LOCUS       NM_181334               2155 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens PRR5-ARHGAP8 readthrough (PRR5-ARHGAP8), mRNA.
ACCESSION   NM_181334
VERSION     NM_181334.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Winham SJ, Cuellar-Barboza AB, McElroy SL, Oliveros A, Crow S,
            Colby CL, Choi DS, Chauhan M, Frye MA and Biernacka JM.
  TITLE     Bipolar disorder with comorbid binge eating history: a genome-wide
            association study implicates APOB
  JOURNAL   J Affect Disord 165, 151-158 (2014)
   PUBMED   24882193
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Johnstone CN, Castellvi-Bel S, Chang LM, Sung RK, Bowser MJ, Pique
            JM, Castells A and Rustgi AK.
  TITLE     PRR5 encodes a conserved proline-rich protein predominant in
            kidney: analysis of genomic organization, expression, and mutation
            status in breast and colorectal carcinomas
  JOURNAL   Genomics 85 (3), 338-351 (2005)
   PUBMED   15718101
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE,
            Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida
            JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O,
            Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD,
            O'Brien KP et al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98743.1, BX335168.2,
            AF195968.1 and Z83838.2.
            
            On Aug 13, 2020 this sequence version replaced NM_181334.5.
            
            Summary: The PRR5-ARHGAP8 mRNA is an infrequent but naturally
            occurring read-through transcript of the neighboring proline rich
            5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8)
            genes. The resulting fusion protein contains sequence identity with
            each individual gene product, and it includes domains
            characteristic of a RhoGAP protein. The significance of this
            read-through transcript and the function of its protein product
            have not yet been determined. [provided by RefSeq, Nov 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145313,
                              SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 23779, 55615
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                Z98743.1           71281-71309
            30-250              BX335168.2         1-221
            251-289             Z98743.1           71531-71569
            290-795             BX335168.2         259-764
            796-2087            AF195968.1         393-1684
            2088-2155           Z83838.2           48168-48235
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..2155
                     /gene="PRR5-ARHGAP8"
                     /note="PRR5-ARHGAP8 readthrough"
                     /db_xref="GeneID:553158"
                     /db_xref="HGNC:HGNC:34512"
     exon            1..405
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1966
                     /gene="PRR5-ARHGAP8"
                     /note="PRR5-ARHGAP8 fusion"
                     /codon_start=1
                     /product="PRR5-ARHGAP8 fusion protein"
                     /protein_id="NP_851851.3"
                     /db_xref="GeneID:553158"
                     /db_xref="HGNC:HGNC:34512"
                     /translation="MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWN
                     SIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDK
                     IRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDD
                     RFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSL
                     GWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSEL
                     HEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDK
                     NQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDI
                     HIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLR
                     YLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYY
                     EKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL"
     exon            406..486
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            487..535
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            536..593
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            594..743
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            744..831
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            832..963
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1050
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1149
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1260
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1334
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1412
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1541
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1645
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2155
                     /gene="PRR5-ARHGAP8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2091
                     /gene="PRR5-ARHGAP8"
                     /note="major polyA site"
     polyA_site      2155
                     /gene="PRR5-ARHGAP8"
                     /note="major polyA site"
ORIGIN      
        1 ggcctccgtt tgcgccgggt ctgtgctggc cgcgcgcctg gcgctccacg ctgagcctct
       61 ccgtgcaatg attaacccgg cggggcggcc ggcgcgggac ccgagacgga ggcgcggggc
      121 cggggcggga ccccgcagga ccgctcggct tcctgctctc gccggagttt ccgcgtagag
      181 ggcgcatcgc cggcccgggg cccttggtgc ggcgtggcgc agggcgcggc gtggggcgcg
      241 cgtgggcgcg gcgcaggcgg cccgggtcac catgaggact ctccgcaggt tgaagttcat
      301 gagttcgccc agcctcagtg acctgggcaa gagagagccg gccgccgccg cggacgagcg
      361 gggcacgcag cagcgccggg cctgcgccaa cgccacctgg aacagcatcc acaacggggt
      421 gatcgccgtc ttccagcgca aggggctgcc cgaccaggag ctcttcagcc tcaacgaggg
      481 cgtccggcag ctgttgaaga cagagctggg gtccttcttc acggagtacc tgcagaacca
      541 gctgctgaca aaaggcatgg tgatccttcg ggacaagatt cgcttctatg aggagctgca
      601 gagagacaag gcggcggcgg ctgctgtgct gggtgcagtg aggaagaggc cctcggtggt
      661 gcccatggct ggccaggatc ctgcgctgag cacgagtcac ccgttctacg acgtggccag
      721 acatggcatt ctgcaggtgg caggggatga ccgctttgga agacgtgttg tcacgttcag
      781 ctgctgccgg atgccaccct cccacgagct ggaccaccag cggctgctgg agtatttgaa
      841 gtacacactg gaccaatacg ttgagaacga ttataccatc gtctatttcc actacgggct
      901 gaacagccgg aacaagcctt ccctgggctg gctccagagc gcatacaagg agttcgatag
      961 gaagtacaag aagaacttga aggccctcta cgtggtgcac cccaccagct tcatcaaggt
     1021 cctgtggaac atcttgaagc ccctcatcag tcacaagttt gggaagaaag tcatctattt
     1081 caactacctg agtgagctcc acgaacacct taaatacgac cagctggtca tccctcccga
     1141 agttttgcgg tacgatgaga agctccagag cctgcacgag ggccggacgc cgcctcccac
     1201 caagacacca ccgccgcggc ccccgctgcc cacacagcag tttggcgtca gtctgcaata
     1261 cctcaaagac aaaaatcaag gcgaactcat cccccctgtg ctgaggttca cagtgacgta
     1321 cctgagagag aaaggcctgc gcaccgaggg cctgttccgg agatccgcca gcgtgcagac
     1381 cgtccgcgag atccagaggc tctacaacca agggaagccc gtgaactttg acgactacgg
     1441 ggacattcac atccctgccg tgatcctgaa gaccttcctg cgagagctgc cccagccgct
     1501 tctgaccttc caggcctacg agcagattct cgggatcacc tgtgtggaga gcagcctgcg
     1561 tgtcactggc tgccgccaga tcttacggag cctcccagag cacaactacg tcgtcctccg
     1621 ctacctcatg ggcttcctgc atgcggtgtc ccgggagagc atcttcaaca aaatgaacag
     1681 ctctaacctg gcctgtgtct tcgggctgaa tttgatctgg ccatcccagg gggtctcctc
     1741 cctgagtgcc cttgtgcccc tgaacatgtt cactgaactg ctgatcgagt actatgaaaa
     1801 gatcttcagc accccggagg cacctgggga gcacggcctg gcaccatggg aacaggggag
     1861 cagggcagcc cctttgcagg aggctgtgcc acggacacaa gccacgggcc tcaccaagcc
     1921 taccctacct ccgagtcccc tgatggcagc cagaagacgt ctctagtgtt gcgaacactc
     1981 tgtatatttc gagctacctc ccacacctgt ctgtgcactt gtatgttttg taaacttggc
     2041 atctgtaaaa ataaccagcc attagatgaa ttcagaacct tctaatgaaa actccatgcc
     2101 tctggtcctt ggactcttgt ccatggttcc tgagctgtgg accgggatag aataa
//
