgtataggt gcagatattg aaactaggtg ggcacttcaa
     1621 tgccaagtat atactcttct ttacatggtg atgagtttca tttgtagaaa aattttgttg
     1681 ccttcttaaa aattagacac actttaaacc ttcaaacagg tattataaat aacatgtgac
     1741 tccttaatgg acttattctc agggtcctac tctaagaaga atctaatagg atgctggttg
     1801 tgtattaaat gtgaaattgc atagataaag gtagatggta aagcaattag tatcagaata
     1861 gagacagaaa gttacaacac agtttgtact actctgagat ggatccattc agctcatgcc
     1921 ctcaatgttt atattgtgtt atctgttggg tctgggacat ttagtttagt ttttttgaag
     1981 aattacaaat cagaagaaaa agcaagcatt ataaacaaaa ctaataactg ttttactgct
     2041 ttaagaaata acaattacaa tgtgtattat ttaaaaatgg gagaaatagt ttgttctatg
     2101 aaataaacct agtttagaaa tagggaagct gagacatttt aagatctcaa gtttttattt
     2161 aactaatact caaaatatgg acttttcatg tatgcatagg gaagacactt cacaaattat
     2221 gaatgatcat gtgttgaaag ccacattatt ttatgctata cattctatgt atgaggtgct
     2281 acatttttag gacaaagaat tctgtaatct ttttcaagaa agagtctttt tctccttgac
     2341 aaaatccagc ttttgtatga ggactatagg gtgaattctc tgattagtaa ttttagatat
     2401 gtcctttcct aaaaatgaat aaaatttatg aatatgactt aaaa
//
