LOCUS       NM_145270               2245 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proline rich 35 (PRR35), mRNA.
ACCESSION   NM_145270
VERSION     NM_145270.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z97986.3 and BC016613.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145270.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016613.1, SRR3476690.934490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409413.4/ ENSP00000386499.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                Z97986.3           28969-28996
            29-263              BC016613.1         1-235
            264-264             Z97986.3           29232-29232
            265-2041            BC016613.1         237-2013
            2042-2042           Z97986.3           33901-33901
            2043-2245           BC016613.1         2015-2217
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2245
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /note="proline rich 35"
                     /db_xref="GeneID:146325"
                     /db_xref="HGNC:HGNC:14139"
     exon            1..268
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            269..1389
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2023
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /codon_start=1
                     /product="proline-rich protein 35"
                     /protein_id="NP_660313.1"
                     /db_xref="CCDS:CCDS45365.1"
                     /db_xref="GeneID:146325"
                     /db_xref="HGNC:HGNC:14139"
                     /translation="MSREAGSCRVGTGARARSRKPKKPHYIPRPWGKPYNYKCFQCPF
                     TCLEKSHLYNHMKYSLCKDSLSLLLDSPDWACRRGSTTPRPHAPTPDRPGESDPGRQP
                     QGARPTGAAPAPDLVVADIHSLHCGGGPKSRAKGSPGPPPPVARATRKGPGPSGLLPE
                     SWKPGMGGDPRGVGAGDMASAGPEGSVPCYPPPAPGEFPEAHSLHLSLLGVNYPLSPG
                     LFSYLGPSLAAAAHVPFLASASPLLPPATAFPAVQPPQRPTPAPRLYYPLLLEHTLGL
                     PAGKAALAKAPVSPRSPSGTPAPGLLKVPVPGLGPWPRVTPRDPGQEGELERAAQSDP
                     RRRLSLGSRLELPKASPSLTRFCSRSSLPTGSSVMLWPEDGDPGGPETPGPEGPLPLQ
                     PRGPVPGSPEHVGEDLTRALGDYARVEQRLGQLGPAGGLAPRPLREQLGKIRLELLTI
                     HQALEQAVRPPDAPLDLSVKRAPAKGPQALGEAWGRPELGPVLTGGTPEPPGMLGPAA
                     PQPFSGHTTKCEADSSVPPPGLPLAAPDDPVIPGSGWGTCVATRSSQTPEAVCGLQSP
                     QGAEV"
     exon            1390..2245
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /note="hexamer: ATTAAA"
     polyA_site      2245
                     /gene="PRR35"
                     /gene_synonym="C16orf11; LA16c-366D1.2"
                     /note="major polyA site"
ORIGIN      
        1 aacttcggga ggtgcgagcg gcgtcggggg gacgcgggcg gcggcggagg ctgcgggagt
       61 cgctgccgct cgagggaccg cggacccggg aggtccggct cccggcgccg ggcctcagtt
      121 tcccccacgg gagccgcatc ccacccccag agccccagcg cgtccgcggg gtccgagtcg
      181 cggccggcgc ggggcgggga ggggcgggaa gtttgcgccc tacacgcggc ctcgcagact
      241 tggcggctcc gctcccggcc gggcgcaggt ggccatggtg cccggccctg cctcatagca
      301 ggctgccatg tcgcgggagg cgggctcatg ccgcgtgggc acaggggcga gggcgcggtc
      361 tcggaagccc aagaagccac actacatccc gcggccctgg ggcaaaccct acaactacaa
      421 atgcttccag tgccccttca cctgcctgga gaagtcacac ctctacaacc acatgaagta
      481 cagcctctgc aaggactccc tgtccctgct gctagactcc ccagactggg cgtgccgccg
      541 tggctccacc acgcctaggc cccacgcacc caccccagac cgccctgggg agtccgaccc
      601 cggcaggcaa ccccagggag cacggcccac aggtgctgcc cccgcgcctg acctcgtggt
      661 cgccgacatc cactccctgc actgtggcgg aggccccaag tccagggcca aggggtcccc
      721 agggccacca ccccctgtgg ctagggccac ccggaagggt cccggcccca gtgggctcct
      781 gcctgagtcg tggaagccgg ggatgggagg ggacccaagg ggcgtgggtg cgggggacat
      841 ggcctcagca ggccctgagg gcagcgtccc ctgctatccc ccgcctgccc caggggagtt
      901 ccctgaggcc cacagcctcc acctgtctct gctgggcgtc aactacccgc tcagccccgg
      961 cctcttctcc tacttggggc cctcactggc cgctgcagcc catgtgccct tcctggcctc
     1021 ggccagcccc ctgctgcccc cggccacggc cttcccagcc gtgcagcccc ctcagcgccc
     1081 caccccggcc ccccgcctgt actacccgct gcttctggag cacactctgg ggctgccagc
     1141 aggcaaagct gcccttgcca aggcccctgt ctcccccagg agcccctctg ggactccggc
     1201 tcctggcctg ctgaaggtgc cagttccagg gctggggccc tggccccgag tcacccccag
     1261 ggacccaggg caggaggggg agctggagcg ggcagcccag agtgacccca ggaggaggct
     1321 gtccctggga agcaggctgg agcttccgaa ggcatccccc agcctgacaa ggttctgttc
     1381 ccggagcagc ctgcccaccg gctcctctgt gatgctgtgg cctgaggacg gggatccagg
     1441 cggccctgag acccccggcc ctgagggccc cctccccctg cagccacggg gcccagtgcc
     1501 aggaagcccg gagcatgtgg gcgaggacct gacccgagcc ctcggtgact acgccagggt
     1561 ggagcagcgc ctgggacagt tggggcccgc ggggggcctg gccccgagac ccctgcggga
     1621 gcagctgggc aagatccgcc tggagctgct caccattcac caggcgctgg agcaggccgt
     1681 gaggccgcca gacgcacccc tcgacctctc tgtgaaacgt gcgcccgcca aggggcccca
     1741 ggctcttgga gaggcgtggg ggcggcccga gctgggtccc gtgttgaccg ggggcacccc
     1801 cgagccaccc ggcatgctgg gccctgcagc gccccaaccc ttctctggcc acaccaccaa
     1861 gtgtgaggcc gactccagcg tcccaccccc agggctcccc ctcgcagccc cagatgaccc
     1921 tgtcattcct ggcagtggct ggggcacctg tgttgcgacg aggagttccc agacccctga
     1981 ggctgtctgt ggcctgcaga gcccccaggg cgccgaggtc tgacctgcag cgcctgaggt
     2041 ctgactgtct ctgcctgcag catgccggcc cctctcctgc agcccctgcc cctcacctgc
     2101 ctgggacctg ccccgcctcc gcatgcatgt ggatagaccc ccacgggccg tggccaacgc
     2161 ttgtccctgg ggccacacag ggacactgga ggtcacagtt atttattgat cacaattgtg
     2221 gacattaaaa cagaaactgt tcaca
//
