LOCUS       NM_016307               1305 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens paired related homeobox 2 (PRRX2), mRNA.
ACCESSION   NM_016307
VERSION     NM_016307.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Jiang,Y., Zhao,J., Li,R., Liu,Y., Zhou,L., Wang,C., Lv,C., Gao,L.
            and Cui,D.
  TITLE     CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1
            mediated ferroptosis
  JOURNAL   J Exp Clin Cancer Res 41 (1), 307 (2022)
   PUBMED   36266731
  REMARK    GeneRIF: CircLRFN5 inhibits the progression of glioblastoma via
            PRRX2/GCH1 mediated ferroptosis.
            Erratum:[J Exp Clin Cancer Res. 2022 Nov 10;41(1):320. doi:
            10.1186/s13046-022-02527-7.. PMID: 36352462]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1305)
  AUTHORS   Lu,Z.D., Yang,Z.C., Jin,L.Y., Nie,G., Wang,Y.Y., Kong,B. and
            Wang,H.B.
  TITLE     [Effects of Prrx2 gene silencing on the proliferation of breast
            cancer and its molecular mechanisms]
  JOURNAL   Zhonghua Yi Xue Za Zhi 100 (12), 942-946 (2020)
   PUBMED   32234171
  REMARK    GeneRIF: Silencing Prrx2 expression can effectively inhibit the
            proliferation and growth of breast cancer
REFERENCE   3  (bases 1 to 1305)
  AUTHORS   Chai,W.X., Sun,L.G., Dai,F.H., Shao,H.S., Zheng,N.G. and Cai,H.Y.
  TITLE     Inhibition of PRRX2 suppressed colon cancer liver metastasis via
            inactivation of Wnt/beta-catenin signaling pathway
  JOURNAL   Pathol Res Pract 215 (10), 152593 (2019)
   PUBMED   31471104
  REMARK    GeneRIF: PRRX2 inhibition may reduce invasive and migrating
            abilities to hinder epithelial-mesenchymal transition (EMT), and
            suppress colon cancer liver metastasis through inactivation of
            Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 1305)
  AUTHORS   Li,H., Jiang,H., Yin,X., Bard,J.E., Zhang,B. and Feng,J.
  TITLE     Attenuation of PRRX2 and HEY2 enables efficient conversion of adult
            human skin fibroblasts to neurons
  JOURNAL   Biochem Biophys Res Commun 516 (3), 765-769 (2019)
   PUBMED   31255287
  REMARK    GeneRIF: Attenuation of PRRX2 and HEY2 enables efficient conversion
            of adult human skin fibroblasts to neurons.
REFERENCE   5  (bases 1 to 1305)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 1305)
  AUTHORS   Gervais,C., Mauvieux,L., Perrusson,N., Helias,C., Struski,S.,
            Leymarie,V., Lioure,B. and Lessard,M.
  TITLE     A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel
            homeobox partner gene, PRRX2, in a therapy-related acute myeloid
            leukemia
  JOURNAL   Leukemia 19 (1), 145-148 (2005)
   PUBMED   15496970
REFERENCE   7  (bases 1 to 1305)
  AUTHORS   Scott,K.K., Norris,R.A., Potter,S.S., Norrington,D.W., Baybo,M.A.,
            Hicklin,D.M. and Kern,M.J.
  TITLE     GeneChip microarrays facilitate identification of Protease Nexin-1
            as a target gene of the Prx2 (S8) homeoprotein
  JOURNAL   DNA Cell Biol 22 (2), 95-105 (2003)
   PUBMED   12713735
REFERENCE   8  (bases 1 to 1305)
  AUTHORS   Jones,F.S., McKean,D.M., Meech,R., Edelman,D.B., Oakey,R.J. and
            Jones,P.L.
  TITLE     Regulation of vascular smooth muscle cell growth and adhesion by
            paired-related homeobox genes
  JOURNAL   Chest 121 (3 Suppl), 89S-90S (2002)
   PUBMED   11893718
  REMARK    GeneRIF: Encodes homeobox transcription factors that are expressed
            during vasculogenesis.
REFERENCE   9  (bases 1 to 1305)
  AUTHORS   Norris,R.A., Scott,K.K., Moore,C.S., Stetten,G., Brown,C.R.,
            Jabs,E.W., Wulfsberg,E.A., Yu,J. and Kern,M.J.
  TITLE     Human PRRX1 and PRRX2 genes: cloning, expression, genomic
            localization, and exclusion as disease genes for Nager syndrome
  JOURNAL   Mamm Genome 11 (11), 1000-1005 (2000)
   PUBMED   11063257
REFERENCE   10 (bases 1 to 1305)
  AUTHORS   Stelnicki,E.J., Arbeit,J., Cass,D.L., Saner,C., Harrison,M. and
            Largman,C.
  TITLE     Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless
            fetal wounds
  JOURNAL   J Invest Dermatol 111 (1), 57-63 (1998)
   PUBMED   9665387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014645.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016307.3.
            
            Summary: The DNA-associated protein encoded by this gene is a
            member of the paired family of homeobox proteins. Expression is
            localized to proliferating fetal fibroblasts and the developing
            dermal layer, with downregulated expression in adult skin.
            Increases in expression of this gene during fetal but not adult
            wound healing suggest a possible role in mechanisms that control
            mammalian dermal regeneration and prevent formation of scar
            response to wounding. The expression patterns provide evidence
            consistent with a role in fetal skin development and a possible
            role in cellular proliferation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014645.1, AF061970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372469.6/ ENSP00000361547.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1305              BC014645.1         7-1311
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..1305
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /note="paired related homeobox 2"
                     /db_xref="GeneID:51450"
                     /db_xref="HGNC:HGNC:21338"
                     /db_xref="MIM:604675"
     exon            1..480
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..983
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /note="paired-like homeodomain protein PRX2; PRX-2;
                     paired-related homeobox protein 2; testicular tissue
                     protein Li 160; testicular tissue protein Li 148"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 2"
                     /protein_id="NP_057391.1"
                     /db_xref="CCDS:CCDS6926.1"
                     /db_xref="GeneID:51450"
                     /db_xref="HGNC:HGNC:21338"
                     /db_xref="MIM:604675"
                     /translation="MDSAAAAFALDKPALGPGPPPPPPALGPGDCAQARKNFSVSHLL
                     DLEEVAAAGRLAARPGARAEAREGAAREPSGGSSGSEAAPQDGECPSPGRGSAAKRKK
                     KQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFR
                     RNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGS
                     SGPATPGVNMANSIASLRLKAKEFSLHHSQVPTVN"
     exon            481..668
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..847
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1305
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1278..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /note="hexamer: AATAAA"
     polyA_site      1305
                     /gene="PRRX2"
                     /gene_synonym="PMX2; PRX2"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgcacca gcggctccgg agcgagcggc cgtggctgag aaggggaggg cggaaagttt
       61 gtttccccga cgtcagcgcc gggcgggccg cgaggctagg aggcggcggg agctgggcag
      121 agcgcggggc ggccggggct ctcgctccga cccgcgcccg cgacccttcc tgggacccga
      181 gcccgagacc cccgccggcc cccccggggc cgctcgcggg catggacagc gcggccgccg
      241 ccttcgccct ggacaagccg gcgctgggcc cggggccgcc gccgcctcca cccgcgctgg
      301 ggcccggcga ctgcgcccag gcgcgcaaga acttctcggt gagccacctc ctggacctgg
      361 aagaggtggc ggcggccggg cggctggcgg cgcgccccgg ggccagggcc gaggcgcggg
      421 agggcgcagc acgggagccg tccgggggca gcagcggcag cgaggcggcg ccgcaggatg
      481 gtgagtgtcc cagcccgggg cgcggtagcg ccgccaagcg gaagaagaag cagcggcgga
      541 accgcaccac gttcaacagc agccaactgc aggcgctgga gcgcgtgttc gagcgcacgc
      601 actaccccga cgcctttgtg cgcgaggagc ttgcccggcg cgtcaacctc agcgaggcgc
      661 gcgttcaggt ctggtttcag aaccgccgcg ccaagttccg caggaatgaa agggccatgc
      721 tggccagccg ctctgcctcg ctgctcaagt cctacagcca ggaggccgcc atcgagcagc
      781 ccgtggctcc ccggcccacc gccctgagtc cagattatct ctcctggaca gcctcgtccc
      841 cctacagcac agtgccaccc tacagccctg ggagctcagg ccccgcaacc ccaggggtca
      901 acatggccaa cagcatcgcc agcctccgtc tcaaggccaa ggagttcagc ctgcaccaca
      961 gccaggtgcc tacggtgaac tgaagtccag tcccaccagg acccagacgc ctccctgggt
     1021 ggacagcaat agaaaagggg gcagacgccc aggaagtgac cttctcctgg atgagctctc
     1081 ctggcccgtc tgtccagcct ggactcccga gcccacgagg ctgttgaggc ccctgcagcc
     1141 gggcccagct cttctgtcct tggccaccag agactgcagc ccacaaccct tggaggggtt
     1201 gggccggaag gtggaagagc ctgccaagga cctcatttag tttgtgtatt aaaaccaaaa
     1261 agcttttgtc tttaagaaat aaaaccattt ttttaagccc caaaa
//
