LOCUS       NM_002770                809 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens serine protease 2 (PRSS2), transcript variant 2, mRNA.
ACCESSION   NM_002770 XM_003846729 XM_003960942
VERSION     NM_002770.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Wang,F., Yi,J., Chen,Y., Bai,X., Lu,C., Feng,S. and Zhou,X.
  TITLE     PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer
  JOURNAL   Acta Histochem 125 (6), 152071 (2023)
   PUBMED   37331089
  REMARK    GeneRIF: PRSS2 regulates EMT and metastasis via MMP-9 in gastric
            cancer.
REFERENCE   2  (bases 1 to 809)
  AUTHORS   Qin,H., Zhang,S., Shen,L., Mao,C., Gao,G. and Wang,H.
  TITLE     High expression of serine protease 2 (PRSS2) associated with
            invasion, metastasis, and proliferation in gastric cancer
  JOURNAL   Aging (Albany NY) 15 (7), 2473-2484 (2023)
   PUBMED   37022096
  REMARK    GeneRIF: High expression of serine protease 2 (PRSS2) associated
            with invasion, metastasis, and proliferation in gastric cancer.
REFERENCE   3  (bases 1 to 809)
  AUTHORS   Fu,D., Blobner,B.M., Greer,P.J., Lafyatis,R., Bellin,M.D. and
            Whitcomb,D.C.
  CONSRTM   Prospective Autos Study; GREAT1 Study; North American Pancreatitis
            Study Group
  TITLE     Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell
            Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression
  JOURNAL   Gastroenterology 164 (2), 289-292 (2023)
   PUBMED   36191639
  REMARK    GeneRIF: Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters
            T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1
            Expression.
REFERENCE   4  (bases 1 to 809)
  AUTHORS   Sui,L., Wang,S., Ganguly,D., El Rayes,T.P., Askeland,C.,
            Borretzen,A., Sim,D., Halvorsen,O.J., Knutsvik,G., Arnes,J.,
            Aziz,S., Haukaas,S., Foulkes,W.D., Bielenberg,D.R., Ziemys,A.,
            Mittal,V., Brekken,R.A., Akslen,L.A. and Watnick,R.S.
  TITLE     PRSS2 remodels the tumor microenvironment via repression of Tsp1 to
            stimulate tumor growth and progression
  JOURNAL   Nat Commun 13 (1), 7959 (2022)
   PUBMED   36575174
  REMARK    GeneRIF: PRSS2 remodels the tumor microenvironment via repression
            of Tsp1 to stimulate tumor growth and progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 809)
  AUTHORS   Rowen,L., Koop,B.F. and Hood,L.
  TITLE     The complete 685-kilobase DNA sequence of the human beta T cell
            receptor locus
  JOURNAL   Science 272 (5269), 1755-1762 (1996)
   PUBMED   8650574
REFERENCE   6  (bases 1 to 809)
  AUTHORS   Belorgey,D., Dirrig,S., Amouric,M., Figarella,C. and Bieth,J.G.
  TITLE     Inhibition of human pancreatic proteinases by mucus proteinase
            inhibitor, eglin c and aprotinin
  JOURNAL   Biochem J 313 (Pt 2) (Pt 2), 555-560 (1996)
   PUBMED   8573092
REFERENCE   7  (bases 1 to 809)
  AUTHORS   Vercaigne-Marko,D., Carrere,J., Guy-Crotte,O., Figarella,C. and
            Hayem,A.
  TITLE     Human cationic and anionic trypsins: differences of interaction
            with alpha 1-proteinase inhibitor
  JOURNAL   Biol Chem Hoppe Seyler 370 (11), 1163-1171 (1989)
   PUBMED   2610933
REFERENCE   8  (bases 1 to 809)
  AUTHORS   Kimland,M., Russick,C., Marks,W.H. and Borgstrom,A.
  TITLE     Immunoreactive anionic and cationic trypsin in human serum
  JOURNAL   Clin Chim Acta 184 (1), 31-46 (1989)
   PUBMED   2598466
REFERENCE   9  (bases 1 to 809)
  AUTHORS   Emi,M., Nakamura,Y., Ogawa,M., Yamamoto,T., Nishide,T., Mori,T. and
            Matsubara,K.
  TITLE     Cloning, characterization and nucleotide sequences of two cDNAs
            encoding human pancreatic trypsinogens
  JOURNAL   Gene 41 (2-3), 305-310 (1986)
   PUBMED   3011602
REFERENCE   10 (bases 1 to 809)
  AUTHORS   Figarella,C., Negri,G.A. and Guy,O.
  TITLE     The two human trypsinogens. Inhibition spectra of the two human
            trypsins derived from their purified zymogens
  JOURNAL   Eur J Biochem 53 (2), 457-463 (1975)
   PUBMED   1079768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005814.2, BC030260.1,
            AC245427.3 and CA867206.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002770.3.
            
            Summary: This gene belongs to the trypsin family of serine
            proteases and encodes anionic trypsinogen. It is part of a cluster
            of trypsinogen genes that are located within the T cell receptor
            beta locus. Enzymes of this family cleave peptide bonds that follow
            lysine or arginine residues. This protein is found at high levels
            in pancreatic juice and its upregulation is a characteristic
            feature of pancreatitis. This protein has also been found to
            activate pro-urokinase in ovarian tumors, suggesting a function in
            tumor invasion. In addition, this enzyme is able to cleave across
            the type II collagen triple helix in rheumatoid arthritis synovitis
            tissue, potentially participating in the degradation of type II
            collagen-rich cartilage matrix. Alternative splicing results in
            multiple transcript variants.[provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) lacks an in-frame exon
            compared to variant 1. The encoded isoform (2) is shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA772699.1, CA776091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539842.6/ ENSP00000488338.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BC005814.2         28-39
            13-730              BC030260.1         1-718
            731-731             AC245427.3         65582-65582
            732-808             BC030260.1         720-796
            809-809             CA867206.1         6-6                 c
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..809
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /note="serine protease 2"
                     /db_xref="GeneID:5645"
                     /db_xref="HGNC:HGNC:9483"
                     /db_xref="MIM:601564"
     exon            1..53
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..757
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /EC_number="3.4.21.4"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; trypsinogen 2; anionic trypsinogen; trypsin II;
                     trypsin-2; protease serine 2 preproprotein; protease,
                     serine, 2 (trypsin 2); protease, serine 2"
                     /codon_start=1
                     /product="trypsin-2 isoform 2 preproprotein"
                     /protein_id="NP_002761.1"
                     /db_xref="CCDS:CCDS83236.1"
                     /db_xref="GeneID:5645"
                     /db_xref="HGNC:HGNC:9483"
                     /db_xref="MIM:601564"
                     /translation="MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSG
                     YHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSR
                     TLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQC
                     LDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGY
                     GCAQKNRPGVYTKVYNYVDWIKDTIAANS"
     exon            54..213
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..467
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..604
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..809
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      788..793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /note="hexamer: AATAAA"
     polyA_site      809
                     /gene="PRSS2"
                     /gene_synonym="TRY2; TRY8; TRYP2"
                     /note="major polyA site"
ORIGIN      
        1 acactctacc accatgaatc tacttctgat ccttaccttt gttgcagctg ctgttgctgc
       61 cccctttgat gatgatgaca agatcgttgg gggctacatc tgtgaggaga attctgtccc
      121 ctaccaggtg tccttgaatt ctggctacca cttctgcggt ggctccctca tcagcgaaca
      181 gtgggtggtg tcagcaggtc actgctacaa gtcccgcatc caggtgagac tgggagagca
      241 caacatcgaa gtcctggagg ggaatgaaca gttcatcaat gcggccaaga tcatccgcca
      301 ccccaaatac aacagccgga ctctggacaa tgacatcctg ctgatcaagc tctcctcacc
      361 tgccgtcatc aattcccgcg tgtccgccat ctctctgccc actgcccctc cagctgctgg
      421 caccgagtcc ctcatctccg gctggggcaa cactctgagt tctggtgccg actacccaga
      481 cgagctgcag tgcctggatg ctcctgtgct gagccaggct gagtgtgaag cctcctaccc
      541 tggaaagatt accaacaaca tgttctgtgt gggcttcctc gagggaggca aggattcctg
      601 ccagggtgat tctggtggcc ctgtggtctc caatggagag ctccaaggaa ttgtctcctg
      661 gggctatggc tgtgcccaga agaacaggcc tggagtctac accaaggtct acaactatgt
      721 ggactggatt aaggacacca tagctgccaa cagctaaagc ccctggtccc tctgcagtct
      781 ctataccaat aaagtgaccc tgctctcac
//
