LOCUS       NM_001190467            4467 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens proline rich 36 (PRR36), transcript variant 1, mRNA.
ACCESSION   NM_001190467 XM_001717591 XM_001719253 XM_001719282
VERSION     NM_001190467.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4467)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010336.8, KF459711.1 and AL537525.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001190467.1.
            
            Summary: This gene encodes a large protein of unknown function that
            contains internal regions of low complexity sequence. Alternative
            splicing results in multiple transcript variants. The transcript
            structure of the protein-coding variant at this locus is conserved
            between human and mouse. [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2154665,
                              SAMEA2162328 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000618550.5/ ENSP00000482374.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC010336.8         55497-55601         c
            106-224             AC010336.8         54789-54907         c
            225-348             KF459711.1         1-124
            349-383             AL537525.3         335-369
            384-427             KF459711.1         279-322
            428-486             AC010336.8         54409-54467         c
            487-599             AC010336.8         54061-54173         c
            600-3641            AC010336.8         50927-53968         c
            3642-4467           AC010336.8         49931-50756         c
FEATURES             Location/Qualifiers
     source          1..4467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4467
                     /gene="PRR36"
                     /note="proline rich 36"
                     /db_xref="GeneID:80164"
                     /db_xref="HGNC:HGNC:26172"
     exon            1..105
                     /gene="PRR36"
                     /inference="alignment:Splign:2.1.0"
     exon            106..383
                     /gene="PRR36"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..4153
                     /gene="PRR36"
                     /codon_start=1
                     /product="proline-rich protein 36"
                     /protein_id="NP_001177396.1"
                     /db_xref="CCDS:CCDS74276.1"
                     /db_xref="GeneID:80164"
                     /db_xref="HGNC:HGNC:26172"
                     /translation="MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAAL
                     RVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGER
                     APPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGA
                     RRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTT
                     EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKG
                     LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPS
                     PPVTPPPPAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT
                     PPSQVPPTQLIMSFPEAGVSSLATAAFVASVSPSVSSPLQSMPPTQANPALPSLPTLL
                     SPLATPPLSAMSPLQGPVSPATSLGNSAFPLAALPQPGLSALTTPPPQASPSPSPPSL
                     QATPHTLATLPLQDSPLLATLPLQASPSPLTTVSLQDPPLVSPSLLASPPLQAPPHPQ
                     APPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQA
                     THSFLTMSPRQTQASLISPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP
                     LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSL
                     APPPLQTASAPLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPL
                     TTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPALALPPLQAPP
                     SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP
                     SQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPS
                     ATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFP
                     GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS
                     VSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAA
                     SPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE
                     SATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLS
                     RTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASIT
                     SVTSFSPDDVASPQGDWTVVEVETFH"
     exon            384..486
                     /gene="PRR36"
                     /inference="alignment:Splign:2.1.0"
     exon            487..599
                     /gene="PRR36"
                     /inference="alignment:Splign:2.1.0"
     exon            600..3641
                     /gene="PRR36"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..4467
                     /gene="PRR36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4441..4446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR36"
                     /note="hexamer: AATAAA"
     polyA_site      4467
                     /gene="PRR36"
                     /note="major polyA site"
ORIGIN      
        1 agccccctcc cctcgcctcc tcgccgctgg cggccaccgc gtcgctccgg cccgggcccc
       61 accccaggcg actctgtgag gagcggccgg aggccggagg cggaggtgca agatggacaa
      121 caagagagac aaggcgaagg caggggccgc cgcgcggacg ccggctgctc gcgctcctgg
      181 acttctgacc cccaggcccc caggctctcc tcgaccccct cccccagtaa ctcccgcagc
      241 cctccgagtt ctgggagctg cgggagcagt ggggcgaaag cctctggcag agcgagcggg
      301 gggcatcggc ggggccacta ttcccgagtc tgctccccga gcgggaccaa cgcggagtgc
      361 tgggacaagt tcccgaaacc ctgcctccag gcccccagcc tctgggagag gggagagagc
      421 tcctcctgcc aagaacacca gcccaggccc tgtttctagc ccagggcgtg ccagcgggac
      481 caccaggcca ggccctcttg gccagaaggg actccggatc tcagcggagg aaactgtggc
      541 cagaggaaaa gctacagagg ctcccaaaag gagtgccctc agcgctgggg cacggagaga
      601 cacttccggg cctaccccag gaaccccgtc cccggccatg gcccgtcggt cccgggctgc
      661 gggcaccgag gtggggctcc cccggccagc tccgagtgcc cggccacggc ccccgacaga
      721 gggcccccgg aaatcagtga gcagcgcctc ggagcacagt accaccgagc caagcccggc
      781 tgccaggagg cggcccagcg ccggtggggg tctccagagg ccggcctcgc gctccctgag
      841 ctccagcgcc acccctctct cctccccagc ccgttctggg ccctcagccc gcggaacacc
      901 cagggctcct gcgcatccct cgcagcccaa gccgaaagga ctgcaggctc tgcgaccccc
      961 tcaggtcaca cccccaagga aggacgcagc cccagcacta ggaccgcttt cttcctctcc
     1021 tttggccaca ccctctccat cgggtaccaa ggcaagaccc gtaccgcctc ccgacaatgc
     1081 agccactccc ctgccagcca cgctccctcc ctctccaccg gtaacgcccc ctccgccagc
     1141 cgctctccaa agtcaggccc cgcccaccct gccggccacg ccccactcgt cgagccttac
     1201 ctgtcagttg gccacgcccc ttcctctagc ccctccttct ccctctgctc caccttctct
     1261 gcagaccctc ccctctccac cagccacgcc cccctcgcaa gttccaccca cacagctgat
     1321 tatgtccttt ccagaagcag gcgtctcttc cctggccaca gccgcttttg tggcttcagt
     1381 ctctccatca gtttcatccc ctctgcagag tatgcccccc acccaagcta atccagcgtt
     1441 gccctctctt ccgactctcc tctctccctt ggccacacct cctctgtcag ccatgtctcc
     1501 tctacaaggc cctgtttctc cggcaacatc tctggggaat tcggcttttc ccctggccgc
     1561 actccctcag ccaggccttt ctgctctgac cacgccccct ccgcaggcca gtccttcccc
     1621 gtctccgccc tctctccagg ccacgcccca cactctggcc actcttcctc tgcaggactc
     1681 tcctcttctg gccacattgc ctctgcaggc ctctccctct cctttgacca cagtctctct
     1741 gcaggatcct cctctagttt ctccctctct tttggcctca ccgcctctgc aggctccgcc
     1801 ccacccacag gccccacctt ctatgactac gccccctatg caggccccgc cctctctcca
     1861 gaccattccc ccaatacagg tcccacattc tctgacctca ccgtctctgc aggcacctcc
     1921 ctctcctctg gctttgtcct ctctgcaggc cacaacttct ttgggctcac ccactctgca
     1981 ggccacacat tctttcctga caatgtcccc taggcaaacc caagcttctt tgatctcacc
     2041 ttctcggccg gcctctactc cccctgattc accccctctg caggcccctc tttcccttcc
     2101 tgcctcaccc cctctgcaga cttctctctc tcctgctgtc tcacccctaa gctcacccct
     2161 gaccatacac cctctgcagg cgctatcttc tctggcctcc cactctcctc aggcacctct
     2221 ctcttccctg atcatgcccc ctctggagac ccaatcttcc ctagccccac cctctctgca
     2281 gacacctcct gcttccctga ccacaccccc tctggagaac ctaccttctc tagccccgcc
     2341 tcctctgcag acagcttctg ctcccctgac cacaccccct ctggagaacc taccttctct
     2401 agccccgcct cctctgcaga cagcttctgc tcccctgacc acaccccatc tggagactcc
     2461 accttgtcca gccccatgcc ctctgcaagc accaccttcg ccattgacca cgccccctcc
     2521 ggagacgccc tcttccatag ccacgcctcc tccacaggcc ccacctgctc tggcctcacc
     2581 ccctttgcag ggcctgccct ctccccctct gtctcctttg gccacgcccc ctccacaggc
     2641 cccacctgcc ctggccttgc ctcctctgca ggcccctccc tctccccctg cctcaccccc
     2701 tctgtctcct ttggccacac cctctccaca ggccccaaat gctctggcag tgcaccttct
     2761 gcaggcccct ttctctcccc ctccctcacc cccagtgcag gcccctttct ctccccctgc
     2821 ctcaccccca gtgtctcctt cggccacgcc cccttcacag gccccaccct ctctagccgc
     2881 acctcctctg caggtcccac cctctccccc tgcctctccc ccaatgtctc cttcagccac
     2941 gccccctcca caggccccac cccctctcgc tgcgcctcct ctgcaggtcc caccctctcc
     3001 ccctgcctct cccccaatgt ctccttcggc cacgccccct ccacgggtcc caccccttct
     3061 tgccgctcct cctctgcagg tcccgccctc tccccctgcc tcactcccaa tgtctccttt
     3121 ggctaagccc cctccacagg ccccacctgc tctggccaca cctcctctgc aggcccttcc
     3181 ctctccgcct gcctcattcc ctgggcaggc ccctttctca ccctctgcct cactcccaat
     3241 gtctcctttg gccacgcctc ctccacaggc cccacctgtt ctggcagcgc cccttctgca
     3301 ggtccctccc tctccccctg cctcacccac cctgcaggcc ccacgccgcc ccccgacccc
     3361 gggtccggat acctccgtct cgggcccacg gctgaccctg gcgttggccc ccggcccgcc
     3421 gccgccgccc tcgcgcagcc cgtccagcac gctgagcggc ccagacctgg ccggccacag
     3481 cagcagcgcc acgagcacgc cagaggagct gcgtggctac gacagcgggc ccgagggcgg
     3541 tgccgcagcc tccccgcccc ccgacgcaga gctcgccgct tgccacccgg ctgcctggag
     3601 tcgaggcccc gctccgccgc tggctttccg cggagcccca ggtgcgcccc tgccgtggcc
     3661 tcccgctacc ggaccgggct ctgctgacgg tctgtgcacc atctacgaga ctgaagggcc
     3721 cgagtcggcg acccccgccc ctggcgcact ggatccgggg cccagtcccg gcacgagcgg
     3781 tgggaaggcg gcggctgggg ccggggccgg ggcgtcctcg cggagcccga agcaggcgcg
     3841 cctgggcgag ctgccactgg gggcgctgca ggcgagcgtc gtgcagcacc tgctgagccg
     3901 gacgctgctg ctggcggctg ccgagggtgc cgcgggcggc agcggcgggg gcccaggagg
     3961 tgcggagggt ggtggcgtca cagggggcgc ccgggctgca ctcagcgacg ccgaactcgg
     4021 ccgctgggcc gaactactgt ctcccctgga cgagtcccgt gccagcatca cctcggtcac
     4081 cagcttctct ccggacgacg tggcctcccc gcagggtgac tggaccgtgg tggaggtgga
     4141 gaccttccac tgagccagac cacagccccg cctgctacac cccacccctg ccttaggatc
     4201 cgcccctccg ggtacgccgt ttgttttaga ccccgcctcc actgccctgg agccccgctg
     4261 ggtggattag tcttagctcc ctagagcctg agcctttggc ctcggaggct cgggacctac
     4321 ccacagcttt gacctaggcc cgcccctcga gctccgcccc tttggcctag gacacgcccc
     4381 gtttccccga gtcccgcccc gtgtgcagtg tattgcccac cccgcacagc ctgagtttgc
     4441 aataaaactg ggacactggg acttgca
//
