LOCUS       NM_001293179            3708 bp    mRNA    linear   PRI 09-OCT-2022
DEFINITION  Homo sapiens serine protease 23 (PRSS23), transcript variant 3,
            mRNA.
ACCESSION   NM_001293179
VERSION     NM_001293179.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3708)
  AUTHORS   Qin S, Wang Z, Huang C, Huang P and Li D.
  TITLE     Serine protease PRSS23 drives gastric cancer by enhancing tumor
            associated macrophage infiltration via FGF2
  JOURNAL   Front Immunol 13, 955841 (2022)
   PUBMED   36189305
  REMARK    GeneRIF: Serine protease PRSS23 drives gastric cancer by enhancing
            tumor associated macrophage infiltration via FGF2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3708)
  AUTHORS   Wang Z, Gao D, Wang S, Lin H, Wang Y and Xu W.
  TITLE     Exosomal microRNA-1246 from human umbilical cord mesenchymal stem
            cells potentiates myocardial angiogenesis in chronic heart failure
  JOURNAL   Cell Biol Int 45 (11), 2211-2225 (2021)
   PUBMED   34270841
  REMARK    GeneRIF: Exosomal microRNA-1246 from human umbilical cord
            mesenchymal stem cells potentiates myocardial angiogenesis in
            chronic heart failure.
REFERENCE   3  (bases 1 to 3708)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3708)
  AUTHORS   Han B, Yang Y, Chen J, He X, Lv N and Yan R.
  TITLE     PRSS23 knockdown inhibits gastric tumorigenesis through EIF2
            signaling
  JOURNAL   Pharmacol Res 142, 50-57 (2019)
   PUBMED   30769097
  REMARK    GeneRIF: PRSS23 knockdown could suppress tumor growth of gastric
            cancer in vitro and in vivo through inhibiting EIF2 signaling, and
            EIF4E maybe a potential target of PRSS23. PRSS23 could serve as a
            potential target for gastric cancer therapy, and also a biomarker
            for the prediction of prognosis of gastric cancer.
REFERENCE   5  (bases 1 to 3708)
  AUTHORS   LeBleu VS, Teng Y, O'Connell JT, Charytan D, Muller GA, Muller CA,
            Sugimoto H and Kalluri R.
  TITLE     Identification of human epididymis protein-4 as a
            fibroblast-derived mediator of fibrosis
  JOURNAL   Nat Med 19 (2), 227-231 (2013)
   PUBMED   23353556
REFERENCE   6  (bases 1 to 3708)
  AUTHORS   Chan HS, Chang SJ, Wang TY, Ko HJ, Lin YC, Lin KT, Chang KM and
            Chuang YJ.
  TITLE     Serine protease PRSS23 is upregulated by estrogen receptor alpha
            and associated with proliferation of breast cancer cells
  JOURNAL   PLoS One 7 (1), e30397 (2012)
   PUBMED   22291950
  REMARK    GeneRIF: PRSS23 might be a critical component of estrogen-mediated
            cell proliferation of ERalpha-positive breast cancer cells.
REFERENCE   7  (bases 1 to 3708)
  AUTHORS   Miyakoshi K, Murphy MJ, Yeoman RR, Mitra S, Dubay CJ and Hennebold
            JD.
  TITLE     The identification of novel ovarian proteases through the use of
            genomic and bioinformatic methodologies
  JOURNAL   Biol Reprod 75 (6), 823-835 (2006)
   PUBMED   16870946
REFERENCE   8  (bases 1 to 3708)
  AUTHORS   Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J,
            Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A,
            Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P and
            Collins C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP206707.1 and AP000654.4.
            
            On May 24, 2018 this sequence version replaced NM_001293179.1.
            
            Summary: This gene encodes a conserved member of the trypsin family
            of serine proteases. Mouse studies found a decrease of mRNA levels
            of this gene after ovulation was induced. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.164967.1, DR762215.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               BP206707.1         30-582
            554-3708            AP000654.4         28627-31781
FEATURES             Location/Qualifiers
     source          1..3708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..3708
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="serine protease 23"
                     /db_xref="GeneID:11098"
                     /db_xref="HGNC:HGNC:14370"
                     /db_xref="MIM:618376"
     exon            1..110
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            111..3708
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1270
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="serine protease, umbilical endothelium; putative
                     secreted protein Zsig13; protease, serine 23"
                     /codon_start=1
                     /product="serine protease 23 precursor"
                     /protein_id="NP_001280108.1"
                     /db_xref="CCDS:CCDS8278.1"
                     /db_xref="GeneID:11098"
                     /db_xref="HGNC:HGNC:14370"
                     /db_xref="MIM:618376"
                     /translation="MAGIPGLLFLLFFLLCAVGQVSPYSAPWKPTWPAYRLPVVLPQS
                     TLNLAKPDFGAEAKLEVSSSCGPQCHKGTPLPTYEEAKQYLSYETLYANGSRTETQVG
                     IYILSSSGDGAQHRDSGSSGKSRRKRQIYGYDSRFSIFGKDFLLNYPFSTSVKLSTGC
                     TGTLVAEKHVLTAAHCIHDGKTYVKGTQKLRVGFLKPKFKDGGRGANDSTSAMPEQMK
                     FQWIRVKRTHVPKGWIKGNANDIGMDYDYALLELKKPHKRKFMKIGVSPPAKQLPGGR
                     IHFSGYDNDRPGNLVYRFCDVKDETYDLLYQQCDAQPGASGSGVYVRMWKRQQQKWER
                     KIIGIFSGHQWVDMNGSPQDFNVAVRITPLKYAQICYWIKGNYLDCREG"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="hexamer: ATTAAA"
     polyA_site      1652
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="major polyA site"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="hexamer: AATAAA"
     polyA_site      3708
                     /gene="PRSS23"
                     /gene_synonym="SIG13; SPUVE; ZSIG13"
                     /note="major polyA site"
ORIGIN      
        1 gcactcggct gtgcggcggg gcaggcatgg gagccgcgcg ctctctcccg gcgcccacac
       61 ctgtctgagc ggcgcagcga gccgcggccc gggcgggctg ctcggcgcgg tgctcggcat
      121 ggcagggatt ccagggctcc tcttccttct cttctttctg ctctgtgctg ttgggcaagt
      181 gagcccttac agtgccccct ggaaacccac ttggcctgca taccgcctcc ctgtcgtctt
      241 gccccagtct accctcaatt tagccaagcc agactttgga gccgaagcca aattagaagt
      301 atcttcttca tgtggacccc agtgtcataa gggaactcca ctgcccactt acgaagaggc
      361 caagcaatat ctgtcttatg aaacgctcta tgccaatggc agccgcacag agacgcaggt
      421 gggcatctac atcctcagca gtagtggaga tggggcccaa caccgagact cagggtcttc
      481 aggaaagtct cgaaggaagc ggcagattta tggctatgac agcaggttca gcatttttgg
      541 gaaggacttc ctgctcaact accctttctc aacatcagtg aagttatcca cgggctgcac
      601 cggcaccctg gtggcagaga agcatgtcct cacagctgcc cactgcatac acgatggaaa
      661 aacctatgtg aaaggaaccc agaagcttcg agtgggcttc ctaaagccca agtttaaaga
      721 tggtggtcga ggggccaacg actccacttc agccatgccc gagcagatga aatttcagtg
      781 gatccgggtg aaacgcaccc atgtgcccaa gggttggatc aagggcaatg ccaatgacat
      841 cggcatggat tatgattatg ccctcctgga actcaaaaag ccccacaaga gaaaatttat
      901 gaagattggg gtgagccctc ctgctaagca gctgccaggg ggcagaattc acttctctgg
      961 ttatgacaat gaccgaccag gcaatttggt gtatcgcttc tgtgacgtca aagacgagac
     1021 ctatgacttg ctctaccagc aatgcgatgc ccagccaggg gccagcgggt ctggggtcta
     1081 tgtgaggatg tggaagagac agcagcagaa gtgggagcga aaaattattg gcattttttc
     1141 agggcaccag tgggtggaca tgaatggttc cccacaggat ttcaacgtgg ctgtcagaat
     1201 cactcctctc aaatatgccc agatttgcta ttggattaaa ggaaactacc tggattgtag
     1261 ggaggggtga cacagtgttc cctcctggca gcaattaagg gtcttcatgt tcttatttta
     1321 ggagaggcca aattgttttt tgtcattggc gtgcacacgt gtgtgtgtgt gtgtgtgtgt
     1381 gtgtaaggtg tcttataatc ttttacctat ttcttacaat tgcaagatga ctggctttac
     1441 tatttgaaaa ctggtttgtg tatcatatca tatatcattt aagcagtttg aaggcatact
     1501 tttgcataga aataaaaaaa atactgattt ggggcaatga ggaatatttg acaattaagt
     1561 taatcttcac gtttttgcaa actttgattt ttatttcatc tgaacttgtt tcaaagattt
     1621 atattaaata tttggcatac aagagatatg aattcttata tgtgtgcatg tgtgttttct
     1681 tctgagattc atcttggtgg tgggtttttt tgttttttta attcagtgcc tgatctttaa
     1741 tgcttccata aggcagtgtt cccatttagg aactttgaca gcatttgtta ggcagaatat
     1801 tttggatttg gaggcatttg catggtagtc tttgaacagt aaaatgatgt gttgactata
     1861 ctgatacaca tattaaacta taccttatag taaaccagta tcccaagctg cttttagttc
     1921 caaaaatagt ttcttttcca aaggttgttg ctctactttg taggaagtct ttgcatatgg
     1981 ccctcccaac tttaaagtca taccagagtg gccaagagtg tttatcccaa cccttccatt
     2041 taacaggatt tcactcacat ttctggaact agctattttt cagaagacaa taatcagggc
     2101 ttaattagaa caggctgtat ttcctcccag caaacagttg tggccacact aaaaacaatc
     2161 atagcatttt acccctggat tatagcacat ctcatgtttt atcatttgga tggagtaatt
     2221 taaaatgaat taaattccag agaacaatgg aagcattgcc tggcagatgt cacaacagaa
     2281 taaccacttg tttggagcct ggcacagtcc tccagcctga tcaaaaatta ttctgcatag
     2341 ttttcagtgt gctttctggg agctatgtac ttcttcaatt tggaaacttt tctctctcat
     2401 ttatagtgaa aatacttgga agttacttta agaaaaccag tgtggccttt ttccctctag
     2461 ctttaaaagg gccgcttttg ctggaatgct ctaggttata gataaacaat taggtataat
     2521 agcaaaaatg aaaattggaa gaatgcaaaa tggatcagaa tcatgccttc caataaaggc
     2581 ctttacacat gttttatcaa tatgattatc aaatcacagc atatacagaa aagacttgga
     2641 cttattgtat gtttttattt tatggctctc ggcctaagca cttctttcta aatgtatcgg
     2701 agaaaaaatc aaatggacta caagcacgtg tttgctgtgc ttgcacccca ggtaaacctg
     2761 cattgtagca atttgtaagg atattcagat ggagcactgt cacttagaca ttctctgggg
     2821 gattttctgc ttgtctttct tgagcttttt ggaaggataa ttctgataag gcactcaaga
     2881 aacgtacaac cacagtgctt tcttcaaatc atatgagaaa tactatgcat agcaaggaga
     2941 tgcagagccg ccaggaaaat tctgagttcc agcacaattt tctttggaat ctaacaggaa
     3001 tctagcctga ggaagaaggg aggtctccat ttctatgtct ggtatttggg ggttttgttt
     3061 gtttttgctt tagcttggtg aaaaaaagtt cactgaacac caagaccaga atggattttt
     3121 ttaaaaaaat agatgttcct tttgtgaagc accttgattc cttgattttg attttttgca
     3181 aagttagaca atggcacaaa gtcaaaatga aatcaatgtt tagttcacaa gtagatgtaa
     3241 tttactaaag aatgatacac ccatatgcta tatacagctt aactcacaga actgtaaaag
     3301 aaaattataa aataattcaa catgtccatc tttttagtga taataaaaga aagcatggta
     3361 ttaaactatc atagaagtag acagaaaaag aaaaaaggac tcatggcatt attaatataa
     3421 ttagtgcttt acatgtgtta gttatacata ttagaagcat atttgcctag taaggctagt
     3481 agaaccacat ttcccaaagt gtgctcctta aacactcatg ccttatgatt ttctaccaaa
     3541 agtaaaaagg gttgtattaa gtcagaggaa gatgcctctc cattttccct ctctttatca
     3601 gaggttcaca tgcctgtctg cacattaaaa gctctgggaa gacctgttgt aaagggacaa
     3661 gttgaggttg taaaatctgc atttaaataa acatctttga tcacaaaa
//
