LOCUS       NM_152891               1619 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens serine protease 33 (PRSS33), transcript variant 3,
            mRNA.
ACCESSION   NM_152891 XM_011522451
VERSION     NM_152891.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Toyama,S., Okada,N., Matsuda,A., Morita,H., Saito,H., Fujisawa,T.,
            Nakae,S., Karasuyama,H. and Matsumoto,K.
  TITLE     Human eosinophils constitutively express a unique serine protease,
            PRSS33
  JOURNAL   Allergol Int 66 (3), 463-471 (2017)
   PUBMED   28216055
  REMARK    GeneRIF: activated eosinophils may induce fibroblast extracellular
            matrix protein synthesis through cell-surface expression of PRSS33,
            which would at least partly explain eosinophils' role(s) in airway
            remodeling.
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Chen,C., Darrow,A.L., Qi,J.S., D'Andrea,M.R. and Andrade-Gordon,P.
  TITLE     A novel serine protease predominately expressed in macrophages
  JOURNAL   Biochem J 374 (Pt 1), 97-107 (2003)
   PUBMED   12795636
  REMARK    GeneRIF: highly expressed in spleen and moderately expressed in
            intestine, colon, lung and brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092117.4.
            
            On or before Jul 17, 2020 this sequence version replaced
            XM_011522451.2, NM_152891.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2537660.1,
                                           SRR11853561.10848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682474.1/ ENSP00000507560.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC092117.4         178604-178631       c
            29-131              AC092117.4         177573-177675       c
            132-164             AC092117.4         177160-177192       c
            165-327             AC092117.4         176870-177032       c
            328-599             AC092117.4         176446-176717       c
            600-769             AC092117.4         176073-176242       c
            770-1619            AC092117.4         175024-175873       c
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1619
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /note="serine protease 33"
                     /db_xref="GeneID:260429"
                     /db_xref="HGNC:HGNC:30405"
                     /db_xref="MIM:613797"
     exon            1..28
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     exon            29..131
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..928
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /note="serine protease EOS; protease, serine 33"
                     /codon_start=1
                     /product="serine protease 33 precursor"
                     /protein_id="NP_690851.2"
                     /db_xref="CCDS:CCDS42110.1"
                     /db_xref="GeneID:260429"
                     /db_xref="HGNC:HGNC:30405"
                     /db_xref="MIM:613797"
                     /translation="MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSSRIVGGRDGR
                     DGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSP
                     RTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPC
                     RVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAG
                     YPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQA
                     RVSF"
     exon            132..164
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     exon            165..327
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     exon            328..599
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     exon            600..769
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1619
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1597..1602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /note="hexamer: AATAAA"
     polyA_site      1619
                     /gene="PRSS33"
                     /gene_synonym="EOS"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcaga aggcgccagg ctgtgaggac cagagtccaa gccctaggca gtgccaccct
       61 tacccagccc agccttgaag acagaatgag aggggtttcc tgtctccagg tcctgctcct
      121 tctggtgctg ggagctgctg ggactcaggg aaggaagtct gcagcctgcg ggcagccccg
      181 catgtccagt cggatcgttg ggggccggga tggccgggac ggagagtggc cgtggcaggc
      241 gagcatccag catcgtgggg cacacgtgtg cggggggtcg ctcatcgccc cccagtgggt
      301 gctgacagcg gcgcactgct tccccaggag ggcactgcca gctgagtacc gcgtgcgcct
      361 gggggcgctg cgtctgggct ccacctcgcc ccgcacgctc tcggtgcccg tgcgacgggt
      421 gctgctgccc ccggactact ccgaggacgg ggcccgcggc gacctggcac tgctgcagct
      481 gcgtcgcccg gtgcccctga gcgctcgcgt ccaacccgtc tgcctgcccg tgcccggcgc
      541 ccgcccgccg cccggcacac catgccgggt caccggctgg ggcagcctcc gcccaggagt
      601 gcccctccca gagtggcgac cgctacaagg agtaagggtg ccgctgctgg actcgcgcac
      661 ctgcgacggc ctctaccacg tgggcgcgga cgtgccccag gctgagcgca ttgtgctgcc
      721 tgggagtctg tgtgccggct acccccaggg ccacaaggac gcctgccagg gtgattctgg
      781 gggacctctg acctgcctgc agtctgggag ctgggtcctg gtgggcgtgg tgagctgggg
      841 caagggttgt gccctgccca accgtccagg ggtctacacc agtgtggcca catatagccc
      901 ctggattcag gctcgcgtca gcttctaatg ctagccggtg aggctgacct ggagccagct
      961 gctggggtcc ctcagcctcc tggttcatcc aggcacctgc ctatacccca catcccttct
     1021 gcctcgaggc caagatgcct aaaaaagcta aaggccaccc caccccccac ccaccacctc
     1081 ctgcctcctc tcctctttgg ggatcaccag ctctgactcc accaaccctc atccaggaat
     1141 ctgccatgag tcccagggag tcacactccc cactcccttc ctggcttgta tttacttttc
     1201 ttggccctgg ccagggctgg gcgcaaggca cgcagtgatg ggcaaaccaa ttgctgccca
     1261 tctggcctgt gtgcccatct ttttctggag aaagtcagat tcacagcatg acagagattt
     1321 gacaccaggg agatcctcca tagctggctt tgaggacacg gggaccacag ccatgagcgg
     1381 cctctaagag ctgagagaca gccggcaggg aatcggaacc ctcagaccca cagccgcaag
     1441 gcactggatt ctggcagcac cctgaaggag ctgggaagta agttcttccc cagcctccag
     1501 ataagagccc cgccggccaa tcccttcatt tcaacctaaa gagaccctaa gcagagaacc
     1561 tagctgagcc actcctgacc tacaaagttg tgacttaata aatgtgtgct ttaagctgc
//
