LOCUS       NM_001160167            3851 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline rich 5 like (PRR5L), transcript variant 1,
            mRNA.
ACCESSION   NM_001160167
VERSION     NM_001160167.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Gan,X., Wang,J., Wang,C., Sommer,E., Kozasa,T., Srinivasula,S.,
            Alessi,D., Offermanns,S., Simon,M.I. and Wu,D.
  TITLE     PRR5L degradation promotes mTORC2-mediated PKC-delta
            phosphorylation and cell migration downstream of Galpha12
  JOURNAL   Nat Cell Biol 14 (7), 686-696 (2012)
   PUBMED   22609986
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Holmes,B., Artinian,N., Anderson,L., Martin,J., Masri,J.,
            Cloninger,C., Bernath,A., Bashir,T., Benavides-Serrato,A. and
            Gera,J.
  TITLE     Protor-2 interacts with tristetraprolin to regulate mRNA stability
            during stress
  JOURNAL   Cell Signal 24 (1), 309-315 (2012)
   PUBMED   21964062
  REMARK    GeneRIF: Protor-2 associates with tristetraprolin (TTP) to
            accelerate TTP-mediated mRNA turnover and functionally links the
            control of TTP-regulated mRNA stability to mTORC2 activity
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3851)
  AUTHORS   Pearce,L.R., Huang,X., Boudeau,J., Pawlowski,R., Wullschleger,S.,
            Deak,M., Ibrahim,A.F., Gourlay,R., Magnuson,M.A. and Alessi,D.R.
  TITLE     Identification of Protor as a novel Rictor-binding component of
            mTOR complex-2
  JOURNAL   Biochem J 405 (3), 513-522 (2007)
   PUBMED   17461779
  REMARK    GeneRIF: It was demonstrated that immunoprecipitation of Protor-1
            or Protor-2 results in the co-immunoprecipitation of other mTORC2
            subunits, but not Raptor, a specific component of mTORC1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055042.1, DA344861.1, DA449593.1, AC009656.11 and BX640959.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001160167.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Both variants 1 and
            2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055042.1, SRR1803612.199352.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530639.6/ ENSP00000435050.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               AK055042.1         1-396
            397-521             DA344861.1         397-521
            522-915             AK055042.1         522-915
            916-1304            DA449593.1         64-452
            1305-3404           AC009656.11        75413-77512
            3405-3851           BX640959.1         3485-3931
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13-p12"
     gene            1..3851
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="proline rich 5 like"
                     /db_xref="GeneID:79899"
                     /db_xref="HGNC:HGNC:25878"
                     /db_xref="MIM:611728"
     exon            1..151
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..440
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1383
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="isoform a is encoded by transcript variant 1;
                     Protein observed with Rictor-2; protor-2; proline-rich
                     protein 5-like"
                     /codon_start=1
                     /product="proline-rich protein 5-like isoform a"
                     /protein_id="NP_001153639.1"
                     /db_xref="CCDS:CCDS31463.1"
                     /db_xref="GeneID:79899"
                     /db_xref="HGNC:HGNC:25878"
                     /db_xref="MIM:611728"
                     /translation="MTRGFAPILPVEFHKMGSFRRPRPRFMSSPVLSDLPRFQAARQA
                     LQLSSSSAWNSVQTAVINVFKGGGLQSNELYALNENIRRLLKSELGSFITDYFQNQLL
                     AKGLFFVEEKIKLCEGENRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLL
                     GFRDLVLLKVKLGDLLLLAQSKLPSSIVQMLLILQSVHEPTGPSESYLQLEELVKQVV
                     SPFLGISGDRSFSGPTYTLARRHSRVRPKVTVLNYASPITAVSRPLNEMVLTPLTEQE
                     GEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEEASSENKCLLLPPSFPPPHR
                     QCSSEPNITDNPDGLEEGARGSQEGSELNCASLS"
     exon            441..521
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..570
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..628
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..720
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..861
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..988
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..3851
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3827..3832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="hexamer: AATAAA"
     polyA_site      3851
                     /gene="PRR5L"
                     /gene_synonym="PROTOR2"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcagg ccccaggtca gtgagtggca agccaggccc agagatctct gcgcccgttg
       61 gaacatcccc ttctcgggag gctggaaggc catggtcatt cacctctccc cagcaaggtg
      121 ggacctgccc tggaagaaga aaccagacca ggtgttggct acgtttgtgg ttttaagaaa
      181 gcctgagggc ctgaaggcag cccctggaga agccctttcc gagggcattc ggaaccttct
      241 ggtcctagag gtgaagctga actgtcacca ggacttatga cccgcggctt cgctcccatt
      301 ctgcccgtcg agttccacaa gatgggctcc ttccgcaggc ctagaccgcg cttcatgagc
      361 tcccccgtgc tcagcgacct tccccgattc caagcagctc ggcaggctct gcagctgagc
      421 tccagctcag cctggaacag cgttcagact gctgtgatca acgttttcaa agggggtggc
      481 ttgcaaagca acgagctcta tgccctgaac gaaaacatca ggcggctgtt gaagagtgaa
      541 cttggatcat tcattacaga ctattttcag aaccagcttc ttgcaaaagg actgttcttt
      601 gtggaggaga agatcaagct gtgtgaaggt gaaaatcgca ttgaggttct ggctgaagtc
      661 tgggaccact tcttcactga gactctccct accctgcagg caatatttta tccagttcag
      721 ggccaggagc tgactatccg ccagatctcc ctgctgggct tccgagacct agtcttgctg
      781 aaggtgaagc tgggtgacct gctgctgctg gcccagtcca agctgccctc gtccattgtc
      841 cagatgttgc tcatcctgca gagtgttcac gagcccacag gcccaagtga gagttatttg
      901 caactggagg agctggtgaa gcaagtggtt tctcctttcc tcggcatcag cggggaccgt
      961 agcttctcag gccccacgta cacgctggcc aggcggcact ccagggtccg gcccaaggtg
     1021 actgtcctga actatgcctc cccgataacc gcagtcagcc ggccactgaa tgagatggtc
     1081 ttgaccccac tgacagagca ggagggggaa gcctacctgg agaagtgtgg cagcgtgcgg
     1141 cggcacacgg tggccaatgc ccactcggac atccagctgc tggccatggc caccatgatg
     1201 cactcgggcc tgggggagga ggccagcagt gagaacaagt gcctgctcct gccacccagc
     1261 ttccccccgc cccaccggca gtgctccagt gagcccaaca tcactgacaa ccctgacgga
     1321 ctggaggagg gggccagggg cagccaggag ggctcggagc tgaactgtgc ttccctcagc
     1381 tgagtcgcca cccctgggcc tttccatctc ctgttttgca accaggatga ggacccctcc
     1441 atctccgtgg attactgagg ggggctcttg ctttatgcga tgctgcctta tttcctttag
     1501 ggtactgtcc tggtcaaaat gacctaaggg gaaaccgttg ttgtaaacct ctttattttg
     1561 gtgactgtga ccacttcttt gtagccacca attgtagtga ccagttgcct aatggtcact
     1621 ttctgactcc agccttgcca gcctgactca gatcctcatc tctgggcctt tctccctccg
     1681 atgttggact gcctgatgct cccaatgaca tatccaatgc tcctggcatt tctggagcag
     1741 gaggttgtca ggacaacaca tataaccacc aaggatgtgt tggcctttgg agttcccctt
     1801 taggttccta gtgatgtgga ggtttatggg tgaaaaatta gtggagaggg aactcctctc
     1861 ccccattttg tgtagagtga aaatagcctg aagcccctac tcagcagggc tctgggaatg
     1921 tgccttcctt attttagttt cagaattgct gggaaagtta ccccactggt gggtgaggat
     1981 ctatcctcaa cctacatcca gatcctatgt gctgcttgca cagaggcctt tggcttttga
     2041 cccaggaggg ccgcgaggct ggagctgccc tgtctttcat tgagccttag catttccctc
     2101 tcaggcttcc tctcaagctc aaggaactca cccccagata agaagctggt gcctcttgtc
     2161 tctctcattt cagaaacgga ctttctcatc atgctttcct atggtgggta tgaggggcca
     2221 gctgatacca accaactggc ctgtatctat ctatctggat ttgacttgaa tttttaaaat
     2281 gtgtatcgtt taaaaaaaaa aatgtttgca aattttgcac ataggatctt gcactgttca
     2341 ttttcagtgg ggtgagtctt cacactaaaa acacaagcag agctcctggg aaaagagact
     2401 ggaagtggtt caggataaag agatccatgg tgggcagggc tgttaggtca cagagctcta
     2461 gaagcagctg gacttgaacc cacaatggct tgtgtaaatt cgtaaatttc atggtttcta
     2521 ggaaaagctg cattggggtg gggagaccca gtttgcctca taggcagagg attctccagg
     2581 aagcatggaa aatggaatgt ttccatgctt tacagtgctg ggagagaggg gagatgtggg
     2641 caggaccttt tggaaggatg tttattctct gtggttaaag aaatgctgag aatttctagc
     2701 atgtgaagca cttgggggca gcaggccttg gcacggtgct gcatccttct actgctccct
     2761 ccaggtctgg gggcttttat ccaccttgaa tccctatcct cctctttgta gttgtcggtc
     2821 tcactgataa cagctccaga aaaaaagaca aggctccccc tctgaccctt cctgttggta
     2881 tttatgaaat ctcaaagaga tgagccacct tggcttccaa tatggcaaga gggtgctggg
     2941 agaaggtgaa gatcagtcta agctgccacg gtgatgagac cttctcatta tgtaactctt
     3001 gatggcattt cccttctgag tgaagatttg aaatatgatt gattagaatt gtgctcttga
     3061 tggctgggaa tttagaaatt ttattttaag agttatttca ttttcatcct aagagtgatg
     3121 ggagagaaat gtccaaaaga gatctgctga tctgctgaga gtttcaaaca aacaaaaaaa
     3181 taatctctat gtatgtgttg gataaagtct acagactgac taacatgcat tagcaaatgg
     3241 agcatcagta ggtagcaaca tgataattta tgtaactgat agcttctgtc cttattagta
     3301 cacttaacat ttgagactag tatttattga tccaggcaaa gtaattaatt aatcatgctt
     3361 gggcttactt tttcagtttg taaggttaag catatgtgca tgcgtgcgtg tgtatataaa
     3421 tgccttttcc atatcttaaa tgtccctgat gaggagagca gtcatcaatt aaatatataa
     3481 gctcttaaaa tgagaatgga agtgtcagta tagacccagt gtacttaagt gctgatgact
     3541 gttagccagt ttacaacttt ttaccatcga tgtacacatt tgatatttgt gcagtaaata
     3601 gactgtacct ataaaaaatt ttattgatgt ttatggtcat gttagctatc agagagctat
     3661 tggagtgaga gctgaggtgt ccttaaccac tttttctctc ctagattcat tttcattatt
     3721 tatgctagga ttttcttatg gttgacattt gatgacagga agcaatcatg actcttcaag
     3781 tgagctcaca gaaacctttc atgttgtctg tttccaaaat ggattcaata aacaacattt
     3841 tgtccatgtt a
//
