LOCUS       NM_001405496            2169 bp    mRNA    linear   PRI 07-AUG-2024
DEFINITION  Homo sapiens proline rich transmembrane protein 4 (PRRT4),
            transcript variant 8, mRNA.
ACCESSION   NM_001405496 XM_047420367
VERSION     NM_001405496.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010655.7.
            
            On Apr 25, 2022 this sequence version replaced XM_047420367.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14327317.143618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162823 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC010655.7         31310-31439         c
            131-854             AC010655.7         29089-29812         c
            855-959             AC010655.7         28898-29002         c
            960-1079            AC010655.7         28430-28549         c
            1080-2169           AC010655.7         20074-21163         c
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..2169
                     /gene="PRRT4"
                     /note="proline rich transmembrane protein 4"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
     exon            1..130
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..854
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1609
                     /gene="PRRT4"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 8"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 4 isoform 4
                     precursor"
                     /protein_id="NP_001392425.1"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
                     /translation="MARHGCLGLGLFCCVLFAATVGPQPTPSIPGAPATTLTPVPQSE
                     ASMLSLNLGLNFKFHLRGPAAVWGSPVTETQPLSLGPGQEPGEEVASGLRTDPLWELL
                     VGSSGNSLTEWGSTEGGSKPRASSLLPESTSRRSGPSDGPTAPYQPRRSTVTWDTALM
                     VTALPSSAPRPHQSELELKFDMALRAGAAPTLGHRTLPLLPSLRASLAEIAGRLGPFG
                     FFGTTLSPLRNFSGLSPPGETTSTSSASGVSGSLGFLGTTLSLPPYSLERKLSSPSPL
                     DPAASLSFASIATTSLAITPWTSARPPQSTCDAASRRPSAARPCLRLASSRALPSRTL
                     CLGSDSTAPPRWGPGAGPVRDQGRPLAPLRPRSSPPLGLGPQAAASHLARSADSRGTA
                     RPCCCVPAPTGPRAALWSASSVPRGPQEAAPASRPQDPTRPCPHPLATPQSLLLSCRP
                     RRPCCRSSSWTPADRSTS"
     exon            855..959
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1079
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..2169
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRT4"
                     /note="hexamer: AATAAA"
     polyA_site      2169
                     /gene="PRRT4"
                     /note="major polyA site"
ORIGIN      
        1 agagccggct gccgcggagc cccggcgcgg gcggcttcgc cggggagcga ggctcggagc
       61 caggaggcgg cgccgctggg agggagcgcg gagtgcggag tgcggagcgc ggggcctggc
      121 cgcccgcctg gaccttcctc ctcaaaagct gctgaacaac tgagtccctg cccaccaagg
      181 ccacccgaag ccaggtgggg ccatggccag gcatggctgt ctagggctgg gactgttctg
      241 ctgcgtcctg tttgctgcta ctgtgggccc ccagcccacc ccctccatcc caggtgcccc
      301 tgccaccact ttgacccccg tacctcaaag tgaggcctct atgctgtctc tcaacctggg
      361 acttaacttc aaattccatc ttcggggacc tgctgctgtc tgggggagcc cagtcacaga
      421 gacccagcca ctctctcttg ggccaggcca ggagccaggg gaagaggtgg ccagtgggct
      481 gaggactgac cccctttggg aattgctggt gggctcctca gggaactctc tcactgagtg
      541 gggctccacc gaaggtggct caaagccccg ggcctcctcc ctgcttccgg agtccacatc
      601 ccggcgctct gggcccagcg atgggcccac tgccccctat cagcccagga ggagcactgt
      661 gacctgggac actgctctga tggtgacagc acttccatcc agtgctccca ggccccacca
      721 gagcgagctg gagctgaagt ttgacatggc actgagagca ggtgcagccc ccacgcttgg
      781 gcatcgaacg ctgcccctgc tgcccagcct gcgggccagc ctggcagaga ttgctgggcg
      841 cctgggaccc tttggattct ttggcactac tctgtcccca ctccggaact tctccggcct
      901 gagcccccca ggtgaaacta catccacaag ctctgcctct ggagtttcgg gttctctggg
      961 gttccttggt accactctgt ccctgccccc atactccctg gagaggaagc tctccagccc
     1021 aagtcctctg gacccagctg cttccctaag ttttgcctcg attgcaacaa catcattagc
     1081 gattacaccg tggacttccg cccgccctcc ccaatcaacc tgcgacgcag catcgaggag
     1141 gccctctgca gcgaggccct gcttgcgcct ggcctcttcc agggccctgc cttcgaggac
     1201 gctctgcctg ggctcggact ctaccgcacc gcctcgctgg ggaccggggg cagggccagt
     1261 gagagatcag gggaggcctc tggccccgct gcgcccccgg agctcccctc ccctggggct
     1321 tggcccgcag gcagcagcgt ctcatctggc tcgttctgcg gactctcgcg ggacagctcg
     1381 tccatgctgc tgtgttccag ccccgacagg cccccgcgct gccctctggt ctgcgtcctc
     1441 agtcccccgc ggccctcagg aagcagcccc agcctcccgg cctcaggatc ctaccaggcc
     1501 ctgtccccac cctctcgcga ctccccagag cctgcttctg agctgcaggc cgaggaggcc
     1561 ttgctgcagg agcagttcct ggacgcctgc cgacagatcg acgagctgag cgtgggcagc
     1621 gacaccatag acctgtgaag aggtggccac cttgctaccc tgcgatatgc ccctttctgg
     1681 cgcctgccct gcccgagacc tgcacactgt aatccttccc caatcctccc tggctcagat
     1741 acctctccag attccttccc catccagggg tccctgggtg ggtgggtcag cagccaggct
     1801 ctatcgattg ggaatcagtg ccaccttctc tggagccctg ggtgctgatg ccctcagctg
     1861 caaatctagg ttggcagggg tcccattttc cttggcattc accagcaata aagctccaag
     1921 gtgctccact cctgaccacc actccccact ctggtgctga gtgagagggg ctgtcctcag
     1981 aggaccctgg gacctgcctc aggcccccct acccacctct gccatgccta ggaatcccac
     2041 ccctgtgtga atgggactcc ctttcctcca tgtgacaccc acaggggtcc atgacccatc
     2101 taggagactt tatagcagtt gggtgggagg ggaatgctct taatttatca ataaaatatt
     2161 ttcagagga
//
