LOCUS       NM_022119               1383 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serine protease 22 (PRSS22), mRNA.
ACCESSION   NM_022119
VERSION     NM_022119.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Chen,C.Y., Chung,I.H., Tsai,M.M., Tseng,Y.H., Chi,H.C., Tsai,C.Y.,
            Lin,Y.H., Wang,Y.C., Chen,C.P., Wu,T.I., Yeh,C.T., Tai,D.I. and
            Lin,K.H.
  TITLE     Thyroid hormone enhanced human hepatoma cell motility involves
            brain-specific serine protease 4 activation via ERK signaling
  JOURNAL   Mol Cancer 13, 162 (2014)
   PUBMED   24980078
  REMARK    GeneRIF: Our findings collectively support a potential role of T3
            in cancer cell progression through regulation of the BSSP4 protease
            via the ERK 1/2-C/EBPbeta-VEGF cascade
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1383)
  AUTHORS   Mitsui,S., Okui,A., Kominami,K., Konishi,E., Uemura,H. and
            Yamaguchi,N.
  TITLE     A novel serine protease highly expressed in the pancreas is
            expressed in various kinds of cancer cells
  JOURNAL   FEBS J 272 (19), 4911-4923 (2005)
   PUBMED   16176265
  REMARK    GeneRIF: prosemin is a novel serine protease of the chromosome 16
            cluster that is highly expressed in the pancreas.
REFERENCE   5  (bases 1 to 1383)
  AUTHORS   Yasuda,S., Morokawa,N., Wong,G.W., Rossi,A., Madhusudhan,M.S.,
            Sali,A., Askew,Y.S., Adachi,R., Silverman,G.A., Krilis,S.A. and
            Stevens,R.L.
  TITLE     Urokinase-type plasminogen activator is a preferred substrate of
            the human epithelium serine protease tryptase epsilon/PRSS22
  JOURNAL   Blood 105 (10), 3893-3901 (2005)
   PUBMED   15701722
  REMARK    GeneRIF: Tryptase epsilon also was able to induce
            pro-uPA-expressing smooth muscle cells to increase their migration
REFERENCE   6  (bases 1 to 1383)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   7  (bases 1 to 1383)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1383)
  AUTHORS   Wong,G.W., Yasuda,S., Madhusudhan,M.S., Li,L., Yang,Y.,
            Krilis,S.A., Sali,A. and Stevens,R.L.
  TITLE     Human tryptase epsilon (PRSS22), a new member of the chromosome
            16p13.3 family of human serine proteases expressed in airway
            epithelial cells
  JOURNAL   J Biol Chem 276 (52), 49169-49182 (2001)
   PUBMED   11602603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ893064.1, AF321182.1 and
            AW083723.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022119.3.
            
            Summary: This gene encodes a member of the trypsin family of serine
            proteases. The enzyme is expressed in the airways in a
            developmentally regulated manner. The gene is part of a cluster of
            serine protease genes on chromosome 16. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358396.1, BC009726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000161006.8/ ENSP00000161006.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BQ893064.1         9-57
            50-1381             AF321182.1         1-1332
            1382-1383           AW083723.1         9-10                c
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1383
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /note="serine protease 22"
                     /db_xref="GeneID:64063"
                     /db_xref="HGNC:HGNC:14368"
                     /db_xref="MIM:609343"
     exon            1..148
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1020
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /note="protease, serine S1 family member 22; tryptase
                     epsilon; brain-specific serine protease 4; prosemin;
                     serine protease 26; protease, serine 22"
                     /codon_start=1
                     /product="brain-specific serine protease 4 precursor"
                     /protein_id="NP_071402.1"
                     /db_xref="CCDS:CCDS10481.1"
                     /db_xref="GeneID:64063"
                     /db_xref="HGNC:HGNC:14368"
                     /db_xref="MIM:609343"
                     /translation="MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKP
                     QQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLF
                     SVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPI
                     CLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQ
                     GPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYI
                     SLSAHRSWVEKIVQGVQLRGRAQGGGALRAPSQGSGAAARS"
     exon            149..175
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            176..347
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            348..625
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            626..783
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1383
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1364..1369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /note="hexamer: AATAAA"
     polyA_site      1383
                     /gene="PRSS22"
                     /gene_synonym="BSSP-4; hBSSP-4; SP001LA"
                     /note="major polyA site"
ORIGIN      
        1 acacaccctg acccgcatcg ccctgggtct ctcgagcctg ctgcctgctc ccccgcccca
       61 ccagccatgg tggtttctgg agcgccccca gccctgggtg ggggctgtct cggcaccttc
      121 acctccctgc tgctgctggc gtcgacagcc atcctcaatg cggccaggat acctgttccc
      181 ccagcctgtg ggaagcccca gcagctgaac cgggttgtgg gcggcgagga cagcactgac
      241 agcgagtggc cctggatcgt gagcatccag aagaatggga cccaccactg cgcaggttct
      301 ctgctcacca gccgctgggt gatcactgct gcccactgtt tcaaggacaa cctgaacaaa
      361 ccatacctgt tctctgtgct gctgggggcc tggcagctgg ggaaccctgg ctctcggtcc
      421 cagaaggtgg gtgttgcctg ggtggagccc caccctgtgt attcctggaa ggaaggtgcc
      481 tgtgcagaca ttgccctggt gcgtctcgag cgctccatac agttctcaga gcgggtcctg
      541 cccatctgcc tacctgatgc ctctatccac ctccctccaa acacccactg ctggatctca
      601 ggctggggga gcatccaaga tggagttccc ttgccccacc ctcagaccct gcagaagctg
      661 aaggttccta tcatcgactc ggaagtctgc agccatctgt actggcgggg agcaggacag
      721 ggacccatca ctgaggacat gctgtgtgcc ggctacttgg agggggagcg ggatgcttgt
      781 ctgggcgact ccgggggccc cctcatgtgc caggtggacg gcgcctggct gctggccggc
      841 atcatcagct ggggcgaggg ctgtgccgag cgcaacaggc ccggggtcta catcagcctc
      901 tctgcgcacc gctcctgggt ggagaagatc gtgcaagggg tgcagctccg cgggcgcgct
      961 caggggggtg gggccctcag ggcaccgagc cagggctctg gggccgccgc gcgctcctag
     1021 ggcgcagcgg gacgcggggc tcggatctga aaggcggcca gatccacatc tggatctgga
     1081 tctgcggcgg cctcgggcgg tttcccccgc cgtaaatagg ctcatctacc tctacctctg
     1141 ggggcccgga cggctgctgc ggaaaggaaa ccccctcccc gacccgcccg acggcctcag
     1201 gccccgcctc caaggcatca ggccccgccc aacggcctca tgtccccgcc cccacgactt
     1261 ccggccccgc cccgggcccc agcgcttttg tgtatataaa tgttaatgat ttttataggt
     1321 atttgtaacc ctgcccacat atcttattta ttcctccaat ttcaataaat tatttattct
     1381 cca
//
