LOCUS       NM_001372163            5705 bp    mRNA    linear   PRI 12-SEP-2024
DEFINITION  Homo sapiens proline rich and Gla domain 3 (PRRG3), transcript
            variant 3, mRNA.
ACCESSION   NM_001372163
VERSION     NM_001372163.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5705)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   2  (bases 1 to 5705)
  AUTHORS   Kulman,J.D., Harris,J.E., Xie,L. and Davie,E.W.
  TITLE     Identification of two novel transmembrane gamma-carboxyglutamic
            acid proteins expressed broadly in fetal and adult tissues
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1370-1375 (2001)
   PUBMED   11171957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF274854.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a protein which contains a vitamin
            K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded
            protein is a member of a family of vitamin K-dependent
            transmembrane proteins which contain a glutamate-rich extracellular
            domain. [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3646372.1,
                                           SRR14038193.2112424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000674457.1/
                                                  ENSP00000501544.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AF274854.4         120995-121081
            88-125              AF274854.4         124321-124358
            126-286             AF274854.4         125533-125693
            287-5705            AF274854.4         126043-131461
FEATURES             Location/Qualifiers
     source          1..5705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..5705
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /note="proline rich and Gla domain 3"
                     /db_xref="GeneID:79057"
                     /db_xref="HGNC:HGNC:30798"
                     /db_xref="MIM:300685"
     exon            1..87
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /inference="alignment:Splign:2.1.0"
     exon            88..125
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..814
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /note="isoform 1 is encoded by transcript variant 3;
                     proline-rich Gla protein 3; proline-rich
                     gamma-carboxyglutamic acid protein 3; proline rich Gla
                     (G-carboxyglutamic acid) 3 (transmembrane)"
                     /codon_start=1
                     /product="transmembrane gamma-carboxyglutamic acid protein
                     3 isoform 1"
                     /protein_id="NP_001359092.1"
                     /db_xref="CCDS:CCDS14699.1"
                     /db_xref="GeneID:79057"
                     /db_xref="HGNC:HGNC:30798"
                     /db_xref="MIM:300685"
                     /translation="MAVFLEAKDAHSVLKRFPRANEFLEELRQGTIERECMEEICSYE
                     EVKEVFENKEKTMEFWKGYPNAVYSVRDPSQSSDAMYVVVPLLGVALLIVIALFIIWR
                     CQLQKATRHHPSYAQNRYLASRAGHTLPRVMVYRGTVHSQGEPSGHREAANSPQVVLG
                     PSRGGRTTVRLESTLYLPELSLSRLSSTTPPPSYEEVTAPQESSSEEASVSYSDPPPK
                     YEEIVAANPGADK"
     exon            126..286
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /inference="alignment:Splign:2.1.0"
     exon            287..5705
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5678..5683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /note="hexamer: AATAAA"
     polyA_site      5705
                     /gene="PRRG3"
                     /gene_synonym="PRGP3; TMG3"
                     /note="major polyA site"
ORIGIN      
        1 gacagggccc ctgctggaag aggcgcagca gcgaggtggc gggctgcgtg cgcaaacagg
       61 gcggccgcct tctgggcccg gagaacgaga agtgagaccc tgcagctgag ggagcatcat
      121 ggcagtgttt ctggaggcca aggatgccca ttcggtcctg aaacgattcc ctcgtgccaa
      181 tgagttcctg gaggagctgc gccagggcac catcgagcga gagtgcatgg aggagatctg
      241 cagctacgag gaggtcaagg aagtgtttga gaacaaagag aaaacgatgg agttctggaa
      301 agggtaccca aatgcagtct actctgtccg agacccctcg cagagctcag atgccatgta
      361 tgtggtggta ccccttctgg gggtggcact gctgattgtc atcgccttgt tcatcatctg
      421 gaggtgccag ctgcagaaag cgacccgtca ccacccctcc tatgctcaga accggtacct
      481 agccagtcgc gccgggcaca ccctcccccg ggtcatggtg taccggggta ctgtgcatag
      541 ccaaggggag ccttctgggc accgagaggc agcgaacagc ccccaggtgg tgctggggcc
      601 cagtcggggg ggcaggacca cagtccggct agagagcacc ctctacctcc ctgagctctc
      661 tctctccaga ctgtccagca ccacccctcc cccctcctac gaggaggtga ctgcgcccca
      721 agagagcagc agtgaggagg ccagcgtgtc ttacagtgac ccacccccaa agtacgagga
      781 gatagtggcc gccaaccctg gcgctgacaa gtagtgggac gtttgtgccc tgtcctggat
      841 gaacgcctct ttccgaggtc tcctattttc tttttaactt tttaaagact gtgccaccac
      901 aaaacagcct tagcctcctt gttgccaaat aattccctaa ctgtggagtt ttaggaagtc
      961 agttgtcaga gacaggtggg gagggtgggg gtagggacca cgcatgagtc gaagcccccg
     1021 ggaagagcca aaggccaaag tgcccaactc tttgggatga cccccaagcc tccaacatcc
     1081 tgtctttcca tcaggaactg gcttctctta tgccaaagga ataaccccat tgagttgatt
     1141 gtggccagaa tgtccacagg cctggcctgg gggctgtggg actggctgga ggcctgcctg
     1201 tgtctagagc tctgggcctc aggggtaagg gaaggaagcc agcctttcag caccccttac
     1261 cctccacagt tctgtgattt ctgtccttgc ttacatttgg aggacaggga caaggactga
     1321 gcaaaaacaa aatgaaaaaa tcatgacaaa taaataatta acacaataga acaaaactct
     1381 agcacccggg ccgttcatag gaggccaagg gaaatttatc acatggatct gtgatgtccg
     1441 cctcccctaa aacctgtccc cacactcctg gaaggaggac agggtgtgtg aaggatgagg
     1501 gccagagggc tgggtggcag agtttcctct tccacattga ccaaggggcc cacgtggact
     1561 ctgccattca gtttctagtg tgcttgtctc tccagacatg tggaccagct gtgttcaaac
     1621 cactacccac tggcatgagc ctactttttg cgaatggtgc attgaaattg aacttcagat
     1681 tgaggatttc tccttaacga tggtgcgcat ctcaggagaa gatcctaaag tgtccctttt
     1741 aaaacattta tttgtggaga agcccgtggc ctggggttga aggcccatat ggggtttgct
     1801 ctgctgttgc caggtgccag tctgttttca gtgaggcttt ggacagcagt ggggcagaag
     1861 gcacctgccc tttaactgtc agtgaccatg ctagacactg ttgataccac ctccccctac
     1921 ttccgtctcc atcctcctga cctcaacacc aaaccatttc tcctctgtgg tgctttaaaa
     1981 attgtagcaa atttttgtgt ggtgcaagaa tgcatggcct gcgtctattg gcaaccacag
     2041 caatttaaaa tccactgagc tgacaagctt ttttctgtca aaatatctct ctaaggcaga
     2101 cattgggact catttccttg aatgcagccc tgccttcagg ccacagagga cttctggagg
     2161 ctgctctagc cctgaggact tgccctggga cgtgcttcca gttagaaggc ttgtgtccct
     2221 accccagtga ggccaccagc ttggaccact ccaccctgtg gctggggttt tccatccttc
     2281 cccctacctc acaggcccgt tggaggctga ctgagcaaat gcctgcgaag tgcttgaatt
     2341 gccggggagc cagcgaggtt tgccttagga agagtcttct agaaaggtgt aggttataag
     2401 ggagcagtct tagctgaggc cctcatatgc ctctgatgtt gagtctccac ttggagagtc
     2461 aatctcccgt cagttgaccc tttccatcct ctcgtcctcc ctttccagag ctccctgatg
     2521 ccagagatgc tggtgaatgc aggtgacatt ctacctttcg tttccttgtc tttccctccc
     2581 ctgggccttc agcattgcac tcctgccctt catcacaaag gggtttttgg cttaagaggc
     2641 ccctgctttt tccatgttgg gggacctggg gaagcctgaa gctcggggct agccctggct
     2701 ctcccagtat ttcttcaagt aggtgccaga gtgtgacctg ggagcaggtg agaagaaact
     2761 tatcccaata tgtctactca gttagcacag agccaggcat gagctccact gatcagagcc
     2821 aaagggagtt tgccaagaaa tgcccgctgc ctttggcatc tgagttgcag ctgggtggta
     2881 atgggagaga gcaggaagag gcccaaggcc tggcccatgg agggcaacat gtgtccttca
     2941 ggggctgagg acaggccgtg ggaagagtca caggaggttg cttaaggcct gtgatgttcg
     3001 gttcagatgc ttcatggtgt tctgccaggt ggggttgcac cacggtctct gggatggttt
     3061 ctgcagcaca ttgtagaaaa aagactgtac agcacacagc aggcatcact ccttgcgatg
     3121 cacacttgga ttttatgaat gccctgtaca tatcttttca aactctgtgt ttgtatggag
     3181 gtggatttga tacaatgctg actctttcgt ggctacattt ttgctgtttt tggacttcta
     3241 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tctatgtgtg cacgttgcct tttctcattg
     3301 cttatctgaa acaatagccg gtgtgcagct atatttgtac caggagggat ccggtctgaa
     3361 aagaggaatg tcacctcccc tcgcagggct gagtagcctg atgacagggc cctgagcaag
     3421 gaaacgtggc attaactata ttggacaccc aacccccaaa gttgtcactg tttgcctcct
     3481 tgaaaaaggc tttggaagaa gacaaagcag ctccattctg caggtctcca ccctatgcaa
     3541 cccccgctca cacgcccttt tggcatggtg cccctggccc aggcttctgt tctgtgggtg
     3601 tcagcagctg aaagaaatct gagtactcct gggcatggtt tttttttttt tttttttttt
     3661 tttttttttt tttttttttt tttttttttt ttttgtgtgt gtgtgtgtgt gtgtgtgtgt
     3721 gtgtgtgtgt gtgtatggaa agatgtgtga ctattgactt tgggtatcgc gggactagtt
     3781 aattagatgt ttttcatttt tcaaaaagaa aaggttttaa aaattttctt gaaatgtgac
     3841 tgtcacttgt tttcaaccaa aaacttttta agatttttta aaagaaaaat cgaaatcctg
     3901 tccctccccc gcttcccatc gcctccggtt ttcaaaatga aagcacaagt gcaagagtgg
     3961 ggtgcacagg tgcctggcgt gtacacacca cccacacagc tgcgtccagc cctggctgag
     4021 ggagacgcag tgctgagcag tcagccccgg gaggcctctt tttcaacttc caatcccact
     4081 gccatgaatg tgaattcctt agggtgcttc caaaaacagg agtctgcctg atctgttgga
     4141 cattgccttt ttggtagccc gaatatgagg aattcaggac aggaaagtgt ctttttgtca
     4201 agtagtcaga gccggatgct tcccctctcc cagtgggtgg agcatcgcaa cccccagcca
     4261 gagttgatct tttgacaacc cagtgacatc ccatgagaag gaagaaaaaa aattcaacac
     4321 tgcctctaga ttgttatttt gtccaagaga gagatcatgg agagagtctc tctcgctcac
     4381 ggaggctctg tctttctagg agtatgtgtg tgtgctgtct catgtgtgga cactcacagt
     4441 tgaggctgag atggatatct tggcagcaga gctgctggtc taggtggctt ttcagcttga
     4501 caagtaatga agctccattt caggacttca tcgattccga aacaagcaca gccccccacc
     4561 ccccgccacg gaactctact aatactaatc actataatta gctaatttaa aagtacggta
     4621 atcagactgc ttgcaactat tttaaaagcc cattaatttg aagcccacta cttcagaact
     4681 tcgagaaaat cacaacttaa gacaattcac agtagctgtg attctggcta cataaaaata
     4741 tttgaaatat tcttcccttt agtcaatgtt cagggtcttt tgtgtaagag aaatccagtt
     4801 taaaatgagt acccttttca aagaaaaggc tcaagatatt aaggatccct tcaccgtgcc
     4861 ttcagctttg cagttcagca cttctcgtat gtacagggtg atctcttgtt ctctctccat
     4921 cacagggatg ttggatattg cagcctttca ctctactccg ttatttatcc tgtgaataac
     4981 atagtttgtg aactagactg caatttaaac taatacacat gatgtatctt tctaaatatt
     5041 ctgtaaagca gatgcttcgc tgtcagactg gccgctccat cattcgcctc caaatattca
     5101 aacgtgggag cttttccttt cagactgtgg gcagcgagtc tctctctagc aagaatttat
     5161 ctgacaaaca tacccaaata gcacaccctc tcaagctcaa tgcctcaaca gttgtttcac
     5221 tgtactgata tctgactgct gaacagtgcc tgcccttcac ccacccccag cccgagcatt
     5281 aacacagatc ttcaggattg ggacaaatcc cccagctgct tttgcctctc aatccatctc
     5341 ccctcatcga taccaatttc ccaggcctga acacatctgt tattttgctc tgacattgtg
     5401 aatttgtgac agtggaaacc ctgatatgtg caactgagct tatagaaata attactgtga
     5461 aatggattaa ttttgatacc actttaaact gtgcttgtat tcatgtgttg acccttgtca
     5521 gctgggaaat ctgtacattc agtatatgtc agcatttcat tggagcctgg gggcaacaga
     5581 caaacttgct tctgatttct ctctctctct ctttcttttt ataattgttg aatttggctg
     5641 ttacattttg tctccttctt tacaagaaaa caataataat aaagagcaaa tggcatccac
     5701 ttgaa
//
