LOCUS       NM_001405492            2557 bp    mRNA    linear   PRI 07-AUG-2024
DEFINITION  Homo sapiens proline rich transmembrane protein 4 (PRRT4),
            transcript variant 4, mRNA.
ACCESSION   NM_001405492
VERSION     NM_001405492.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2557)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 2557)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010655.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2801223.1,
                                           SRR14038196.3546300.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC010655.7         31562-31732         c
            172-288             AC010655.7         31055-31171         c
            289-1012            AC010655.7         29089-29812         c
            1013-1117           AC010655.7         28898-29002         c
            1118-1237           AC010655.7         28430-28549         c
            1238-1467           AC010655.7         22198-22427         c
            1468-2557           AC010655.7         20074-21163         c
FEATURES             Location/Qualifiers
     source          1..2557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..2557
                     /gene="PRRT4"
                     /note="proline rich transmembrane protein 4"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
     exon            1..171
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..288
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            289..1012
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1650
                     /gene="PRRT4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 4 isoform 2
                     precursor"
                     /protein_id="NP_001392421.1"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
                     /translation="MARHGCLGLGLFCCVLFAATVGPQPTPSIPGAPATTLTPVPQSE
                     ASMLSLNLGLNFKFHLRGPAAVWGSPVTETQPLSLGPGQEPGEEVASGLRTDPLWELL
                     VGSSGNSLTEWGSTEGGSKPRASSLLPESTSRRSGPSDGPTAPYQPRRSTVTWDTALM
                     VTALPSSAPRPHQSELELKFDMALRAGAAPTLGHRTLPLLPSLRASLAEIAGRLGPFG
                     FFGTTLSPLRNFSGLSPPGETTSTSSASGVSGSLGFLGTTLSLPPYSLERKLSSPSPL
                     DPAASLSFASIATTSLDPTVPISGPDDLSPPASLGNPSGQPECGPGSCSVGELPEREG
                     QPPEAPRPLFFLTLEADWAEARARWGLAWEAHVYGRLHRGLPPALPNQPATQHRGGPL
                     QRGPACAWPLPGPCLRGRSAWARTLPHRLAGDRGQGQ"
     exon            1013..1117
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1237
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1467
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2557
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2538..2543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRT4"
                     /note="hexamer: AATAAA"
     polyA_site      2557
                     /gene="PRRT4"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtgttt cctggcgcgc gtgtggatgt gtgtgctggg ccgccctggg agtgtgtgat
       61 tgctctcgcc aggctcacag cgaggcgccc gccgcggctg attgacagcg ctgggtgaat
      121 gagcgcgcgt ggaggcgccc ggcaccgagg tggccgcggc tccgcgctgc tagagaagcg
      181 gtgagatacc acgaagcgtt gcccagctgg gcgccagggc cgccacgacc gccccttttc
      241 ggaggctcgg cgaggagacc tgcctgcggg agagaccccg gggagcagga ccttcctcct
      301 caaaagctgc tgaacaactg agtccctgcc caccaaggcc acccgaagcc aggtggggcc
      361 atggccaggc atggctgtct agggctggga ctgttctgct gcgtcctgtt tgctgctact
      421 gtgggccccc agcccacccc ctccatccca ggtgcccctg ccaccacttt gacccccgta
      481 cctcaaagtg aggcctctat gctgtctctc aacctgggac ttaacttcaa attccatctt
      541 cggggacctg ctgctgtctg ggggagccca gtcacagaga cccagccact ctctcttggg
      601 ccaggccagg agccagggga agaggtggcc agtgggctga ggactgaccc cctttgggaa
      661 ttgctggtgg gctcctcagg gaactctctc actgagtggg gctccaccga aggtggctca
      721 aagccccggg cctcctccct gcttccggag tccacatccc ggcgctctgg gcccagcgat
      781 gggcccactg ccccctatca gcccaggagg agcactgtga cctgggacac tgctctgatg
      841 gtgacagcac ttccatccag tgctcccagg ccccaccaga gcgagctgga gctgaagttt
      901 gacatggcac tgagagcagg tgcagccccc acgcttgggc atcgaacgct gcccctgctg
      961 cccagcctgc gggccagcct ggcagagatt gctgggcgcc tgggaccctt tggattcttt
     1021 ggcactactc tgtccccact ccggaacttc tccggcctga gccccccagg tgaaactaca
     1081 tccacaagct ctgcctctgg agtttcgggt tctctggggt tccttggtac cactctgtcc
     1141 ctgcccccat actccctgga gaggaagctc tccagcccaa gtcctctgga cccagctgct
     1201 tccctaagtt ttgcctcgat tgcaacaaca tcattagacc ccacagtccc catctctggc
     1261 ccagatgacc tctctcctcc cgccagcctc gggaaccctt cggggcagcc agagtgtggg
     1321 ccagggtcct gcagcgtggg agaattgcct gaacgcgagg ggcagcctcc cgaggcgccg
     1381 aggcccctct ttttcctgac cctggaggcc gactgggcag aggccagggc tcgctggggg
     1441 ctggcctggg aggcccacgt gtacgggcga ttacaccgtg gacttccgcc cgccctcccc
     1501 aatcaacctg cgacgcagca tcgaggaggc cctctgcagc gaggccctgc ttgcgcctgg
     1561 cctcttccag ggccctgcct tcgaggacgc tctgcctggg ctcggactct accgcaccgc
     1621 ctcgctgggg accgggggca gggccagtga gagatcaggg gaggcctctg gccccgctgc
     1681 gcccccggag ctcccctccc ctggggcttg gcccgcaggc agcagcgtct catctggctc
     1741 gttctgcgga ctctcgcggg acagctcgtc catgctgctg tgttccagcc ccgacaggcc
     1801 cccgcgctgc cctctggtct gcgtcctcag tcccccgcgg ccctcaggaa gcagccccag
     1861 cctcccggcc tcaggatcct accaggccct gtccccaccc tctcgcgact ccccagagcc
     1921 tgcttctgag ctgcaggccg aggaggcctt gctgcaggag cagttcctgg acgcctgccg
     1981 acagatcgac gagctgagcg tgggcagcga caccatagac ctgtgaagag gtggccacct
     2041 tgctaccctg cgatatgccc ctttctggcg cctgccctgc ccgagacctg cacactgtaa
     2101 tccttcccca atcctccctg gctcagatac ctctccagat tccttcccca tccaggggtc
     2161 cctgggtggg tgggtcagca gccaggctct atcgattggg aatcagtgcc accttctctg
     2221 gagccctggg tgctgatgcc ctcagctgca aatctaggtt ggcaggggtc ccattttcct
     2281 tggcattcac cagcaataaa gctccaaggt gctccactcc tgaccaccac tccccactct
     2341 ggtgctgagt gagaggggct gtcctcagag gaccctggga cctgcctcag gcccccctac
     2401 ccacctctgc catgcctagg aatcccaccc ctgtgtgaat gggactccct ttcctccatg
     2461 tgacacccac aggggtccat gacccatcta ggagacttta tagcagttgg gtgggagggg
     2521 aatgctctta atttatcaat aaaatatttt cagagga
//
