LOCUS       NM_001160168            3363 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens proline rich 5 like (PRR5L), transcript variant 3,
            mRNA.
ACCESSION   NM_001160168
VERSION     NM_001160168.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3363)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3363)
  AUTHORS   Gan,X., Wang,J., Wang,C., Sommer,E., Kozasa,T., Srinivasula,S.,
            Alessi,D., Offermanns,S., Simon,M.I. and Wu,D.
  TITLE     PRR5L degradation promotes mTORC2-mediated PKC-delta
            phosphorylation and cell migration downstream of Galpha12
  JOURNAL   Nat Cell Biol 14 (7), 686-696 (2012)
   PUBMED   22609986
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3363)
  AUTHORS   Holmes,B., Artinian,N., Anderson,L., Martin,J., Masri,J.,
            Cloninger,C., Bernath,A., Bashir,T., Benavides-Serrato,A. and
            Gera,J.
  TITLE     Protor-2 interacts with tristetraprolin to regulate mRNA stability
            during stress
  JOURNAL   Cell Signal 24 (1), 309-315 (2012)
   PUBMED   21964062
  REMARK    GeneRIF: Protor-2 associates with tristetraprolin (TTP) to
            accelerate TTP-mediated mRNA turnover and functionally links the
            control of TTP-regulated mRNA stability to mTORC2 activity
REFERENCE   4  (bases 1 to 3363)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3363)
  AUTHORS   Pearce,L.R., Huang,X., Boudeau,J., Pawlowski,R., Wullschleger,S.,
            Deak,M., Ibrahim,A.F., Gourlay,R., Magnuson,M.A. and Alessi,D.R.
  TITLE     Identification of Protor as a novel Rictor-binding component of
            mTOR complex-2
  JOURNAL   Biochem J 405 (3), 513-522 (2007)
   PUBMED   17461779
  REMARK    GeneRIF: It was demonstrated that immunoprecipitation of Protor-1
            or Protor-2 results in the co-immunoprecipitation of other mTORC2
            subunits, but not Raptor, a specific component of mTORC1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA458327.1, AK024275.1, AC009656.11 and BX640959.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001160168.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. These
            differences cause translation initiation at an alternate AUG and a
            shorter isoform (b) compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024275.1, AU131980.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DA458327.1         1-53
            54-816              AK024275.1         1-763
            817-2916            AC009656.11        75413-77512
            2917-3363           BX640959.1         3485-3931
FEATURES             Location/Qualifiers
     source          1..3363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13-p12"
     gene            1..3363
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="proline rich 5 like"
                     /db_xref="GeneID:79899"
                     /db_xref="HGNC:HGNC:25878"
                     /db_xref="MIM:611728"
     exon            1..174
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..895
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="isoform b is encoded by transcript variant 3;
                     Protein observed with Rictor-2; protor-2; proline-rich
                     protein 5-like"
                     /codon_start=1
                     /product="proline-rich protein 5-like isoform b"
                     /protein_id="NP_001153640.1"
                     /db_xref="GeneID:79899"
                     /db_xref="HGNC:HGNC:25878"
                     /db_xref="MIM:611728"
                     /translation="MRLLKSELGSFITDYFQNQLLAKGLFFVEEKIKLCEGENRIEVL
                     AEVWDHFFTETLPTLQAIFYPVQSVHEPTGPSESYLQLEELVKQVVSPFLGISGDRSF
                     SGPTYTLARRHSRVRPKVTVLNYASPITAVSRPLNEMVLTPLTEQEGEAYLEKCGSVR
                     RHTVANAHSDIQLLAMATMMHSGLGEEASSENKCLLLPPSFPPPHRQCSSEPNITDNP
                     DGLEEGARGSQEGSELNCASLS"
     exon            175..223
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..281
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..373
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..500
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..3363
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3339..3344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="hexamer: AATAAA"
     polyA_site      3363
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="major polyA site"
ORIGIN      
        1 gcttggcagt ttcccattgc ggggcagctg ggccgggggc gggggtcggc tgcagatctc
       61 ccgttgtgtg agagaaacgc aagcacggag ctcccttgac ctgctgcatc ctcctcggca
      121 attttttttt tttaagtcaa aaagcttgga tttcctgaaa ttgttgaact ggatgcggct
      181 gttgaagagt gaacttggat cattcattac agactatttt cagaaccagc ttcttgcaaa
      241 aggactgttc tttgtggagg agaagatcaa gctgtgtgaa ggtgaaaatc gcattgaggt
      301 tctggctgaa gtctgggacc acttcttcac tgagactctc cctaccctgc aggcaatatt
      361 ttatccagtt cagagtgttc acgagcccac aggcccaagt gagagttatt tgcaactgga
      421 ggagctggtg aagcaagtgg tttctccttt cctcggcatc agcggggacc gtagcttctc
      481 aggccccacg tacacgctgg ccaggcggca ctccagggtc cggcccaagg tgactgtcct
      541 gaactatgcc tccccgataa ccgcagtcag ccggccactg aatgagatgg tcttgacccc
      601 actgacagag caggaggggg aagcctacct ggagaagtgt ggcagcgtgc ggcggcacac
      661 ggtggccaat gcccactcgg acatccagct gctggccatg gccaccatga tgcactcggg
      721 cctgggggag gaggccagca gtgagaacaa gtgcctgctc ctgccaccca gcttcccccc
      781 gccccaccgg cagtgctcca gtgagcccaa catcactgac aaccctgacg gactggagga
      841 gggggccagg ggcagccagg agggctcgga gctgaactgt gcttccctca gctgagtcgc
      901 cacccctggg cctttccatc tcctgttttg caaccaggat gaggacccct ccatctccgt
      961 ggattactga ggggggctct tgctttatgc gatgctgcct tatttccttt agggtactgt
     1021 cctggtcaaa atgacctaag gggaaaccgt tgttgtaaac ctctttattt tggtgactgt
     1081 gaccacttct ttgtagccac caattgtagt gaccagttgc ctaatggtca ctttctgact
     1141 ccagccttgc cagcctgact cagatcctca tctctgggcc tttctccctc cgatgttgga
     1201 ctgcctgatg ctcccaatga catatccaat gctcctggca tttctggagc aggaggttgt
     1261 caggacaaca catataacca ccaaggatgt gttggccttt ggagttcccc tttaggttcc
     1321 tagtgatgtg gaggtttatg ggtgaaaaat tagtggagag ggaactcctc tcccccattt
     1381 tgtgtagagt gaaaatagcc tgaagcccct actcagcagg gctctgggaa tgtgccttcc
     1441 ttattttagt ttcagaattg ctgggaaagt taccccactg gtgggtgagg atctatcctc
     1501 aacctacatc cagatcctat gtgctgcttg cacagaggcc tttggctttt gacccaggag
     1561 ggccgcgagg ctggagctgc cctgtctttc attgagcctt agcatttccc tctcaggctt
     1621 cctctcaagc tcaaggaact cacccccaga taagaagctg gtgcctcttg tctctctcat
     1681 ttcagaaacg gactttctca tcatgctttc ctatggtggg tatgaggggc cagctgatac
     1741 caaccaactg gcctgtatct atctatctgg atttgacttg aatttttaaa atgtgtatcg
     1801 tttaaaaaaa aaaatgtttg caaattttgc acataggatc ttgcactgtt cattttcagt
     1861 ggggtgagtc ttcacactaa aaacacaagc agagctcctg ggaaaagaga ctggaagtgg
     1921 ttcaggataa agagatccat ggtgggcagg gctgttaggt cacagagctc tagaagcagc
     1981 tggacttgaa cccacaatgg cttgtgtaaa ttcgtaaatt tcatggtttc taggaaaagc
     2041 tgcattgggg tggggagacc cagtttgcct cataggcaga ggattctcca ggaagcatgg
     2101 aaaatggaat gtttccatgc tttacagtgc tgggagagag gggagatgtg ggcaggacct
     2161 tttggaagga tgtttattct ctgtggttaa agaaatgctg agaatttcta gcatgtgaag
     2221 cacttggggg cagcaggcct tggcacggtg ctgcatcctt ctactgctcc ctccaggtct
     2281 gggggctttt atccaccttg aatccctatc ctcctctttg tagttgtcgg tctcactgat
     2341 aacagctcca gaaaaaaaga caaggctccc cctctgaccc ttcctgttgg tatttatgaa
     2401 atctcaaaga gatgagccac cttggcttcc aatatggcaa gagggtgctg ggagaaggtg
     2461 aagatcagtc taagctgcca cggtgatgag accttctcat tatgtaactc ttgatggcat
     2521 ttcccttctg agtgaagatt tgaaatatga ttgattagaa ttgtgctctt gatggctggg
     2581 aatttagaaa ttttatttta agagttattt cattttcatc ctaagagtga tgggagagaa
     2641 atgtccaaaa gagatctgct gatctgctga gagtttcaaa caaacaaaaa aataatctct
     2701 atgtatgtgt tggataaagt ctacagactg actaacatgc attagcaaat ggagcatcag
     2761 taggtagcaa catgataatt tatgtaactg atagcttctg tccttattag tacacttaac
     2821 atttgagact agtatttatt gatccaggca aagtaattaa ttaatcatgc ttgggcttac
     2881 tttttcagtt tgtaaggtta agcatatgtg catgcgtgcg tgtgtatata aatgcctttt
     2941 ccatatctta aatgtccctg atgaggagag cagtcatcaa ttaaatatat aagctcttaa
     3001 aatgagaatg gaagtgtcag tatagaccca gtgtacttaa gtgctgatga ctgttagcca
     3061 gtttacaact ttttaccatc gatgtacaca tttgatattt gtgcagtaaa tagactgtac
     3121 ctataaaaaa ttttattgat gtttatggtc atgttagcta tcagagagct attggagtga
     3181 gagctgaggt gtccttaacc actttttctc tcctagattc attttcatta tttatgctag
     3241 gattttctta tggttgacat ttgatgacag gaagcaatca tgactcttca agtgagctca
     3301 cagaaacctt tcatgttgtc tgtttccaaa atggattcaa taaacaacat tttgtccatg
     3361 tta
//
