LOCUS       NM_001395380            3818 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens proline rich 33 (PRR33), mRNA.
ACCESSION   NM_001395380
VERSION     NM_001395380.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3818)
  AUTHORS   Lindstrom,S., Thompson,D.J., Paterson,A.D., Li,J., Gierach,G.L.,
            Scott,C., Stone,J., Douglas,J.A., dos-Santos-Silva,I.,
            Fernandez-Navarro,P., Verghase,J., Smith,P., Brown,J., Luben,R.,
            Wareham,N.J., Loos,R.J., Heit,J.A., Pankratz,V.S., Norman,A.,
            Goode,E.L., Cunningham,J.M., deAndrade,M., Vierkant,R.A., Czene,K.,
            Fasching,P.A., Baglietto,L., Southey,M.C., Giles,G.G., Shah,K.P.,
            Chan,H.P., Helvie,M.A., Beck,A.H., Knoblauch,N.W., Hazra,A.,
            Hunter,D.J., Kraft,P., Pollan,M., Figueroa,J.D., Couch,F.J.,
            Hopper,J.L., Hall,P., Easton,D.F., Boyd,N.F., Vachon,C.M. and
            Tamimi,R.M.
  TITLE     Genome-wide association study identifies multiple loci associated
            with both mammographic density and breast cancer risk
  JOURNAL   Nat Commun 5, 5303 (2014)
   PUBMED   25342443
  REMARK    Erratum:[Nat Commun. 2015 Sep 09;6:8358. doi: 10.1038/ncomms9358..
            PMID: 26349435]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3818)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   3  (bases 1 to 3818)
  AUTHORS   Easton,D.F., Pooley,K.A., Dunning,A.M., Pharoah,P.D., Thompson,D.,
            Ballinger,D.G., Struewing,J.P., Morrison,J., Field,H., Luben,R.,
            Wareham,N., Ahmed,S., Healey,C.S., Bowman,R., Meyer,K.B.,
            Haiman,C.A., Kolonel,L.K., Henderson,B.E., Le Marchand,L.,
            Brennan,P., Sangrajrang,S., Gaborieau,V., Odefrey,F., Shen,C.Y.,
            Wu,P.E., Wang,H.C., Eccles,D., Evans,D.G., Peto,J., Fletcher,O.,
            Johnson,N., Seal,S., Stratton,M.R., Rahman,N., Chenevix-Trench,G.,
            Bojesen,S.E., Nordestgaard,B.G., Axelsson,C.K., Garcia-Closas,M.,
            Brinton,L., Chanock,S., Lissowska,J., Peplonska,B., Nevanlinna,H.,
            Fagerholm,R., Eerola,H., Kang,D., Yoo,K.Y., Noh,D.Y., Ahn,S.H.,
            Hunter,D.J., Hankinson,S.E., Cox,D.G., Hall,P., Wedren,S., Liu,J.,
            Low,Y.L., Bogdanova,N., Schurmann,P., Dork,T., Tollenaar,R.A.,
            Jacobi,C.E., Devilee,P., Klijn,J.G., Sigurdson,A.J., Doody,M.M.,
            Alexander,B.H., Zhang,J., Cox,A., Brock,I.W., MacPherson,G.,
            Reed,M.W., Couch,F.J., Goode,E.L., Olson,J.E., Meijers-Heijboer,H.,
            van den Ouweland,A., Uitterlinden,A., Rivadeneira,F., Milne,R.L.,
            Ribas,G., Gonzalez-Neira,A., Benitez,J., Hopper,J.L., McCredie,M.,
            Southey,M., Giles,G.G., Schroen,C., Justenhoven,C., Brauch,H.,
            Hamann,U., Ko,Y.D., Spurdle,A.B., Beesley,J., Chen,X.,
            Mannermaa,A., Kosma,V.M., Kataja,V., Hartikainen,J., Day,N.E.,
            Cox,D.R. and Ponder,B.A.
  CONSRTM   SEARCH collaborators; kConFab; AOCS Management Group
  TITLE     Genome-wide association study identifies novel breast cancer
            susceptibility loci
  JOURNAL   Nature 447 (7148), 1087-1093 (2007)
   PUBMED   17529967
REFERENCE   4  (bases 1 to 3818)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC051649.21.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640310.2/ ENSP00000491327.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3818              AC051649.21        106122-109939
FEATURES             Location/Qualifiers
     source          1..3818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..3818
                     /gene="PRR33"
                     /gene_synonym="C11orf89"
                     /note="proline rich 33"
                     /db_xref="GeneID:102724536"
                     /db_xref="HGNC:HGNC:35118"
     exon            1..3818
                     /gene="PRR33"
                     /gene_synonym="C11orf89"
                     /inference="alignment:Splign:2.1.0"
     CDS             1312..2751
                     /gene="PRR33"
                     /gene_synonym="C11orf89"
                     /codon_start=1
                     /product="proline-rich protein 33"
                     /protein_id="NP_001382309.1"
                     /db_xref="CCDS:CCDS91402.1"
                     /db_xref="GeneID:102724536"
                     /db_xref="HGNC:HGNC:35118"
                     /translation="MLISAASMAPEVCGPSLQGTPGPPPPLLPKPGKDNLRLQKLLRK
                     AARKKMMGGTHLAPPRAFRTSLSPVSEASHDQEVTAPHAAEGPHPAEAPRLPEAPRPA
                     EAPRMVAALPRSPHTPIIHHVASPLQKSTFSIGLTQRRILAAQFRAMGPQVVASAPEP
                     TRPPSGFVPVSGGGGTHVTQVHIQLAPSPHNGTPEPPRTAPEVGSNSQDGDATPSPPR
                     AQPLVPVAHIRPLPTTVQAASPLPEEPPVPRPPPGFQASVPREASARVVVPIAPTCRS
                     LESSPHSLVPMGPGREHLEEPPMAGPAAEAERVSSPAWASSPTPPSGPHPCPVPKVAP
                     KPRLSGWTWLKKQLLEEAPEPPCPEPRQSLEPEVPTPTEQEVPAPTEQEVPALTAPRA
                     PASRTSRMWDAVLYRMSVAEAQGRLAGPSGGEHTPASLTRLPFLYRPRFNARKLQEAT
                     RPPPTVRSILELSPQPKNFNRTATGWRLQ"
ORIGIN      
        1 agggtaggtc atgctggcaa caggaagcaa cttcttagcc agggccgggg ggcgggtgtc
       61 tggctggaat ctcccctggg tacatggagg gtgccagccg gctggacctg cagacccagg
      121 aagctggaac ataggcatgg ggtgcagggg gcattaggct agggtccagg gaggggccac
      181 agacctgcct cctgcaagcc cacagagcct gctccccgag cctctctctg ctggcctccc
      241 tgccctgccc acacccccac tccaccacag gagaagacgt cctgcctcag aggcctgctt
      301 cccagtgcga gcacttgtgc cctgggtcag gacctctggc tggagacctg actcctggtg
      361 gagggaaggc ggcctgcctg ccaagcagcc tgcccaccct gggagctaga actggggttc
      421 tcgtggttcc tgcagtcccg tcatccagag gaggccggta gctgagagca gtcctaagca
      481 ggctccttcc gcccccaccc ctccagcagc tctgttcttg ccttggcaga gccagccccc
      541 accagcggca gcccccagga ctccctcctt ccccaaacca gagagcctct ggctcggaca
      601 gatgccattt gtcaatgtcc ttgcaaacac gtggtgccca gaaaccaggg tgggcggctt
      661 ggccgggcca ccccagacag gaggtctgcg ggaatatccc atttagcata gctcagcgaa
      721 aactgctccc accttccggc caatctacct ctgatgatgc agcctcggct ttcccaagcc
      781 tcttggccgc cacccctcac cgctggctcg cagcggacgc gcctgtggtt gagccggcga
      841 caacagggcg cccctcacgt gtctgggggc agccgctctt ccagccctgg gcttggccag
      901 cagctggcca ggggcatgcc tgtcacttgg ggctcacccg cgtctccgtc tcccacccca
      961 gcccacacgg tgttgcggcc tgacccaggc tgtgtacttg gggcctgctt tgtgctgggg
     1021 tggcatggag gacagagccc tggaggcagg ttctagcccc atccctggag ggactcggcc
     1081 tctgtggcct catttctaca ctagggtgat ggtggggcca ccccaaagtc cccaaggcac
     1141 agtcgagctc agcatgtccc tggcaggttc tgggtgctca ggaagcagaa tactcaggcc
     1201 tccacacccc tggccccagg tcctccttgg accacaggag acacaggcct cccacctcag
     1261 gagggaggag ggctggcctg accactgtcc ctcccaccct aggacacagt catgctcata
     1321 tcggctgcgt cgatggcacc cgaggtgtgc ggcccaagcc tccagggaac ccctggaccc
     1381 ccaccgcccc tgctgcccaa gccagggaag gacaacttgc gtttgcagaa gctcctgagg
     1441 aaggcagccc ggaagaagat gatgggaggc acacacctcg ctccacccag ggccttccgc
     1501 acctccctgt cccccgtgag tgaggccagc catgaccagg aggtcacagc cccgcacgct
     1561 gctgagggcc cgcaccccgc cgaagcccca cgccttcctg aagccccacg ccccgccgag
     1621 gctccccgca tggtggctgc cctaccccgc tccccgcaca cccccatcat ccaccacgtg
     1681 gcatcacccc tgcagaagtc cacgttctcc atcggcctca cccagcgcag gattctagct
     1741 gctcaattca gggccatggg gccccaggtt gtagcctcgg ccccagaacc tacccggccc
     1801 cccagtggct tcgtccctgt ctctgggggt gggggcaccc acgtcaccca ggtgcacatc
     1861 cagctggcac catccccaca caatgggacc cctgagcctc ccaggacagc cccagaagtg
     1921 ggatccaaca gccaggatgg agatgccacc ccaagtcccc ccagggccca gcccctggtc
     1981 ccagtggctc acatccgccc actgcccacc acagtccagg ctgccagtcc cttgcctgag
     2041 gagccccctg taccacggcc gccacccggc ttccaggcct cagtgcccag agaggctagt
     2101 gccagggttg tggtgcccat agccccgacc tgccgctcgc tggagtcctc accgcacagc
     2161 ctggtcccca tgggccctgg cagagagcac ctggaggagc ccccgatggc tggccccgcc
     2221 gctgaggccg agcgagtgtc cagccctgcc tgggcctcat cccctacccc accatcaggc
     2281 cctcacccat gccctgtccc caaagttgca cccaagcccc ggctcagtgg ctggacgtgg
     2341 ctcaagaagc agctgctgga ggaggcccca gagcctccgt gcccagagcc gcggcagagc
     2401 ctggagccag aggtgcccac ccccacagag caggaggtgc ctgcccccac agagcaggag
     2461 gtgcccgccc tcaccgcacc ccgggccccc gcctcccgga cctccaggat gtgggatgcc
     2521 gtgctgtacc gcatgtcagt ggcggaggcc caagggcgcc tggcagggcc cagcggtggg
     2581 gagcacaccc cagccagcct cacccgcctg cccttcctgt accggcctcg cttcaacgcc
     2641 cggaagctgc aggaggccac ccggccccct cccacagtcc gctccatcct ggagctgagc
     2701 ccccagccca agaacttcaa ccgcacagcg actggctgga ggctccagtg aagtggccag
     2761 aatggccccc agagcccagg accatgggat ggacagaaga aggggctgag gctctagctg
     2821 ggggcccata gttgctgcat gaagatgcac cagggcccaa ggggcatggg gtgcagggca
     2881 gcctgggaag ggcacatggg gtgctgaggg aagtctgcat ggttaggagg gtggtcaggt
     2941 ggacggggca gagaggacga gctggagccc ctgggctgca gtggtgtgag gggaacagag
     3001 aaggggtctg cgtcgggatg taggatgggg gccttgggat gaaaacttta ggtaagatgg
     3061 cagaggactg catctactga cctagcccag gctcctcagg ggcctgggcc tctcactgat
     3121 cctccctttt gctgtcacct tttgctgtca aaggtttggg gccagatctc tgcttgctga
     3181 ggcatgggtg cggtcaggct ggcttggcca tcggcgtcag gagcagtcag cagttttgct
     3241 gcctgtgctt cctgatggca gagccagatc ctgggactag ggtgcagggg ggagccctca
     3301 gccagcgtgg gacttggcac caatacaagt gctcaggggc aggcagggag gggctcatca
     3361 ggggtggagg agggcccagc gtgacctctc tctcggccca cctctgcttc ccctacctgg
     3421 gctgacagcc tgagggggca gaactcgagg gattcgctgg tgggacagcg agggtctcag
     3481 cactggccat gcccaggctt tgacagctgg atgaggaggg agccctcagt cccaacccta
     3541 tgggaacagc ttggccaagc gggacagaga aggggctgtg gccctggtgg ggagagtgga
     3601 ggggcctact cagcagtcag ccaggctctg gtgggggtgg ccaaccacag gagagggaca
     3661 cagaggtacc agaaaaagcc tctgccacag ctgcttgaga gtcagggttt ggcaggggaa
     3721 gatggtagga ggacagctgc cccaccctgt ggtgtgatgg gtgctggaaa tggagcctgg
     3781 ggcccaggtc actaataaat gtgtgtctca ccatggca
//
