LOCUS       NM_130809               4664 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens proline rich coiled-coil 1 (PRRC1), transcript variant
            2, mRNA.
ACCESSION   NM_130809
VERSION     NM_130809.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4664)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4664)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4664)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4664)
  AUTHORS   Hosp,F., Vossfeldt,H., Heinig,M., Vasiljevic,D., Arumughan,A.,
            Wyler,E., Landthaler,M., Hubner,N., Wanker,E.E., Lannfelt,L.,
            Ingelsson,M., Lalowski,M., Voigt,A. and Selbach,M.
  CONSRTM   Genetic and Environmental Risk for Alzheimer's Disease GERAD1
            Consortium
  TITLE     Quantitative interaction proteomics of neurodegenerative disease
            proteins
  JOURNAL   Cell Rep 11 (7), 1134-1146 (2015)
   PUBMED   25959826
REFERENCE   5  (bases 1 to 4664)
  AUTHORS   Kamakari,S., Roussou,A., Jefferson,A., Ragoussis,I. and
            Anagnou,N.P.
  TITLE     Structural analysis and expression profile of a novel gene on
            chromosome 5q23 encoding a Golgi-associated protein with six splice
            variants, and involved within the 5q deletion of a Ph(-) CML
            patient
  JOURNAL   Leuk Res 29 (1), 17-31 (2005)
   PUBMED   15541471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA808343.1, BC017066.1 and AC010424.9.
            
            On Jun 2, 2019 this sequence version replaced NM_130809.4.
            
            Transcript Variant: (2) has multiple differences in the coding
            region, compared to variant 1. This variant encodes isoform 2,
            which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.56910.1,
                                           SRR1803615.115533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296666.13/ ENSP00000296666.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA808343.1         32-63
            33-1455             BC017066.1         1-1423
            1456-4664           AC010424.9         120795-124003
FEATURES             Location/Qualifiers
     source          1..4664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..4664
                     /gene="PRRC1"
                     /note="proline rich coiled-coil 1"
                     /db_xref="GeneID:133619"
                     /db_xref="HGNC:HGNC:28164"
     exon            1..137
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..260
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1495
                     /gene="PRRC1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein PRRC1; proline-rich and coiled-coil-containing
                     protein 1"
                     /codon_start=1
                     /product="protein PRRC1 isoform 2"
                     /protein_id="NP_570721.1"
                     /db_xref="CCDS:CCDS4143.1"
                     /db_xref="GeneID:133619"
                     /db_xref="HGNC:HGNC:28164"
                     /translation="MMEESGIETTPPGTPPPNPAGLAATAMSSTPVPLAATSSFSSPN
                     VSSMESFPPLAYSTPQPPLPPVRPSAPLPFVPPPAVPSVPPLVTSMPPPVSPSTAAAF
                     GNPPVSHFPPSTSAPNTLLPAPPSGPPISGFSVGSTYDITRGHAGRAPQTPLMPSFSA
                     PSGTGLLPTPITQQASLTSLAQGTGTTSAITFPEEQEDPRITRGQDEASAGGIWGFIK
                     GVAGNPMVKSVLDKTKHSVESMITTLDPGMAPYIKSGGELDIVVTSNKEVKVAAVRDA
                     FQEVFGLAVVVGEAGQSNIAPQPVGYAAGLKGAQERIDSLRRTGVIHEKQTAVSVENF
                     IAELLPDKWFDIGCLVVEDPVHGIHLETFTQATPVPLEFVQQAQSLTPQDYNLRWSGL
                     LVTVGEVLEKSLLNVSRTDWHMAFTGMSRRQMIYSAARAIAGMYKQRLPPRTV"
     exon            261..650
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..811
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..914
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1078
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1182
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1285
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..4664
                     /gene="PRRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1885
                     /gene="PRRC1"
     regulatory      4640..4645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRRC1"
                     /note="hexamer: AATAAA"
     polyA_site      4664
                     /gene="PRRC1"
                     /note="major polyA site"
ORIGIN      
        1 atcttgtagg cggggacacg ccgaggtaac ttccagggtg cgccttcgtt gtcttctcca
       61 agctgtagtt ctacgtcccg acctccctat cataccacac tcttcagcga ccacgcaggc
      121 actttcccgg tccccagtat accataattg aagaaaaatg atggaagaga gtggaataga
      181 gacaacacca cctgggactc ctccaccaaa tcctgcaggg ctggctgcta ctgctatgtc
      241 ttctacccct gttccattag cggcaaccag ttctttttct tctccaaatg tatcctccat
      301 ggagtccttc ccaccactcg catactctac tcctcagccg ccccttcctc ctgtgaggcc
      361 ttcagcacca ttaccttttg tgcctcctcc tgcagttcct tctgtcccac cacttgttac
      421 ttctatgcca cctcctgttt ctccatcaac tgctgctgcc ttcggtaatc ctcctgtatc
      481 tcacttccca ccttcaactt ctgccccaaa cactctttta cctgcacccc cttcgggtcc
      541 tcctatatca ggattttctg ttggttcaac ttatgacatt acaaggggac atgctgggag
      601 agctccccag acacccctga tgccatcatt ttctgcacct tcaggaacag gtcttttgcc
      661 aactcctatt actcagcaag ccagtttgac atctctggca cagggaactg gaaccacatc
      721 agccattact ttcccagagg agcaagaaga ccctagaatt actagaggtc aggatgaagc
      781 atctgctggt ggaatctggg gttttattaa gggtgtggct gggaatccta tggtgaagtc
      841 tgtgcttgat aagacaaaac attcagtaga aagcatgatt acaacgctgg accctggcat
      901 ggctccctat atcaaatctg gaggtgaact ggatattgta gtgacctcaa ataaagaagt
      961 aaaagttgct gctgtccgag atgccttcca ggaggtcttt ggcttagctg tggttgtagg
     1021 ggaagctgga cagtccaata ttgccccaca accagtgggc tatgcagctg gattaaaagg
     1081 tgctcaggaa cggatagata gcttgcgtcg aactggggtg atccatgaaa aacagacagc
     1141 tgtgtcagta gaaaacttca ttgcagaatt gctgcctgac aaatggtttg acattggttg
     1201 tttggtggtt gaagatcctg tccatggcat tcatctagaa acatttacac aagccacacc
     1261 agtgcctttg gaatttgtac agcaggctca aagtctaact ccccaggact ataatctgag
     1321 gtggtcaggc cttttggtga cagtgggtga agtcctggaa aagagtttac tgaatgtcag
     1381 ccggactgat tggcacatgg catttactgg gatgtcccgt cggcagatga tctacagtgc
     1441 agccagagcg atagcgggca tgtataaaca gcgcctgcca cccaggacag tgtgagagga
     1501 gacctacctg ggagactgag actttccccc acttttagct tgatgttaaa gaagtggttg
     1561 taccttccta aatcgaatag tctaaatgaa tccagtagtt tttatcattt tcctgtagcc
     1621 tgcaattttt ctttctctag aaaggcatca tgtcattcca ggagacaaaa agaaacaaat
     1681 cctttttata gtcataccat ttcacctatc atagtactca aaaaagaaaa tatacaaatc
     1741 tatttacagc acaatttaat ataccagatt tataaggtgg aaattcatgt gcagagacat
     1801 ttaacttaat gccatgtact tgattatttt gttctttaaa gaagacatta ttaaagaaca
     1861 tgttggttga atgtttataa aagcatgatt tgctttggct tcatctcttt tctgtcagtc
     1921 tttgactact tttgtatgtg cacacgatct cagggctggt gctgagcagc ctgctcaaca
     1981 gtcactataa gacacctact tgtcgggaga tgttccacat ttctgtgcat gttttcagta
     2041 atatgggcca aaataatgga attgattatt ttcctttttg gccatcacgt acacatgtaa
     2101 tctggaaaat catacctttg tcaattttaa acataacttt tggcatttcc cagatttata
     2161 ctatgaacat tggggtaata cattttattt tttcattgct atatgacagc taaggggcaa
     2221 atgattcaag tatattttaa atcagaagta ttcaaattat ttttgtataa tactgttcag
     2281 tacttccaag aataagctct gacaacagcc attgtttctg cttccactca tattctctac
     2341 acattttaat acagaaattt ttgagagggg gttactttat tgcttgtggg ttagtatgtc
     2401 tcttacttca attaaggtta cttatttggt ttgccttaag cattactttt ttaactttgt
     2461 gccatttggt ctttactttt tatggatgtt ttcaaagaaa ctattttata ttcaatctag
     2521 tttatttagt ctactgtatt tctatttcgt ggaagccttt tcccctcaaa taatatatta
     2581 tatcattttt ggacttatat aaatgataat taaataaatt tttttcttaa tactgttgga
     2641 ctttgtatat acaagttcaa ataacttttt cgaagatagt ttcttatata aatgtaattt
     2701 aattttttta ctcttctata cagttcttta gatgtaaaag aattagcaca atctctggca
     2761 gttttataaa agctgttgaa gctcttgtcc tgcactgtct ttaggtatca taggtatcag
     2821 gtttgctttg tgttaatgcc acttcaagtc attatttggt ttctgctatt tttttacctg
     2881 aggataagaa gaatgaatat taaatttgaa tattaaatat atgttacttt ccaagcactg
     2941 tataatgact gttcagtgaa tatcagactt ccgtgtcatt aaaagtcatg agagacagca
     3001 cagagaggtt ataggttgcc ttggtgtact tttgtccagg agtaacaggg acagaatact
     3061 ttctttcttt ccttcaagta caagaaggct ttctctacca tttgcgtcta cactttattt
     3121 taaaagctat ccttttctag tagtatttta tcatggcaat ggcatgatga caacaacagt
     3181 ctttcattac agactgaagg gaagcatgtc cttacttaaa atagttctgc tactttccct
     3241 cctattataa ggaaatctta cagattctaa aaatacctta atttttcttt gatttttatt
     3301 ttaccaagtc acaaatgtct ttttgatgtt ttgagaattg ttctcataga atcacaaata
     3361 ctgacatttc attagatgat tattttccta gaatccccaa agagcagtgg cagtccatgg
     3421 cttggttgaa gctagaaatt ttcctgcccc tggtgacctg gtaagcctcc tgctcggaac
     3481 cgtgtgagtg ggtgaggaag atgagagatg gtcagatgga agagagaaat acatgaactg
     3541 ctctggcctc tctggttctg ttcttggccc agagtttttg aaaagcagcg gagcatgact
     3601 gacttcacat gctcagcttt ctcagccttt tgtttatttt gttgtcctta gatttccctg
     3661 ttgtaaaagg ggcaagaaaa gtaactcatc atctctaaca caccatggca gcttagccag
     3721 gtagtcttag tggtggtgtt taggcataag atatgctgat catcagtctc aggccacagt
     3781 ttccttcact aatcgtccag cttgagtgtt ctgttctctt cctgcccatt tccttgaacc
     3841 tcctgctcta gccttggcgg agggagagtg ctatttgctt ttgttctccc tctgtcttag
     3901 gaaaagccat ctttaatata gttcttcacc actgttgggg ttgttttgtg attttttttt
     3961 tcttccgaag aactcctggt tgttattgga ttttgtattt taatacaaat tattgaattt
     4021 tataagcttg tacacaatat ttaattagtg tgaaaggaaa caaagaatgc aggaaaaata
     4081 atttaatatc aacctcagtt gacaaggtgc tcagattatt caattcggga tcctcctttt
     4141 gttaggtttt tgagacaacc ctagacctaa actgtgtcac agacttctga atgtttaggc
     4201 agtgctagta atttcctcgt aatgattctg ttattacttt cctattcttt attcctcttt
     4261 cttctgaaga ttaatgaagt tgaaaattga ggtggataaa tacaaaaagg tagtgtgata
     4321 gtataagtat ctaagtgcag atgaaagtgt gttatataca tccattcaaa attatgcaag
     4381 ttagtaatta ctcagggtta actaaattac tttaatatgc tgttgaatct actctgttcc
     4441 ttggctagaa aaaattataa acaggacttt gtagtttggg aagccaaatt gataatattc
     4501 tatgttctaa aagttgggct atacataaat tattaagaaa tatggatttt tattcccagg
     4561 atatggtgtt cattttatga tattacgcag gatgatgtat tgagtaaaat cagttttgta
     4621 aatatgtaaa tatgtcataa ataaacaatg ctttgactta tttc
//
