LOCUS       NM_207351               3775 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline rich transmembrane protein 3 (PRRT3),
            transcript variant 1, mRNA.
ACCESSION   NM_207351
VERSION     NM_207351.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3775)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   2  (bases 1 to 3775)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM544786.1, AK090993.1, AC018809.5, BC040508.1 and BC089447.1.
            
            On Nov 23, 2018 this sequence version replaced NM_207351.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040508.1, SRR3476690.1129345.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412055.6/ ENSP00000392511.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BM544786.1         32-45
            15-555              AK090993.1         1-541
            556-556             AC018809.5         29385-29385
            557-780             AK090993.1         543-766
            781-1144            BC040508.1         767-1130
            1145-2144           AK090993.1         1131-2130
            2145-3232           BC089447.1         2111-3198
            3233-3605           AC018809.5         33005-33377
            3606-3775           BC089447.1         3199-3368
FEATURES             Location/Qualifiers
     source          1..3775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..3775
                     /gene="PRRT3"
                     /note="proline rich transmembrane protein 3"
                     /db_xref="GeneID:285368"
                     /db_xref="HGNC:HGNC:26591"
                     /db_xref="MIM:619993"
     exon            1..87
                     /gene="PRRT3"
                     /inference="alignment:Splign:2.1.0"
     exon            88..1159
                     /gene="PRRT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..3090
                     /gene="PRRT3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 3 isoform 1
                     precursor"
                     /protein_id="NP_997234.3"
                     /db_xref="CCDS:CCDS43049.1"
                     /db_xref="GeneID:285368"
                     /db_xref="HGNC:HGNC:26591"
                     /db_xref="MIM:619993"
                     /translation="MASSPWGCVCGLLLLLLPLLGTGPALGRGFPRPLENSEIPMIPG
                     AHPKGSVGSEPQAFDVFPENPRADSHRNSDVRHAPAEEMPEKPVASPLGPALYGPKAA
                     QGAQRERLPVTDDLQMAQGPSSHGWTGPLDSQELLQQEAVAPHPVGHPHLTFIPTTPR
                     RQLRVATVPPSLQHEGQEGQWPPRDEGLKAKTKSRVPPTSPSDHQGPPHTLVSHSGTV
                     KRPVLEGQGGFEEHLQEAAQGPHFTQQDPAAPDVGSVPPVEVVYSQEPGAQPDLALAR
                     SLPPAEELPVETPKRAGAEVSWEVSSPGPPPKQADLPDAKDSPGPQPTDPPASEAPDR
                     PSKPERAAMNGADPISPQRVRGAVEAPGTPKSLIPGPSDPGPAVNRTESPMGALQPDE
                     AEEWPGRPQSHPPAPPVQAPSTSRRGLIRVTTQRALGQPPPPEPTASSMASAPASSPP
                     ANATAPPLRWGPLRRVLSFSWELHVYGVGVLFLLPALLALAALAAAPAGPRLALVAAV
                     LVLVASALRSAYMLTDPYGSQARLGVRGGLVLYNLPFPLLLTALAALTLLGLGAGLPP
                     PLQNPLLLGAVALVHGVGLLATDLLSTWSVLNLLTQGLSCAWGAAVALGTLCLCRRRL
                     LDGPRGWDASPGPRLLAVAGALGLLASGLQLAAALWLYPGPGRVGRFSWAWWGVHFWL
                     RLLELTWALALALAAVAAARPRPPTEHACWAKLMRLACPAPSGKSEVPERPNNCYAGP
                     SNVGAGSLDISKSLIRNPAESGQLATPSSGAWGSAASLGRGPQGGPGLSRNGVGPAPS
                     LSELDLRPPSPINLSRSIDAALFREHLVRDSVFQRCGLRGLASPPPGGALRPRRGSHP
                     KAELDDAGSSLLRGRCRSLSDVRVRGPVPQHVVEAPDGAAAAASGSSLDSFSRGSLKI
                     SWNPWRHGLSSVDSLPLDELPSTVQLLPAPTPAPDSTAARQGDGQGEVQPRGKPGESR
                     SASSDTIEL"
     exon            1160..1315
                     /gene="PRRT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..3775
                     /gene="PRRT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3756..3761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRT3"
                     /note="hexamer: AATAAA"
     polyA_site      3775
                     /gene="PRRT3"
                     /note="major polyA site"
ORIGIN      
        1 agccgagtct gagcatctcg gaggatgcgg cgcggcgatc ggctgcaggg acgcgcgcaa
       61 ggtgaacacg ggggctgcgg cgcgcaggct catccagtga ggactggaag gtgggggctt
      121 taggcccagg catcggagta gaccatggcc tccagcccat ggggctgtgt atgtggcctt
      181 ctgctgttgc tgctgccact cctggggact ggccctgccc tggggagggg ctttcccagg
      241 ccacttgaaa actccgaaat ccctatgatc cctggagccc accccaaggg ctctgtgggc
      301 tcagagcccc aggcctttga cgtgttcccg gagaacccca gagctgacag tcacaggaac
      361 tctgatgtcc gccacgcccc tgctgaagag atgcctgaga agcctgtagc ctctcccctt
      421 ggcccagccc tgtacgggcc caaagcagca caaggagctc agagagaacg actcccagta
      481 actgatgacc tccagatggc tcaaggacca agctcccacg gctggacagg acctctggac
      541 tcacaagagc ttctgcagca agaagcagtg gctccccacc cagtgggcca ccctcatctc
      601 actttcatcc ccacaactcc cagacgtcaa ctcagggtag ccacagttcc tccctccctg
      661 cagcatgaag gccaagaggg acagtggcca cctagagatg agggtctgaa ggccaaaact
      721 aagagcaggg tcccacccac ttctccctca gaccaccagg gcccacccca cacccttgtt
      781 tcccactcag gtactgtcaa gaggccagtg ctggaaggac agggtgggtt tgaggaacac
      841 ttgcaggagg cagctcaagg tccccacttc acccagcagg atccagcagc ccctgatgtt
      901 ggctcagtac ccccagttga ggtggtgtac tctcaggagc caggggccca gccagacttg
      961 gcattggcca gaagccttcc tcctgctgag gagctgccgg ttgagacccc caagagggct
     1021 ggcgctgagg tgtcctggga agtcagctcc ccaggtcccc cgcccaagca ggctgacctt
     1081 cctgacgcta aggattcacc aggaccccag cccacggatc cacccgcctc agaggctcct
     1141 gatcggccgt ctaagccaga gagagcagca atgaatggag cagaccccat ctccccccag
     1201 cgggtgagag gagctgtgga ggccccaggc acccccaagt ctctcatccc tggtccctca
     1261 gaccctggcc cagctgtaaa ccgaacagag agccccatgg gggccctgca gccagatgaa
     1321 gccgaggagt ggccggggcg cccccaaagc catcccccag cacccccagt ccaggccccc
     1381 tcgacgtcac gccggggcct cattcgagtc accacgcagc gagccctggg ccagcctccc
     1441 cctccggagc ccaccgccag ctccatggct tcagccccag cctccagccc cccagccaac
     1501 gccactgcac ccccgctacg ctggggcccc cttcggcggg tcctgagctt ctcctgggag
     1561 ctgcacgtct acggggtggg ggtactcttt ctgctgcccg cgttgttggc gctggctgcg
     1621 ctggcagccg ccccagcagg gccccggctg gcattggtgg ccgcggtgct ggtgctcgtg
     1681 gcttcggcgc tgcgatccgc ctacatgctt accgaccctt acggctcgca ggcgcggctg
     1741 ggcgttcgcg ggggcctggt gctctacaac ctgcccttcc ccttgctgct tacggcgctg
     1801 gcagccctga ctctgctcgg cctgggcgcg gggctgccgc caccgctgca aaacccactc
     1861 ctgctgggag cagtggcgct ggtgcatggt gtagggttgc tcgcgacaga cctgctgtcc
     1921 acatggtctg tgctcaacct cctgacgcag ggcttgtcgt gcgcctgggg cgcggccgtg
     1981 gctctgggca cgctctgcct gtgccgtcgc cgcctgctgg acggcccacg gggctgggat
     2041 gccagcccgg gccctcggct gttggctgtg gcgggcgcgc tggggctgct ggctagcggc
     2101 ttgcagctgg cggctgcgct ctggctgtac ccgggcccag gccgcgtggg ccgcttctcg
     2161 tgggcctggt ggggtgtcca cttctggctg cgcctcctgg agctgacatg ggcgctcgcc
     2221 ctggcgttgg ccgcggtggc tgccgcgaga cccaggccgc ccacggagca cgcttgctgg
     2281 gctaagctga tgcgtctggc gtgcccggcg ccgtcaggaa agagcgaggt gccggagcga
     2341 cccaataact gctatgcagg gcccagcaac gttggtgcag gcagcttgga catcagcaag
     2401 agcctcatcc gcaacccggc ggagagtggg cagctggcca cgcccagttc aggcgcctgg
     2461 ggctcggctg cgtcgttggg tcgcggaccc cagggtggcc cgggactgtc ccgcaacggt
     2521 gtgggaccgg cgccatcgct gagcgagctg gatctgcggc cgccatcgcc catcaacctg
     2581 agccgcagca tcgacgccgc gctcttccgc gagcacctag tgcgagacag tgtgttccag
     2641 cgctgcggcc tccgcggcct ggcctccccg ccgcctggag gcgctctgcg gccgcgccgg
     2701 ggcagccatc ccaaagccga gctcgacgac gctggctcct cgctcctccg cggccgctgc
     2761 aggtcgctca gcgacgtgcg cgtgcgcggg ccggtcccac agcacgtagt ggaagcaccc
     2821 gacggggcag ccgctgcggc ttctggcagc tccctcgaca gcttctccag gggttcactc
     2881 aagatcagtt ggaacccctg gcgccacggg ctgtcatcag tggacagtct gcccctagat
     2941 gagttgccca gcacggtaca gctactgcct gccccgaccc cagcccctga ttctaccgcc
     3001 gctcggcagg gggacggcca gggagaggtc cagccgcgcg gcaagcctgg ggaatcccgc
     3061 agcgcctcca gtgataccat cgagctttga agagcggtcc tgacgcaggg ccaggaccct
     3121 gcccgatgcc cacatggcat ggcctactgg gacagttgag cctttaaaaa atgggcatcc
     3181 tggccaggcg cggtggctca cgccaggaat cccagcactt tgggaggccg aggtgggtgg
     3241 aacacgaggt caggagttcg agatcagcct cctggtctcg aacatagcga aaccctcgtc
     3301 tctactaaaa atacaaaaaa attagccagg tggcacacgc ctgtagtccc agctactcgg
     3361 gaggctgagg cgggagaatt gcttgaacag ggaggcagag gttgcagtga gccgagacca
     3421 cgccattgca ctccagcctg ggtgacaaga gtgagactcc gtctcaaaaa aaaaaaaaaa
     3481 aaaaaaaaaa aaaaaggcat ccccaggcct ctctacctga cggcaacccc cgggggacag
     3541 ccaggtttga actcacccca cccccatgcc gttttttgct tttaatattt ctattttttt
     3601 ttcagccggc attttgcaca gaggccgtgt cttatgcgga atacagggtg ggtgtgcatg
     3661 gattcgggca tgaagaacag ggagcaggtg ccccagactc cccaacgtgg agtgatgagc
     3721 ctcgcttgtc tagattgtcc tctttgtgcc aaagaaataa acccttagga cttgg
//
