LOCUS       NM_031948               1135 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens serine protease 27 (PRSS27), transcript variant 1,
            mRNA.
ACCESSION   NM_031948
VERSION     NM_031948.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1135)
  AUTHORS   Kataoka,A., Yamada,K., Hagiwara,T., Terayama,M., Sugimoto,T.,
            Nohara,K., Igari,T., Yokoi,C. and Kawamura,Y.I.
  TITLE     Expression Status of Serine Protease 27: A Prognostic Marker for
            Esophageal Squamous Cell Carcinoma Treated with Preoperative
            Chemotherapy/Chemoradiotherapy
  JOURNAL   Ann Surg Oncol 28 (9), 5373-5381 (2021)
   PUBMED   33452606
  REMARK    GeneRIF: Expression Status of Serine Protease 27: A Prognostic
            Marker for Esophageal Squamous Cell Carcinoma Treated with
            Preoperative Chemotherapy/Chemoradiotherapy.
REFERENCE   2  (bases 1 to 1135)
  AUTHORS   Raman,K., Trivedi,N.N., Raymond,W.W., Ganesan,R., Kirchhofer,D.,
            Verghese,G.M., Craik,C.S., Schneider,E.L., Nimishakavi,S. and
            Caughey,G.H.
  TITLE     Mutational tail loss is an evolutionary mechanism for liberating
            marapsins and other type I serine proteases from transmembrane
            anchors
  JOURNAL   J Biol Chem 288 (15), 10588-10598 (2013)
   PUBMED   23447538
  REMARK    GeneRIF: Mutational tail loss is an evolutionary mechanism for
            liberating marapsins and other type I serine proteases from
            transmembrane anchors.
REFERENCE   3  (bases 1 to 1135)
  AUTHORS   Li,W., Danilenko,D.M., Bunting,S., Ganesan,R., Sa,S., Ferrando,R.,
            Wu,T.D., Kolumam,G.A., Ouyang,W. and Kirchhofer,D.
  TITLE     The serine protease marapsin is expressed in stratified squamous
            epithelia and is up-regulated in the hyperproliferative epidermis
            of psoriasis and regenerating wounds
  JOURNAL   J Biol Chem 284 (1), 218-228 (2009)
   PUBMED   18948266
  REMARK    GeneRIF: Marapsin's restricted expression, localization, and
            cytokine-inducible expression suggest a role in the terminal
            differentiation of keratinocytes in hyperproliferating squamous
            epithelia.
REFERENCE   4  (bases 1 to 1135)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 1135)
  AUTHORS   Bhagwandin,V.J., Hau,L.W., Mallen-St Clair,J., Wolters,P.J. and
            Caughey,G.H.
  TITLE     Structure and activity of human pancreasin, a novel tryptic serine
            peptidase expressed primarily by the pancreas
  JOURNAL   J Biol Chem 278 (5), 3363-3371 (2003)
   PUBMED   12441343
  REMARK    GeneRIF: structure and activity of the human enzyme, a serine
            peptidase found in the pancreas
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036912.2 and BC034294.2.
            
            On Nov 22, 2018 this sequence version replaced NM_031948.4.
            
            Summary: This gene is located within a large protease gene cluster
            on chromosome 16. It belongs to the group-1 subfamily of serine
            proteases. The encoded protein is a secreted tryptic serine
            protease and is expressed mainly in the pancreas. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB056161.1, SRR3476690.427125.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302641.8/ ENSP00000306390.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BC036912.2         339-347
            10-1135             BC034294.2         1-1126
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1135
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /note="serine protease 27"
                     /db_xref="GeneID:83886"
                     /db_xref="HGNC:HGNC:15475"
                     /db_xref="MIM:608018"
     exon            1..110
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..937
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; marapsin; channel-activating protease 2;
                     pancreasin; protease, serine 27"
                     /codon_start=1
                     /product="serine protease 27 isoform 1 precursor"
                     /protein_id="NP_114154.1"
                     /db_xref="CCDS:CCDS10476.1"
                     /db_xref="GeneID:83886"
                     /db_xref="HGNC:HGNC:15475"
                     /db_xref="MIM:608018"
                     /translation="MRRPAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEG
                     EWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLGARQLVQPGPHA
                     MYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWV
                     TGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFE
                     EGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRII
                     PKLQFQPARLGGQK"
     exon            111..137
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /inference="alignment:Splign:2.1.0"
     exon            138..300
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /inference="alignment:Splign:2.1.0"
     exon            301..572
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /inference="alignment:Splign:2.1.0"
     exon            573..742
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1135
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1112..1117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /note="hexamer: AATAAA"
     polyA_site      1135
                     /gene="PRSS27"
                     /gene_synonym="CAPH2; MPN"
                     /note="major polyA site"
ORIGIN      
        1 gctcgtgctc caacgcttct gccaccgccg accacggccc tgcgccccag ccaggcctga
       61 ggacatgagg cggccggcgg cggtgccgct cctgctgctg ctgtgttttg ggtctcagag
      121 ggccaaggca gcaacagcct gtggtcgccc caggatgctg aaccgaatgg tgggcgggca
      181 ggacacgcag gagggcgagt ggccctggca agtcagcatc cagcgcaacg gaagccactt
      241 ctgcgggggc agcctcatcg cggagcagtg ggtcctgacg gctgcgcact gcttccgcaa
      301 cacctctgag acgtccctgt accaggtcct gctgggggca aggcagctag tgcagccggg
      361 accacacgct atgtatgccc gggtgaggca ggtggagagc aaccccctgt accagggcac
      421 ggcctccagc gctgacgtgg ccctggtgga gctggaggca ccagtgccct tcaccaatta
      481 catcctcccc gtgtgcctgc ctgacccctc ggtgatcttt gagacgggca tgaactgctg
      541 ggtcactggc tggggcagcc ccagtgagga agacctcctg cccgaaccgc ggatcctgca
      601 gaaactcgct gtgcccatca tcgacacacc caagtgcaac ctgctctaca gcaaagacac
      661 cgagtttggc taccaaccca aaaccatcaa gaatgacatg ctgtgcgccg gcttcgagga
      721 gggcaagaag gatgcctgca agggcgactc gggcggcccc ctggtgtgcc tcgtgggtca
      781 gtcgtggctg caggcggggg tgatcagctg gggtgagggc tgtgcccgcc agaaccgccc
      841 aggtgtctac atccgtgtca ccgcccacca caactggatc catcggatca tccccaaact
      901 gcagttccag ccagcgaggt tgggcggcca gaagtgagac ccccggggcc aggagcccct
      961 tgagcagagc tctgcaccca gcctgcccgc ccacaccatc ctgctggtcc tcccagcgct
     1021 gctgttgcac ctgtgagccc caccagactc atttgtaaat agcgctcctt cctcccctct
     1081 caaataccct tattttattt atgtttctcc caataaaaac ccagcctgtg tgcca
//
