LOCUS       NM_001387844           10624 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens proline rich coiled-coil 2C (PRRC2C), transcript
            variant 2, mRNA.
ACCESSION   NM_001387844 XM_005245017
VERSION     NM_001387844.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10624)
  AUTHORS   Youn,J.Y., Dunham,W.H., Hong,S.J., Knight,J.D.R., Bashkurov,M.,
            Chen,G.I., Bagci,H., Rathod,B., MacLeod,G., Eng,S.W.M., Angers,S.,
            Morris,Q., Fabian,M., Cote,J.F. and Gingras,A.C.
  TITLE     High-Density Proximity Mapping Reveals the Subcellular Organization
            of mRNA-Associated Granules and Bodies
  JOURNAL   Mol Cell 69 (3), 517-532 (2018)
   PUBMED   29395067
REFERENCE   2  (bases 1 to 10624)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   3  (bases 1 to 10624)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 10624)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 10624)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 10624)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   7  (bases 1 to 10624)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 10624)
  AUTHORS   Sun,N.N., Fastje,C.D., Wong,S.S., Sheppard,P.R., Macdonald,S.J.,
            Ridenour,G., Hyde,J.D. and Witten,M.L.
  TITLE     Dose-dependent transcriptome changes by metal ores on a human acute
            lymphoblastic leukemia cell line
  JOURNAL   Toxicol Ind Health 19 (7-10), 157-163 (2003)
   PUBMED   15747776
  REMARK    GeneRIF: 10 genes were down-regulated following treatment of the
            T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h
REFERENCE   9  (bases 1 to 10624)
  AUTHORS   Huang,W.C., Taylor,S., Nguyen,T.B., Tomaszewski,J.E.,
            Libertino,J.A., Malkowicz,S.B. and McGarvey,T.W.
  TITLE     KIAA1096, a gene on chromosome 1q, is amplified and overexpressed
            in bladder cancer
  JOURNAL   DNA Cell Biol 21 (10), 707-715 (2002)
   PUBMED   12443540
  REMARK    GeneRIF: The KIAA1096 gene is located at 1q23-24 with no
            overexpression or amplification in normal urothelium, but was
            significantly upregulated in 30% of tumors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049762.20, AL021579.2 and Z98750.1.
            
            On Oct 9, 2020 this sequence version replaced XM_005245017.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000647382.2/ ENSP00000495867.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AL049762.20        96252-96457
            207-375             AL021579.2         22279-22447
            376-553             AL021579.2         23242-23419
            554-663             AL021579.2         24783-24892
            664-789             AL021579.2         25981-26106
            790-1013            AL021579.2         27838-28061
            1014-1096           AL021579.2         32424-32506
            1097-1230           AL021579.2         33468-33601
            1231-1318           AL021579.2         33682-33769
            1319-1463           AL021579.2         35068-35212
            1464-1517           AL021579.2         38038-38091
            1518-2136           AL021579.2         42590-43208
            2137-2306           AL021579.2         45675-45844
            2307-2556           AL021579.2         46276-46525
            2557-2767           AL021579.2         47510-47720
            2768-5026           AL021579.2         50218-52476
            5027-5235           AL021579.2         55726-55934
            5236-5390           AL021579.2         60333-60487
            5391-6294           AL021579.2         67487-68390
            6295-6380           AL021579.2         71265-71350
            6381-6569           AL021579.2         76480-76668
            6570-6821           AL021579.2         76839-77090
            6822-6914           AL021579.2         78494-78586
            6915-7016           AL021579.2         81567-81668
            7017-7218           AL021579.2         85174-85375
            7219-7422           AL021579.2         87681-87884
            7423-7535           AL021579.2         89601-89713
            7536-7672           AL021579.2         90075-90211
            7673-7904           AL021579.2         94203-94434
            7905-8012           AL021579.2         94666-94773
            8013-8231           AL021579.2         97250-97468
            8232-8335           AL021579.2         97895-97998
            8336-8462           AL021579.2         98626-98752
            8463-8699           AL021579.2         99616-99852
            8700-10624          Z98750.1           2047-3971
FEATURES             Location/Qualifiers
     source          1..10624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..10624
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /note="proline rich coiled-coil 2C"
                     /db_xref="GeneID:23215"
                     /db_xref="HGNC:HGNC:24903"
                     /db_xref="MIM:617373"
     exon            1..206
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            207..375
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..8960
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /note="isoform 2 is encoded by transcript variant 2; HBxAg
                     transactivated protein 2; BAT2 domain containing 1;
                     protein BAT2-like 2; protein PRRC2C; BAT2
                     domain-containing protein 1; HBV XAg-transactivated
                     protein 2; HBV X-transactivated gene 2 protein;
                     HLA-B-associated transcript 2-like 2; proline-rich and
                     coiled-coil-containing protein 2C"
                     /codon_start=1
                     /product="protein PRRC2C isoform 2"
                     /protein_id="NP_001374773.1"
                     /db_xref="CCDS:CCDS91104.1"
                     /db_xref="GeneID:23215"
                     /db_xref="HGNC:HGNC:24903"
                     /db_xref="MIM:617373"
                     /translation="MSEKSGQSTKAKDGKKYATLSLFNTYKGKSLETQKTTVAARHGL
                     QSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKTPEVP
                     PAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQEKKEKE
                     TNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLPGQDESTAGTSEQNDILKV
                     VEKRIACGPPQAKLNGQQAALASQYRAMMPPYMFQQYPRMTYPPLHGPMRFPPSLSET
                     NKGLRGRGPPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQL
                     NFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPY
                     GKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQR
                     RRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRE
                     REREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKE
                     KELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNK
                     EEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQE
                     QMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWL
                     MMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARDH
                     AISLSEPRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQL
                     EAHPKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERI
                     SAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKE
                     GFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEER
                     EQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEK
                     FPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISK
                     DLVIERPRPDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRG
                     SYGGRGRGGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRRQ
                     RGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKPDNHVRIDNRLL
                     EKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWN
                     PRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKP
                     PRFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQA
                     NEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAKRSFSSQRPVD
                     RQNRRGNNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHH
                     QEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKEKVDALSQFDLNNYASVVIIDDHPEV
                     TVIEDPQSNLNDDGFTEVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSK
                     LPPRFAKKQATGIQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTS
                     APVPASTLAPVLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPASAPAP
                     TPILASVSTPASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPTIPASAP
                     TASVPLAPASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPP
                     SIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPISP
                     PQPPSVSAWNKPLTSFGSAPSSEGAKNGQESGLEIGTDTIQFGAPASNGNENEVVPVL
                     SEKSADKIPEPKEQRQKQPRAGPIKAQKLPDLSPVENKEHKPGPIGKERSLKNRKVKD
                     AQQVEPEGQEKPSPATVRSTDPVTTKETKAVSEMSTEIGTMISVSSAEYGTNAKESVT
                     DYTTPSSSLPNTVATNNTKMEDTLVNNVPLPNTLPLPKRETIQQSSSLTSVPPTTFSL
                     TFKMESARKAWENSPNVREKGSPVTSTAPPIATGVSSSASGPSTANYNSFSSASMPQI
                     PVASVTPTASLSGAGTYTTSSLSTKSTTTSDPPNICKVKPQQLQTSSLPSASHFSQLS
                     CMPSLIAQQQQNPQVYVSQSAAAQIPAFYMDTSHLFNTQHARLAPPSLAQQQGFQPGL
                     SQPTSVQQIPIPIYAPLQGQHQAQLSLGAGPAVSQAQELFSSSLQPYRSQPAFMQSSL
                     SQPSVVLSGTAIHNFPTVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQASGLGGS
                     QLIDTHLLQARANLTQASNLYSGQVQQPGQTNFYNTAQSPSALQQVTVPLPASQLSLP
                     NFGSTGQPLIALPQTLQPPLQHTTPQAQAQSLSRPAQVSQPFRGLIPAGTQHSMIATT
                     GKMSEMELKAFGSGIDIKPGTPPIAGRSTTPTSSPFRATSTSPNSQSSKMNSIVYQKQ
                     FQSAPATVRMTQPFPTQFAPQILSQPNLVPPLVRAPHTNTFPAPVQRPPMALASQMPP
                     PLTTGLMSHARLPHVARGPCGSLSGVRGNQAQAALKAEQDMKAKQRAEVLQSTQRFFS
                     EQQQSKQIGGGKAQKVDSDSSKPPETLTDPPGVCQEKVEEKPPPAPSIATKPVRTGPI
                     KPQAIKTEETKS"
     exon            376..553
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..663
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..789
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1013
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1096
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1230
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1318
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1463
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1517
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..2136
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2306
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2556
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2767
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..5026
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5235
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5236..5390
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5391..6294
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            6295..6380
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            6381..6569
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            6570..6821
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            6822..6914
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            6915..7016
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7017..7218
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7219..7422
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7423..7535
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7536..7672
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7673..7904
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            7905..8012
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8013..8231
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8232..8335
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8336..8462
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8463..8699
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            8700..10624
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10601..10606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /note="hexamer: AATAAA"
     polyA_site      10624
                     /gene="PRRC2C"
                     /gene_synonym="BAT2-iso; BAT2D1; BAT2L2; XTP2"
                     /note="major polyA site"
ORIGIN      
        1 gccatcttgc ttctttttct cgctcgctcg ctccccctcg gaaagctgcg aaagtgcttt
       61 ggcggtttgt ccatccgcag cttcggcttt tccagtctgg tggcccttcc ggccacccct
      121 ttaaccccag ctttccctcc cccttctttc gatcagagat cggcggagac cctcgaagtg
      181 cgcaaacttg acactcaccc tgaccggact ggggttttaa ggggtgtggc aggaggtttt
      241 ggactcgatg agtttccacc gaaatgtcgg agaagtcagg ccagagcaca aaagcaaagg
      301 atgggaaaaa gtatgcaaca ctcagtttat ttaatactta caaggggaaa tcattagaaa
      361 cacagaaaac cacagttgca gctcgacatg gattacagag tcttggaaaa gtcggtattt
      421 cacggcgtat gcctccacct gctaacctcc caagtcttaa agcagaaaac aaaggcaatg
      481 atcctaatgt aaacattgta cctaaagatg gcacagggtg ggcatcaaaa caagagcaac
      541 atgaagaaga aaaaacacca gaagtgccac cagcacagcc aaaacctggg gttgcagctc
      601 ccccagaagt agcacctgct cccaaatcat gggccagtaa caagcaaggt gggcaaggag
      661 atggaatcca agtgaatagt cagtttcagc aagaatttcc cagcctgcag gcagctgggg
      721 atcaggaaaa aaaagaaaag gaaacaaatg atgacaacta tggacctgga cccagtttac
      781 gtccaccaaa tgttgcttgt tggagagatg gtggtaaggc tgctggctca ccttcgtcat
      841 ctgatcaaga tgaaaagctc cctggccagg atgaaagcac agctggaaca tcagagcaaa
      901 atgatatcct caaagtggtg gaaaagagga tagcttgtgg tcctccacag gctaaactga
      961 atggacagca ggctgctctc gcttcccagt atagagctat gatgcctcct tatatgttcc
     1021 aacagtatcc gaggatgaca tatcctcctc tacatggtcc catgagattc ccaccttctt
     1081 tatctgaaac aaacaaaggc cttcgaggaa gaggcccacc tccttcatgg gcctctgagc
     1141 ctgaacgccc atccattctt agtgcatcag aactgaagga gcttgataaa tttgataacc
     1201 tagatgctga agctgatgaa ggttgggcag gtgctcagat ggaagtagat tatacagagc
     1261 aactgaattt cagtgatgat gatgaacaag gaagtaacag tcctaaagag aataacagtg
     1321 aggatcaagg ttcaaaagcc tctgaaaaca acgaaaacaa aaaagaaaca gatgaagttt
     1381 ccaacactaa atcatcttcc caaatacctg cccaaccatc agtagcaaaa gttccctatg
     1441 ggaaaggacc ttcatttaat caggaacgtg gaacatcttc acatctgcca ccacctccaa
     1501 agttgcttgc acagcagcat ccacctccag atcgacaggc agtacctgga agaccaggcc
     1561 cctttccctc caagcagcaa gtagctgatg aagatgaaat atggaagcaa agacgaagac
     1621 aacaatcaga aatttctgca gcagtagaac gtgctcgtaa acggcgtgaa gaggaagagc
     1681 gaagaatgga agaacaaagg aaggcagctt gtgcggagaa actgaaacga ttggatgaga
     1741 agcttggcat cctggaaaaa caaccatctc cagaggaaat tagggaaagg gagcgagaaa
     1801 aagaacggga gcgtgagaaa gaacttgaaa aagaacaaga acaggagcga gagaaggaga
     1861 gggaaaaaga cagagagaga cagcaggaaa aggagaaaga gctggagaag gagcaggaaa
     1921 aacaaagaga aatggagaaa gaaagaaagc aagaaaaaga aaaagaacta gaacggcaga
     1981 aagaaaagga aaaagaacta caaaagatga aagaacaaga aaaggaatgt gagctggaga
     2041 aggaaaggga aaaattagag gagaaaattg aacccagaga acctaattta gagcccatgg
     2101 tagaaaaaca agaaagtgaa aacagctgta ataaagagga ggaacccgtt ttcactagac
     2161 aagacagcaa tcgcagtgaa aaggaagcca caccagtggt gcatgaaaca gaaccagaat
     2221 cagggtctca acctcggccg gctgtattat ctggctattt caaacagttt cagaagtctt
     2281 tacctccacg attccagcgg cagcaggaac agatgaaaca gcagcagtgg cagcagcagc
     2341 aacagcaagg tgtacttcca cagactgttc cttcacaacc gtccagtagt actgtccctc
     2401 ctccaccaca cagacctctt tatcagccta tgcagcctca tcctcagcat ttggcttcta
     2461 tgggttttga tccaaggtgg ctcatgatgc agtcctacat ggatcctcga atgatgtcag
     2521 gaagacctgc tatggatatt ccacccattc atcctggaat gattcctcct aaaccattaa
     2581 tgagaagaga ccagatggaa gggtcaccga acagttctga gtcatttgag catatagctc
     2641 gatctgcaag agatcacgca atttcccttt ctgagcctcg tatgctgtgg gggtcagatc
     2701 cctatcctca tgctgagcct caacaagcaa ctactcccaa agcaacagaa gagcctgagg
     2761 atgtaaggtc tgaagctgcg ttggaccagg aacagattac tgctgcttat tctgtagaac
     2821 ataatcaatt agaggctcac ccaaaggcag actttatcag agaatcaagt gaggcacaag
     2881 tacaaaagtt tttaagcaga tctgtggaag atgttagacc tcaccatact gatgcaaata
     2941 atcagtctgc ttgttttgaa gcacctgatc aaaagacctt atccgctcct caagaggagc
     3001 ggatttcagc tgtagaaagt cagccttccc ggaaaagaag tgtttcccat ggatctaacc
     3061 atacgcaaaa accagacgag cagagaagtg aaccatctgc aggcattcct aaagtaacca
     3121 gcagatgcat tgattcaaaa gaaccaatag aaaggccaga ggagaaacca aaaaaggaag
     3181 gctttatacg atcttctgaa ggaccaaaac ctgaaaaagt atataaatct aaatcagaaa
     3241 ctcgttgggg cccacgacca agctctaaca gaagggaaga agttaatgat agacctgtga
     3301 gaagatcagg tcccattaaa aaacctgtac ttagagatat gaaagaggaa cgggaacaga
     3361 ggaaggagaa agaaggagaa aaggccgaaa aggtcactga aaaagtagtt gtaaagcctg
     3421 aaaagacgga aaagaaggat cttcctcctc ccccaccacc acctcagcca ccagcaccaa
     3481 ttcagccaca gtcagttcca ccaccaattc aaccagaagc agagaaattt ccttcaacag
     3541 aaactgcaac tttggctcaa aaaccatctc aggatactga gaagcctctg gaacctgtga
     3601 gtactgttca ggtagagcct gcagttaaga ctgtaaacca acagactatg gcagcaccag
     3661 tagtcaaaga agaaaaacaa cctgagaaag tcatcagcaa agaccttgtt atagagaggc
     3721 ctcgaccaga ttcaagacca gcagttaaaa aagaatcaac tttgcctccc aggacctatt
     3781 ggaaagaagc tagagagaga gattggtttc cagatcaagg atacagaggt cgaggccgag
     3841 gtgaatatta ctccagaggt cgaagctata gaggttctta tggagggcgt ggcaggggtg
     3901 gtaggggaca cactcgagat tatcctcagt atagagacaa taagccaaga gcagagcata
     3961 taccctcagg gcctctcaga cagcgagaag aaagtgaaac acggagtgag agctctgatt
     4021 ttgaagttgt ccccaaaaga agacgacagc ggggttcaga gactgacaca gacagtgaaa
     4081 ttcatgaaag tgcaagtgac aaggacagtt taagtaaagg caaacttccc aaaagagagg
     4141 aacggcctga aaacaaaaaa cctgtaaagc ctcattcttc tttcaagcct gataatcatg
     4201 ttcgaataga taatagactg ctagaaaagc cttatgtaag ggatgacgat aaagctaaac
     4261 caggctttct tcctaaagga gagcctacaa ggagaggcag agggggaaca ttcaggcgtg
     4321 gtggaaggga tcctggaggc cgtccatcac gcccttccac tttacgaaga ccagcttatc
     4381 gggacaatca gtggaaccca aggcagtcag aagttcctaa accagaagat ggagagccgc
     4441 caagaagaca tgagcagttt attcctatag cagcagataa acgacctcca aaatttgagc
     4501 gaaaatttga cccagctaga gaaaggcctc gaaggcagcg tcctactcga ccaccaaggc
     4561 aagacaagcc acctcgattt agacggctaa gagagaggga ggctgcttca aaatcaaatg
     4621 aggtggtagc agtgcccaca aatggcacag ttaataatgt ggctcaagaa ccagttaata
     4681 ctcttgggga tatttccggg aataagacac cagatttatc taatcagaac tcttcagatc
     4741 aggcaaatga agaatgggaa acagcttctg aaagcagtga tttcaatgag aggcgagaga
     4801 gggatgaaaa aaaaaatgct gacttgaatg cacaaacagt tgtaaaggtt ggagagaatg
     4861 ttctacctcc aaagagggaa attgcaaaga gaagtttttc tagtcagaga ccagtagatc
     4921 gtcagaatcg acgtggcaac aatggtccac ccaaatcagg aaggaatttc tcaggtccta
     4981 gaaatgaaag gagaagtggc ccaccatcaa aaagtgggaa gagagggcca tttgatgacc
     5041 agcctgcagg cacaactggg gttgacctca tcaatggcag ctctgcacac catcaggaag
     5101 gagtacctaa tggtacagga caaaagaact ccaaagattc tactgggaaa aaaagagaag
     5161 accccaaacc aggccctaaa aaaccaaaag agaaagtgga tgctctatca cagtttgatc
     5221 tcaacaatta tgcaagtgtt gttataattg atgatcatcc tgaagtaaca gtaattgaag
     5281 atccccagtc aaatttgaat gatgatggtt ttactgaagt ggtatccaaa aaacaacaaa
     5341 aacgtttaca ggatgaagaa cgccgaaaga aggaagaaca agtcatacag gtctggaaca
     5401 aaaagaatgc aaatgaaaaa ggaagaagcc agacttctaa gcttcctcca agatttgcca
     5461 aaaaacaggc tacagggatc cagcaagcac agtcttcagc ctcagttcca cctctagctt
     5521 cggctccact tccaccttca acctcagctt cagttccagc ctcaacctca gctccacttc
     5581 cggcaacctt aactccagtt ccagcctcaa cctcagctcc ggttccagcc tcaactttag
     5641 ctccagttct ggcctcaacc tcagctccag ttccagcctc acccttagct ccagtttcag
     5701 cctcagcctc agtctcagct tcagttccag cctctacttc agctgcagct ataacctctt
     5761 cttcagctcc agcctcagcc ccagctccaa cccccatcct tgcctcagtt tcaaccccag
     5821 cttctgtcac cattcttgcc tcagcctcaa ttcccattct tgcttcagcc ctagcatcaa
     5881 cttcagctcc aacgccagcc ccagcagcct cttccccagc tgccccagtc atcacagcac
     5941 caactatccc agcctcagcc ccaactgcct cagtcccact tgcccctgcc tcagcttcag
     6001 ccccagcccc agcccctacc ccagtctcag ccccaaatcc tgccccacct gccccagccc
     6061 agactcaggc acagacccac aaaccagtcc agaatccact acagactaca tctcagtctt
     6121 caaaacaacc accaccatca attaggctgc cttcagctca aacacctaat ggcacagatt
     6181 atgtagcctc aggaaaatcc atccagaccc cacagtcaca tggcactctg acagctgaat
     6241 tatgggataa caaggtggcc ccaccagctg tgctgaatga tatctctaag aaattaggtc
     6301 ccattagtcc accacagcca ccttcagtca gtgcatggaa taagccctta acatcgtttg
     6361 gatcagctcc ttcatcagag ggagcgaaga atggtcaaga aagtggactc gaaattggaa
     6421 ctgacacaat tcagtttggt gctccagcct caaatggaaa tgaaaatgaa gttgttcctg
     6481 tgctttcgga aaaatctgct gacaaaatac ctgaacctaa agaacagcgg cagaagcagc
     6541 cacgagcagg acctatcaaa gcccagaagc ttccagattt gagtccagta gaaaacaaag
     6601 aacacaaacc tggtcccatt ggaaaggaac gttcattaaa aaatagaaaa gtaaaagatg
     6661 cccaacaggt ggagccagaa ggacaagaga aaccaagccc agctacagtc agaagcacag
     6721 atcctgtcac gacaaaggag actaaagcag tctcagaaat gtctactgaa ataggaacaa
     6781 tgatctcggt atcatctgca gaatatggta ctaatgcaaa ggagtctgta acagactata
     6841 ctacaccctc ttcttctttg cctaacaccg tggctactaa taatacaaag atggaggata
     6901 ctttggttaa taatgtgccc ctgcccaaca cccttcccct ccctaagagg gagactatac
     6961 aacagagctc cagcctaact tcagttcctc ccactacttt cagcctcacc ttcaagatgg
     7021 agtctgcacg caaagcatgg gagaattctc caaatgtaag ggaaaagggg tctccagtaa
     7081 cttccacagc acctccaatt gcaactggag tcagcagtag tgccagtgga ccaagcactg
     7141 ctaattacaa ttcgttctca agtgcatcca tgccccagat tcctgttgct tcagtcactc
     7201 ctacagcatc actatcagga gctggtacat acactacctc ttctttgagc acaaaatcta
     7261 caaccacatc ggaccctcca aatatttgta aagtgaaacc tcagcagtta cagacaagca
     7321 gcctgccttc tgcaagtcat ttttcacagt taagctgtat gccttccctt attgcccagc
     7381 agcaacagaa tccgcaagtt tatgtgtctc agtctgcagc agctcaaatc ccagccttct
     7441 atatggacac aagtcattta ttcaataccc aacatgcacg attggctccg ccatccttgg
     7501 ctcaacaaca gggtttccaa ccaggtctct ctcagccaac ttcagttcag cagattccaa
     7561 tccctattta tgcaccactg caagggcagc atcaagccca actgagtttg ggggctggcc
     7621 ctgctgtttc ccaggctcag gaattgttca gctcctcact tcaaccatat agatctcagc
     7681 cagcttttat gcaaagcagt ttatcccagc catctgtggt cctttctggt actgctattc
     7741 acaactttcc aactgtccaa caccaagaac ttgccaaggc acaatccggt cttgcctttc
     7801 agcaaacatc aaatactcag cccattccta tattgtatga acatcaactg gggcaggcat
     7861 caggactagg aggttcccag ctgattgaca cacatcttct ccaggccaga gcaaatctta
     7921 cccaggcctc aaatctttat tctggacaag tacaacagcc tggtcagaca aatttttata
     7981 acactgccca gtcaccaagt gctctccagc aggttacagt acctttacca gcatcgcagc
     8041 tttccttgcc taattttgga tctacagggc aacctctaat tgctttgcct cagactcttc
     8101 agcccccatt acagcatacc actccccaag cacaggctca gagtctgagt cgtcctgcac
     8161 aagtaagcca gcctttcaga ggattaattc ctgctggaac acagcatagc atgattgcaa
     8221 ccacaggaaa aatgtctgaa atggaactaa aagcctttgg aagtggcatt gatataaaac
     8281 caggcacacc tccaatcgct ggtagaagca ccacaccaac atctagtccc ttccgggcta
     8341 cttctacaag tccgaacagc cagtccagca aaatgaacag cattgtctac cagaagcagt
     8401 tccagtcagc ccctgccact gtgagaatga cacaaccatt tcctacacag tttgcacccc
     8461 agattctctc ccagcctaac ctggtccctc cattggtaag agccccacat actaacacct
     8521 tcccagcgcc tgttcagagg ccaccaatgg cactggccag tcagatgcct cctccgctga
     8581 ccacaggcct catgagccat gctcgtttgc cacatgtagc caggggtcct tgtggatcac
     8641 tatctggagt cagaggtaat caggcccagg ctgcgttgaa ggctgaacaa gacatgaagg
     8701 caaagcagag agcagaggtt cttcagtcca cgcaacggtt cttctctgaa cagcaacaga
     8761 gcaaacagat aggaggaggc aaagcccaga aagtggacag tgattcaagt aaacctcctg
     8821 aaacactgac cgaccctcct ggggtctgtc aggaaaaagt agaagaaaag ccaccccctg
     8881 caccctccat agccaccaaa cctgttagaa ctggaccaat caaacctcag gcgatcaaaa
     8941 ccgaagaaac aaaatcttaa aggctatggt ttattgcagg ggattgggag gggggcggga
     9001 aaacatggag aattaagtca gataatgctg gcagccaaag gggcaaaatg gcctgtgaca
     9061 ttatcctgtt cagagcttgg agatgtacaa gggacatagg agcaatttac actgacacac
     9121 agctgctgta ccagtgaaaa cgaggctttg caagcttgta cctactatat aacatgtgct
     9181 tggttgatgg ccatgcatct tcagtcagaa tttatatata aatgtatgca cccatttttt
     9241 tgagtgcata taatttagac ctaaaaatcc ttatgattag atgaaacacc aaaaatataa
     9301 ggaaaataac acagcagagg aatagctcag cctgaacagt gtgatggtcc cagctactac
     9361 atcagatgcg gtttttttgc tcccttatgt tcttcggata tggttatggc atttgtaggc
     9421 ttggaggtaa agaactgaag ataactggtg ctggatagag gagccttatt ttttattatg
     9481 gcagcttgct atttttataa catggtgatt gagttgaaca caatcaaagt acagtagtaa
     9541 ctgatgtccc cttcttcctg gatgaatgag cagataaata ttgatgtcag catccttgaa
     9601 ccatatcaaa gtgagcagtg tttggctact gcttctattt gaaatggtgc tgtgttttgg
     9661 ttgtggtctg aagctttgaa gcgctactta gcatctcctt tcttccatgg agctctcacg
     9721 attcaaacat gacagatttg gtaaaatgct ggttaggttg agtcttcctt gcccccactc
     9781 agtcatcttt gtatgaatcc catgatttgg gggttttttt cttttttttt ttataccagt
     9841 ttttagctgg tgtttatgaa gaacagtgag tacctagaac tgtgccacta attaaaggaa
     9901 atcctaagaa ggtgcatttc tttacagagc tgtgtcatgc catcctttgg gccctctgct
     9961 ggaaaagtag aatcaagtct caaataatgc ctttttaatt gtatcctcta gtattataga
    10021 tataggacag tactgtatca tacctctgtg aatgtaaaat atcttgtacc tgctttatga
    10081 tacgtagtag tgaccgtgct ttatcagagc tgtttttaat gatgttattc tagaatgttt
    10141 tctttccaga tgatgattca gaagctaatt ttaaaaaacg gtgccaggta ccacaacagt
    10201 aacagaactt tgcaattttc tggggttttg ttttttacct ttttcccccc ttttttttaa
    10261 atggagtgtg ctggatgtct ctataatttt attcagatga ctgcagaacc tggaaaagct
    10321 gttgctgcta ttgatgcata acatactgct attggtcttt ttatataaat atatatatat
    10381 atatacatat atatatataa tttgaatttt tggaaacttt agctgtgctg tcaactttgg
    10441 aaaaagtatc ccggtttact gtgttgagtt ggcattgtac agaaattaac agccatattg
    10501 gtctagaaac gttaaactta atttttttcc atttgtacag gggtaacgca ctgtattaaa
    10561 tatgtaaggt cttatctaca tgggtttgat tacagaaact aataaagtat tctctaaata
    10621 atga
//
