LOCUS       NM_007173               3713 bp    mRNA    linear   PRI 09-OCT-2022
DEFINITION  Homo sapiens serine protease 23 (PRSS23), transcript variant 1,
            mRNA.
ACCESSION   NM_007173
VERSION     NM_007173.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3713)
  AUTHORS   Qin S, Wang Z, Huang C, Huang P and Li D.
  TITLE     Serine protease PRSS23 drives gastric cancer by enhancing tumor
            associated macrophage infiltration via FGF2
  JOURNAL   Front Immunol 13, 955841 (2022)
   PUBMED   36189305
  REMARK    GeneRIF: Serine protease PRSS23 drives gastric cancer by enhancing
            tumor associated macrophage infiltration via FGF2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3713)
  AUTHORS   Wang Z, Gao D, Wang S, Lin H, Wang Y and Xu W.
  TITLE     Exosomal microRNA-1246 from human umbilical cord mesenchymal stem
            cells potentiates myocardial angiogenesis in chronic heart failure
  JOURNAL   Cell Biol Int 45 (11), 2211-2225 (2021)
   PUBMED   34270841
  REMARK    GeneRIF: Exosomal microRNA-1246 from human umbilical cord
            mesenchymal stem cells potentiates myocardial angiogenesis in
            chronic heart failure.
REFERENCE   3  (bases 1 to 3713)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3713)
  AUTHORS   Han B, Yang Y, Chen J, He X, Lv N and Yan R.
  TITLE     PRSS23 knockdown inhibits gastric tumorigenesis through EIF2
            signaling
  JOURNAL   Pharmacol Res 142, 50-57 (2019)
   PUBMED   30769097
  REMARK    GeneRIF: PRSS23 knockdown could suppress tumor growth of gastric
            cancer in vitro and in vivo through inhibiting EIF2 signaling, and
            EIF4E maybe a potential target of PRSS23. PRSS23 could serve as a
            potential target for gastric cancer therapy, and also a biomarker
            for the prediction of prognosis of gastric cancer.
REFERENCE   5  (bases 1 to 3713)
  AUTHORS   LeBleu VS, Teng Y, O'Connell JT, Charytan D, Muller GA, Muller CA,
            Sugimoto H and Kalluri R.
  TITLE     Identification of human epididymis protein-4 as a
            fibroblast-derived mediator of fibrosis
  JOURNAL   Nat Med 19 (2), 227-231 (2013)
   PUBMED   23353556
REFERENCE   6  (bases 1 to 3713)
  AUTHORS   Chan HS, Chang SJ, Wang TY, Ko HJ, Lin YC, Lin KT, Chang KM and
            Chuang YJ.
  TITLE     Serine protease PRSS23 is upregulated by estrogen receptor alpha
            and associated with proliferation of breast cancer cells
  JOURNAL   PLoS One 7 (1), e30397 (2012)
   PUBMED   22291950
  REMARK    GeneRIF: PRSS23 might be a critical component of estrogen-mediated
            cell proliferation of ERalpha-positive breast cancer cells.
REFERENCE   7  (bases 1 to 3713)
  AUTHORS   Miyakoshi K, Murphy MJ, Yeoman RR, Mitra S, Dubay CJ and Hennebold
            JD.
  TITLE     The identification of novel ovarian proteases through the use of
            genomic and bioinformatic methodologies
  JOURNAL   Biol Reprod 75 (6), 823-835 (2006)
   PUBMED   16870946
REFERENCE   8  (bases 1 to 3713)
  AUTHORS   Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J,
            Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A,
            Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P and
            Collins C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA910788.1 and AP000654.4.
            
            On May 24, 2018 this sequence version replaced NM_007173.5.
            
            Summary: This gene encodes a conserved member of the trypsin family
            of serine proteases. Mouse studies found a decrease of mRNA levels
            of this gene after ovulation was induced. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.135436.1, AK075362.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280258.6/ ENSP00000280258.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               DA910788.1         94-203
            111-3713            AP000654.4         28179-31781
FEATURES             Location/Qualifiers
     source          1..3713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..3713
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="serine protease 23"
                     /db_xref="GeneID:11098"
                     /db_xref="HGNC:HGNC:14370"
                     /db_xref="MIM:618376"
     exon            1..110
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            111..3713
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1275
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="serine protease, umbilical endothelium; putative
                     secreted protein Zsig13; protease, serine 23"
                     /codon_start=1
                     /product="serine protease 23 precursor"
                     /protein_id="NP_009104.3"
                     /db_xref="GeneID:11098"
                     /db_xref="HGNC:HGNC:14370"
                     /db_xref="MIM:618376"
                     /translation="MAGIPGLLFLLFFLLCAVGQVSPYSAPWKPTWPAYRLPVVLPQS
                     TLNLAKPDFGAEAKLEVSSSCGPQCHKGTPLPTYEEAKQYLSYETLYANGSRTETQVG
                     IYILSSSGDGAQHRDSGSSGKSRRKRQIYGYDSRFSIFGKDFLLNYPFSTSVKLSTGC
                     TGTLVAEKHVLTAAHCIHDGKTYVKGTQKLRVGFLKPKFKDGGRGANDSTSAMPEQMK
                     FQWIRVKRTHVPKGWIKGNANDIGMDYDYALLELKKPHKRKFMKIGVSPPAKQLPGGR
                     IHFSGYDNDRPGNLVYRFCDVKDETYDLLYQQCDAQPGASGSGVYVRMWKRQQQKWER
                     KIIGIFSGHQWVDMNGSPQDFNVAVRITPLKYAQICYWIKGNYLDCREG"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="hexamer: ATTAAA"
     polyA_site      1657
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="major polyA site"
     regulatory      3691..3696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="hexamer: AATAAA"
     polyA_site      3713
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="major polyA site"
ORIGIN      
        1 gcactcggct gtgcggcggg gcaggcatgg gagccgcgcg ctctctcccg gcgcccacac
       61 ctgtctgagc ggcgcagcga gccgcggccc gggcgggctg ctcggcgcgg aacagtgctc
      121 ggcatggcag ggattccagg gctcctcttc cttctcttct ttctgctctg tgctgttggg
      181 caagtgagcc cttacagtgc cccctggaaa cccacttggc ctgcataccg cctccctgtc
      241 gtcttgcccc agtctaccct caatttagcc aagccagact ttggagccga agccaaatta
      301 gaagtatctt cttcatgtgg accccagtgt cataagggaa ctccactgcc cacttacgaa
      361 gaggccaagc aatatctgtc ttatgaaacg ctctatgcca atggcagccg cacagagacg
      421 caggtgggca tctacatcct cagcagtagt ggagatgggg cccaacaccg agactcaggg
      481 tcttcaggaa agtctcgaag gaagcggcag atttatggct atgacagcag gttcagcatt
      541 tttgggaagg acttcctgct caactaccct ttctcaacat cagtgaagtt atccacgggc
      601 tgcaccggca ccctggtggc agagaagcat gtcctcacag ctgcccactg catacacgat
      661 ggaaaaacct atgtgaaagg aacccagaag cttcgagtgg gcttcctaaa gcccaagttt
      721 aaagatggtg gtcgaggggc caacgactcc acttcagcca tgcccgagca gatgaaattt
      781 cagtggatcc gggtgaaacg cacccatgtg cccaagggtt ggatcaaggg caatgccaat
      841 gacatcggca tggattatga ttatgccctc ctggaactca aaaagcccca caagagaaaa
      901 tttatgaaga ttggggtgag ccctcctgct aagcagctgc cagggggcag aattcacttc
      961 tctggttatg acaatgaccg accaggcaat ttggtgtatc gcttctgtga cgtcaaagac
     1021 gagacctatg acttgctcta ccagcaatgc gatgcccagc caggggccag cgggtctggg
     1081 gtctatgtga ggatgtggaa gagacagcag cagaagtggg agcgaaaaat tattggcatt
     1141 ttttcagggc accagtgggt ggacatgaat ggttccccac aggatttcaa cgtggctgtc
     1201 agaatcactc ctctcaaata tgcccagatt tgctattgga ttaaaggaaa ctacctggat
     1261 tgtagggagg ggtgacacag tgttccctcc tggcagcaat taagggtctt catgttctta
     1321 ttttaggaga ggccaaattg ttttttgtca ttggcgtgca cacgtgtgtg tgtgtgtgtg
     1381 tgtgtgtgta aggtgtctta taatctttta cctatttctt acaattgcaa gatgactggc
     1441 tttactattt gaaaactggt ttgtgtatca tatcatatat catttaagca gtttgaaggc
     1501 atacttttgc atagaaataa aaaaaatact gatttggggc aatgaggaat atttgacaat
     1561 taagttaatc ttcacgtttt tgcaaacttt gatttttatt tcatctgaac ttgtttcaaa
     1621 gatttatatt aaatatttgg catacaagag atatgaattc ttatatgtgt gcatgtgtgt
     1681 tttcttctga gattcatctt ggtggtgggt ttttttgttt ttttaattca gtgcctgatc
     1741 tttaatgctt ccataaggca gtgttcccat ttaggaactt tgacagcatt tgttaggcag
     1801 aatattttgg atttggaggc atttgcatgg tagtctttga acagtaaaat gatgtgttga
     1861 ctatactgat acacatatta aactatacct tatagtaaac cagtatccca agctgctttt
     1921 agttccaaaa atagtttctt ttccaaaggt tgttgctcta ctttgtagga agtctttgca
     1981 tatggccctc ccaactttaa agtcatacca gagtggccaa gagtgtttat cccaaccctt
     2041 ccatttaaca ggatttcact cacatttctg gaactagcta tttttcagaa gacaataatc
     2101 agggcttaat tagaacaggc tgtatttcct cccagcaaac agttgtggcc acactaaaaa
     2161 caatcatagc attttacccc tggattatag cacatctcat gttttatcat ttggatggag
     2221 taatttaaaa tgaattaaat tccagagaac aatggaagca ttgcctggca gatgtcacaa
     2281 cagaataacc acttgtttgg agcctggcac agtcctccag cctgatcaaa aattattctg
     2341 catagttttc agtgtgcttt ctgggagcta tgtacttctt caatttggaa acttttctct
     2401 ctcatttata gtgaaaatac ttggaagtta ctttaagaaa accagtgtgg cctttttccc
     2461 tctagcttta aaagggccgc ttttgctgga atgctctagg ttatagataa acaattaggt
     2521 ataatagcaa aaatgaaaat tggaagaatg caaaatggat cagaatcatg ccttccaata
     2581 aaggccttta cacatgtttt atcaatatga ttatcaaatc acagcatata cagaaaagac
     2641 ttggacttat tgtatgtttt tattttatgg ctctcggcct aagcacttct ttctaaatgt
     2701 atcggagaaa aaatcaaatg gactacaagc acgtgtttgc tgtgcttgca ccccaggtaa
     2761 acctgcattg tagcaatttg taaggatatt cagatggagc actgtcactt agacattctc
     2821 tgggggattt tctgcttgtc tttcttgagc tttttggaag gataattctg ataaggcact
     2881 caagaaacgt acaaccacag tgctttcttc aaatcatatg agaaatacta tgcatagcaa
     2941 ggagatgcag agccgccagg aaaattctga gttccagcac aattttcttt ggaatctaac
     3001 aggaatctag cctgaggaag aagggaggtc tccatttcta tgtctggtat ttgggggttt
     3061 tgtttgtttt tgctttagct tggtgaaaaa aagttcactg aacaccaaga ccagaatgga
     3121 tttttttaaa aaaatagatg ttccttttgt gaagcacctt gattccttga ttttgatttt
     3181 ttgcaaagtt agacaatggc acaaagtcaa aatgaaatca atgtttagtt cacaagtaga
     3241 tgtaatttac taaagaatga tacacccata tgctatatac agcttaactc acagaactgt
     3301 aaaagaaaat tataaaataa ttcaacatgt ccatcttttt agtgataata aaagaaagca
     3361 tggtattaaa ctatcataga agtagacaga aaaagaaaaa aggactcatg gcattattaa
     3421 tataattagt gctttacatg tgttagttat acatattaga agcatatttg cctagtaagg
     3481 ctagtagaac cacatttccc aaagtgtgct ccttaaacac tcatgcctta tgattttcta
     3541 ccaaaagtaa aaagggttgt attaagtcag aggaagatgc ctctccattt tccctctctt
     3601 tatcagaggt tcacatgcct gtctgcacat taaaagctct gggaagacct gttgtaaagg
     3661 gacaagttga ggttgtaaaa tctgcattta aataaacatc tttgatcaca aaa
//
