LOCUS       NM_001142395            4400 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens proline rich and Gla domain 1 (PRRG1), transcript
            variant 2, mRNA.
ACCESSION   NM_001142395
VERSION     NM_001142395.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4400)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4400)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   3  (bases 1 to 4400)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 4400)
  AUTHORS   Kulman,J.D., Harris,J.E., Haldeman,B.A. and Davie,E.W.
  TITLE     Primary structure and tissue distribution of two novel proline-rich
            gamma-carboxyglutamic acid proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9058-9062 (1997)
   PUBMED   9256434
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060833.1 and BC030786.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001142395.1.
            
            Summary: This gene encodes a vitamin K-dependent,
            gamma-carboxyglutamic acid (Gla)-containing, single-pass
            transmembrane protein. This protein contains a Gla domain at the
            N-terminus, preceded by a propeptide sequence required for
            post-translational gamma-carboxylation of specific glutamic acid
            residues by a vitamin K-dependent gamma-carboxylase. The C-terminus
            is proline-rich containing PPXY and PXXP motifs found in a variety
            of signaling and cytoskeletal proteins. This gene is highly
            expressed in the spinal cord. Several alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (2) is missing a 5' non-coding
            exon compared to variant 1. Variants 1-4 encode the same isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060833.1, SRR18074967.1928482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378628.9/ ENSP00000367894.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1102              BC060833.1         29-1130
            1103-4400           BC030786.2         1175-4472
FEATURES             Location/Qualifiers
     source          1..4400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.1"
     gene            1..4400
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /note="proline rich and Gla domain 1"
                     /db_xref="GeneID:5638"
                     /db_xref="HGNC:HGNC:9469"
                     /db_xref="MIM:300935"
     exon            1..32
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            33..83
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..730
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; proline-rich Gla (G-carboxyglutamic acid)
                     polypeptide 1; transmembrane gamma-carboxyglutamic acid
                     protein 1; proline rich Gla (G-carboxyglutamic acid) 1"
                     /codon_start=1
                     /product="transmembrane gamma-carboxyglutamic acid protein
                     1 isoform 1 precursor"
                     /protein_id="NP_001135867.1"
                     /db_xref="CCDS:CCDS14239.1"
                     /db_xref="GeneID:5638"
                     /db_xref="HGNC:HGNC:9469"
                     /db_xref="MIM:300935"
                     /translation="MGRVFLTGEKANSILKRYPRANGFFEEIRQGNIERECKEEFCTF
                     EEAREAFENNEKTKEFWSTYTKAQQGESNRGSDWFQFYLTFPLIFGLFIILLVIFLIW
                     RCFLRNKTRRQTVTEGHIPFPQHLNIITPPPPPDEVFDSSGLSPGFLGYVVGRSDSVS
                     TRLSNCDPPPTYEEATGQVNLQRSETEPHLDPPPEYEDIVNSNSASAIPMVPVVTTIK
                     "
     exon            84..244
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..4400
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4378..4383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /note="hexamer: AATAAA"
     polyA_site      4400
                     /gene="PRRG1"
                     /gene_synonym="PRGP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagaacggc gagtagcgga gcgggacccg ctggaatcat catccaggga cgtgccagaa
       61 accacaagaa aacatgggga gggttttcct cacgggagaa aaagccaatt ccatattaaa
      121 acgctaccca agagctaatg ggttttttga agaaataaga cagggcaaca ttgagcgtga
      181 gtgcaaagaa gaattctgta catttgaaga agcaagagaa gcttttgaaa ataatgaaaa
      241 aactaaggag ttttggagca cctacacaaa agcgcaacaa ggggagagta accgaggaag
      301 tgactggttt cagttttacc ttacctttcc gttaatcttt ggcctcttca ttatcctcct
      361 tgtcattttc ctaatctgga gatgcttcct aagaaacaaa actcgtagac agacagtgac
      421 tgaaggccac attcctttcc ctcagcacct taatattatc accccacccc ccccaccaga
      481 tgaagtgttt gacagcagtg gattgtctcc aggctttctg ggatatgtag ttgggcgctc
      541 agattccgtc tctactcgcc tgtccaattg tgatcccccg ccaacctatg aggaagccac
      601 tggccaagtg aacctgcaga ggagtgaaac agaacctcat ttagacccac ccccagagta
      661 tgaggacata gtcaactcca actcagccag tgccattcct atggtgcctg tggtcaccac
      721 catcaaatga agctgcaaac ttctttttac tctaatcatt tttaaaatac taatggaaga
      781 actttctagc actttaccac tacataaatg ttcattgact tattttattg gactcttacc
      841 gcataccact tcacacttgt tttattttct ttagttttgt ttcttgttat agaatcatta
      901 tccatgctca tttttgctag gggaaatata tgaagaggga aaacatacta atgggggtct
      961 ttctgtgatg tgatgagaca tacatgtaag tgtatatatg tgtgtatagg catatatacg
     1021 tgtgtatgca tcaacacagt atatgtaaaa ctgtcttaaa aatccattaa cttctaccta
     1081 aatcacctgg aaggagagca ttactcacca aaattgcaaa acaagggtat caagaatttg
     1141 tgtaatagcc agtgacatgc tgtagatttt tgcaaactgg atgtacttag catgttttct
     1201 aattctgact ggcttttgtt aacttgataa ttcttcatct accttaaaaa gaaaaaaatt
     1261 acacatagtc attcttgatg ttataaatag agaaaaagtg tgtgtgagca ataatgcata
     1321 agctactgat aacttgctta cagcagatag caataaggta tttggtggca ttcggcttgt
     1381 tttgtaatag ggattttttt tttggttgac cactccccca cacttccaaa attaaacagt
     1441 gttttcttag catcttgaat atctcctgcg gtgtatatta acatcttgat gagacagatt
     1501 tccaggcaac aaaataattt ctaaaatgga tatatgtgtg gattaatgac aggcagtaaa
     1561 tacccattac tcctttactc atagctggta aaattattcc cactgtttta ttgcctttta
     1621 ctgtacgttc tacactctgt cctactccca cagaattttc aagcccttaa gagtttagtt
     1681 aaaataaaat ttttgaaatt attgtcttaa tatttttata taggctgatg tctttgcctc
     1741 aagattgtta ggaggtaatt ttccattgaa ttatcaactg tgatttttat attgccctcc
     1801 aagtggtaga agaagattgc aaagtccatg ttatgctagg tgcacaataa atctagtaat
     1861 agccccacac agatctcatc attgttgcta cttccttttg tattttcatc aggtattttt
     1921 ttaactgtag ggtttttact tttttcttgg agcagagaga acaggctgta aatgggttgc
     1981 caacataagc tggctgagaa ataaaagaaa acaagacagt tgttcataaa gtttcatttt
     2041 gtatgcactg atggcaaatt cattaggtca gttaagggaa atatttgtac cacttccaaa
     2101 cttttcagcg ttggataaaa tgattgatga ggcaggcaga aggaatgtag gtttcaggtg
     2161 tgtcatttcc tgctgcttcc agctccatcc ctacagactc ctccccgagt cctgccctgg
     2221 aaccaaagga aggaggaaca ctgaggggaa tcctgaagta ggagtcagat gacctgaact
     2281 cagatctccc tctatcacat gcttgccacc actgtacctt gagcaagaat catatctgac
     2341 cctcaacctc ctcaactcta aaatggggat aacatcattt gtcctgcact tctctaaggg
     2401 ctttacaagg atcaaataag atggtgtgta tgtaagaaat ttgtaaaatg tgaagagcta
     2461 tctacactaa gttcgtaatg ttattattat tgtgcttcat ggagaatttt cccctctgtt
     2521 ttcctaaatt gtatgagagc tttcacacag tgagaaatag agcaggctgc cccataaatg
     2581 ggtaacatat tcctaatctg agtgtgtggg ctgttagaga acccctgcca tgctctggtc
     2641 tgttctgaaa ctgtgccaac tgaaagatga tagtccacac agcacaaaca ggtttaagca
     2701 aatgatagaa agggaagtaa ggcgtgtgtg ctagttaata ggtttagtag cttttatgga
     2761 ctaaaaatga ttgattgtat cttgaccctg gtctcagaaa tgacattttt acttttgcca
     2821 tgagtacaca tcagatatct ttggcttcta tttaaagcta aaggtagaag tgtttgatcc
     2881 agtgaactgt gtatgtatgt gtggggtttt tttctttatt tttaaatgaa aattaagaca
     2941 ccttttgtgt ggacatgttt ttgtctttaa tgtcaggctt tagattagac cagcagtttt
     3001 caaagtatgg ccaatggacc cctgggttcc ttgagagcct ttcagggggg actatgagat
     3061 caaaatattt ttattataat gtgaagacat tgtcttttca ctctatctca aaaaaagtgt
     3121 tgcaaatgta aaacattgcc atcttctcac aaatctcttt ttttgttttt gaaaatatgg
     3181 ccatttttca taaaatgtta tttgtgttag catgtaatgg gtttactatg tttaaataag
     3241 ttaatacttt aaaaattttc aggttttttt agtatggtga atattgatag atataaacct
     3301 catgaacaaa agtactttgg catccagatt ctcaataaat gttaagagcg taagtgtaag
     3361 ggggtccaga gaccaaaagt tttagagcta caggattaga cataggagca ggatattctg
     3421 ttagtgtgat ttcttgcaac tttattttac attttaaact gctgatattg gatataatgc
     3481 tgctttttag agacacctaa attgcagtat cagaatgaat gttgatgttt gaagccaaaa
     3541 agccaaatgc ttaaactgat caatgactgt agctttttag actgttggtc aaagaacatt
     3601 ctacttcaca gtaatagctc tatcagccac agatctcatg gtggctgttg catgataatg
     3661 ataggataaa caaaatacca ctgtcttcaa gaaacattat cttaggtttg tttgtttggt
     3721 ttgagtttga tttggctttt atatttttta aaatcccttt tgctacccca tctggtttta
     3781 taaactgagt ttcttagcat tcgttaaaat taaggggttt gtttggaata atatatattt
     3841 tttatgcttt tgtctttctt acctgattga tattacattc acctttgatt gttttttaaa
     3901 agtttatttt tacagaatat atttagtacc tttcttaagg agtaactgaa ttgaatcaac
     3961 cagtttgcat ttaaataaaa gaacaggctc agtggtcttc ctgtagaatg gtttacatgc
     4021 ctgcatgtgc agtagttgtg tctggaatcc tagaattggc actttctgcc tccttgctct
     4081 aaatgtcaca aaaaattata cttccttaaa gtaaatgtaa tgatttcttc ttttcctatt
     4141 gaccagtaca gatagatatg ttgtgtttgc ttcattttta atgatgactt caagattgat
     4201 gatgtgatcc aataactgtg gaggtagctt taacttggtt ctgtgtaaat agtatgtatt
     4261 ttattataat atttctcatt ttaagatgct tggtttacat taaattatgg tatttaacta
     4321 tttttatgtt tatactaggt agggtctttc ttatgtttct gtgtttttgg tatgctaaat
     4381 aaagctattt ttaaacccaa
//
