LOCUS       NM_001405493            3350 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens proline rich transmembrane protein 4 (PRRT4),
            transcript variant 5, mRNA.
ACCESSION   NM_001405493
VERSION     NM_001405493.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010655.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2977647.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC010655.7         31562-31732         c
            172-288             AC010655.7         31055-31171         c
            289-1805            AC010655.7         29089-30605         c
            1806-1910           AC010655.7         28898-29002         c
            1911-2030           AC010655.7         28430-28549         c
            2031-2260           AC010655.7         22198-22427         c
            2261-3350           AC010655.7         20074-21163         c
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..3350
                     /gene="PRRT4"
                     /note="proline rich transmembrane protein 4"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
     exon            1..171
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..288
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            289..1805
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1154..2443
                     /gene="PRRT4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 5"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 4 isoform 2
                     precursor"
                     /protein_id="NP_001392422.1"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
                     /translation="MARHGCLGLGLFCCVLFAATVGPQPTPSIPGAPATTLTPVPQSE
                     ASMLSLNLGLNFKFHLRGPAAVWGSPVTETQPLSLGPGQEPGEEVASGLRTDPLWELL
                     VGSSGNSLTEWGSTEGGSKPRASSLLPESTSRRSGPSDGPTAPYQPRRSTVTWDTALM
                     VTALPSSAPRPHQSELELKFDMALRAGAAPTLGHRTLPLLPSLRASLAEIAGRLGPFG
                     FFGTTLSPLRNFSGLSPPGETTSTSSASGVSGSLGFLGTTLSLPPYSLERKLSSPSPL
                     DPAASLSFASIATTSLDPTVPISGPDDLSPPASLGNPSGQPECGPGSCSVGELPEREG
                     QPPEAPRPLFFLTLEADWAEARARWGLAWEAHVYGRLHRGLPPALPNQPATQHRGGPL
                     QRGPACAWPLPGPCLRGRSAWARTLPHRLAGDRGQGQ"
     exon            1806..1910
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2030
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2260
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..3350
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRT4"
                     /note="hexamer: AATAAA"
     polyA_site      3350
                     /gene="PRRT4"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtgttt cctggcgcgc gtgtggatgt gtgtgctggg ccgccctggg agtgtgtgat
       61 tgctctcgcc aggctcacag cgaggcgccc gccgcggctg attgacagcg ctgggtgaat
      121 gagcgcgcgt ggaggcgccc ggcaccgagg tggccgcggc tccgcgctgc tagagaagcg
      181 gtgagatacc acgaagcgtt gcccagctgg gcgccagggc cgccacgacc gccccttttc
      241 ggaggctcgg cgaggagacc tgcctgcggg agagaccccg gggagcagat gtgtgcgcac
      301 agaggagaga gttctgggga gggggtagga gtccgccgca gctgcctgca gttcgcccag
      361 cttgcctgcc tggcgttctc ctccaggaag ccggagatcg ccaagctgcc cctcccccga
      421 atacttcaag ggtcctaggg aagggaacag gcccagcccc aggaaacggg aggggcggga
      481 gggagggtgc ttctgccaga ttgggaacct tgcttctctg gccagagcct gggcggcctt
      541 ctgactgggc cagatcactc agctctggct ttacccctcc cgaggccctg tgccccctgg
      601 ggtctgagag tgagggcgcc agcacttctg gctggggcgg gaggtggggg ttggaatagg
      661 tcaagacatc ggaagggctt gcttgttcac agttatatgc ccagaagggt gcttggcaaa
      721 cggtaagcct gcgtaaagac ttgaggctca gcagagggaa ggaagagagg aatccatgtc
      781 tggaagccca agtccatccc ttttgctact agttaaggat gagggcccct ggttgcagtc
      841 agaccccagc ttctgcatga gcagaggggg aaggaggaac ccccaggcag ggatttgtgc
      901 tggggcctga aggtacagga agggcccggc aagaagagcc agagccatgg acaggacact
      961 ttgcatcctg cccacactac ctgcttctct gagatcagaa gcctctctct gggacatccg
     1021 atcctgggaa agggaagagg ggggccacag ccagggctca cagggcctct cctctctcca
     1081 ggaccttcct cctcaaaagc tgctgaacaa ctgagtccct gcccaccaag gccacccgaa
     1141 gccaggtggg gccatggcca ggcatggctg tctagggctg ggactgttct gctgcgtcct
     1201 gtttgctgct actgtgggcc cccagcccac cccctccatc ccaggtgccc ctgccaccac
     1261 tttgaccccc gtacctcaaa gtgaggcctc tatgctgtct ctcaacctgg gacttaactt
     1321 caaattccat cttcggggac ctgctgctgt ctgggggagc ccagtcacag agacccagcc
     1381 actctctctt gggccaggcc aggagccagg ggaagaggtg gccagtgggc tgaggactga
     1441 ccccctttgg gaattgctgg tgggctcctc agggaactct ctcactgagt ggggctccac
     1501 cgaaggtggc tcaaagcccc gggcctcctc cctgcttccg gagtccacat cccggcgctc
     1561 tgggcccagc gatgggccca ctgcccccta tcagcccagg aggagcactg tgacctggga
     1621 cactgctctg atggtgacag cacttccatc cagtgctccc aggccccacc agagcgagct
     1681 ggagctgaag tttgacatgg cactgagagc aggtgcagcc cccacgcttg ggcatcgaac
     1741 gctgcccctg ctgcccagcc tgcgggccag cctggcagag attgctgggc gcctgggacc
     1801 ctttggattc tttggcacta ctctgtcccc actccggaac ttctccggcc tgagcccccc
     1861 aggtgaaact acatccacaa gctctgcctc tggagtttcg ggttctctgg ggttccttgg
     1921 taccactctg tccctgcccc catactccct ggagaggaag ctctccagcc caagtcctct
     1981 ggacccagct gcttccctaa gttttgcctc gattgcaaca acatcattag accccacagt
     2041 ccccatctct ggcccagatg acctctctcc tcccgccagc ctcgggaacc cttcggggca
     2101 gccagagtgt gggccagggt cctgcagcgt gggagaattg cctgaacgcg aggggcagcc
     2161 tcccgaggcg ccgaggcccc tctttttcct gaccctggag gccgactggg cagaggccag
     2221 ggctcgctgg gggctggcct gggaggccca cgtgtacggg cgattacacc gtggacttcc
     2281 gcccgccctc cccaatcaac ctgcgacgca gcatcgagga ggccctctgc agcgaggccc
     2341 tgcttgcgcc tggcctcttc cagggccctg ccttcgagga cgctctgcct gggctcggac
     2401 tctaccgcac cgcctcgctg gggaccgggg gcagggccag tgagagatca ggggaggcct
     2461 ctggccccgc tgcgcccccg gagctcccct cccctggggc ttggcccgca ggcagcagcg
     2521 tctcatctgg ctcgttctgc ggactctcgc gggacagctc gtccatgctg ctgtgttcca
     2581 gccccgacag gcccccgcgc tgccctctgg tctgcgtcct cagtcccccg cggccctcag
     2641 gaagcagccc cagcctcccg gcctcaggat cctaccaggc cctgtcccca ccctctcgcg
     2701 actccccaga gcctgcttct gagctgcagg ccgaggaggc cttgctgcag gagcagttcc
     2761 tggacgcctg ccgacagatc gacgagctga gcgtgggcag cgacaccata gacctgtgaa
     2821 gaggtggcca ccttgctacc ctgcgatatg cccctttctg gcgcctgccc tgcccgagac
     2881 ctgcacactg taatccttcc ccaatcctcc ctggctcaga tacctctcca gattccttcc
     2941 ccatccaggg gtccctgggt gggtgggtca gcagccaggc tctatcgatt gggaatcagt
     3001 gccaccttct ctggagccct gggtgctgat gccctcagct gcaaatctag gttggcaggg
     3061 gtcccatttt ccttggcatt caccagcaat aaagctccaa ggtgctccac tcctgaccac
     3121 cactccccac tctggtgctg agtgagaggg gctgtcctca gaggaccctg ggacctgcct
     3181 caggcccccc tacccacctc tgccatgcct aggaatccca cccctgtgtg aatgggactc
     3241 cctttcctcc atgtgacacc cacaggggtc catgacccat ctaggagact ttatagcagt
     3301 tgggtgggag gggaatgctc ttaatttatc aataaaatat tttcagagga
//
