LOCUS       NM_001174164            3550 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens proline rich transmembrane protein 4 (PRRT4),
            transcript variant 1, mRNA.
ACCESSION   NM_001174164
VERSION     NM_001174164.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010655.7, BX355277.2, BX327107.2 and BU688038.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001174164.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352441.129236.1,
                                           ERR4352443.834286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446477.7/ ENSP00000415026.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC010655.7         31328-31439         c
            113-203             BX355277.2         54-144
            204-204             AC010655.7         31098-31098         c
            205-273             BX355277.2         146-214
            274-881             AC010655.7         29179-29786         c
            882-1491            BX327107.2         42-651
            1492-2919           AC010655.7         20705-22132         c
            2920-3550           BU688038.1         18-648              c
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..3550
                     /gene="PRRT4"
                     /note="proline rich transmembrane protein 4"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
     exon            1..130
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..247
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            248..971
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..3019
                     /gene="PRRT4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 4 isoform 1
                     precursor"
                     /protein_id="NP_001167635.1"
                     /db_xref="CCDS:CCDS55160.1"
                     /db_xref="GeneID:401399"
                     /db_xref="HGNC:HGNC:37280"
                     /translation="MARHGCLGLGLFCCVLFAATVGPQPTPSIPGAPATTLTPVPQSE
                     ASMLSLNLGLNFKFHLRGPAAVWGSPVTETQPLSLGPGQEPGEEVASGLRTDPLWELL
                     VGSSGNSLTEWGSTEGGSKPRASSLLPESTSRRSGPSDGPTAPYQPRRSTVTWDTALM
                     VTALPSSAPRPHQSELELKFDMALRAGAAPTLGHRTLPLLPSLRASLAEIAGRLGPFG
                     FFGTTLSPLRNFSGLSPPGETTSTSSASGVSGSLGFLGTTLSLPPYSLERKLSSPSPL
                     DPAASLSFASIATTSLDPTVPISGPDDLSPPASLGNPSGQPECGPGSCSVGELPEREG
                     QPPEAPRPLFFLTLEADWAEARARWGLAWEAHVYGVGALFGLVALLALLALALLPWRC
                     PPGAPCLALLDLLLLSAGTTRAFPLFYDAYGHRDRLPALAWLLLQDLPLPCLAAGLGL
                     ACLLLARPRPPRCPTGLAALLLLGLGLAAAAALGSAAHRPLRPLRLASRGLHAFLAAF
                     LSGLLLALSCWGGRRRRAGAPLGGSGFKGATPLPQGRSPFAPRESWRRAARTAPVAGT
                     FGLLSGALQGYEVLHALGYGGQSGLEGPWPWWAFQLGLRLGEVGVALPLALLGLYPAL
                     CSPRVPPRCWAKLFRLSPGHAAPLLPGGWVTGPPDKEPLGSAIARGDAELLQLCALAG
                     PGPDLLLQGGGCRGFEGAAANPAPSPASSPCSDYTVDFRPPSPINLRRSIEEALCSEA
                     LLAPGLFQGPAFEDALPGLGLYRTASLGTGGRASERSGEASGPAAPPELPSPGAWPAG
                     SSVSSGSFCGLSRDSSSMLLCSSPDRPPRCPLVCVLSPPRPSGSSPSLPASGSYQALS
                     PPSRDSPEPASELQAEEALLQEQFLDACRQIDELSVGSDTIDL"
     exon            972..1076
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1196
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..3550
                     /gene="PRRT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRT4"
                     /note="hexamer: AATAAA"
     polyA_site      3550
                     /gene="PRRT4"
                     /note="major polyA site"
ORIGIN      
        1 agagccggct gccgcggagc cccggcgcgg gcggcttcgc cggggagcga ggctcggagc
       61 caggaggcgg cgccgctggg agggagcgcg gagtgcggag tgcggagcgc ggggcctggc
      121 cgcccgcctg agagaagcgg tgagatacca cgaagcgttg cccagctggg cgccagggcc
      181 gccacgaccg ccccttttcg gaggctcggc gaggagacct gcctgcggga gagaccccgg
      241 ggagcaggac cttcctcctc aaaagctgct gaacaactga gtccctgccc accaaggcca
      301 cccgaagcca ggtggggcca tggccaggca tggctgtcta gggctgggac tgttctgctg
      361 cgtcctgttt gctgctactg tgggccccca gcccaccccc tccatcccag gtgcccctgc
      421 caccactttg acccccgtac ctcaaagtga ggcctctatg ctgtctctca acctgggact
      481 taacttcaaa ttccatcttc ggggacctgc tgctgtctgg gggagcccag tcacagagac
      541 ccagccactc tctcttgggc caggccagga gccaggggaa gaggtggcca gtgggctgag
      601 gactgacccc ctttgggaat tgctggtggg ctcctcaggg aactctctca ctgagtgggg
      661 ctccaccgaa ggtggctcaa agccccgggc ctcctccctg cttccggagt ccacatcccg
      721 gcgctctggg cccagcgatg ggcccactgc cccctatcag cccaggagga gcactgtgac
      781 ctgggacact gctctgatgg tgacagcact tccatccagt gctcccaggc cccaccagag
      841 cgagctggag ctgaagtttg acatggcact gagagcaggt gcagccccca cgcttgggca
      901 tcgaacgctg cccctgctgc ccagcctgcg ggccagcctg gcagagattg ctgggcgcct
      961 gggacccttt ggattctttg gcactactct gtccccactc cggaacttct ccggcctgag
     1021 ccccccaggt gaaactacat ccacaagctc tgcctctgga gtttcgggtt ctctggggtt
     1081 ccttggtacc actctgtccc tgcccccata ctccctggag aggaagctct ccagcccaag
     1141 tcctctggac ccagctgctt ccctaagttt tgcctcgatt gcaacaacat cattagaccc
     1201 cacagtcccc atctctggcc cagatgacct ctctcctccc gccagcctcg ggaacccttc
     1261 ggggcagcca gagtgtgggc cagggtcctg cagcgtggga gaattgcctg aacgcgaggg
     1321 gcagcctccc gaggcgccga ggcccctctt tttcctgacc ctggaggccg actgggcaga
     1381 ggccagggct cgctgggggc tggcctggga ggcccacgtg tacggggtag gcgcgctctt
     1441 cggcctggtt gccttgctgg cgctgctggc tctggccctc ttgccctggc ggtgcccgcc
     1501 cggcgccccc tgcctggcgc tgctggacct gctgctgctg tcggccggga ccacgcgggc
     1561 cttcccgctc ttctacgacg cctatgggca cagggatcga ctgcccgcgc tcgcctggct
     1621 gctgctgcag gaccttccgc tgccctgctt ggctgccggc ctggggctgg cctgcctgct
     1681 gctggcccgg ccgcgcccgc cgcggtgccc caccggcctg gctgcgctgc tgctcctggg
     1741 gctggggctg gcggccgccg ccgccctcgg gagcgccgcg catcgcccgc tgcggcccct
     1801 gcggctcgcc tcgcgcgggc tgcacgcctt tctcgccgct ttcctttccg ggctgctgct
     1861 ggcgctctcc tgctggggcg ggcggcggcg gcgggccggg gcgcccctgg gagggtcggg
     1921 cttcaagggc gccacacccc tgccgcaggg gcgcagcccc ttcgcccctc gggagtcctg
     1981 gcggcgcgcg gcgcgcacgg ccccggtggc gggcaccttc gggctgctga gcggagccct
     2041 gcagggctat gaggtgctgc acgccctggg ctacggcggc caatccggcc tggaagggcc
     2101 ctggccctgg tgggccttcc agctaggcct gcgcctgggc gaggtgggcg tcgcgctccc
     2161 gttggcgctg ctgggcctct acccggcgct ctgcagtcct cgcgtgccgc cgcgctgctg
     2221 ggccaagctc ttccgcttgt ccccgggcca cgcggctccg ctgctgccgg gaggctgggt
     2281 cactgggccc ccagacaagg agcccctggg gagcgccatc gctcgcgggg acgcggagct
     2341 gctgcagctg tgcgcgctgg cagggccagg cccagacctc ctactccagg gcggaggttg
     2401 ccggggcttc gaaggcgcgg cggccaaccc ggccccgtcc ccggcttcct ctccctgcag
     2461 cgattacacc gtggacttcc gcccgccctc cccaatcaac ctgcgacgca gcatcgagga
     2521 ggccctctgc agcgaggccc tgcttgcgcc tggcctcttc cagggccctg ccttcgagga
     2581 cgctctgcct gggctcggac tctaccgcac cgcctcgctg gggaccgggg gcagggccag
     2641 tgagagatca ggggaggcct ctggccccgc tgcgcccccg gagctcccct cccctggggc
     2701 ttggcccgca ggcagcagcg tctcatctgg ctcgttctgc ggactctcgc gggacagctc
     2761 gtccatgctg ctgtgttcca gccccgacag gcccccgcgc tgccctctgg tctgcgtcct
     2821 cagtcccccg cggccctcag gaagcagccc cagcctcccg gcctcaggat cctaccaggc
     2881 cctgtcccca ccctctcgcg actccccaga gcctgcttct gagctgcagg ccgaggaggc
     2941 cttgctgcag gagcagttcc tggacgcctg ccgacagatc gacgagctga gcgtgggcag
     3001 cgacaccata gacctgtgaa gaggtggcca ccttgctacc ctgcgatatg cccctttctg
     3061 gcgcctgccc tgcccgagac ctgcacactg taatccttcc ccaatcctcc ctggctcaga
     3121 tacctctcca gattccttcc ccatccaggg gtccctgggt gggtgggtca gcagccaggc
     3181 tctatcgatt gggaatcagt gccaccttct ctggagccct gggtgctgat gccctcagct
     3241 gcaaatctag gttggcaggg gtcccatttt ccttggcatt caccagcaat aaagctccaa
     3301 ggtgctccac tcctgaccac cactccccac tctggtgctg agtgagaggg gctgtcctca
     3361 gaggaccctg ggacctgcct caggcccccc tacccacctc tgccatgcct aggaatccca
     3421 cccctgtgtg aatgggactc cctttcctcc atgtgacacc cacaggggtc catgacccat
     3481 ctaggagact ttatagcagt tgggtgggag gggaatgctc ttaatttatc aataaaatat
     3541 tttcagagga
//
