LOCUS       NM_004638               6903 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens proline rich coiled-coil 2A (PRRC2A), transcript
            variant 2, mRNA.
ACCESSION   NM_004638
VERSION     NM_004638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6903)
  AUTHORS   Tan,X., Zheng,C., Zhuang,Y., Jin,P. and Wang,F.
  TITLE     The m6A reader PRRC2A is essential for meiosis I completion during
            spermatogenesis
  JOURNAL   Nat Commun 14 (1), 1636 (2023)
   PUBMED   36964127
  REMARK    GeneRIF: The m6A reader PRRC2A is essential for meiosis I
            completion during spermatogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6903)
  AUTHORS   Zhang,J., Chen,M.J., Zhao,G.X., Li,H.F., Wu,L., Xu,Y.F., Liao,Y.,
            Yuan,Z. and Wu,Z.Y.
  TITLE     Common genetic variants in PRRC2A are associated with both
            neuromyelitis optica spectrum disorder and multiple sclerosis in
            Han Chinese population
  JOURNAL   J Neurol 268 (2), 506-515 (2021)
   PUBMED   32862241
  REMARK    GeneRIF: Common genetic variants in PRRC2A are associated with both
            neuromyelitis optica spectrum disorder and multiple sclerosis in
            Han Chinese population.
REFERENCE   3  (bases 1 to 6903)
  AUTHORS   Piras,I.S., Angius,A., Andreani,M., Testi,M., Lucarelli,G.,
            Floris,M., Marktel,S., Ciceri,F., La Nasa,G., Fleischhauer,K.,
            Roncarolo,M.G., Bulfone,A., Gregori,S. and Bacchetta,R.
  TITLE     BAT2 and BAT3 polymorphisms as novel genetic risk factors for
            rejection after HLA-related SCT
  JOURNAL   Bone Marrow Transplant 49 (11), 1400-1404 (2014)
   PUBMED   25111513
  REMARK    GeneRIF: The BAT2/BAT3 polymorphisms and specifically the A/C
            haplotype may represent a novel immunogenetic factor associated
            with graft rejection in patients undergoing allo-HSCT.
            Erratum:[Bone Marrow Transplant. 2014 Nov;49(11):1452. Nasa, G La
            [corrected to La Nasa, G]]
REFERENCE   4  (bases 1 to 6903)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 6903)
  AUTHORS   Kanazawa,T., Ikeda,M., Glatt,S.J., Tsutsumi,A., Kikuyama,H.,
            Kawamura,Y., Nishida,N., Miyagawa,T., Hashimoto,R., Takeda,M.,
            Sasaki,T., Tokunaga,K., Koh,J., Iwata,N. and Yoneda,H.
  TITLE     Genome-wide association study of atypical psychosis
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (7), 679-686 (2013)
   PUBMED   24132900
REFERENCE   6  (bases 1 to 6903)
  AUTHORS   Singal,D.P., Li,J. and Zhu,Y.
  TITLE     HLA class III region and susceptibility to rheumatoid arthritis
  JOURNAL   Clin Exp Rheumatol 18 (4), 485-491 (2000)
   PUBMED   10949724
REFERENCE   7  (bases 1 to 6903)
  AUTHORS   Hashimoto,M., Nakamura,N., Obayashi,H., Kimura,F., Moriwaki,A.,
            Hasegawa,G., Shigeta,H., Kitagawa,Y., Nakano,K., Kondo,M., Ohta,M.
            and Nishimura,M.
  TITLE     Genetic contribution of the BAT2 gene microsatellite polymorphism
            to the age-at-onset of insulin-dependent diabetes mellitus
  JOURNAL   Hum Genet 105 (3), 197-199 (1999)
   PUBMED   10987645
REFERENCE   8  (bases 1 to 6903)
  AUTHORS   Iris,F.J., Bougueleret,L., Prieur,S., Caterina,D., Primas,G.,
            Perrot,V., Jurka,J., Rodriguez-Tome,P., Claverie,J.M., Dausset,J.
            et al.
  TITLE     Dense Alu clustering and a potential new member of the NF kappa B
            family within a 90 kilobase HLA class III segment
  JOURNAL   Nat Genet 3 (2), 137-145 (1993)
   PUBMED   8499947
REFERENCE   9  (bases 1 to 6903)
  AUTHORS   Banerji,J., Sands,J., Strominger,J.L. and Spies,T.
  TITLE     A gene pair from the human major histocompatibility complex encodes
            large proline-rich proteins with multiple repeated motifs and a
            single ubiquitin-like domain
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2374-2378 (1990)
   PUBMED   2156268
REFERENCE   10 (bases 1 to 6903)
  AUTHORS   Spies,T., Bresnahan,M. and Strominger,J.L.
  TITLE     Human major histocompatibility complex contains a minimum of 19
            genes between the complement cluster and HLA-B
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 8955-8958 (1989)
   PUBMED   2813433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC345271.1, BC042295.1,
            AL662801.7, BC060668.1, AI989927.1 and AA969275.1.
            
            On May 17, 2019 this sequence version replaced NM_004638.3.
            
            Summary: A cluster of genes, BAT1-BAT5, has been localized in the
            vicinity of the genes for TNF alpha and TNF beta. These genes are
            all within the human major histocompatibility complex class III
            region. This gene has microsatellite repeats which are associated
            with the age-at-onset of insulin-dependent diabetes mellitus (IDDM)
            and possibly thought to be involved with the inflammatory process
            of pancreatic beta-cell destruction during the development of IDDM.
            This gene is also a candidate gene for the development of
            rheumatoid arthritis. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376033.3/ ENSP00000365201.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DC345271.1         43-74
            33-1305             BC042295.1         1-1273
            1306-1306           AL662801.7         99522-99522
            1307-1672           BC042295.1         1275-1640
            1673-1673           AL662801.7         100574-100574
            1674-1874           BC042295.1         1642-1842
            1875-1875           AL662801.7         100776-100776
            1876-4751           BC060668.1         1805-4680
            4752-4752           AL662801.7         106238-106238
            4753-5892           BC042295.1         4721-5860
            5893-5893           AL662801.7         108904-108904
            5894-5926           BC042295.1         5862-5894
            5927-5927           AL662801.7         108938-108938
            5928-6802           BC042295.1         5896-6770
            6803-6892           AI989927.1         1-90                c
            6893-6903           AA969275.1         14-24               c
FEATURES             Location/Qualifiers
     source          1..6903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..6903
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /note="proline rich coiled-coil 2A"
                     /db_xref="GeneID:7916"
                     /db_xref="HGNC:HGNC:13918"
                     /db_xref="MIM:142580"
     exon            1..144
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            145..356
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..6718
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /note="large proline-rich protein BAT2; protein G2;
                     HLA-B-associated transcript 2; proline-rich and
                     coiled-coil-containing protein 2A"
                     /codon_start=1
                     /product="protein PRRC2A"
                     /protein_id="NP_004629.3"
                     /db_xref="CCDS:CCDS4708.1"
                     /db_xref="GeneID:7916"
                     /db_xref="HGNC:HGNC:13918"
                     /db_xref="MIM:142580"
                     /translation="MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGL
                     QSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDAST
                     AQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASS
                     LLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDEL
                     EGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTP
                     DGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVD
                     YTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPNSEPPTPKTAW
                     AETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWR
                     QRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEP
                     AAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAA
                     PTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIG
                     PTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPP
                     QPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPP
                     LDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTA
                     TPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPL
                     EEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPP
                     PPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQG
                     DETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGE
                     YFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETR
                     SEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPP
                     SPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPP
                     SKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQ
                     ERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEE
                     WETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAK
                     DLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSP
                     KNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPG
                     GHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAG
                     VSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHI
                     WNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQ
                     RSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQ
                     PLPPGPIGTERSQRTDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKE
                     LTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAG
                     PSSSQISGGAMDSQLHPNSGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQ
                     FLDFSTMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYS
                     TPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPAL
                     QPPSLAVRPPPAPATRVLPSPARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSS
                     RTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVDLYQQASPPDALRWIPKPWERTGPPP
                     REGPSRRAEEPGSRGDKEPGLPPPR"
     exon            357..534
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..634
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..707
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..851
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1003
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1083
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1226
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1317
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1534
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..2009
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2200
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2498
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2709
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..4563
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            4564..4832
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            4833..4963
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            4964..5093
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5179
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5404
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5405..5545
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5546..5617
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5618..5785
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5786..5868
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            5869..6079
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            6080..6178
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            6179..6391
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            6392..6486
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            6487..6577
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     exon            6578..6903
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6889
                     /gene="PRRC2A"
                     /gene_synonym="BAT2; D6S51; D6S51E; G2"
                     /note="major polyA site"
ORIGIN      
        1 agtcggggct cagccgcgga gtgagcgagg gagacgggag gagccgaacc cggcgccatc
       61 cgccgccatc ctcccccgcc ccaccgccat cccgtcccgg ggagccccta ggcccgggtc
      121 ccggatcccc gcgcacccgg ccaggggaca gagactgaga cacttgctgt ctggcccaca
      181 ggctctggca cgttttgggg gaggtgcctg caggacccaa catactcaat gagcttccag
      241 cgcaatgtcc gatcgctcgg ggccgactgc caagggaaag gatggaaaga agtattcctc
      301 gctcaacctg tttgatacgt ataagggcaa gtccttagag atccagaaac ccgctgttgc
      361 ccctcgccat ggcctgcaga gtctcgggaa agttgccatt gcccggcgta tgccacctcc
      421 agccaacctt ccaagcctga aagccgagaa caaaggcaat gaccccaatg tctcactagt
      481 gccaaaagac ggaacaggat gggcaagcaa acaggagcag tccgacccca agagttccga
      541 tgcctcaacc gctcagccgc cggaatcgca gccactgccg gcttcacaga cgcctgcctc
      601 caaccagccg aaacgacccc cagcagcccc cgagaacact cctttggttc caagcggggt
      661 aaagtcctgg gcacaagcca gcgtcaccca tggagcacat ggagatggtg gaagggcatc
      721 aagcctactg tcacgattct ctcgagagga atttccgacc ctgcaggcgg ctggcgacca
      781 ggacaaggct gccaaggaaa gggagtctgc cgaacagtcg tctgggcccg gaccaagcct
      841 ccgcccccaa aattctacaa cttggaggga cggaggtggg cgtggccctg atgagctgga
      901 gggcccggac tccaaacttc atcatggtca tgatccccgg ggtgggctac agccttcagg
      961 cccaccccag ttccctccct accgcggaat gatgccgcct ttcatgtatc ccccatatct
     1021 cccgttccct ccgccctatg gaccccaggg gccttaccga taccccactc ctgatgggcc
     1081 cagccgtttt ccccgtgtgg cgggcccccg aggctcaggg ccaccaatgc gcttagtaga
     1141 gcctgtgggt cgtccctcta ttctcaaaga ggataatctc aaagagtttg atcagttgga
     1201 tcaggagaat gatgatggtt gggcaggggc ccatgaagag gttgactaca ctgaaaagct
     1261 caagttcagc gatgaggaag atgggcgaga ctctgatgag gagggtgctg agggccacag
     1321 ggattcccaa tcagcttctg gtgaggaacg gccccctgaa gcagatggca aaaagggcaa
     1381 ctcccccaac agcgaaccgc ccactcctaa gacggcctgg gcagaaacct ctcggcctcc
     1441 agagacagag ccgggacctc ctgccccaaa gcctccccta cccccacctc accggggccc
     1501 cgccgggaac tggggccccc ctggggacta cccagatcgt gggggtcctc cctgcaagcc
     1561 cccagcacct gaagatgagg atgaggcatg gcggcagcga cgaaagcagt cgtcatctga
     1621 gatttccctg gcagtggagc gggcccggcg acggcgagaa gaagaggagc ggcgcatgca
     1681 agaagagcgc cgggcagcct gtgctgagaa gctcaagcga ctcgatgaaa agtttggggc
     1741 acctgacaag cggctcaaag cagagcctgc tgccccacct gctgcccctt ctaccccagc
     1801 tccaccacct gcagtcccta aagaactccc tgcacctcca gctccacctc cagcatcagc
     1861 cccaacacca gagacagaac ctgaagagcc agcacaggcc cctcctgccc aatctactcc
     1921 tactccaggt gtggctgcgg ctcccactct ggtgagtggt ggtggcagta ccagtagcac
     1981 cagcagtggc agcttcgaag ccagcccagt ggaaccacaa ctgccctcaa aagagggtcc
     2041 tgaaccacca gaagaggttc ctcctcctac cacaccccca gttccaaagg tggaacccaa
     2101 gggtgatggg attggtccca cccgccagcc ccctagtcag ggcttgggct accccaaata
     2161 tcagaagtcg ttgcctcctc gtttccagcg gcagcagcag gagcagctcc tgaagcagca
     2221 gcagcagcac cagtggcagc agcatcaaca gggctctgcc cctcctaccc cagtgccccc
     2281 atcaccacca cagcctgtga ccctgggggc tgtgccagct ccacaggctc cacccccgcc
     2341 ccccaaggcc ctgtacccag gtgctctggg ccggccccca cccatgcccc caatgaactt
     2401 tgatccccga tggatgatga ttcctcctta tgtggacccc cggctcctcc agggtcgtcc
     2461 ccctctagac ttctaccctc ctggtgtgca tccctctggc ctagttcccc gagagcgttc
     2521 agacagtggg ggctcaagct cagagccatt tgaccgtcat gcacctgcta tgttacggga
     2581 acggggcact ccaccggtgg atccaaagtt ggcctgggta ggagatgtct tcaccgccac
     2641 acccgctgaa ccccgcccac ttacctcacc tctgcgccag gctgcggatg aggatgacaa
     2701 ggggatgagg agcgagactc ctccagtacc tcccccacca ccctatctgg ccagttatcc
     2761 aggctttcct gagaatggag cccctgggcc cccaatctct cgctttcctc tggaggaacc
     2821 agggccccgt ccactcccct ggcccccagg cagtgatgaa gtggccaaga tacaaactcc
     2881 accacccaag aaggagcccc ctaaggagga gactgcacag ctgacggggc cagaagcagg
     2941 ccgaaagcct gcccgcggag tcgggagtgg aggccagggc cccccaccac cacgcagaga
     3001 gagtcgcaca gagacccgct ggggccctcg tccagggagc agtcgtcgtg gaatccctcc
     3061 agaggagcca ggggccccac cccgccgggc tgggcctata aagaaacctc caccacctac
     3121 aaaagtagaa gagctgcctc ccaagcccct cgaacagggg gatgaaaccc ccaaaccccc
     3181 aaagccagac ccactcaaga taaccaaggg gaagctaggg ggccccaagg agaccccacc
     3241 caatggaaat ctttcccctg ccccaaggct tcggagggac tattcgtatg aaagagtggg
     3301 tcctacctct tgccggggtc ggggccgagg cgagtatttt gccagaggga ggggttttcg
     3361 ggggacctat gggggacgag ggcggggagc ccgaagccgg gaattccgca gttaccgaga
     3421 gtttcgagga gatgatgggc gtggaggtgg gacaggggga ccaaaccacc ctcctgctcc
     3481 ccgaggccgc actgccagcg agacacggag cgagggttca gagtatgagg aaatccccaa
     3541 gcggcgccgg cagcggggct cagaaacagg cagcgagacc catgagagtg atctggctcc
     3601 ttcagacaag gaggctccca cacccaagga gggaacactc acccaggtcc ctctcgctcc
     3661 cccaccacca ggagccccac cttcaccagc cccagcccgc ttcactgccc ggggtgggcg
     3721 agtcttcact cccagagggg tgccatctcg ccggggccga ggaggaggga ggccccctcc
     3781 tcaagtttgc ccaggctgga gccctccagc caagtctctg gctcccaaga aacctcccac
     3841 aggccctttg ccaccaagta aggagccttt gaaagagaag ttgatcccag ggcctctgtc
     3901 ccctgtggcg cgcggaggca gcaatggagg tagcaatgtg ggcatggaag atggggagcg
     3961 accccgaagg aggcgacatg ggagggctca gcagcaggat aaaccgcctc gtttccggag
     4021 gctgaagcag gaacgggaga atgccgcaag ggggtctgag ggcaagccct ccctaaccct
     4081 tccagcctcc gctcctggac ctgaggaggc cctcacaaca gtcacagtgg ccccagcacc
     4141 tcgccgggca gctgccaagt ctcctgatct gtcaaaccag aactcagacc aagccaatga
     4201 ggaatgggag actgcatcag agagcagtga cttcaccagt gagcgccgag gggacaaaga
     4261 ggcaccccca ccagtactgc tgacacccaa ggctgtggga actcctgggg gaggtggagg
     4321 tggagccgta ccaggtattt cagccatgtc ccgcggagat ctgagccaga gagccaagga
     4381 tttgagtaaa cggagcttct caagtcagcg gccaggcatg gaacggcaga atcggcgccc
     4441 tggcccaggg ggcaaggctg gcagcagtgg cagcagcagt ggaggaggcg gtgggggtcc
     4501 tggaggaagg accgggccag gacgaggcga caagaggagc tggccctctc ccaagaaccg
     4561 aagtcgtcct ccagaggagc gtcccccggg gcttcccctg cctcccccac ctcccagcag
     4621 ttctgctgtc ttccgcctgg accaagttat ccacagcaac cctgctggca tccaacaggc
     4681 tctggcccag cttagtagcc gtcaagggag tgtaactgca ccagggggtc atccaaggca
     4741 caagcctggg cttccccaag cccctcaggg cccctctcct aggcccccaa cccgatacga
     4801 gccccagagg gtcaacagcg gcctcagttc tgacccccac tttgaggagc cggggccaat
     4861 ggtgagaggg gtgggtggga ctcctcggga ctctgccggg gttagtccct ttccccctaa
     4921 acgtcgggag cggcctccca gaaaaccaga gctgctacag gaggaatctt tgccacctcc
     4981 tcatagctct ggattcttgg gctctaagcc tgagggccca ggccctcagg cagagtccag
     5041 agatacaggc acagaggccc tgacccctca catctggaac cgtttacata ctgccactag
     5101 ccgaaagagt taccggccca gctccatgga gccttggatg gagcccctga gtccttttga
     5161 ggatgtggct ggcacagaaa tgagtcagtc tgacagtggg gtggacctga gtggggattc
     5221 tcaggtgtca tcaggtccct gcagccagcg aagttcccct gatggaggac tcaagggggc
     5281 agcagaggga ccccccaaga ggcctggagg ctcctcaccc ctgaatgctg ttccttgtga
     5341 gggtccacct ggctctgaac ctcctaggag accaccacct gccccccacg atggggacag
     5401 aaaggagctg ccccgggagc agcctctgcc ccctggcccc attggcacag aacgatcaca
     5461 gcgtacagac cgaggcacag agcctggccc cattcggcca tcccatcgac ctggtccccc
     5521 agtccagttt ggcactagtg acaaggactc agacttacgc ctagtggtag gagacagctt
     5581 gaaagcagag aaggagctaa cagcatcagt cactgaggcc attcctgtat cacgagactg
     5641 ggagctgctt cccagtgctg ctgcctctgc tgagccacaa tccaagaacc tggattctgg
     5701 gcactgtgtc ccggagccca gctcctcagg ccagcgcctg tatcctgagg ttttctatgg
     5761 cagtgctggg ccttccagtt ctcagatctc tgggggagcc atggactctc aattacatcc
     5821 aaacagtgga ggcttccgcc ctgggacacc ctcactgcac ccttacagat cacagcccct
     5881 atacctaccc cccggcccag cccctccctc agcactgctc tctgggttag ctctcaaggg
     5941 ccagtttctg gatttctcca caatgcaagc tacagagctg gggaagttgc cggctggagg
     6001 agttctctac cctccacctt ccttcctcta ctctccggct ttctgcccca gtcctttgcc
     6061 tgacacatcg ttgcttcagg tacgccagga tctgccatcc ccttcggatt tttattctac
     6121 tcctctgcag cctggtggcc aaagtggctt tctcccttca ggggctcctg cccagcagat
     6181 gcttctaccc atggtagact cacagctgcc tgtggtgaac tttggctccc tgccgccagc
     6241 accacctcct gccccacctc ccctttctct gttacctgtg ggccctgctc tgcagccccc
     6301 cagcctggct gtgcggcccc cacctgctcc tgctactcgg gtgctgcctt cacctgccag
     6361 gcccttcccc gctagcttgg ggcgagcaga gctgcatcca gtggaactaa agccgttcca
     6421 ggattatcaa aaactgagca gcaaccttgg gggacctgga tcatcacgga ctcccccaac
     6481 tggaaggtcc ttctctggcc tcaattcccg tctcaaggcc acgccttcca cctacagtgg
     6541 agtcttccgc acccagcgcg tcgaccttta ccagcaggcc tccccaccag atgccctgcg
     6601 ctggatacct aagccttggg agcggacagg gccgccacct cgagaagggc cctcccgacg
     6661 ggcagaggag cctgggtccc gaggggacaa ggagcctggg ttgcccccac cccgctgagg
     6721 gagttcctct tgccccctac ccccggggct tgtatataga ttataaatat ataaggggga
     6781 aaggggtggg cggggagggg ttctggggct ggggcctcac ttcccctcct cccccttccc
     6841 ctggtcccct gtccctgggg ctgtttgtta aaaaagagta ataaaaggat ttaaaaaaaa
     6901 aaa
//
