LOCUS       NM_005865               2887 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine protease 16 (PRSS16), mRNA.
ACCESSION   NM_005865
VERSION     NM_005865.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Serre,L., Girard,M., Ramadan,A., Menut,P., Rouquie,N., Lucca,L.E.,
            Mahiddine,K., Leobon,B., Mars,L.T. and Guerder,S.
  TITLE     Thymic-Specific Serine Protease Limits Central Tolerance and
            Exacerbates Experimental Autoimmune Encephalomyelitis
  JOURNAL   J Immunol 199 (11), 3748-3756 (2017)
   PUBMED   29061767
  REMARK    GeneRIF: the level of TSSP expression by thymic dendritic cells may
            modify the risk factors for multiple sclerosis conferred by some
            MHC class II haplotypes
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Kitazawa,M., Ohnuma,T., Takebayashi,Y., Shibata,N., Baba,H.,
            Ohi,K., Yasuda,Y., Nakamura,Y., Aleksic,B., Yoshimi,A., Okochi,T.,
            Ikeda,M., Naitoh,H., Hashimoto,R., Iwata,N., Ozaki,N., Takeda,M.
            and Arai,H.
  TITLE     No associations found between the genes situated at 6p22.1,
            HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with
            schizophrenia
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 159B (4), 456-464 (2012)
   PUBMED   22488895
  REMARK    GeneRIF: The genes HIST1H2BJ, PRSS16, and PGBD1 were not associated
            with Japanese patients with schizophrenia.
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Girgenti,M.J., LoTurco,J.J. and Maher,B.J.
  TITLE     ZNF804a regulates expression of the schizophrenia-associated genes
            PRSS16, COMT, PDE4B, and DRD2
  JOURNAL   PLoS One 7 (2), e32404 (2012)
   PUBMED   22384243
  REMARK    GeneRIF: ZNF804a regulates expression of the
            schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Shi,J., Levinson,D.F., Duan,J., Sanders,A.R., Zheng,Y., Pe'er,I.,
            Dudbridge,F., Holmans,P.A., Whittemore,A.S., Mowry,B.J., Olincy,A.,
            Amin,F., Cloninger,C.R., Silverman,J.M., Buccola,N.G.,
            Byerley,W.F., Black,D.W., Crowe,R.R., Oksenberg,J.R., Mirel,D.B.,
            Kendler,K.S., Freedman,R. and Gejman,P.V.
  TITLE     Common variants on chromosome 6p22.1 are associated with
            schizophrenia
  JOURNAL   Nature 460 (7256), 753-757 (2009)
   PUBMED   19571809
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Stefansson,H., Ophoff,R.A., Steinberg,S., Andreassen,O.A.,
            Cichon,S., Rujescu,D., Werge,T., Pietilainen,O.P., Mors,O.,
            Mortensen,P.B., Sigurdsson,E., Gustafsson,O., Nyegaard,M.,
            Tuulio-Henriksson,A., Ingason,A., Hansen,T., Suvisaari,J.,
            Lonnqvist,J., Paunio,T., Borglum,A.D., Hartmann,A., Fink-Jensen,A.,
            Nordentoft,M., Hougaard,D., Norgaard-Pedersen,B., Bottcher,Y.,
            Olesen,J., Breuer,R., Moller,H.J., Giegling,I., Rasmussen,H.B.,
            Timm,S., Mattheisen,M., Bitter,I., Rethelyi,J.M.,
            Magnusdottir,B.B., Sigmundsson,T., Olason,P., Masson,G.,
            Gulcher,J.R., Haraldsson,M., Fossdal,R., Thorgeirsson,T.E.,
            Thorsteinsdottir,U., Ruggeri,M., Tosato,S., Franke,B.,
            Strengman,E., Kiemeney,L.A., Melle,I., Djurovic,S., Abramova,L.,
            Kaleda,V., Sanjuan,J., de Frutos,R., Bramon,E., Vassos,E.,
            Fraser,G., Ettinger,U., Picchioni,M., Walker,N., Toulopoulou,T.,
            Need,A.C., Ge,D., Yoon,J.L., Shianna,K.V., Freimer,N.B.,
            Cantor,R.M., Murray,R., Kong,A., Golimbet,V., Carracedo,A.,
            Arango,C., Costas,J., Jonsson,E.G., Terenius,L., Agartz,I.,
            Petursson,H., Nothen,M.M., Rietschel,M., Matthews,P.M., Muglia,P.,
            Peltonen,L., St Clair,D., Goldstein,D.B., Stefansson,K. and
            Collier,D.A.
  CONSRTM   Genetic Risk and Outcome in Psychosis (GROUP)
  TITLE     Common variants conferring risk of schizophrenia
  JOURNAL   Nature 460 (7256), 744-747 (2009)
   PUBMED   19571808
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Luther,C., Wienhold,W., Oehlmann,R., Heinemann,M.K., Melms,A. and
            Tolosa,E.
  TITLE     Alternatively spliced transcripts of the thymus-specific protease
            PRSS16 are differentially expressed in human thymus
  JOURNAL   Genes Immun 6 (1), 1-7 (2005)
   PUBMED   15592422
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 2887)
  AUTHORS   Lie,B.A., Akselsen,H.E., Bowlus,C.L., Gruen,J.R., Thorsby,E. and
            Undlien,D.E.
  TITLE     Polymorphisms in the gene encoding thymus-specific serine protease
            in the extended HLA complex: a potential candidate gene for
            autoimmune and HLA-associated diseases
  JOURNAL   Genes Immun 3 (5), 306-312 (2002)
   PUBMED   12140752
  REMARK    GeneRIF: The gene encoding thymus-specific serine protease (PRSS16)
            maps to the extended HLA complex, which harbours several genes
            predisposing for autoimmune diseases.
REFERENCE   9  (bases 1 to 2887)
  AUTHORS   Bowlus,C.L., Ahn,J., Chu,T. and Gruen,J.R.
  TITLE     Cloning of a novel MHC-encoded serine peptidase highly expressed by
            cortical epithelial cells of the thymus
  JOURNAL   Cell Immunol 196 (2), 80-86 (1999)
   PUBMED   10527559
REFERENCE   10 (bases 1 to 2887)
  AUTHORS   Gruen,J.R., Nalabolu,S.R., Chu,T.W., Bowlus,C., Fan,W.F.,
            Goei,V.L., Wei,H., Sivakamasundari,R., Liu,Y., Xu,H.X., Parimoo,S.,
            Nallur,G., Ajioka,R., Shukla,H., Bray-Ward,P., Pan,J. and
            Weissman,S.M.
  TITLE     A transcription map of the major histocompatibility complex (MHC)
            class I region
  JOURNAL   Genomics 36 (1), 70-85 (1996)
   PUBMED   8812418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021808.2, AK314037.1,
            AF052514.1, AK093590.1 and BG119060.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005865.3.
            
            Summary: This gene encodes a serine protease expressed exclusively
            in the thymus. It is thought to play a role in the alternative
            antigen presenting pathway used by cortical thymic epithelial cells
            during the positive selection of T cells. The gene is found in the
            large histone gene cluster on chromosome 6, near the major
            histocompatibility complex (MHC) class I region. A second
            transcript variant has been described, but its full length nature
            has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF052514.1, AK314037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465418 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230582.8/ ENSP00000230582.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL021808.2         32929-32950
            23-572              AK314037.1         1-550
            573-1254            AF052514.1         548-1229
            1255-1769           AK093590.1         1122-1636
            1770-2527           AF052514.1         1745-2502
            2528-2748           AK093590.1         2395-2615
            2749-2887           BG119060.1         290-428
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..2887
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="serine protease 16"
                     /db_xref="GeneID:10279"
                     /db_xref="HGNC:HGNC:9480"
                     /db_xref="MIM:607169"
     exon            1..107
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1582
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="thymus specific serine peptidase; protease, serine,
                     16 (thymus); protease, serine 16"
                     /codon_start=1
                     /product="thymus-specific serine protease"
                     /protein_id="NP_005856.1"
                     /db_xref="CCDS:CCDS4623.1"
                     /db_xref="GeneID:10279"
                     /db_xref="HGNC:HGNC:9480"
                     /db_xref="MIM:607169"
                     /translation="MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQG
                     LGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGE
                     GSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADV
                     VSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDF
                     SEYNDVVSRSLMSTAIGGSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLG
                     RAENQAELLGALQALVGGVVQYDGQTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRA
                     VQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCENPRC
                     PFSQLPALPSQLDLCEQVFGLSALSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWH
                     VLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKES
                     QIKGEV"
     exon            108..274
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            275..374
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            375..504
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            505..628
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            629..706
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            707..754
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1045
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1187
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1367
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1513
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2887
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="hexamer: AATATA"
     polyA_site      1810
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="major polyA site"
     regulatory      2700..2705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="hexamer: AATAAA"
     polyA_site      2724
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="major polyA site"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
                     /note="hexamer: TATAAA"
     polyA_site      2887
                     /gene="PRSS16"
                     /gene_synonym="TSSP"
ORIGIN      
        1 aaaggtcctc ctgggggaga acagagtccc gaacaccatg gccgtctggc ttgcccagtg
       61 gctgggccct ctgctcttgg tttccctctg gggactcttg gctccagcct cccttcttag
      121 gcgcctgggt gagcacattc agcagtttca ggagagctct gcccagggcc tgggcctgag
      181 cctggggcca ggtgctgcag ccctcccaaa agtggggtgg ctggagcaac tgctggaccc
      241 cttcaacgtg tccgacagac gatccttcct acagcgttac tgggtgaatg accaacattg
      301 ggttggccag gatggaccca tattcctgca tctagggggt gagggcagcc ttgggcctgg
      361 ctcagtgatg agaggccatc ccgcagcctt ggccccagcc tggggcgccc tggtgataag
      421 cctggaacac agattttatg gcctgagtat acctgctgga ggcctggaaa tggcccagct
      481 ccgcttcttg tccagccgcc ttgcgctggc tgatgtggtc tctgcccgcc tggcactttc
      541 ccgcctcttt aacatctcct cctccagccc ctggatctgc ttcggaggct cctatgccgg
      601 ctccttggcc gcctgggccc ggctgaagtt cccccatctc attttcgcgt cggtcgcctc
      661 ctccgccccg gtgcgggccg tgctggattt ctccgagtat aatgacgtgg tatcccgaag
      721 cctaatgagc accgcgatcg gcgggtccct ggagtgccgg gcggcggtgt ccgtcgcctt
      781 cgctgaagtg gagcggcggc tgcgctcggg tggggcggct caagcagcat tgcggacgga
      841 gctgagcgct tgcgggcccc tgggccgcgc tgaaaaccag gcggagctgt tgggggcgct
      901 gcaggcactg gtgggaggtg tagtgcagta tgatgggcag acgggagcgc cgctaagcgt
      961 gcgacagctc tgcggacttc tcctcggggg cgggggcaac cgcagccact ccacgcccta
     1021 ctgcgggctt cgtcgggcgg tgcagattgt cttgcacagc ctgggccaga agtgtttaag
     1081 cttttcccga gcagagacag tggcacagct gaggagcaca gaacctcaac tgtctggtgt
     1141 gggtgaccgg cagtggttgt atcagacatg taccgagttc ggcttctatg tcacctgtga
     1201 gaatcccaga tgtcctttct cccagctccc agcactgccc tcccagctag acctatgtga
     1261 gcaggtgttt gggctctcag ccttgtcagt agcccaggct gtggctcaga cgaactccta
     1321 ctacggtggc cagacccctg gggctaacaa agtgctgttt gttaatgggg acacagaccc
     1381 ctggcatgtg ctaagtgtaa cacaggcttt aggatcctca gaatcaactc ttcttatccg
     1441 cactggctcc cactgcttgg acatggcacc tgagaggccc tcagactccc ccagcctccg
     1501 cctagggcgc cagaacatct tccagcagct acagacctgg ctcaagctgg caaaggagag
     1561 ccagattaag ggtgaagtct gaatctcata ccctttccac tccctgcatg gtcacctcag
     1621 tcctggacat acttgttcac tgaacaaaag aaagcagctt gttttgaaag aagaaactcc
     1681 caggaattgg aattcagcac ctgttccgca cgtaattggc atgtgtctgc aaacatcctt
     1741 attcccaact taaagtgctt tattgcagag agttatggaa atataagtgg atgattattc
     1801 tcattgtaaa tattggtatt ttgaatgtta aatgtcaaac aaatgtgact tatgctggtg
     1861 ccctcgccct gctgatcaga ttctggttca aattctgcca ctccagctcc tgggttaggg
     1921 gctttgctgt aagtttcttt ttctggactt tagatcctga acctgtcctt gcttctcagt
     1981 ttctctcact gtaccccttt ccctcagtct cttcctctct ctttcccctg tcactatttg
     2041 tctttctaat ctccttctgt ttctctgaat atcttcattt ctatctctgt gtttctgtct
     2101 atttctctgt ttatctttct gtccttcaat ctgtgttttt gtttctggct ctccgtcagt
     2161 gtctttttct ctcctctctc tcttgctctg ccatggctat ttccactgct ctatttctga
     2221 ctctcatttt tggtctctgt gtgtctccta gtcactttct ttctcactct gtctctgtct
     2281 ctatttctgt ctctcctctg ctgtgtcctc aatctctctg tctccctgag gctctatttc
     2341 tgtctctcct ctgctgtgtc ctcaatctct ctgtctccct gaggctctat ttctgtctct
     2401 gatgctcttc ttctgtgtct ctatttctct tcctgtcact taatcttttc cttctctatc
     2461 tctcttattt agtcttcctt ccacaccctt cactcaccat cttttcccac aatcaaatat
     2521 cactccctgg tacttccagc ttccaactct agggattcat gattctggtg gagattcctt
     2581 cttccagggc ctgggaggat agggctaatc ccaagggtgc ctgcttaggc tatgttagct
     2641 gtgacaggaa cctgccatag atttgcactg ttctttccta aagatcaatt attttcagca
     2701 ataaatactt ctcagctttt tgtatgtctt tgtatgcaca gagatggtag ttttagagtt
     2761 ttatccagtt tcatatttcc ttgtgggtaa gaggcaacct cctcatgctg tcataccaaa
     2821 gtcaatctcc actacacttt agttctgcct gttcttgatc tttatataaa tggaaacttg
     2881 cagtata
//
